期刊
BRAIN RESEARCH
卷 1433, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2011.11.028
关键词
MAP1B; Microtubule binding; Neuronal death; Caspase
资金
- Mitsui Sumitomo Insurance Welfare Foundation
Previously we reported that overexpression of MAP1B containing N-terminal 126 amino acids promoted neuronal death. Here, we identified alpha-, beta-, and beta III-tubulins as proteins interacting with MAP1B 1-126 by two-hybrid and pull-down assays. Transfection experiments indicated that MAP1B 1-126 interacts with microtubules, but to a much lesser extent than two previously reported microtubule-binding domains. Overexpression of MAP1B 1-126 induced both neurite extension and neuronal death, suggesting that MAP1B 1-126 could be involved in neuronal degeneration and aberrant sprouting. (C) 2011 Elsevier B.V. All rights reserved.
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