Review
Biochemistry & Molecular Biology
Yaqian Fan, Yuedong Wang, Pengyu Gu, Junhai Han, Yao Tian
Summary: Temperature plays a crucial role in regulating sleep, and understanding its influence can reveal important physiological processes necessary for survival and guide strategies for managing sleep disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Mechanical
Miaomiao Xing, Zhuoqin Yang, Yong Chen
Summary: This study investigates the effect of temperature on the bursting discharge behavior of temperature-sensitive ion channels in neurons. The results show that an increase in temperature can promote the generation of bursting discharge, but eventually the bursting discharge phenomenon disappears. It is also found that even if the dynamic paths are consistent, the bursting discharge types and waveforms may be different, and vice versa.
NONLINEAR DYNAMICS
(2023)
Article
Biology
Jianhui Xu, Wenmin Gao, Tianhui He, Lan Yao, Hanghong Wu, Zhenwei Chen, Yupei Lai, Yajun Chen, Jie Zhang
Summary: This study found that injection of agmatine into the preoptic area (POA) of male rats induced hyperthermic responses associated with increased heat production and locomotor activity. The most effective injection sites were located in the medial preoptic area (MPA). Results suggest that agmatine injection can cause thermogenic, shivering, and locomotor responses by inhibiting warm-sensitive neurons in the POA.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Neurosciences
Qian Zhou, Xin Fu, Jianhui Xu, Shiming Dong, Changhao Liu, Dali Cheng, Cuicui Gao, Minhua Huang, Zhiduo Liu, Xinyan Ni, Rong Hua, Hongqing Tu, Hongbin Sun, Qiwei Shen, Baoting Chen, Jin Zhang, Liye Zhang, Haitao Yang, Ji Hu, Wei Yang, Weihua Pei, Qiyuan Yao, Xing Sheng, Jie Zhang, Wen Z. Yang, Wei L. Shen
Summary: Precise monitoring of internal temperature is crucial for thermal homeostasis in mammals. Through a genetic screen, TRPC4 channel was identified as essential for warm sensing in GABAergic WSNs, playing a role in basal temperature setting, warm defense, and fever responses. TRPC4 may serve as a potential therapeutic target for managing core body temperature.
Article
Physiology
Nicolas M. Diaz, Shannon A. Gordon, Richard A. Lang, Ethan D. Buhr
Summary: Mammals regulate their body temperature by utilizing internal circadian clocks and thermosensitivity. The preoptic area of the hypothalamus houses temperature-sensitive circadian clocks that are influenced by temperature changes but not by light cues.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Tang, Siyuan Liu, Lingzhi Xu, Min Huang, Ke Zhang
Summary: This study investigated the effects of AVP on membrane potential responses of temperature-sensitive and -insensitive POA neurons. The results showed that AVP enhanced the membrane potential thermosensitivity of nearly 50% of the temperature-insensitive neurons, while there was no difference in the effects on membrane potential of temperature-sensitive neurons. Furthermore, AVP induction did not result in any changes in resting potential of POA neurons.
Review
Neurosciences
Rebecca Rothhaas, Shinjae Chung
Summary: Sleep and body temperature are tightly interconnected in mammals, with the preoptic area of the hypothalamus playing a crucial role in regulating these behaviors. Recent research on sleep- and thermo-regulatory POA neurons has raised new questions about the overlap and pathways of these neurons and the role of signaling molecules in coordinating sleep and body temperature regulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yunyun Zhang, Huiming Li, Xinxin Zhang, Sa Wang, Dan Wang, Jiajia Wang, Tingting Tong, Zhen Zhang, Qianzi Yang, Hailong Dong
Summary: A recent study has found that there are sex differences in response to general anesthesia, but the neural mechanisms behind this are unclear. This study showed that male mice were more sensitive to sevoflurane anesthesia and that estrogen receptor alpha in the medial preoptic area played a critical role in regulating sleep in males. Furthermore, pharmacological inhibition of estrogen receptor alpha eliminated sex differences in sevoflurane anesthesia.
NEUROSCIENCE BULLETIN
(2022)
Article
Chemistry, Analytical
Yuting Ye, Chao Chen, Wentao Li, Xingzhou Guo, Haifeng Yang, Haomin Guan, Hua Bai, Wei Liu, Guangcheng Xi
Summary: A rapid and green microwave synthetic route was developed for the preparation of plasmonic W18O49 mesocrystals with no additives. The ultrathin nanowires and oxygen vacancy-rich building units, along with the periodic mesocrystal structure, significantly enhanced the SERS properties, achieving outstanding enhancement factor and ultralow detectable limit. The large-area SERS substrate fabricated showed a low relative standard deviation, indicating good reproducibility.
