Article
Neurosciences
Sara Spadone, Annalisa Tosoni, Stefania Della Penna, Carlo Sestieri
Summary: This study investigates the dynamic properties and spatial distribution of oscillatory power modulations in the lateral parietal lobe during an item recognition task. The findings suggest that the alpha ERD in the intraparietal sulcus might represent a neural signature of the evidence accumulation process during simple memory-based decisions.
Article
Multidisciplinary Sciences
Anna Backestrom, Konstantin Papadopoulos, Sture Eriksson, Tommy Olsson, Micael Andersson, Kaj Blennow, Henrik Zetterberg, Lars Nyberg, Olov Rolandsson
Summary: The study revealed that acute hyperglycaemia did not affect episodic, semantic, and working memory performance in individuals with and without type 2 diabetes, but individuals with type 2 diabetes showed reduced working memory during certain tests, possibly due to decreased activity in important frontal brain areas.
Article
Neurosciences
Hendrik Heinbockel, Conny W. E. M. Quaedflieg, Till R. Schneider, Andreas K. Engel, Lars Schwabe
Summary: Acute stress may enhance theta oscillations in the medial temporal lobe during memory formation for emotionally negative stimuli. While the exact impact of stress on emotional memory remains unclear, it may aid in storing emotionally significant events in the context of a stressful encounter.
NEUROBIOLOGY OF STRESS
(2021)
Article
Neurosciences
Zai-Fu Yao, Shulan Hsieh
Summary: Explored age differences in the functional hierarchical organization of the frontal lobe. Found that older adults had slower reaction time and lower efficiency in selecting stimulus-response mappings as abstraction levels increased. Brain imaging indicated hierarchical organization trends along the rostro-caudal axis, and neural dedifferentiation was observed in older adults. Behavioral performance and age difference activations were associated with working memory capacity.
Article
Behavioral Sciences
Nathalie Giroud, Matthias Keller, Martin Meyer
Summary: This study investigated the relationship between working memory capacity, age-related structural decline in the brain, and speech-in-noise reception thresholds in older adults. The results showed that older adults with greater age-related atrophy in specific brain regions had higher speech-in-noise reception thresholds. Moreover, individual working memory capacity moderated the association between certain brain regions and speech-in-noise reception thresholds.
Article
Psychology, Multidisciplinary
Natalia Guerra, Raquel Pinto, Pedro S. Mendes, Pedro F. S. Rodrigues, Pedro B. Albuquerque
Summary: Face masks may compromise our capacity for face recognition, as encoding with a mask and testing without it leads to the worst performance. Holistic face processing and the encoding specificity principle have different effects on performance.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Audrey E. Branch, Lucas R. Glover, Michela Gallagher
Summary: Cognitive decline is common in aging, especially in memory domains supported by the medial temporal lobe. Identifying intervention strategies is challenging due to variability between individuals. Aged Long-Evans rats have been useful for studying age-related memory decline. The study aimed to test if impairments in water maze learning could predict delayed recognition memory impairments in these rats.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ozdem Erturk Cetin, Nermin Gorkem Sirin, Ayse Deniz Elmali, Betul Baykan, Nerses Bebek
Summary: Frontal lobe epilepsy (FLE) is the second most common drug-resistant focal epilepsy, presenting difficulties in diagnosis and localization. The study found that hyperkinetic movements were the most common semiologic feature, while non-localizing or lateralizing ictal EEG patterns were prevalent. Low percentage of localized FDG-PET results were observed, suggesting challenges in determining epileptogenic zone of FLE.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Behavioral Sciences
Shir Ben-Zvi Feldman, Nachum Soroker, Daniel A. Levy
Summary: Previous studies have shown that face recognition memory involves the temporal, frontal, and parietal regions, but the specific functions of these areas remain unclear.
Article
Neurosciences
Paul W. Burgess, James Crum, Paola Pinti, Clarisse Aichelburg, Dominic Oliver, Frida Lind, Sarah Power, Elizabeth Swingler, Uzair Hakim, Arcangelo Merla, Sam Gilbert, Ilias Tachtsidis, Antonia Hamilton
Summary: Activation of rostral PFC during prospective memory tasks can be attributed to monitoring of the environment, spontaneous intention retrieval, or a combination of the two. This study found widespread activation in medial and right hemisphere rostral prefrontal cortex when individuals maintained both social and non-social intentions, with increased activation in lateral prefrontal cortex during social intentions. The spatial and temporal distribution of functional events in BA 10 suggests a specific role in prospective memory tasks.
Article
Neurosciences
Qiong Zhang, Weifeng Sun, Kailing Huang, Li Qin, Shirui Wen, Xiaoyan Long, Quan Wang, Li Feng
Summary: This study explored the characteristics and mechanisms of working memory impairment in patients with frontal lobe epilepsy (FLE) using a memory game paradigm and eye tracking technology. The results showed that FLE patients had lower memory scores and took longer to complete the memory game compared to healthy controls. Eye tracking data also revealed deficits in attentional maintenance among FLE patients. These findings contribute to understanding the underlying mechanisms of memory impairment in FLE.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Bryan Kolb
Summary: This article discusses Milner's contribution to our understanding of frontal lobes through her studies on patients who had undergone frontal lobe excisions. Her research has had a significant impact on our understanding of frontal lobe function.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Oncology
Mitsutoshi Nakada, Riho Nakajima, Hirokazu Okita, Yusuke Nakade, Takeo Yuno, Shingo Tanaka, Masashi Kinoshita
Summary: The study demonstrates that awake surgery for right frontal lobe glioma can successfully preserve visuospatial cognition and spatial working memory with satisfying resection rates.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Neurosciences
Jin Wang, Brianna L. Yamasaki, Yael Weiss, James R. Booth
Summary: The study examined brain specialization in 7- to 8-year-old children for phonological and semantic processing, finding linguistic specialization in both the temporal and frontal lobes. The left posterior dorsal inferior frontal gyrus showed greater activation for phonological processing, while the left anterior ventral inferior frontal gyrus and posterior middle temporal gyrus showed greater activation for semantic processing.
HUMAN BRAIN MAPPING
(2021)
Article
Behavioral Sciences
C. Papagno, A. Pisoni, G. Gainotti
Summary: Research has shown that patients with right temporal tumours have significantly higher false alarms in voice recognition compared to those with left temporal tumours, while normal subjects exhibit increased voice processing after right ATL stimulation, with only marginal effects on face sensitivity.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.