Article
Cell & Tissue Engineering
Kenneth N. Grise, Nelson X. Bautista, Krystal Jacques, Brenda L. K. Coles, Derek van der Kooy
Summary: This study identified synthetic glucocorticoid agonists as regulators of retinal stem cell proliferation in culture, showing that they can increase RSC self-renewal and progenitor proliferation without influencing differentiation in vitro. Injection of these agonists into adult mouse eyes also induced proliferation in the ciliary epithelium, where adult RSCs reside, suggesting a potential activation of endogenous RSCs by glucocorticoids.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Maki Kato, Norihiro Sudou, Kaori Nomura-Komoike, Tomohiro Iida, Hiroki Fujieda
Summary: Mammalian Muller glia express transcription factors and cell cycle regulators essential for retinal progenitor function. The expression of these regulators increases during development and is partially induced by photoreceptor injury. The cell cycle progression in Muller glia is associated with the expression of these regulators, which likely affects their cell fate decision.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yanjing Zhu, Ruiqi Huang, Zhourui Wu, Simin Song, Liming Cheng, Rongrong Zhu
Summary: The differentiation of neural stem cells into neurons is crucial for potential cell-based therapeutic strategies for CNS diseases. Using deep learning, researchers have developed a reliable model for predicting NSCs fate, demonstrating high precision in identifying differentiated cell types early in culture and applicability across various inducers.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Dhanushika Ratnayake, Phong D. Nguyen, Fernando J. Rossello, Verena C. Wimmer, Jean L. Tan, Laura A. Galvis, Ziad Julier, Alasdair J. Wood, Thomas Boudier, Abdulsalam I. Isiaku, Silke Berger, Viola Oorschot, Carmen Sonntag, Kelly L. Rogers, Christophe Marcelle, Graham J. Lieschke, Mikael M. Martino, Jeroen Bakkers, Peter D. Currie
Summary: Through muscle injury models in zebrafish, it has been found that specific macrophage populations 'dwell' within the injury site, providing a transient niche for stem cell proliferation. The signals released by these macrophages directly stimulate stem cell proliferation, governing the repair process.
Review
Cell & Tissue Engineering
Nan Hu, Linqing Zou, Cheng Wang, Guoqi Song
Summary: RUNX1T1 plays important roles in acute myeloid leukemia, neuronal development, intestinal development, adipogenesis, angiogenesis, and carcinogenesis, affecting cell fate through transcriptional regulation and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Douglas G. Brownfield, Alex Diaz de Arce, Elisa Ghelfi, Astrid Gillich, Tushar J. Desai, Mark A. Krasnow
Summary: The study reveals that FGF signaling plays a critical role in initiating alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains the existence of AT2 cells throughout life.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Xuan Jiang, Siqing Liu, Ya-Ru Fu, Xi-Juan Liu, Xiao-Jun Li, Bo Yang, Hai-Fei Jiang, Zhang-Zhou Shen, Endalkachew Ashenafi Alemu, Pavel Vazquez, Yaping Tang, Mari Kaarbo, Michael A. A. McVoy, Simon Rayner, Min-Hua Luo
Summary: Human cytomegalovirus (HCMV) infection in fetal brains can cause neurodevelopmental disorders by targeting neural progenitor cells (NPCs). This study investigated the expression of cellular and viral microRNAs (miRNAs) in HCMV-infected NPCs during early infection. Several differentially expressed cellular miRNAs and upregulated HCMV miRNAs were identified. Deep learning methods were used to predict miRNA targets and their associations with cellular mRNA expression changes. The study revealed the involvement of these miRNAs in neurodevelopmental and cell-cycle processes, and confirmed the regulatory role of hcmv-miR-US25-1 on the Jag1 gene, an important factor for neurogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guoliang Chen, Xianlong Li, Hongzhang Zhu, Huachuan Wu, Dacheng He, Liangyu Shi, Fuxin Wei, Xizhe Liu, Ningning Chen, Shaoyu Liu
Summary: The knockout of NF-1 improves the survival and efficiency of stem cell transplants for spinal cord injury. It enhances the neuronal differentiation and tissue repair, leading to functional recovery in rat models. This findings highlight the valuable role of NF-1 in neural stem cell biology and provide a promising strategy for spinal cord injury treatment.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Ismael Hernandez-Nunez, Diego Robledo, Helene Mayeur, Sylvie Mazan, Laura Sanchez, Fatima Adrio, Anton Barreiro-Iglesias, Eva Candal
Summary: Neurogenesis is the process of generating new neurons by progenitor cells, which is restricted to specific neurogenic niches. The retina of cartilaginous fish such as catsharks shows active proliferation and neurogenesis in juveniles but a reduction in cell proliferation after sexual maturation. RNA-Seq analysis revealed a decrease in gene expression related to cell proliferation and neurogenesis in adult catsharks, providing valuable insight into signaling pathways controlling neurogenesis in vertebrate retinas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Kevin Yueh Lin Ho, Rosalyn Leigh Carr, Alexandra Dmitria Dvoskin, Guy Tanentzapf
Summary: In this study, a long-term organ culture and imaging strategy for hematopoiesis in flies was developed, and it was found that fly blood progenitors undergo symmetric cell divisions that are linked to both cell size and spatial orientation. Additionally, infection-induced activation of hematopoiesis was shown to occur through modulation of the kinetics of cell differentiation.
