Article
Food Science & Technology
Soheila Safarpour, Ebrahim Zabihi, Maryam Ghasemi-Kasman, Nasrin Nosratiyan, Farideh Feizi
Summary: The study showed that exposure of mothers to low doses of DEHP during pregnancy and lactation can lead to behavioral deficits in rat pups, especially affecting the working and spatial memory of male rats. Additionally, increased oxidative stress and decreased antioxidant activity were observed in the hippocampus of rats receiving low doses of DEHP.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Behavioral Sciences
Kethely L. Marques, Milena L. Moreira, Maria C. Thiele, Marta C. Cunha-Rodrigues, Penha C. Barradas
Summary: Perinatal hypoxia-ischemia (HI) is a major cause of morbidity and mortality in newborns, and infants with HI encephalopathy may suffer from long-term consequences such as depression in adulthood. This study investigated the effects of a prenatal HI model on depressive-like behavior, neuronal population, and markers of monoaminergic and synaptic plasticity in the prefrontal cortex of adolescent rats. The results showed that the HI group exhibited reduced sucrose consumption and increased immobility in behavioral tests, as well as decreased neuronal density and synaptic marker levels. These findings highlight the importance of this model in studying the effects of HI-induced injuries on mood modulation circuits.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Gabrielle K. Crombie, Hannah K. Palliser, Julia C. Shaw, Deborah M. Hodgson, David W. Walker, Jonathan J. Hirst
Summary: This study showed that prenatal stress disrupts inhibitory pathways in the offspring, leading to behavioral, myelin, and GABAergic/glutamatergic pathway deficits. The effects differed between male and female offspring, with males displaying hyperactive-like behavior and females displaying anxious-like behavior. However, when prenatal stress was paired with postnatal stress, many of the deficits were improved, highlighting the importance of the early postnatal period as a critical treatment window.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Fernanda Cardoso Teixeira, Mayara Sandrielly Pereira Soares, Eduardo Bierhaus Blodorn, William Borges Domingues, Karine Paula Reichert, Adriana Maria Zago, Fabiano Barbosa Carvalho, Jessie Martins Gutierres, Relber Aguiar Goncales, Marilda da Cruz Fernandes, Vinicius Farias Campos, Maria Rosa Chitolina, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: This study found that inosine can prevent memory deficits, reduce the immunoreactivity of the brain A2A adenosine receptor, increase levels of brain anti-inflammatory cytokines, enhance brain-derived neurotrophic factor expression, and attenuate changes in the hippocampus induced by STZ in rats with AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Leah DeFlitch, Estibaliz Gonzalez-Fernandez, Ilan Crawley, Shin H. Kang
Summary: Oligodendrocyte population and changes in the adult hippocampus vary among subregions, with the CA3 and CA4 subregions showing the most prominent oligodendrogenesis. These subregion-dependent oligodendrocyte changes may be related to myelin plasticity and disease-associated vulnerability in the hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Qinghong Li, Dongge Cai, Huimei Huang, Huiping Zhang, Ruimiao Bai, Xiaolin Zhao, Hongli Sun, Pei Qin
Summary: This study investigated the molecular mechanisms underlying depressive-like behavior in offspring rats exposed to prenatal stress. Using phosphoproteomics, the researchers identified different phosphoproteins involved in myelin, microtubule, and synapse formation and plasticity in the hippocampus of susceptible offspring rats. These findings provide new insights into the biological mechanisms of depression affected by prenatal stress.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Huajie Liu, Anouk Wolters, Yasin Temel, Faisal Alosaimi, Ali Jahanshahi, Sarah Hescham
Summary: The study demonstrated that biphasic, low frequency, and intermittent NBM DBS was effective in reversing memory impairments caused by scopolamine, promoting neurogenesis and synaptic plasticity while increasing the length of cholinergic fibers in specific brain regions. The findings suggest that the memory enhancement induced by NBM DBS may be attributed to selective neuroplastic and neurochemical changes.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Medicine, General & Internal
Regina L. Triplett, Rachel E. Lean, Amisha Parikh, J. Philip Miller, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Christopher Adamson, Tara A. Smyser, Cynthia E. Rogers, Deanna M. Barch, Barbara Warner, Joan L. Luby, Christopher D. Smyser
Summary: This prospective study found that prenatal exposure to maternal social disadvantage is associated with global reductions in brain volumes and cortical folding in newborns, highlighting the importance of addressing parental socioeconomic hardships in preventive interventions for fetal brain development.
