Article
Neurosciences
Sangyep Shin, Sukwon Lee
Summary: Neonatal maternal separation is a common method to create early-life stress models in rodents. This study investigated the effects of different environmental conditions during maternal separation on the behavior of adolescent mice. The results showed that neonatal maternal separation led to impaired recognition memory, motor coordination, and motor skill learning across all groups. However, the different groups exhibited varying anxiety-like behaviors, fear memory extinction, and exploratory behaviors.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P. Guiard
Summary: The study found that 5d-RFSS mice exhibited strong depressive characteristics in the FST, but the model has limitations in replicating the broad spectrum of depressive symptoms observed in other chronic models. However, it showed a significant impact on the hypothalamic-pituitary-adrenal axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Brandon L. Oliver, Alma E. Pahua, Kristianna Hitchcock, Dionisio A. Amodeo
Summary: The study investigated the effects of 5-HT6 receptor modulation on locomotor activity and anxiety levels in mice, finding that different doses of drugs had varying impacts on female and male mice. The findings suggest that 5-HT6 receptor modulation has distinct effects on locomotor activity in C57BL/6J mice.
Letter
Oncology
Lingyu Wei, Can Liu, Jia Wang, Xiang Zheng, Qiu Peng, Qiurong Ye, Zailong Qin, Zhengshuo Li, Xiaoyue Zhang, Yangge Wu, Yuqing Wen, Xuemei Zhang, Qun Yan, Jian Ma
Summary: Lactoferrin is essential for early B cell development in mice, with lactoferrin deficiency leading to a blockade in early B cell development, potentially mediated through signaling pathways, transcription factors, and alterations in bone marrow microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olatunji Anthony Akerele, Sarah Jane Manning, Sarah Emily Dixon, Amelia Estelle Lacey, Sukhinder Kaur Cheema
Summary: The study found that a maternal diet high in Ω-3 PUFA can prevent dyslipidemia in non-pregnant mice and maintain the expected lipid profile during pregnancy, while a very low Ω-3 PUFA diet can lead to hyperlipidemia in mice before pregnancy and during pregnancy. Omega (n)-3 polyunsaturated fatty acids are crucial for maintaining maternal metabolic profile and fetal sustainability during pregnancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Simin Lu, Kang Zheng, Jianye Wang, Man Xu, Yafeng Xie, Shuai Yuan, Chuan Wang, Yimou Wu
Summary: The study evaluated the response of mice to Treponema pallidum, showing that the pathogen could colonize multiple organs and potentially penetrate the blood-brain barrier in mice. Following infection, bacterial loads were higher in tissues than in blood, and a significant Th1 immune response was recorded.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nozomi Endo, Manabu Makinodan, Takayo Mannari-Sasagawa, Noriko Horii-Hayashi, Nami Somayama, Takashi Komori, Toshifumi Kishimoto, Mayumi Nishi
Summary: Early adverse experiences can impact neuronal circuits and lead to psychiatric disorders. A study found that repeated maternal separation in mice led to inappropriate social distance and behavioral abnormalities in a group-housing setting.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Haixia Wang, Hong Huang, Ning Jiang, Yiwen Zhang, Jingwei Lv, Xinmin Liu
Summary: It is widely accepted that stress affects the central nervous system and can lead to cognitive problems. This study found that Tenuifolin (TEN), the major constituent of Polygala tenuifolia, has potential neuroprotective properties and improves cognitive impairment induced by chronic restraint stress (CRS). TEN regulates interleukin (IL)-6 and IL-10 levels, inhibits toll-like receptor 4/nuclear factor-kappa B-mediated inflammation, and decreases levels of adrenocorticotropic hormone and corticosterone in serum. Furthermore, TEN upregulates the expressions of brain-derived neurotrophic factor, tropomyosin kinase B, glucocorticoid receptor, glutamate receptor 1, and synapse-associated proteins.