Article
Cell Biology
Jiajing Wang, Na Sun, Yahan Ju, Ni Ni, Zhimin Tang, Dandan Zhang, Xiaochan Dai, Moxin Chen, Yiqi Wang, Ping Gu, Jing Ji
Summary: In this study, it was shown that miR-381-3p regulates the proliferation and differentiation of RPCs by targeting Hes1, providing an experimental basis for the potential therapeutic use of RPCs transplantation in treating retinal degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jhoanne L. Bautista, Nathan T. Cramer, Corey N. Miller, Jessica Chavez, David I. Berrios, Lauren E. Byrnes, Joe Germino, Vasilis Ntranos, Julie B. Sneddon, Trevor D. Burt, James M. Gardner, Chun J. Ye, Mark S. Anderson, Audrey V. Parent
Summary: Single-cell RNA sequencing of human thymic stroma reveals the crucial roles of different cell types in the diversity of thymic cells and the induction of immune tolerance.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Hani Jieun Kim, Michelle O'Hara-Wright, Daniel Kim, To Ha Loi, Benjamin Y. Lim, Robyn V. Jamieson, Anai Gonzalez-Cordero, Pengyi Yang
Summary: Characterizing cell identities in the human retina is important for studying its development and disease. This study evaluated the fidelity of retinal organoids in mimicking the human eye by systematically assessing the molecular and cellular characteristics of both the organoids and human eye tissues. The results provided new biomarkers for major retinal cell types and insights into the maturation process, allowing for comprehensive benchmarking of current protocols for retinal organoid generation.
Article
Biochemistry & Molecular Biology
Xiaokun Zhou, Danping Lu, Wenxiang Yi, Dan Xu
Summary: The study investigated the role of CDC25C in neural progenitor cell division and differentiation by knocking down the gene in developing rat brains. The results showed that CDC25C is essential for maintaining the proliferative state of neural progenitor cells during cortical development. Knockdown of CDC25C resulted in early cell cycle exit and premature differentiation of neural progenitor cells, revealing a novel role for CDC25C in NPC division and cell fate determination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Evelyn Tran, Tuo Shi, Xiuwen Li, Adnan Y. Chowdhury, Du Jiang, Yixin Liu, Hongjun Wang, Chunli Yan, William D. Wallace, Rong Lu, Amy L. Ryan, Crystal N. Marconett, Beiyun Zhou, Zea Borok, Ite A. Offringa
Summary: In this study, we successfully established alveolar epithelial cell lines using de-identified human remnant transplant lungs. These cell lines were validated in both 2D and 3D cultures. In 3D culture, the cells formed alveolar-like organoids and expressed mature alveolar epithelial cell markers. Single-cell RNA sequencing revealed increased cellular heterogeneity and induction of cytokine and lipoprotein signaling in the 3D organoids.
Article
Computer Science, Artificial Intelligence
Xi Wang, Yu Zhao, Guangping Zeng, Peng Xiao, Zhiliang Wang
Summary: This research applies machine learning technology to the Satir theory model, intelligently classifying communication stances based on language and behavior information. By collecting dialogue language materials and utilizing a Chinese word segmentation system, a psychological consultation database was created. Training sets were constructed using speech filtering, text word vectorization, and annotation with the Satir model. Experimental results show high success rates in classifying four inconsistent coping stances.
