Article
Engineering, Biomedical
Yihua Zhong, Xu Zhang, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: A new axonal conduction model was used to analyze the interaction between intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation. The results show that the block duration can be shortened by increasing the HFBS intensity, and the block can be maintained if the intensity is above a certain threshold.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Jialiang Chen, Yihua Zhong, Jicheng Wang, Bing Shen, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: This study investigates the impact of temperature on nerve conduction block induced by high-frequency (kHz) stimulation. Results show that at a lower temperature of 15 degrees C, both 2- and 10-kHz stimulations caused an initial muscle contraction followed by nerve block. The threshold for acute block was significantly higher for 10 kHz compared to 2 kHz. However, at a higher temperature of 20 degrees C, the threshold for acute block with 10-kHz stimulation decreased, while 2-kHz stimulation induced a tonic muscle contraction and a poststimulation block.
Article
Medicine, Research & Experimental
Katherine Shapiro, Wenbin Guo, Kody Armann, Natalie Pace, Bing Shen, Jicheng Wang, Jonathan Beckel, William de Groat, Changfeng Tai
Summary: The study found that low-frequency biphasic stimulation can induce poststimulation block, which is reversible, and the duration of stimulation required for inducing block increases with frequency. The results of this study provide an opportunity for the development of new neuromodulation devices.
Article
Engineering, Biomedical
Yue Yuan, Lvpiao Zheng, Zhouyan Feng, Gangsheng Yang
Summary: The experiment on rat hippocampal CA1 region reveals that high-frequency monophasic pulses can induce abnormal neuron activity, while high-frequency biphasic pulses lead to persisting attenuation of neuronal excitability, indicating potential damages caused by monophasic stimulations in brain tissues.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Clinical Neurology
Katsuya Kobayashi, Riki Matsumoto, Kiyohide Usami, Masao Matsuhashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Summary: The study on 29 patients with intractable partial epilepsy undergoing CCEP recording showed that CCEP is a safe procedure, especially when used under the established protocol. The incidence of clinical seizures varied significantly between stimulation of seizure onset zone and non-seizure onset zone, highlighting the importance of caution in stimulating SOZ.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Mark A. Hays, Golnoosh Kamali, Mohamad Z. Koubeissi, Sridevi Sarma, Nathan E. Crone, Rachel J. Smith, Joon Y. Kang
Summary: This study systematically explored the effects of different parameters of single pulse electrical stimulation (SPES) on cortico-cortical evoked potentials (CCEPs). The results showed that the combinations of current intensity, pulse width, and charge interacted to affect CCEP amplitude, distribution, latency, morphology, and stimulus artifact amplitude. The optimal SPES setting was high current intensity, short pulse width, which elicited strong and consistent CCEP responses while minimizing charge.
Article
Medicine, Research & Experimental
Yihua Zhong, Jicheng Wang, Jonathan Beckel, William C. de Groat, Changfeng Tai
Summary: This study reveals the possible ionic mechanisms underlying poststimulation block induced by high-frequency biphasic stimulation, including short-duration and long-duration block. By adjusting stimulation frequency and duration, the block effect can be controlled.
Article
Clinical Neurology
Alexandra Boogers, Jana Peeters, Tine Van Bogaert, Boateng Asamoah, Philippe De Vloo, Wim Vandenberghe, Bart Nuttin, Myles Mc Laughlin
Summary: This study aimed to investigate the effect of anodic and symmetric biphasic pulses on the therapeutic window in essential tremor patients. The results showed that anodic stimulation and symmetric biphasic stimulation could increase the therapeutic window in ET patients.
Article
Clinical Neurology
Karen Wendt, Majid Memarian Sorkhabi, Charlotte J. Stagg, Melanie K. Fleming, Timothy Denison, Jacinta O'Shea
Summary: This study compared the effects of monophasic and biphasic iTBS using a custom-made device and found that monophasic iTBS induced a stronger increase in motor corticospinal excitability, suggesting its potential for greater functional impact.
Article
Engineering, Geological
Xian Shi, Hongxing Xu, Mingguang Che, Caiyun Xiao, Hongjian Ni, Qi Gao
Summary: Pulse fracturing can reduce fracture initiation pressure and increase stimulation effectiveness. Both pulse frequency and amplitude play critical roles in fracture propagation behavior and stimulation parameters. Pulse fracturing has a strong capability to create a larger stimulated area compared to monotonic fracturing.
INTERNATIONAL JOURNAL OF ROCK MECHANICS AND MINING SCIENCES
(2023)
Article
Biology
Musa Ozturk, Ashwin Viswanathan, Sameer A. Sheth, Nuri F. Ince
Summary: Therapeutic high-frequency stimulation induces high-frequency oscillations similar to those observed with pharmacological treatment, along with evoked compound activity. The interaction between stimulation pulse and the phase of ECA affects the degree of enhancement in HFO power. High-frequency STN-DBS tunes neural oscillations to their healthy state, and the stimulation frequency can be inferred from the phase of ECA waveforms of individual subjects.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Alessandro Cruciani, Giovanni Pellegrino, Antonio Todisco, Francesco Motolese, Marco Sferruzzi, Davide Norata, Francesca Santoro, Gabriella Musumeci, Mariagrazia Rossi, Fabio Pilato, Vincenzo Di Lazzaro, Fioravante Capone
Summary: tACS is a technique that modulates brain activity through electrical current, and its effects can be precisely controlled by synchronizing with an individual's high-frequency oscillation frequency. This study provides initial evidence that tACS synchronized with an individual's high-frequency oscillation can specifically modulate thalamocortical activity, which may pave the way for innovative personalized neuromodulation methods for the somatosensory system.
