Review
Environmental Sciences
Wolfgang Grisold, Valentina Alda Carozzi
Summary: Toxic neuropathies are caused by various substances through different mechanisms, with a wide range of toxic agents that can affect the nervous system in different ways. Clinically, the most common type is cumulative toxicities, presenting as axonal symmetric neuropathies.
Article
Multidisciplinary Sciences
Thomas Grueter, Nuwin Mohamad, Niklas Rilke, Alina Blusch, Melissa Sgodzai, Seray Demir, Xiomara Pedreiturria, Katharina Lemhoefer, Barbara Gisevius, Aiden Haghikia, Anna Lena Fisse, Jeremias Motte, Ralf Gold, Kalliopi Pitarokoili
Summary: In inflammatory neuropathies, treatment with propionate showed immunoregulatory and neuroprotective effects. Activation of FFAR3 and histone acetylation resulted in increased resistance to oxidative stress and enhanced neuroregeneration. This pathway provides potential neuroprotection and neuroregeneration for patients with immune-mediated neuropathies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Alice M. Fuller, Ana Luiz, Naxi Tian, Manuel Arcangeletti, Federico Iseppon, Jane E. Sexton, Queensta Millet, Sara Caxaria, Niloofar Ketabi, Petek Celik, John N. Wood, Shafaq Sikandar
Summary: Melzak and Wall's gate control theory suggests that innocuous input can inhibit pain-inducing nociceptive input. In this study, it is shown that proprioceptive parvalbumin-expressing sensory neurons tonically suppress nociceptor activation in the dorsal root ganglia. Deletion of these sensory neurons leads to increased nociceptor activity, enhanced input into spinal cord neurons, and increased pain behavior, as well as heightened innocuous sensation. These findings support the existence of peripheral gate control mechanisms within the dorsal root ganglia.
Article
Biochemistry & Molecular Biology
Anna Hucke, Rita Schroeter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli
Summary: CDDP is an efficient chemotherapeutic agent, but it has significant unwanted side effects. This study suggests that OCT may play a role in causing these side effects by facilitating the uptake of CDDP. Mice lacking the OCT2 gene showed reduced kidney and neurological impairments compared to wild-type mice. OCT could be potential targets for reducing unwanted side effects and improving CDDP anticancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Larissa de Clauser, Christin Kappert, Julia R. Sondermann, David Gomez-Varela, Sarah J. L. Flatters, Manuela Schmidt
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side-effect of cancer therapies. This study used quantitative proteome profiling and network analysis to explore the mechanistic basis of CIPN in a rat model. The researchers identified a differential protein signature associated with the development and maintenance of CIPN. Validation in an independent rat cohort confirmed the increase of beta-catenin (CTNNB1) at the pre-CIPN stage, and analysis of protein networks associated with beta-catenin highlighted potential druggable targets. This study provides unprecedented insights into the molecular basis of CIPN and suggests new avenues for developing therapeutic options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Lei Yang, Beibei Liu, Shang Zheng, Longsheng Xu, Ming Yao
Summary: Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous pain accompanied by hyperalgesia. It is caused by bone metastases or primary bone tumors. The perception and transmission of pain signals involve peripheral nerves, spinal cord, and the brain. The mechanisms of bone cancer pain within the brain are not fully understood, but with advancements in brain science and technology, further research is being conducted.
