期刊
BRAIN RESEARCH
卷 1524, 期 -, 页码 26-33出版社
ELSEVIER
DOI: 10.1016/j.brainres.2013.05.030
关键词
Corticosteroid; Dopamine receptors; Hippocampal CA1; Memory consolidation; Contextual fear conditioning
资金
- Scientific Research Foundation of Sun Yat-Sen University [50003171314]
This study investigated the role of dopamine (DA) receptors in area CA1 of the hippocampus in modulating the effects of glucocorticoids on the contextual fear memory consolidation. Adult male rats were given systemic injections of corticosterone (CORT; 3 mg/kg) immediately after training in a contextual fear conditioning (CFC) task and the percentage of time spent freezing in the CFC context was recorded 24 h after training. Intra-CA1 infusion of the DA type 1 (D1) receptor antagonist SCH 23390 (SCH; 30 ng/0.5 mu l per side) immediately after CORT injection attenuated CORT-induced enhancement of memory consolidation. However, intra-CA1 infusion of the DA type 2 (D2) receptor antagonist sulpiride (SUL; 60 ng/0.5 mu l per side) was ineffective. Neither antagonist alone altered freezing behavior in the 24 h CFC retention test. Furthermore, the memory enhancing dose of CORT used in these experiments reduced D1, but not D2, receptor mRNA expression in area CA1. Neither D1 nor D2 antagonism in area CA1 affected total locomotor activity. These findings provide evidence for the involvement of hippocampal D1 receptor activity in area CA1 in CORT-induced enhancement of contextual fear memory consolidation. (C) 2013 Elsevier B.V. All rights reserved.
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