ANALYTICAL CHEMISTRY
(2021)
Article
Construction & Building Technology
Enhui Yang, Jiaqiu Xu, Haoyuan Luo, Bing Huang, Kelvin C. P. Wang, Joshua Qiang Li, Yanjun Qiu
Summary: This study evaluates the performance of warm mix asphalt (WMA) with different additives in high-altitude plateau regions. Solid additives are suitable for improving the high-temperature performance in high-temperature areas, while surface-active liquid additives are suitable for low-temperature plateau areas.
ROAD MATERIALS AND PAVEMENT DESIGN
(2022)
Article
Medicine, Research & Experimental
Jungyoon Ohn, Kyung Wook Been, Jin Yong Kim, Eun Ju Kim, Taeyong Park, Jeong Seok Ji, Masato Iwabu, Toshimasa Yamauchi, Yeon Kyung Kim, Chaok Seok, Ohsang Kwon, Kyu Han Kim, Hyung Ho Lee, Jin Ho Chung
Summary: The study identifies a small peptide P5 that promotes hair growth by activating AdipoR1 and increasing expression of hair growth factors via the AMPK signaling pathway. P5 accelerates hair growth ex vivo and induces anagen hair cycle in mice in vivo.
EMBO MOLECULAR MEDICINE
(2021)
Article
Microbiology
Yu-Min Chuang, Helen Stone, Selma Abouneameh, Xiaotian Tang, Erol Fikrig
Summary: When female mosquitoes feed on mammalian hosts, the components of the blood meal can affect the fitness of the mosquitoes and indirectly influence the infectivity of pathogens. This study demonstrates that mammalian adiponectin, ingested during Anopheles gambiae blood feeding, co-localizes within mosquito midguts and reduces Plasmodium infection in the vector. Transcriptomic and RNAi studies show that the A. gambiae adiponectin receptor is involved in downregulating lipophorin, a lipid transporter that is important for mosquito egg development and Plasmodium infection. These findings reveal a cross-phyla interaction between the mammalian host and A. gambiae that negatively impacts Plasmodium survival in its arthropod vector.
Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Alisa A. Omelchenko, Hua Bai, Emma C. Spina, Jordan J. Tyrrell, Jackson T. Wilbourne, Lina Ni
Summary: This study investigates the mechanism of temperature sensing and response in fruit fly larvae. It finds that the Rh1 and PLC cascade regulate fast and slow temperature responses. Ionotropic receptors play different roles in response to different temperature changes, while the Rh1 cascade and warm receptors are crucial in selecting preferred temperatures and guiding larvae to suitable temperature zones.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Abir A. Rahman, Brad E. Morrison
Article
Clinical Neurology
Manuel Sanchez-Alavez, Jessica Benedict, Derek N. Wills, Cindy L. Ehlers
Article
Cell Biology
Tanner B. Pollock, Jacob M. Mack, Ryan J. Day, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Substance Abuse
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N. Wills, Dennis Otero, Carlos A. Aguirre, Mona Singh, Cindy L. Ehlers, Bruno Conti
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Substance Abuse
Leslie R. Amodeo, Derek N. Wills, Manuel Sanchez-Alavez, Cindy L. Ehlers
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Neurosciences
Abir A. Rahman, Alejandro Soto-Avellaneda, Hyun Yong Jin, Iva Stojkovska, Nathan K. Lai, Joshua E. Albright, Abby R. Webb, Emily Oe, Jacob P. Valarde, Alexandra E. Oxford, Paige E. Urquhart, Brandon Wagner, Connor Brown, Isabella Amado, Peyton Vasquez, Nicholas Lehning, Veselin Grozdanov, Xinzhu Pu, Karin M. Danzer, Brad E. Morrison
Review
Biochemistry & Molecular Biology
Alejandro Soto-Avellaneda, Brad E. Morrison
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Carlos Guijas, J. Rafael Montenegro-Burke, Rigo Cintron-Colon, Xavier Domingo-Almenara, Manuel Sanchez-Alavez, Carlos A. Aguirre, Kokila Shankar, Erica L-W Majumder, Elizabeth Billings, Bruno Conti, Gary Siuzdak
Review
Chemistry, Medicinal
Maranda S. Cantrell, Alejandro Soto-Avellaneda, Jackson D. Wall, Aaron D. Ajeti, Brad E. Morrison, Lisa R. Warner, Owen M. McDougal
Summary: Drug development is a complex, slow, and expensive process, but repurposing existing drugs with known safety profiles approved by the FDA for clinical trials can mitigate these challenges. Cardiovascular and neurodegenerative diseases pose significant treatment obstacles, necessitating the exploration of new drugs with better efficacy, guided by mechanistic insights into disease progression. Researchers are focusing on repurposing drugs for potential pharmacological treatments targeting inflammation in cardiovascular and neurodegenerative diseases.