PHYTOTHERAPY RESEARCH
(2022)
Article
Neurosciences
Giuseppe Talani, Francesca Biggio, Ashish Avinash Gorule, Valentina Licheri, Eleonora Saolini, Daniele Colombo, Gabriele Sarigu, Michele Petrella, Francescangelo Vedele, Giovanni Biggio, Enrico Sanna
Summary: The repeated maternal separation (RMS) model was used to study the long-term effects of early-life stress on brain neurophysiology in mice. The study found significant changes in synaptic transmission and cognitive performance in male mice exposed to RMS. Female mice also showed some changes, but to a lesser extent. Furthermore, the study found that early injection of estrogen prevented the effects of RMS.
Article
Chemistry, Analytical
Miao Qi, Rong Liu, Bing Li, Shuai Wang, Runze Fan, Xinyi Zhao, Dehui Xu
Summary: This study investigated the behavioral effects of terahertz radiation on mice, and the results suggest that terahertz waves may enhance anti-anxiety, anti-depression, and social interaction in mice.
Article
Agriculture, Dairy & Animal Science
Amy L. Miller, Johnny V. Roughan
Summary: This study used welfare monitoring methods to determine the welfare of mice developing lung cancer and explored the impact of non-aversive handling on welfare and result consistency. The findings showed that lung cancer caused changes in behavior and reduced food consumption, indicating declining welfare. However, non-aversive handling did not have a significant effect on welfare or result consistency.
Article
Biochemistry & Molecular Biology
Qingcai Chen, Wei Chu, Rui Sheng, Shaoyong Song, Jianping Yang, Fuhai Ji, Xin Jin
Summary: The study found that maternal anesthesia with sevoflurane could induce social interaction deficits in offspring mice, particularly impacting the preference for social novelty in a long-lasting manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Andres Rojas-Ruiz, Magali Boucher, Rebecka Gill, Louis Gelinas, Fun-Qun Tom, Liah Fereydoonzad, Percival Graham, Jorge Soliz, Ynuk Bosse
Summary: This study compared the lung mechanical properties and lung volumes between C57BL/6 and BALB/c mice and found that the greater lung elastance in C57BL/6 mice is not due to a smaller lung volume but rather a stiffer lung tissue with a higher content of collagen.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Michael Zenzes, Paul Zaslansky
Summary: Micro-CT technology was used to quantify changes in the fine architecture of bone in the spine of young mice, providing critical data for musculoskeletal research. The 3D scans of female C57BL/6 mice pups at different post-partum days reveal micro-morphology down to individual trabeculae, serving as a reference for normal bone growth modeling and other experiments assessing tissue growth and regeneration. The validity and accuracy of the 3D scans were confirmed through conventional histomorphometry, showcasing the potential of the data for benchmarking experiments related to biomaterials and healing.
Article
Health Policy & Services
Rebecca L. Toback, Sandra A. Graham-Bermann, Paresh D. Patel
PSYCHIATRIC SERVICES
(2016)
Review
Pediatrics
Neera Ghaziuddin, Melissa Hendriks, Paresh Patel, Lee E. Wachtel, Dirk M. Dhossche
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Jia Zhang, Yan Fan, Muhammad U. Raza, Yanqiang Zhan, Xiang-Dong Du, Paresh D. Patel, Meng-Yang Zhu
NEUROCHEMISTRY INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P. Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grunblatt, Erik Andersson, Diana R. Djurfeldt, Paresh D. Patel, Michele Koltookian, Christina M. Hultman, Michele T. Pato, Carlos N. Pato, Steven A. Rasmussen, Michael A. Jenike, Gregory L. Hanna, S. Evelyn Stewart, James A. Knowles, Stephan Ruhrmann, Hans-Joergen Grabe, Michael Wagner, Christian Ruck, Carol A. Mathews, Susanne Walitza, Danielle C. Cath, Guoping Feng, Elinor K. Karlsson, Kerstin Lindblad-Toh
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
