Article
Geriatrics & Gerontology
Danbin Zhang, Pingyi Zhu, Bo Yin, Pinghui Zhao, Shan Wang, Limei Ye, Lijun Bai, Zhihan Yan, Guanghui Bai
Summary: The functional connectivity of the brain depends not only on the integrity of the cortex, but also on the white matter pathways. White matter hyperintensities (WMH) affect the default-mode network (DMN) connectivity in patients with acute mild traumatic brain injury (mTBI). Patients with higher frontal lobe WMH volume experience more severe symptoms and poorer information processing speed. WMH volume in specific regions of the brain may be a useful biomarker for the diagnosis and prognosis of acute mTBI.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neuroimaging
J. Bruijel, C. W. E. M. Quaedflieg, T. Otto, V. van de Ven, S. Z. Stapert, C. van Heugten, A. Vermeeren
Summary: This study used rs-fMRI to investigate the associations between functional connectivity changes and task-induced subjective fatigue in people with moderate-severe TBI. The results showed that the subjective experience of fatigue was linked to DMN connectivity in both groups, but differently associated with striatal connectivity in people with TBI compared to the healthy controls. These findings are important for the development of treatments targeting abnormal neuronal activity after TBI.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Carissa L. Philippi, Carmen S. Velez, Benjamin S. C. Wade, Ann Marie Drennon, Douglas B. Cooper, Jan E. Kennedy, Amy O. Bowles, Jeffrey D. Lewis, Matthew W. Reid, Gerald E. York, Mary R. Newsome, Elisabeth A. Wilde, David F. Tate
Summary: Research indicates that individuals with mTBI and PTSD exhibit decreased rsFC in DMN and FPN regions compared to controls, with PTSD group showing more reduced connectivity. Additionally, mTBI group displayed an increase in rsFC with the middle frontal gyrus of the FPN, while the PTSD group demonstrated a decrease. These findings suggest that PTSD symptoms may have a more consistent signal than mTBI and highlight a potential biomarker for differentiating between the two conditions.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Ze Wang
Summary: The study reveals that resting brain entropy is negatively associated with general functionality in the default mode network (DMN) and executive control network (ECN), independently of age and sex. Furthermore, resting brain entropy in DMN/ECN increases with age but decreases with education years, suggesting it may reflect a latent functional reserve that can be enhanced by education.
Article
Radiology, Nuclear Medicine & Medical Imaging
Florence L. Chiang, Max Feng, Rebecca S. Romero, Larry Price, Crystal G. Franklin, Shengwen Deng, Jodie P. Gray, Fang F. Yu, Bundhit Tantiwongkosi, Susie Y. Huang, Peter T. Fox
Summary: The study defined the atrophy-based functional network model using coordinate-based meta-analysis, revealing the association of functional network disruption in multiple sclerosis and finding a strong positive correlation with clinical disability on resting-state functional MRI scans.
Article
Psychology, Clinical
Lizhu Luo, Christelle Langley, Laura Moreno-Lopez, Keith Kendrick, David K. Menon, Emmanuel A. Stamatakis, Barbara J. Sahakian
Summary: This study examined the association between depressive symptoms in traumatic brain injury (TBI) patients and altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. The results showed a positive association between depression scores and rs-fc between limbic regions and cognitive control regions, while there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. These findings contribute to a better understanding of the mechanisms underlying depression following TBI and can inform treatment decisions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Paolo Finotelli, Carlo Piccardi, Edie Miglio, Paolo Dulio
Summary: The paper introduces a graphlet-based topological algorithm for studying the brain network at resting state, highlighting brain regions most frequently interacting. The analysis shows that the approach provides a viable tool for the topological characterization of brain regions. Through the graphlet analysis, the paper also validates the power of catching network differences and investigates the relationship between different groups of subjects based on graph correlation distances.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Davin K. Quinn, Jacqueline Story-Remer, Emma Brandt, Violet Fratzke, Rebecca Rieger, John Kevin Wilson, Darbi Gill, Nickolas Mertens, Michael Hunter, Joel Upston, Thomas R. Jones, Jessica D. Richardson, Orrin Myers, David B. Arciniegas, Richard Campbell, Vincent P. Clark, Ronald A. Yeo, C. William Shuttleworth, Andrew R. Mayer
