Article
Endocrinology & Metabolism
Danilo A. Moraes, Ricardo B. Machado, Michael Koban, Gloria E. Hoffman, Deborah Suchecki
Summary: This study compared the stress responses of animals exposed to different stressors to those of animals subjected to paradoxical sleep deprivation (PSD). The results showed that the pituitary-adrenal response to PSD was similar to that induced by psychological stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hebatullah Helmy, Nermin Abdel Hamid Sadik, Laila Badawy, Noha H. Sayed
Summary: The current study highlights the prophylactic role of eugenol in protecting against reproductive disturbances induced by chronic stress in female rats. It improves animals' behaviors, corrects hormonal imbalances, and repairs ovarian damage.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Shane B. Johnson, Ryan T. Lingg, Timothy D. Skog, Dalton C. Hinz, Sara A. Romig-Martin, Victor Viau, Nandakumar S. Narayanan, Jason J. Radley
Summary: This study explores the link between behavioral and biological features of stress responses in the brain. It identifies the involvement of the medial prefrontal cortex (mPFC) and midbrain dorsolateral periaqueductal gray (PAG) in active stress coping behaviors, while a different circuit involving the rostral mPFC and ventrolateral PAG limits passive behaviors. Furthermore, the activation of the caudal mPFC-dorsolateral PAG projection can attenuate the increase in stress hormone output and immobility associated with a passive coping response. These findings provide insights into how the brain coordinates different responses to stress and contributes to stress resilience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Sophida Phuthong, Cynthia Guadalupe Reyes-Hernandez, Pilar Rodriguez-Rodriguez, David Ramiro-Cortijo, Marta Gil-Ortega, Raquel Gonzalez-Blazquez, M. Carmen Gonzalez, Angel Luis Lopez de Pablo, Silvia M. Arribas
Summary: Fetal undernutrition has a significant impact on cardiometabolic diseases, with males showing higher susceptibility. The study revealed that male fetuses demonstrate poorer adaptation to undernutrition, associated with oxidative imbalance, reduced vascularization, and glucocorticoid barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tiago Silveira-Rosa, Antonio Mateus-Pinheiro, Joana Sofia Correia, Joana Margarida Silva, Joana Martins-Macedo, Bruna Araujo, Ana Rita Machado-Santos, Nuno Dinis Alves, Mariana Silva, Eduardo Loureiro-Campos, Ioannis Sotiropoulos, Joao Miguel Bessa, Ana Joao Rodrigues, Nuno Sousa, Patricia Patricio, Luisa Pinto
Summary: Our study demonstrates that regulation of the HPA axis response by hABN is sex-differentiated. Male GFAP-Tk rats show heightened acute stress response, while female GFAP-Tk rats exhibit increased corticosterone secretion at nadir and a heightened yet delayed response to an acute stress stimulus.
CELL PROLIFERATION
(2022)
Article
Ecology
Coline Marciau, Thierry Raclot, Sophie Bestley, Christophe Barbraud, Karine Delord, Mark Andrew Hindell, Akiko Kato, Charline Parenteau, Timothee Poupart, Cecile Ribout, Yan Ropert-Coudert, Frederic Angelier
Summary: In Antarctica, there is growing concern about the impact of human activities on wildlife. A study comparing Adelie penguins in disturbed and undisturbed areas found no significant impact on adults, but chicks from disturbed colonies had higher stress-induced corticosterone levels. Overall, the study suggests that Adelie penguins are tolerant to human disturbance, but chicks may be more sensitive.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Mie S. Berke, Louise K. D. Fensholdt, Sara Hestehave, Otto Kalliokoski, Klas S. P. Abelson
Summary: The present study investigated the effect of buprenorphine on animal welfare and pain-related behavior in a rat model of CFA-induced monoarthritis. Buprenorphine treatment reduced pain expression scores, improved mobility, and did not suppress the CFA-induced ankle swelling. The study suggests that buprenorphine can improve animal welfare in this model without interfering with the development of the intended pathology.