Article
Pharmacology & Pharmacy
Lawrence M. Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G. Hohmann
Summary: This study suggests that CB2 activation may alleviate HIV-associated antiretroviral neuropathy and identifies a previously unreported mechanism through which CB2 activation produces antinociceptive efficacy. The study also demonstrates that a CB2 agonist can reverse established morphine tolerance and shows that CB2 localized to peripheral sensory neurons mediates the opioid tolerance sparing efficacy of CB2 agonists.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jia-wen Xu, Xu Xu, Yun Ling, Yan-chun Wang, Yu-jie Huang, Juan-zhen Yang, Jia-ying Wang, Xu Shen
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes without cure. In this study, the therapeutic potential of vincamine (Vin), a GPR40 agonist, in ameliorating DPN-like pathology was evaluated in diabetic mice. The results showed that Vin administration improved neurological dysfunctions, blood flow velocities, blood perfusion areas, myelin sheath injury, and intraepidermal nerve fiber density impairment in DPN mice, suggesting that pharmacological activation of GPR40 could be a promising therapeutic strategy for DPN.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Immunology
Nilesh M. Agalave, Prapti H. Mody, Thomas A. Szabo-Pardi, Han S. Jeong, Michael D. Burton
Summary: The study found that chemotherapy-induced peripheral neuropathy (CIPN) causes pain-like behaviors in both male and female subjects, and is linked to eIF4E. Male subjects show a significant increase in spinal astrocyte immunoreactivity, while female subjects do not.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Meng, Siyan Qiu, Ling Zhang, Min You, Haizhu Xing, Jing Zhu
Summary: The study found that berberine can improve chemotherapy-induced peripheral neuropathy through anti-inflammatory mechanisms, possibly involving TRPV1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yuxin Zhang, Wei Wang, Zhihao Gong, Yuan Peng, Xin Li, Zuojing Zhang, Xiaoxuan Zhang, Xingji You, Jingxiang Wu
Summary: This study found that activation of the STING pathway leads to neuroinflammation and peripheral sensitization in bone cancer pain. Furthermore, inhibition of STING can alleviate symptoms associated with bone cancer pain.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Nea Korvenlaita, Lauri Louhivuori
Summary: Increasing evidence suggests that macrophages play an important role in peripheral nerve injury (PNI) and associated pain. Differences in in vivo models and methodologies may explain the variations between peripheral nerve macrophages and dorsal root ganglia (DRG) macrophages. Using single-nucleus transcriptomic analysis, this study compared the effects of sciatic nerve transection, spinal nerve transection, and nerve crush on DRG macrophage phenotypes. The findings demonstrate unique and time-dependent gene expression profiles of DRG macrophages in the different PNI models, suggesting a carefully orchestrated response of various DRG macrophage subtypes in PNI.
Article
Anesthesiology
Vanessa L. L. Ehlers, Katelyn E. E. Sadler, Cheryl L. L. Stucky
Summary: This study reveals the significant role of TRPV4 in chronic pain of sickle cell disease. Blocking TRPV4 can reduce mechanical sensitivity in patients, and it is also found that keratinocytes have excessive responses to TRPV4, which contributes to the heightened sensitivity observed in SCD.
Article
Biochemical Research Methods
Daniele Capitanio, Michele Vasso, Sara De Palma, Chiara Fania, Enrica Torretta, Francesco P. Cammarata, Valerio Magnaghi, Patrizia Procacci, Cecilia Gelfi
Article
Gastroenterology & Hepatology
Nicoletta Gagliano, Giuseppe Celesti, Lorenza Tacchini, Stefano Pluchino, Chiarella Sforza, Marco Rasile, Vincenza Valerio, Luigi Laghi, Vincenzo Conte, Patrizia Procacci