Article
Behavioral Sciences
Anna L. Arzuaga, Daisy D. Edmison, Jessica Mroczek, John Larson, Michael E. Ragozzino
Summary: Autism spectrum disorder (ASD) is characterized by social communication impairments and restricted and repetitive behaviors (RRBs). Maternal stress during pregnancy and selective serotonin reuptake inhibitor (SSRI) treatment may affect autism-related behaviors and synaptic plasticity in offspring. This study found that prenatal stress and SSRI exposure increased self-grooming and impaired spatial reversal learning in male offspring, whereas in female offspring, prenatal stress or SSRI exposure impaired spatial reversal learning. Prenatal stress reduced anxiety-related behavior in both male and female offspring, and synaptic plasticity was affected in female offspring.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Anatomy & Morphology
Cristina Garcia-Diaz, Isis Gil-Miravet, Hector Albert-Gasco, Aroa Manas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gomez, Andrew L. Gundlach, Francisco E. Olucha-Bordonau
Summary: The study focused on the neurophysiological interactions between the hippocampus, entorhinal cortex, and the NI/relaxin-3 innervation in the parahippocampal cortex. Results demonstrate the significant functional role of the NI/relaxin-3-parahippocampal innervation on processes related to memory, spatial navigation, and contextual analysis.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chie Hisada, Kyoko Kajimoto, Hiroko Tsugane, Iinuma Mitsuo, Kagaku Azuma, Kin-ya Kubo
Summary: This study investigated the effects of prenatal stress on hippocampal microglia-mediated neuroinflammation in mice offspring. Results showed that prenatal stress increased serum corticosterone levels, induced hippocampal microglial activation, and facilitated the release of interleukin-1 beta and tumor necrosis factor-alpha. Moreover, maternal chewing effectively suppressed the increase in corticosterone levels, inhibited excessive microglial activation, and normalized inflammatory cytokine levels under prenatal stress conditions and after LPS administration.
JOURNAL OF PROSTHODONTIC RESEARCH
(2023)
Article
Psychiatry
Peter Falkai, Moritz J. Rossner, Florian J. Raabe, Elias Wagner, Daniel Keeser, Isabel Maurus, Lukas Roell, Emily Chang, Johanna Seitz-Holland, Thomas G. Schulze, Andrea Schmitt
Summary: There is a disconnectivity between hippocampal and prefrontal brain regions in schizophrenia, which leads to cognitive impairment. The deficient maturation of oligodendrocyte precursor cells (OPCs) contributes to abnormal frontotemporal connectivity and cognitive deficits in schizophrenia. Aerobic exercise training can increase hippocampal volume, specifically in the CA4 region, and improve cognition in individuals with schizophrenia. The exercise-induced CA4 volume increase is significantly correlated with OPCs.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Jan Spaas, Lieve van Veggel, Melissa Schepers, Assia Tiane, Jack van Horssen, David M. Wilson, Pablo R. Moya, Elisabeth Piccart, Niels Hellings, Bert O. Eijnde, Wim Derave, Rudy Schreiber, Tim Vanmierlo
Summary: Oligodendrocyte precursor cells (OPCs) play a crucial role in various neurodegenerative disorders, with oxidative/carbonyl stress potentially impacting their differentiation and function, contributing to disease progression. Investigating how oxidative/carbonyl stress disrupts OPC differentiation may offer new directions for therapeutic strategies in neurodegenerative disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Maria Serena Paladini, Davide Marangon, Andrea C. Rossetti, Alice Guidi, Giusy T. Coppolino, Camilla Negri, Vittoria Spero, Maria Pia Abbracchio, Davide Lecca, Raffaella Molteni