JOURNAL OF EXPERIMENTAL & THEORETICAL ARTIFICIAL INTELLIGENCE
(2023)
Review
Genetics & Heredity
Xiaoyue Zhang, Zhenzhong Wang, Shengqiang Ge, Yuanyuan Zuo, Haodong Lu, Yan Lv, Naijun Han, Yumei Cai, Xiaodong Wu, Zhiliang Wang
Summary: This review summarizes studies on attenuated strains of African swine fever virus obtained through cell passage over the last 60 years, aiming to provide inspiration for future vaccine design.
Article
Engineering, Environmental
Yijian Li, Jiyu Cui, Qingju Wang, Lifeng Yang, Liyuan Chen, Huabin Xing, Xili Cui
Summary: By utilizing the adaptive nano-traps of hybrid porous material ZU-61, the responsive shape recognition of styrene over ethylbenzene was achieved for the first time based on conformational differences caused by different substituent groups, demonstrating excellent separation selectivity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Software Engineering
Tao Xu, Xinheng Wang, Xie Lun, Hang Pan, Zhiliang Wang
Summary: With the global aging problem becoming more serious, the initial screening for Alzheimer's disease (AD) is increasingly important. This study attempts to establish a facial video-based AD recognition dataset through a human-computer interaction method, and analyzes and evaluates this dataset.
COMPUTER ANIMATION AND VIRTUAL WORLDS
(2023)
Article
Nursing
Jiang-Ping Chen, Yu-Mei Dai, Yong Qin, Sheng-Peng Liang, Gen Cheng, Yang Liu, Cheng-Zu Yang, Hong-Gu He, Qu Shen
Summary: This study aimed to explore the correlation among turnover intention, emotional intelligence, and job burnout in male nurses and identify the influencing factors. The results revealed a weak negative correlation between turnover intention and emotional intelligence, a moderate positive correlation between turnover intention and job burnout, and a moderate negative correlation between emotional intelligence and job burnout. Factors such as job burnout, young age, lack of interest in nursing, and working in the emergency department significantly affected turnover intention among male nurses. The study also highlighted the relationships between turnover intention, emotional intelligence, and job burnout.
INTERNATIONAL NURSING REVIEW
(2023)
Article
Chemistry, Multidisciplinary
Yixuan Zhu, Yu Zhou, Lu Ren, Jingyao Ye, Haichuan Wang, Xinyuan Liu, Ruiyun Huang, Haojie Liu, Junyang Liu, Jia Shi, Peng Gao, Wenjing Hong
Summary: The charge transport through single-molecule electronic devices can be mechanically controlled by changing the molecular geometrical configuration in situ, achieving conductance variations of more than four orders of magnitude. This is achieved by switching between constructive and destructive quantum interference pathways through designing molecules with multiple anchoring groups and shifting the electrodes within a range of about 0.6 nm. The tunable conductance range achieved using this mechanical tuning strategy is the highest reported so far.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Yujiao Xiahou, Junyang Liu, Junrong Zheng, Jun Yi, Dayang Wang, Haibing Xia
Summary: Macroscopically monocrystalline, self-assembled monolayers (M2-SAM) of gold nanoparticles coated with oleylamine (Au@OLA NPs) are achieved by optimizing their surface charges. The resulting M2-SAM of Au@OLA NPs exhibit unconventional Moire ' patterns beyond the imaging limit of scanning electron microscopy. The mono-crystallinity enables the M2-SAM to be used as SERS substrates for quantitative analysis and fabricate high precision and broad measurement span temperature sensors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Hardware & Architecture
Shicheng Wang, Menghao Zhang, Guanyu Li, Chang Liu, Zhiliang Wang, Ying Liu, Mingwei Xu
Summary: Multi-string pattern matching is crucial for network security applications but often becomes a performance bottleneck. Existing solutions cannot keep up with the increasing network bandwidth and traffic demands. In this paper, we propose BOLT, a scalable and cost-efficient multi-string pattern matching system leveraging programmable switches. Extensive evaluations show that BOLT achieves high throughput and scalability with various pattern sets and workloads.