Article
Oncology
Egbert F. Smit, Christophe Dooms, Jo Raskin, Ernest Nadal, Lye M. Tho, Xiuning Le, Julien Mazieres, How S. Hin, Masahire Morise, Viola W. Zhu, Daniel Tan, Kristina H. Holmberg, Barbara Ellers-Lenz, Svenja Adrian, Sabine Brutlach, Karl M. Schumacher, Niki Karachaliou, Yi-Long Wu
Summary: Combining osimertinib with MET inhibitor like tepotinib could potentially overcome resistance driven by MET amplification in NSCLC patients, and the ongoing study INSIGHT 2 aims to evaluate the efficacy and safety of this combination therapy for patients with acquired resistance to osimertinib due to MET amplification.
Article
Immunology
Mark S. Freedman, Jerome Wojcik, Kristina H. Holmberg, Markus Fluck, Mauro D'Antonio, Yann Hyvert, Sofia Stinchi, Vittorio D'Urso, Fernando Dangond
Summary: This study confirmed MX1, 2'5'OAS, and IL1RA as effective biomarkers for the efficacy of subcutaneous IFNβ-1a treatment, while also identifying Neopterin, TRAIL, and IP-10 as biomarkers associated with long-term treatment efficacy.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Nicholas A. Lehning, Brad E. Morrison
Summary: Protein degradation is a crucial process in cellular life, and dysfunction in this process is linked to human diseases. neben der Antarktis Die Ubiquitinierung ist der am besten charakterisierte Mechanismus, um ein Protein für den Abbau zu markieren; Es wurden jedoch auch eine wachsende Anzahl von verschiedenen Mechanismen identifiziert, die diese wesentliche Funktion ausüben. Zum Beispiel zielt die kovalente Markierung von Proteinen mit Sequestosom-1 auf eine selektive Autophagie ab. Abbausignale sind nicht ausschließlich Polypeptide wie Ubiquitin, NEDD8 und Sequestosom-1, sondern können auch durch Phosphorylierung, Acetylierung und Methylierung von Proteinen bestimmt werden. Die Vielfalt der Substratsequenzen und die Überlappung mit anderen pleiotropen Funktionen dieser kleineren Signalmoleküle erschweren ihre Charakterisierung zunehmend. Diese kleinen Signale könnten jedoch für die Organisation eines großen Teils der Proteinverseigungstätigkeit in der Zelle verantwortlich sein. Aus diesem Grund besteht ein wachsendes Interesse an Lysinmethylierung und den damit verbundenen Lysinmethyltransferasen (KMTs), die über die kanonische Modifikation von Histoprotein hinaus an der Proteinverseitung in verschiedenen Kontexten beteiligt sind. Diese Übersicht konzentriert sich auf die derzeitigen Hinweise auf Lysinmethylierung als ein Signal für die Proteinverseitung mit einer ausführlichen Diskussion über die Klasse der Enzyme, die für dieses Phänomen verantwortlich sind。
JOURNAL OF CHEMISTRY
(2022)
Article
Clinical Neurology
Cristian O. Mancilla-Corona, Manuel Sanchez-Alavez, Gisela Pineda-Garcia, Julieta Y. Islas-Limon, Oscar E. Zazueta, Jonathan Lopez-Baena, Jesus I. Rodriguez-Vasquez, Idanya R. Serafin-Higuera
Summary: Fatigue has been identified as a persistent condition following COVID-19 infection, affecting cognitive function and performance. This study aimed to investigate the impact of post-COVID fatigue on neuropsychological performance. Participants with post-COVID fatigue and age-matched controls were randomly selected from a database. Both groups completed a health survey and a neuropsychological assessment test via telephone call. Statistical analysis revealed significant regression coefficients between post-COVID fatigue and global parameters of the assessment, indicating a decrease in neuropsychological performance.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Cell Biology
Alejandro Soto-Avellaneda, Brad E. Morrison
NEURAL REGENERATION RESEARCH
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.