Summary: Prenatal stress exposure can have severe consequences on offspring's brain development and long-term repercussions in adulthood. It can also increase the severity of EAE symptoms and alter the maturation of spinal cord oligodendrocytes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Yabin Hu, Jian Cheng, Yong Yin, Shijian Liu, Jianguo Tan, Shenghui Li, Meiqin Wu, Chonghuai Yan, Guangjun Yu, Yi Hu, Shilu Tong
Summary: The study found that both intra- and inter-day temperature variability may trigger childhood asthma, with higher diurnal temperature range having greater impacts in the cold season and temperature changes between neighboring days having bigger effects in the warm season.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Yihong Wang, Yaqian Wang, Chonghuai Yan
Summary: This study explored the influence of trace element levels on the intellectual development of school-aged children. The results showed a negative correlation between lead (Pb) and copper (Cu) levels in cord blood and children's cognitive abilities. Prenatal low-level exposure to arsenic (As) was found to adversely affect girls' intelligence quotient. Additionally, differences in selenium (Se) levels in blood were observed between boys and girls, with high Se levels associated with different effects on cognitive abilities based on gender.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Chenyin Dong, Junxia Liu, Paul Harvey, Chonghuai Yan
Summary: Household dust is an important pathway for children's environmental Pb exposure. This study examines the Pb concentration and isotopic compositions in household dust samples from Shanghai, and finds that children living in lower priced homes have higher risk of Pb exposure. The data indicate that Pb in household dust is mainly derived from coal combustion and solid waste incineration.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Richard Fuller, Philip J. Landrigan, Kalpana Balakrishnan, Glynda Bathan, Stephan Bose-O'Reilly, Michael Brauer, Jack Caravanos, Tom Chiles, Aaron Cohen, Lilian Corra, Maureen Cropper, Greg Ferraro, Jill Hanna, David Hanrahan, Howard Hu, David Hunter, Gloria Janata, Rachael Kupka, Bruce Lanphear, Maureen Lichtveld, Keith Martin, Adetoun Mustapha, Ernesto Sanchez-Triana, Karti Sandilya, Laura Schaefli, Joseph Shaw, Jessica Seddon, William Suk, Martha Maria Tellez-Rojo, Chonghuai Yan
Summary: The Lancet Commission on pollution and health reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Updated data from 2019 shows that pollution is still responsible for approximately 9 million deaths per year, with reductions in some types of pollution offset by increases in others. Despite efforts, little progress has been made in addressing pollution, particularly in low-income and middle-income countries.
LANCET PLANETARY HEALTH
(2022)
Article
Environmental Sciences
Yaqian Wang, Susu Wang, Yihong Wang, Anxin Lu, Lulu Cao, Ju Wang, Zhenyan Gao, Chonghuai Yan
Summary: This study investigated the prenatal exposure to arsenic and its effects on birth size in Wujiang City, Jiangsu, China. The results showed that low-level prenatal exposure to arsenic could have negative effects on birth weight, especially among male infants.