IEEE-ACM TRANSACTIONS ON NETWORKING
(2023)
Article
Chemistry, Physical
Xingzhou Yang, Songjun Hou, Meiling Su, Qian Zhan, Hanjun Zhang, Sergio M. Quintero, Xiaodong Liu, Junyang Liu, Wenjing Hong, Juan Casado, Qingqing Wu, Colin J. Lambert, Yonghao Zheng
Summary: It is found that the transport properties of a series of fluorene derivatives can be tuned by controlling the degree of localization of certain orbitals, leading to a significant enhancement in conductance. This new understanding of the role of radicals in single-molecule junctions opens up a novel design strategy for single-molecule-based spintronic devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Haojie Liu, Lijue Chen, Hao Zhang, Zhangqiang Yang, Jingyao Ye, Ping Zhou, Chao Fang, Wei Xu, Jia Shi, Junyang Liu, Ye Yang, Wenjing Hong
Summary: Researchers developed a single-molecule photoelectron tunnelling spectroscopy approach to map the transmission spectrum beyond the HOMO-LUMO gap. This is important for understanding and controlling charge transport in molecular devices and materials.
Article
Multidisciplinary Sciences
Chun Tang, Thijs Stuyver, Taige Lu, Junyang Liu, Yiling Ye, Tengyang Gao, Luchun Lin, Jueting Zheng, Wenqing Liu, Jia Shi, Sason Shaik, Haiping Xia, Wenjing Hong
Summary: By utilizing a strategy of redox control and electric field modulation, we successfully achieve single-molecule control of a keto-enol equilibrium at room temperature. Through the control of charge injection in the single-molecule junction, we can access charged potential energy surfaces with opposite thermodynamic driving forces, preferentially favoring the conducting enol form and significantly reducing the isomerization barrier. This allows us to selectively obtain desired and stable tautomers, leading to significant modulation of the single-molecule conductance. This work highlights the concept of single-molecule control of chemical reactions on multiple potential energy surfaces. Keto-enol tautomerism offers a promising platform for modulating charge transport at the nanoscale.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Tengyang Gao, Abdalghani Daaoub, Zhichao Pan, Yong Hu, Saisai Yuan, Yaoguang Li, Gang Dong, Ruiyun Huang, Junyang Liu, Sara Sangtarash, Jia Shi, Yang Yang, Hatef Sadeghi, Wenjing Hong
Summary: Supramolecular radical chemistry is an emerging field that combines supramolecular chemistry and radical chemistry. This study demonstrates the fabrication and charge transport properties of a supramolecular radical junction. The results show that the conductance of the supramolecular radical junction is significantly higher than that of a junction without a radical and even higher than that of a fully conjugated oligophenylenediamine molecule. The research reveals that the radical increases the binding energy and decreases the energy gap, enabling efficient transport through the supramolecular radical.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Xiaohui Li, Yan Zheng, Yu Zhou, Zhiyu Zhu, Jiayi Wu, Wenhui Ge, Yuxuan Zhang, Yuqing Ye, Lichuan Chen, Jia Shi, Junyang Liu, Jie Bai, Zitong Liu, Wenjing Hong
Summary: This study investigates the charge transport in supramolecular transistors and demonstrates the configuration-dependent quantum interference effects. It reveals the potential of supramolecular channels for molecular electronics and provides a fundamental understanding of intermolecular charge transport.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Li-Chuan Chen, Jie Shi, Zhi-Xing Lu, Rong-Jian Lin, Tai-Ge Lu, Yu-Ling Zou, Qing-Man Liang, Ruiyun Huang, Jia Shi, Zong-Yuan Xiao, Yanxi Zhang, Junyang Liu, Yang Yang, Wenjing Hong
Summary: This study developed a strategy for fabricating photoresponsive devices with high reversibility using transition metal dichalcogenides (TMDCs) electrodes and thiol azobenzene self-assembled monolayers (SAMs). The coupling strength between the molecule and the TMDCs electrodes decreased, leading to improved reversibility of the molecular photoswitches.
Article
Engineering, Electrical & Electronic
Ligang Zuo, Lun Xie, Hang Pan, Zhiliang Wang
Summary: This paper proposes a lightweight two-terminal feature fusion network for accurate object pose estimation using images and point clouds. By extracting features with Pointno problemNet network and improved PointNet++ network, and applying depthwise separable convolutions to reduce the number of model parameters, the method exhibits good performance and robustness in various experiments.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.