M-S Lee, Y-H Kim, W-S Park, O-K Park, S-H Kwon, K. S. Hong, H. Rhim, I. Shim, K. Morita, D. L. Wong, P. D. Patel, D. M. Lyons, A. F. Schatzberg, S. Her
MOLECULAR PSYCHIATRY
(2016)
Article
Health Policy & Services
Sheila Marcus, Nasuh Malas, Richard Dopp, Joanna Quigley, Anne C. Kramer, Elizabeth Tengelitsch, Paresh D. Patel
PSYCHIATRIC SERVICES
(2019)
Article
Health Policy & Services
Peter P. Zandi, Yu-Hsun Wang, Paresh D. Patel, David Katzelnick, Carolyn L. Turvey, Jesse H. Wright, Olusola Ajilore, William Coryell, Christopher D. Schneck, Constance Guille, Erika F. H. Saunders, Sophie A. Lazarus, Valeria A. Cuellar, Sudhakar Selvaraj, Patricia Dill Rinvelt, John F. Greden, J. Raymond Depaulo
PSYCHIATRIC SERVICES
(2020)
Article
Pharmacology & Pharmacy
Sydnee Cohen, Jolene R. Bostwick, Vincent D. Marshall, Kathleen Kruse, Gregory W. Dalack, Paresh Patel
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Young-Min Han, Min Sun Kim, Juyeong Jo, Daiha Shin, Seung-Hae Kwon, Jong Bok Seo, Dongmin Kang, Byoung Dae Lee, Hoon Ryu, Eun Mi Hwang, Jae-Min Kim, Paresh D. Patel, David M. Lyons, Alan F. Schatzberg, Song Her
Summary: The study reveals the trajectory of NF kappa B and GR activities in the brain during inflammation, identifying three phases in the transition from sickness to depression. The differential involvement of GR in normal and depressive-like phases, along with the cryptic role of basal GR activity in early NF kappa B signal transition, are highlighted.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
Peter P. Zandi, Michael Morreale, Irving M. Reti, Daniel F. Maixner, William M. McDonald, Paresh D. Patel, Eric Achtyes, Mahendra T. Bhati, Brent R. Carr, Susan K. Conroy, Mario Cristancho, Marc J. Dubin, Andrew Francis, Kara Glazer, Wendy Ingram, Khurshid Khurshid, Shawn M. McClintock, Omar F. Pinjari, Kevin Reeves, Nelson F. Rodriguez, Shirlene Sampson, Stephen J. Seiner, Salih Selek, Yvette Sheline, Roy W. Smetana, Takahiro Soda, Nicholas T. Trapp, Jesse H. Wright, Mustafa Husain, Richard D. Weiner
Summary: Electroconvulsive therapy (ECT) is a highly effective treatment for severe depression, but there are challenges in standardizing its delivery and documentation. A task group from the National Network of Depression Centers was formed to promote best clinical practices for ECT and facilitate quality improvement and research efforts. This article focuses on harmonizing the clinical documentation of ECT and its implications for nationwide collaboration and research.
Article
Health Policy & Services
Leslie M. Swanson, Paresh D. Patel, Roen Montalva, Katherine H. Bullard, Sagar V. Parikh, Gregory W. Dalack
Summary: This study investigated the impact of high-reliability changes in the administration of measurement-based care questionnaires on questionnaire completion rates among patients. Medical record data from an outpatient psychiatry clinic were examined before and after process changes were implemented. The results showed a 79% increase in questionnaire completion rates after the process changes. Women, older patients, and white patients were more likely to complete the questionnaires after the process changes. It is important to address racial, age, and sex disparities in questionnaire completion rates in future implementation efforts.
PSYCHIATRIC SERVICES
(2023)
Letter
Psychology, Developmental
Thomas Zimmer, Paresh Patel
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
J. Raymond DePaulo, Patricia Rinvelt, Paresh Dinubhai Patel, Peter Zandi, David Katzelnick, Carolyn Turvey
BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychiatry
Rajeev Krishna, Jessica Jeffrey, Paresh D. Patel
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
(2020)
Article
Psychiatry
Sheila M. Marcus, Nasuh M. Malas, Joanna M. Quigley, Katherine L. Rosenblum, Maria Muzik, Dayna J. LePlatte-Ogini, Paresh D. Patel
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
(2017)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