Article
Psychology, Developmental
Xiangrong Guo, Shiwei Jiang, Jian Xu, Ying Tian, Fengxiu Ouyang, Xiaodan Yu, Junxia Liu, Chonghuai Yan, Jun Zhang
Summary: This study found that both single and combined prenatal exposures to lead/stress impaired infant neurodevelopment, and the effects of combined exposure may be more profound than single exposures. Combined exposure in early pregnancy may be associated with worse neurodevelopmental outcomes than combined exposure around birth, especially in social-emotional development.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Review
Environmental Sciences
Yabin Hu, Jian Cheng, Shijian Liu, Jianguo Tan, Chonghuai Yan, Guangjun Yu, Yong Yin, Shilu Tong
Summary: Global climate change is a significant threat to children's health, particularly in relation to childhood asthma and allergies. Various adaptation measures have been proposed, such as improving ventilation and heating, but their effectiveness needs further research and evaluation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Su-Su Wang, Xi Xu, An-Xin Lu, Wan-he Li, Jun-xia Liu, Chen Liu, Chong-Huai Yan
Summary: This study demonstrates that cholesterol sulfate (CS) can protect rat brain astrocytes against lead-induced damage by regulating the BDNF/TrkB signaling pathway and cholesterol metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
An-xin Lu, Su-su Wang, Xi Xu, Mei-qin Wu, Jun-xia Liu, Min Xu, Lu-Lu Cao, Ju Wang, Wei Wu, Hui Li, Chong-huai Yan
Summary: This study aimed to investigate the impact of cord blood lead on neurodevelopment in children within sex subgroups. The results showed that cord blood lead concentrations were negatively associated with fine motor scores in female children, but not in male children. Additionally, cord serum DHA levels were positively correlated with fine motor scores in male children. These findings suggest that prenatal lead exposure may lead to decreased motor function, but this phenomenon is only observed in female children. Furthermore, DHA may serve as a protective factor against lead exposure in boys. Further studies are needed to explore the associations between prenatal lead exposure and neurobehavioral development, as well as the mechanism of sex differences.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Neurosciences
Olivia M. Halabicky, Xiaopeng Ji, Raquel E. Gur, Ruben C. Gur, Chonghuai Yan, Aimin Chen, Jianghong Liu
Summary: This study examined the relationship between lead exposure and neurobehavioral functioning in adolescence. The results showed that lead exposure was associated with deficits in executive and visual-motor functioning for both males and females, although in different domains and timing of exposure.
Article
Environmental Sciences
Yabin Hu, Yiting Chen, Shijian Liu, Jianguo Tan, Guangjun Yu, Chonghuai Yan, Yong Yin, Shenghui Li, Shilu Tong
Summary: The interest in assessing the effects of exposure to greenspace on human health, especially asthma in children, has been increasing due to urbanization, physical inactivity, and air pollution. This study conducted a city-wide cross-sectional study in Shanghai, China, involving 16,605 children to investigate the association between residential greenspace and asthma. The study found that an increase in greenspace was associated with a decreased odds of asthma, and the association was modified by ambient temperature and residential area.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Hui Hua, Lihua Huang, Bo Yang, Shiwei Jiang, Yijing Zhang, Junxia Liu, Chonghuai Yan, Jian Xu
Summary: This study found that prenatal combined exposure to lead and stress had a greater impact on neurodevelopment, as well as on the composition of intestinal microbiota and the bidirectional communication with the central nervous system. Gut microbiota may mediate the effects of prenatal lead and stress co-exposure on neurodevelopmental deficits.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yabin Hu, Yiting Chen, Shijian Liu, Jianguo Tan, Guangjun Yu, Chonghuai Yan, Yong Yin, Shenghui Li, Shilu Tong
Summary: Previous studies on the link between greenspace exposure and childhood asthma have focused only on residential or school greenspace and have not considered the combined exposure at both homes and schools. This study conducted in Shanghai, China, found that increased greenspace exposure was associated with a lower risk of childhood asthma, and this association was modified by various socio-environmental factors.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yi-Hong Wang, Ya-Qian Wang, Xiao-Gang Yu, Yin Lin, Jun-Xia Liu, Wei-Ye Wang, Chong-Huai Yan
Summary: Juvenile zebrafish exposed to environmental arsenic showed behavioral abnormalities, including anxiety and social deficits, along with increased oxidative stress in the brain, decreased dopamine content, and altered gene transcription related to dopamine metabolism. However, treatment with N-acetylcysteine helped reduce oxidative stress and improve social behavior, dopamine levels, monoamine oxidase activity, and gene transcription in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Clinical Neurology
Ting Yu, Dongqing Xu, Jue Fan, Hui Hua, Xiangrong Guo, Yijing Zhang, Shiwei Jiang, Lihua Huang, Yining Jiang, Yuefen Wang, Chonghuai Yan, Jian Xu
Summary: This study found that high homework burdens were associated with neurobehavioral problems in adolescents. Sleep durations may mediate these associations, and sex may modify the relationships. The study collected information on homework burdens, bedtime/wake-up-time, and neurobehavioral problems from 609 middle-school students and identified patterns and associations through statistical analysis.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.