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Oncology
Davide Cervia, Emma Assi, Clara De Palma, Matteo Giovarelli, Laura Bizzozero, Sarah Pambianco, Ilaria Di Renzo, Silvia Zecchini, Claudia Moscheni, Chiara Vantaggiato, Patrizia Procacci, Emilio Clementi, Cristiana Perrotta
Article
Neurosciences
Alessandro Faroni, Luca Franco Castelnovo, Patrizia Procacci, Lucia Caffino, Fabio Fumagalli, Simona Melfi, Giovanna Gambarotta, Bernhard Bettler, Lawrence Wrabetz, Valerio Magnaghi
Article
Nanoscience & Nanotechnology
Balsam M. Mirdan, Dimitri Batani, Luca Volpe, Anna Maria Villa, Marco Bussoli, Rashida Jafer, Mina Veltcheva, Patrizia Procacci, Vincenzo Conte
JOURNAL OF LASER MICRO NANOENGINEERING
(2013)
Article
Neurosciences
A. Faroni, R. J. P. Smith, P. Procacci, L. F. Castelnovo, E. Puccianti, A. J. Reid, V. Magnaghi, A. Verkhratsky
JOURNAL OF NEUROSCIENCE RESEARCH
(2014)
Article
Neurosciences
E. Blum, P. Procacci, V. Conte, M. Hanani
Article
Biotechnology & Applied Microbiology
Valerio Magnaghi, Luca Franco Castelnovo, Alessandro Faroni, Erica Cavalli, Lucia Caffino, Alessandra Colciago, Patrizia Procacci, Giorgio Pajardi
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Cell Biology
Marco Coazzoli, Alessandra Napoli, Paulina Roux-Biejat, Clara De Palma, Claudia Moscheni, Elisabetta Catalani, Silvia Zecchini, Vincenzo Conte, Matteo Giovarelli, Sonia Caccia, Patrizia Procacci, Davide Cervia, Emilio Clementi, Cristiana Perrotta
Article
Biochemistry & Molecular Biology
Andrei C. Ionescu, Elena Vezzoli, Vincenzo Conte, Patrizia Sartori, Patrizia Procacci, Eugenio Brambilla
Summary: The study found that DNA-RNA compounds have a protective effect against oxidative stress but do not have a preventive effect. DNA-RNA in mouthwashes was more effective than in gels. Excipients play a crucial role in enhancing or decreasing the effect of bioactive molecules.
Article
Biochemistry & Molecular Biology
Giada Amodeo, Benedetta Verduci, Patrizia Sartori, Patrizia Procacci, Vincenzo Conte, Gianfranco Balboni, Paola Sacerdote, Silvia Franchi
Summary: The study indicates that mice treated with the proteasome inhibitor bortezomib may develop anxiety and depression, which are related to neuroinflammation and prokineticin system activation. Treatment with the prokineticin system antagonist PC1, which has anti-pain and anti-neuroinflammation effects, can prevent mood alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Francesca Selmin, Umberto M. Musazzi, Silvia Franze, Edoardo Scarpa, Loris Rizzello, Patrizia Procacci, Paola Minghetti
Summary: Experimentally evaluating the impact of storage conditions, materials, and mechanical stress on lipid nanoparticles and mRNA stability, the results indicate that stability can be maintained after 5 hours in a syringe, with only strong mechanical stress causing degradation.
Article
Cell Biology
Vincenzo La Mura, Nicoletta Gagliano, Francesca Arnaboldi, Patrizia Sartori, Patrizia Procacci, Luca Denti, Eleonora Liguori, Niccolo Bitto, Giuseppe Ristagno, Roberto Latini, Daniele Dondossola, Francesco Salerno, Armando Tripodi, Massimo Colombo, Flora Peyvandi
Summary: This study investigated the hemostatic changes induced by endotoxemia and the protective effects of simvastatin on liver vascular microthrombosis. The results showed that simvastatin prevented fibrin deposition and hypo-coagulability caused by endotoxemia, and preserved the antithrombotic properties of sinusoidal endothelial cells. It suggests that simvastatin has potential pharmacological properties to counteract sepsis-associated coagulopathy and hepatic failure.
Meeting Abstract
Neurosciences
L. F. Castelnovo, S. Melfi, V. Bonalume, A. Faroni, A. Reid, P. Procacci, L. Wrabetz, A. Verkhratsky, V. Magnaghi
Meeting Abstract
Neurosciences
R. Smith, A. Faroni, S. Martin, P. Procacci, V. Conte, E. Puccianti, L. Castelnovo, A. Reid, V. Magnaghi, A. Verkhratsky