Article
Behavioral Sciences
Mariana A. Cortes, Katelynn M. Corder, Lynn E. Dobrunz
Summary: Anxiety disorders are commonly diagnosed in adolescence and adulthood. Stress can increase anxiety-related behaviors, but the effects of stress differ between adolescents and adults, including differences in behaviors and stress-relevant molecules such as NPY expression.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Neurosciences
Zhen Yao, Bei-Xuan Zhang, Hui Chen, Xiao-Wei Jiang, Wei-Min Qu, Zhi-Li Huang
Summary: Elevated glucocorticoid levels triggered by stress potentially contribute to sleep disturbances in stress-induced depression. However, the effects of the major glucocorticoid corticosterone (CORT) on sleep in rodents remain unclear. In this study, acute or chronic administration of CORT in mice resulted in rapid promotion of wakefulness, suppression of REM and NREM sleep, and altered EEG activity. Prolonged CORT exposure led to excessive wakefulness and REM sleep, decreased NREM sleep, and persistent sleep changes even after drug withdrawal. The observed sleep alterations were associated with elevated plasma CORT levels and depressive phenotypes. These findings provide insight into the neural link between insomnia and depression.
Article
Neurosciences
Yu-Fen Lin, Kao Chin Chen, Yen Kuang Yang, Ya-Hsin Hsiao
Summary: CRMP5 expression in the hippocampus was increased in stress-susceptible mice compared to control and stress-resilient mice, with a negative correlation between CRMP5 levels and social interaction ratio. Lowering hippocampal CRMP5 levels improved social interactions in stress-susceptible mice, while overexpression of CRMP5 induced social avoidance behaviors. Furthermore, increased CRMP5 expression also elevated serum corticosterone concentrations in stress-susceptible and CRMP5-treated mice. These findings shed light on how CRMP5 may contribute to susceptibility to social stress and suggest potential therapeutic targets for stress disorders in humans.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura Becker, Anne S. Mallien, Natascha Pfeiffer, Christiane Brandwein, Steven R. Talbot, Andre Bleich, Rupert Palme, Heidrun Potschka, Peter Gass
Summary: The forced swim test (FST) is a traditional assay used to assess the antidepressant effects of drugs. There has been a debate about the test's potential aversiveness and burden on animals. This study conducted an evidence-based assessment of the test's severity in rats and found that it causes only mild effects, primarily hypothermia. The researchers suggest refining the test by using warmer water temperatures to maintain the animals' physiological body temperature.
Review
Neurosciences
Amalie Floriou-Servou, Lukas von Ziegler, Rebecca Waag, Christa Schlappi, Pierre-Luc Germain, Johannes Bohacek
Summary: Studying the stress response is crucial in neuroscience research, with a focus on understanding the complex molecular cascades triggered by acute stressors to predict healthy or maladaptive responses.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Suzanne H. Austin, Rayna M. Harris, April M. Booth, Andrew S. Lang, Victoria S. Farrar, Jesse S. Krause, Tyler A. Hallman, Matthew MacManes, Rebecca M. Calisi
Summary: The study focused on the role of corticosterone (CORT) in regulating the transcriptomic stress response of the HPG axis in male and female rock doves. It revealed causal and sex-specific effects of CORT on gene expression, with females showing more transcriptional changes compared to males in response to elevated CORT. The research provides insights into potential therapeutic strategies for reproductive dysregulation in vertebrates, including humans, by targeting the HPG system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Muhammad Afzal, Imran Kazmi, Sami I. Alzarea, K. K. Sharma, Chetan Kumar Dubey, Piyush Mittal, Anurag Verma, Arinjay Jain, Ali Alquraini
Summary: This study evaluated the antistress activity of eucalyptus leaf oil. The results showed that eucalyptus leaf oil can reduce immobility time in animals, indicating its antistress effects.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Isabelle Rodrigues-Santos, Bruna Kalil-Cutti, Janete Aparecida Anselmo-Franci
Summary: The study demonstrated inadequate secretion of corticosterone in response to acute stress during reproductive aging in a perimenopausal rat model, along with hypoactivation of the PaMP region of the PVN, while adrenal P4 response is preserved. Furthermore, progesterone therapy was shown to mitigate the effects of progressive ovarian failure on adrenal functioning during stress.
NEUROENDOCRINOLOGY
(2022)