Article
Neurosciences
Lvpiao Zheng, Zhouyan Feng, Yipeng Xu, Yue Yuan, Yifan Hu
Summary: This study reveals a facilitation effect of the anodic phase on biphasic-pulse stimulations, which provides important information for designing electrical stimulations for neural therapies.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ezra E. Smith, Ki Sueng Choi, Ashan Veerakumar, Mosadoluwa Obatusin, Bryan Howell, Andrew H. Smith, Vineet Tiruvadi, Andrea L. Crowell, Patricio Riva-Posse, Sankaraleengam Alagapan, Christopher J. Rozell, Helen S. Mayberg, Allison C. Waters
Summary: Precision targeting of specific white matter bundles in the subcallosal cingulate has been linked to effectiveness of deep brain stimulation for treatment resistant depression. Confirming optimal target engagement in this region is crucial for developing an objective treatment protocol. This study examined the time-frequency features of the SCC evoked potential in TRD patients with implanted SCC stimulators and found enhanced phase clustering at the theta frequency, particularly during left SCC stimulation. The results suggest a shared generative mechanism between evoked potentials by electrical stimulation and those evoked by auditory/visual stimuli and behavioral tasks.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Kyoung Hoon Jeong, Jing Zhu, Soojin Park, Won-Joo Kim
Summary: The role of TRPV6 in epilepsy is unclear. This study found that TRPV6 expression is upregulated in the hippocampus of a pilocarpine-induced status epilepticus model and is related to abnormal MF sprouting (MFS) and the incidence of seizures. In vitro experiments showed that TRPV6 expression can regulate axonal formation in cultured hippocampal neurons. Furthermore, TRPV6 is involved in the regulation of Akt-glycogen synthase kinase-3-beta activity, which is related to axonal outgrowth. Therefore, TRPV6 may regulate the formation of aberrant synaptic circuits during epileptogenesis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Engineering, Biomedical
Yazan M. Dweiri, Thomas Eggers, Grant McCallum, Dominique M. Durand
JOURNAL OF NEURAL ENGINEERING
(2015)
Article
Neurosciences
Chen Qiu, Rajat S. Shivacharan, Mingming Zhang, Dominique M. Durand
JOURNAL OF NEUROSCIENCE
(2015)
Article
Clinical Neurology
Hyun-Joo Park, Dominique M. Durand
Article
Multidisciplinary Sciences
Mingming Zhang, Andrew B. Kibler, Luis E. Gonzales-Reyes, Dominique M. Durand
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Neurosciences
Mingming Zhang, Rajat S. Shivacharan, Chia-Chu Chiang, Luis E. Gonzalez-Reyes, Dominique M. Durand
JOURNAL OF NEUROSCIENCE
(2016)
Article
Engineering, Biomedical
Thomas E. Eggers, Yazan M. Dweiri, Grant A. McCallum, Dominique M. Durand
JOURNAL OF NEURAL ENGINEERING
(2017)
Article
Engineering, Electrical & Electronic
Yazan M. Dweiri, Thomas E. Eggers, Luis E. Gonzalez-Reyes, Joseph Drain, Grant A. McCallum, Dominique M. Durand
PROCEEDINGS OF THE IEEE
(2017)
Article
Multidisciplinary Sciences
Grant A. McCallum, Xiaohong Sui, Chen Qiu, Joseph Marmerstein, Yang Zheng, Thomas E. Eggers, Chuangang Hu, Liming Dai, Dominique M. Durand
SCIENTIFIC REPORTS
(2017)
Article
Clinical Neurology
Nicholas H. Couturier, Dominique M. Durand
Article
Clinical Neurology
Nicholas H. Couturier, Dominique M. Durand
Article
Clinical Neurology
Rajat S. Shivacharan, Chia-Chu Chiang, Xile Wei, Muthumeenakshi Subramanian, Nicholas H. Couturier, Nrupen Pakalapati, Dominique M. Durand
Summary: Research has shown that ephaptic coupling, a nonsynaptic mechanism, can recruit neurons during seizures, potentially explaining the low success rate of surgical transections in epilepsy patients. Experimental results indicate that electric fields can recruit neurons across tissue transections, affecting the overall neural network activity.
Article
Chemistry, Analytical
Joseph T. Marmerstein, Grant A. McCallum, Dominique M. Durand
Summary: In this study, a carbon nanotube yarn biosensor was used to chronically record and decode activity in the vagus nerve of freely moving rats. The study provides important insights into understanding spontaneous vagus nerve function.
Article
Computer Science, Information Systems
Yazan Dweiri, Mousa Al-Zanina, Dominique Durand
Summary: In this study, ensemble learning is used to enhance the performance of the convolutional neural network Axondeepseg (ADS) when applied to optical microscopy images. The results demonstrate that the ensemble model achieves a higher accuracy compared to the individual base models, and it provides automated segmentation and measurement of axon diameters and myelin thicknesses in neural images.
Review
Clinical Neurology
Sheela Toprani, Dominique M. Durand
Summary: This review discusses the use of neurostimulation therapies for epilepsy treatment, including vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation. Different therapeutic strategies and their underlying mechanisms are explored, with a focus on optimizing parameters for seizure reduction. The review also highlights the paradigm shift toward a more diverse and multimodal approach to deep brain neuromodulation.
Article
Neurosciences
Zhouyan Feng, Zhaoxiang Wang, Zheshan Guo, Wenjie Zhou, Ziyan Cai, Dominique M. Durand
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