Summary: In patients with mild-moderate traumatic brain injury (mmTBI), transcranial direct current stimulation (tDCS) combined with training can improve executive functions and post-TBI cognitive symptoms, and increase resting state connectivity of the stimulated region (left dorsolateral prefrontal cortex). The study findings also generate important hypotheses for the mechanism of recovery from persistent posttraumatic symptoms (PPS) after mmTBI.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Ramana V. Vishnubhotla, Rupa Radhakrishnan, Kestas Kveraga, Rachael Deardorff, Chithra Ram, Dhanashri Pawale, Yu-Chien Wu, Janelle Renschler, Balachundhar Subramaniam, Senthilkumar Sadhasivam
Summary: The intensive Samyama meditation program positively increased brain functional connectivity, particularly between the salience network and default mode network. Meditators showed improved mindfulness scores correlated with increased connectivity within the salience network, indicating the beneficial effects of the program on brain networks and mindfulness.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Sonia Montemurro, Nicola Filippini, Giulio Ferrazzi, Dante Mantini, Giorgio Arcara, Marco Marino
Summary: In healthy aging, education plays a role in differentiating cognitive and neural profiles in older adults. Higher education is associated with better cognitive performance in aging. This study investigates the influence of education on age-related differences in cognition and resting state functional connectivity.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Adam Runyan, Carissa L. Philippi, Sally Pessin, Carmen S. Velez, Benjamin S. C. Wade, Ann Marie Drennon, Douglas B. Cooper, Jan E. Kennedy, Amy O. Bowles, Jeffrey D. Lewis, Matthew W. Reid, Gerald E. York, Mary R. Newsome, Elisabeth A. Wilde, David F. Tate
Summary: The study found overlapping patterns of reduced rsFC in WM brain regions in both mTBI and PTSD groups. Decreased vlPFC connectivity associated with WM is consistent with previous clinical and neuroimaging studies. These results provide support for shared neural sub-strates of WM in individuals with either mTBI or PTSD.
Article
Multidisciplinary Sciences
Mariko Osaka, Mizuki Kaneda, Miyuki Azuma, Ken Yaoi, Tetsuya Shimokawa, Naoyuki Osaka
Summary: This study compared the connectivity of resting-state networks between participants with high and low working memory capacity. It found that differences in working memory capacity are associated with network connectivity variations in attentional control-associated regions during both resting and task performance conditions. The high capacity group showed stronger connectivity in attention control-related areas.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Brandon J. Lew, Marie C. McCusker, Jennifer O'Neill, Sara H. Bares, Tony W. Wilson, Gaelle E. Doucet
Summary: This study investigates the relationship between aging and resting-state functional connectivity (FC) in people with HIV (PWH). The results show that both aging and HIV infection have independent effects on between-network FC. Furthermore, HIV infection leads to additional increases in FC, particularly between the default-mode and executive control networks. This suggests that HIV infection may cause a reorganization of major brain networks similar to aging.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Hector Arciniega, Jorja Shires, Sarah Furlong, Alexandrea Kilgore-Gomez, Adelle Cerreta, Nicholas G. Murray, Marian E. Berryhill
Summary: This study found persistent cognitive deficits even years after a mild traumatic brain injury in some college students. These deficits were associated with long-term reduction in connectivity, unaffected by the duration of college education.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Emma -Jane Mallas, Nikos Gorgoraptis, Sophie Dautricourt, Yoni Pertzov, Gregory Scott, David J. Sharp
Summary: Associative binding is disrupted during post-traumatic amnesia (PTA) following traumatic brain injury (TBI). This disruption is caused by pathological slowing of brain activity, leading to misbinding in working memory. The study found that PTA patients showed abnormalities in working memory function and made more misbinding errors than controls. Slow-wave activity and increased low-frequency power were associated with binding impairment in working memory. Connectivity changes in TBI did not contribute to binding impairment. Overall, these findings highlight the importance of associative binding in memory function and its disruption in PTA following TBI.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Jacki Janowich, Jyoti Mishra, Adam Gazzaley
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Multidisciplinary Sciences
David A. Ziegler, Jacqueline R. Janowich, Adam Gazzaley
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
J. A. Anguera, J. Boccanfuso, J. L. Rintoul, O. Al-Hashimi, F. Faraji, J. Janowich, E. Kong, Y. Larraburo, C. Rolle, E. Johnston, A. Gazzaley
Review
Psychology, Mathematical
Jacqueline R. Janowich, James F. Cavanagh
PSYCHONOMIC BULLETIN & REVIEW
(2018)
Article
Behavioral Sciences
James F. Cavanagh, Andrea A. Mueller, Darin R. Brown, Jacqueline R. Janowich, Jacqueline H. Story-Remer, Ashley Wegele, Sarah Pirio Richardson
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.