Article
Neurosciences
Thi Ngoc Anh Dinh, Won Beom Jung, Hyun-Ji Shim, Seong-Gi Kim
Summary: This study is the first to explore the functional characteristics of the mouse visual system using fMRI, and found that under anesthesia, mice showed stronger and more widespread BOLD responses compared to the awake state. Additionally, the BOLD response to visual stimuli was faster and stronger in awake mice compared to anesthetized mice.
Article
Engineering, Electrical & Electronic
Cunguang Lou, Xu Yang, Xitong Li, Hongjia Chen, Chao Chang, Xiuling Liu
Summary: A novel, highly sensitive gas sensing system utilizing a graphene-coated quartz tuning fork (QTF) and light-induced thermoelastic spectroscopy (LITES) has been developed. When CO2 is selected as the target analyte, the optimized coating thickness on the commercially available QTF shows improved performance in gas detection compared to traditional bare QTF methods.
IEEE SENSORS JOURNAL
(2021)
Article
Biochemical Research Methods
Schnaude Dorizan, Kevin J. Kleczka, Admir Resulaj, Trevor Alston, Chris S. Bresee, Mitra J. Z. Hartmann
Summary: This article introduces a novel multi-whisker stimulator for assessing neural selectivity for the direction of global motion. The stimulator can generate repeatable, linear sweeps of tactile stimulation across the whisker array in any direction and with a range of speeds.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huiwen Luo, Zhangyan Yang, Pai-Feng Yang, Feng Wang, Jamie L. Reed, John C. Gore, William A. Grissom, Li Min Chen
Summary: The study aims to calculate temperatures from optogenetic fMRI T-2*-weighted images using proton resonance frequency (PRF) shift thermometry, in order to monitor confounding heating effects and determine appropriate light parameters. A motion- and respiration-robust processing pipeline was developed to calculate temperature changes directly from the T-2*-weighted images collected for fMRI. Optogenetic fMRI protocols with different stimulation durations were applied to validate the methods.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Optics
Luigi Consolino, Annamaria Campa, Michele De Regis, Francesco Cappelli, Giacomo Scalari, Jerome Faist, Mattias Beck, Markus Rosch, Saverio Bartalini, Paolo De Natale
Summary: Full phase control of THz-emitting QCL combs has been demonstrated, opening new perspectives for demanding applications. A new method, Small Optical Frequency Tuning (SOFT), has been proposed to control the emission frequencies of a THz QCL comb using a simple experimental setup, allowing tweaking of the complex refractive index without destabilizing laser gain. The SOFT actuator has been characterized and shown to be suitable for frequency and phase stabilization of THz QCL combs.
LASER & PHOTONICS REVIEWS
(2021)
Article
Physics, Multidisciplinary
Yunfei Wang, Yuqing Li, Jizhou Wu, Wenliang Liu, Peng Li, Yongming Fu, Jie Ma, Liantuan Xiao, Suotang Jia
Summary: In this paper, a method for fast and wide-frequency tuning of a stabilized ECDL is reported and compared with previous works. The output frequency of the stabilized ECDL can be shifted within a range of approximately 620 MHz in a short time.
FRONTIERS OF PHYSICS
(2022)
Article
Acoustics
Yufei Ma, Yinqiu Hu, Shunda Qiao, Ziting Lang, Xiaonan Liu, Ying He, Vincenzo Spagnolo
Summary: This paper reports on the performance of quartz tuning fork (QTF) based laser spectroscopy sensing using multiple QTFs. Two resonance frequency matching methods are proposed to avoid degradation of sensor performance. Experimental results validate the effectiveness of the proposed methods.
Article
Neurosciences
Anwar O. Nunez-Elizalde, Michael Krumin, Charu Bai Reddy, Gabriel Montaldo, Alan Urban, Kenneth D. Harris, Matteo Carandini
Summary: Functional ultrasound imaging (fUSI) is an effective method for measuring blood flow and inferring brain activity, showing a strong correlation with slow fluctuations in neural firing rate. The study found that fUSI signals are accurately predicted by the smoothed firing rate of local neurons, particularly inhibitory neurons, and match neural firing spatially across different brain regions.
Article
Medicine, Research & Experimental
Elisabeth C. Caparelli, Brooke Schleyer, Tianye Zhai, Hong Gu, Osama A. Abulseoud, Yihong Yang
Summary: In this study, the modulatory effect of transcranial magnetic stimulation (TMS) was investigated using functional magnetic resonance imaging (fMRI). The results showed that TMS affected both the stimulation sites and remote brain areas, with certain areas/networks common across all TMS sites and others specific to each site. Additionally, differences in TMS site and laterality were observed in the left executive control network and certain prefrontal cortex areas.
Article
Engineering, Electrical & Electronic
Chuxin Liu, Liangjun Lu, Yuyao Guo, Xinhang Li, Jianping Chen, Linjie Zhou
Summary: In this study, a wavelength widely-tunable hybrid integrated external cavity laser (ECL) with synchronous tuning was developed to achieve a large frequency chirp bandwidth and high chirp linearity. The ECL utilized Si3N4 Vernier microring resonators (MRRs) as an optical bandpass filter, providing strong wavelength selectivity and fast frequency tunability. The experimental results showed that the ECL exhibited a wide wavelength tuning range and high output optical power.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Guolu Yin, Rui Jiang, Tao Zhu
Summary: This paper proposes a simplified optical frequency domain reflectometry system by integrating an in-fiber auxiliary interferometer to compensate for laser nonlinear tuning effect. The feasibility of the proposed system in compensating the laser nonlinear tuning effect and distributed sensing capability was experimentally verified.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Zhenpeng Wang, Tao Yu, Yanlin Sui, Zhi Wang
Summary: This study proposes a method based on center of gravity (COG) for multi-frequency estimation, which accurately acquires the three beat-notes of the laser heterodyne interference signal and meets the requirement of space missions.
Article
Neurosciences
Chunxiao Bu, Huan Ren, Qingqing Lv, Huilian Bu, Xinyu Gao, Ruiping Zheng, Huiyu Huang, Weijian Wang, Yarui Wei, Jingliang Cheng, Yong Zhang
Summary: This study found that stSCS can cause dynamic ALFF changes in PHN patients, thereby altering brain functions to relieve pain, sleep, and mood symptoms. These findings provide new insights into the mechanisms of stSCS efficacy in the treatment of patients with PHN.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Physiology
Lana Kralj, Helena Lenasi
Summary: Laser Doppler flowmetry (LDF) is widely regarded as the gold standard for non-invasive assessment of skin microvascular function. Spectral analysis, particularly wavelet analysis (WA), can provide both time and frequency localization of the LD microcirculatory signals, allowing for a more comprehensive analysis of the signals' properties. However, there is a need for analytical standardization and improvements in WA to accurately evaluate microcirculatory signals and enhance prognosis of diseases with microvascular dysfunction.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Mathematics, Applied
JiaJia Li, Peihua Feng, Liang Zhao, Junying Chen, Mengmeng Du, Jian Song, Ying Wu
Summary: This study proposes a neuron-astrocyte network model and finds that noise in astrocytes affects the transitions of epileptic seizures and neuronal firing frequency. Under certain noise intensity, neuronal firing pattern can switch between regular and epileptic states. These findings contribute to understanding the randomness of epilepsy.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.