Article
Biology
Yangyu Wu, Zhuyuan Chen, Fred J. Sigworth, Cecilia M. Canessa
Summary: The study demonstrates that nanobodies derived from alpacas specifically target human ASIC1a, offering potential therapeutic applications in modulating pain, fear, addiction, and ischemia-induced neuronal injury. In addition, the nanobody Nb.C1 can enhance inhibitory effects of tarantula toxin PcTx1 on hASIC1a and serve as a molecular tool for biochemical and structural studies of hASIC1a.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Biochemistry & Molecular Biology
Siqi Wang, Yuting Chen, Chen Xia, Chunyan Yang, Jian Chen, Li Hai, Yong Wu, Zhongzheng Yang
Summary: Glycosylated quercetin (2Glu-Que) significantly enhances the neuroprotective effects of quercetin by improving water solubility, stability, and cell viability, making it a promising candidate in neuroprotection.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Juan Cen, Runfang Zhang, Tingkui Zhao, Xin Zhang, Chuan Zhang, Jie Cui, Keqing Zhao, Shaofeng Duan, Yuqi Guo
Summary: The article introduces a novel treatment drug for ischemic stroke, SS31-HA-QT, which is a water-soluble compound that can specifically bind to CD44 receptors and be released in the ischemic region. Additionally, the drug can penetrate the blood-brain barrier and target mitochondria. In vitro and in vivo experiments demonstrate that SS31 can enhance drug penetration without toxicity. Furthermore, SS31-HA-QT exerts neuroprotective effects by activating mitophagy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Neurosciences
P. Cepparulo, P. Brancaccio, R. Sirabella, S. Anzilotti, N. Guida, G. Laudati, V. Valsecchi, A. Vinciguerra, V. Viscardi, L. D'Esposito, L. Formisano, L. Annunziato, G. Pignataro, O. Cuomo
Summary: This study aimed to evaluate the role of miR135a in cerebral ischemia. The results showed that targeting TRPM7 with miR135a can alleviate ischemic injury and improve neurological functions.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Chase Kingsbury, Alex Shear, Matt Heyck, Nadia Sadanandan, Henry Zhang, Bella Gonzales-Portillo, Blaise Cozene, Michael Sheyner, Lisset Navarro-Torres, Julian Garcia-Sanchez, Jea-Young Lee, Cesario Borlongan
Summary: Exercise before stroke in rats improved behavior, reduced infarct size and increased cell survival, while decreasing levels of inflammatory microbiota and markers in central and peripheral organs. These findings suggest that specific inflammatory microbiota could serve as biomarkers and therapeutic targets for stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Neurosciences
Diego Pichardo-Rojas, Pavel Salvador Pichardo-Rojas, Jose Manuel Cornejo-Bravo, Aracely Serrano-Medina
Summary: The primary mechanism for neuron death after an ischemic stroke is excessive depolarization leading to NMDA-mediated calcium entry and subsequent cellular death. Memantine, a non-competitive NMDA receptor antagonist, has shown promising preclinical and clinical evidence as a neuroprotective drug for ischemic stroke. Clinical trials have found that high-dose memantine can improve neurological function and aphasia in poststroke patients, but limitations such as small sample sizes limit the impact of these findings. Further research is needed to conclusively determine if memantine improves outcomes in patients post-ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Feng Lu, Xiaofeng Xu, Guo Yang, Xiping Hong, Li Chen, Xiaohui Yin, Jingzhi Yan, Chong Li
Summary: The study investigated the interaction between DAPK and DANGER in neuronal cell death following brain ischemia, revealing a significant reduction in their interaction after I/R with peak reduction at 6 h. Additionally, NMDA inhibitor MK-801, DAPK inhibitor, and calcineurin inhibitor FK-506 prevented the dissociation of DANGER from DAPK 6 h after I/R, leading to neuroprotective effects against hippocampal CA1 neuronal death 5 days post-I/R. These findings suggest that the dissociation of DANGER from DAPK may mediate DAPK activation and contribute to neuronal death following I/R injury.
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Review
Pharmacology & Pharmacy
Qian Xie, Hongyan Li, Danni Lu, Jianmei Yuan, Rong Ma, Jinxiu Li, Mihong Ren, Yong Li, Hai Chen, Jian Wang, Daoyin Gong
Summary: Natural products play a significant role in disease prevention and health promotion, especially for stroke. They modulate activities through multiple targets and signaling pathways for neuroprotection, making them suitable candidates for stroke treatment. Further exploration is needed to understand the structure-activity relationship of natural products in neuroprotection.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuanyuan Li, Xiaokun Cheng, Xinying Liu, Le Wang, Jing Ha, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun
Summary: This article reviews the role of NMDA receptors in cerebral ischemia, especially the role of metabotropic signaling. Studies have shown that ion flow interacts with metabotropic signaling to regulate ischemic injury. NMDA receptor antagonists may have important implications for the treatment of cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Vikas Mishra, Bing Shuai, Maheedhar Kodali, Geetha A. Shetty, Bharathi Hattiangady, Xiaolan Rao, Ashok K. Shetty
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Maheedhar Kodali, Vipan K. Parihar, Bharathi Hattiangady, Vikas Mishra, Bing Shuai, Ashok K. Shetty
SCIENTIFIC REPORTS
(2015)
Article
Neurosciences
Maheedhar Kodali, Tarick Megahed, Vikas Mishra, Bing Shuai, Bharathi Hattiangady, Ashok K. Shetty
JOURNAL OF NEUROSCIENCE
(2016)
Article
Clinical Neurology
Stephanie L. Vanhoof-Villalba, Nicole M. Gautier, Vikas Mishra, Edward Glasscock
Article
Biochemistry & Molecular Biology
Vikas Mishra, Bharat K. Karumuri, Nicole M. Gautier, Rui Liu, Timothy N. Hutson, Stephanie L. Vanhoof-Villalba, Ioannis Vlachos, Leonidas Iasemidis, Edward Glasscock
HUMAN MOLECULAR GENETICS
(2017)
Review
Neurosciences
Ashok K. Shetty, Vikas Mishra, Maheedhar Kodali, Bharathi Hattiangady
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Editorial Material
Neurosciences
Sandeep Kumar Barodia, Krishnan Prabhakaran, Smitha Karunakaran, Vikas Mishra, Victor Tapias
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Krystle Trosclair, Hemangini A. Dhaibar, Nicole M. Gautier, Vikas Mishra, Edward Glasscock
NEUROBIOLOGY OF DISEASE
(2020)
Article
Immunology
Maheedhar Kodali, Vikas Mishra, Bharathi Hattiangady, Sahithi Attaluri, Jenny Jaimes Gonzalez, Bing Shuai, Ashok K. Shetty
Summary: Moderate and intermittent physical exercise shows promise in improving cognitive and mood function in veterans with Gulf War Illness, while also suppressing neuroinflammation and enhancing hippocampal neurogenesis.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Vipul Agarwal, Arjun Singh Kaushik, Mujeeba Rehman, Rishabh Chaudhary, Talha Jawaid, Mehnaz Kamal, Vikas Mishra
Summary: Chronic stress can elevate pro-inflammatory cytokines levels, increasing susceptibility to cardiovascular diseases; diacerein, with its ability to modulate IL-6, shows potential in addressing cardiovascular dysfunctions associated with chronic stress.
Review
Clinical Neurology
Rishabh Chaudhary, Vipul Agarwal, Mujeeba Rehman, Arjun Singh Kaushik, Vikas Mishra
Summary: This review paper summarizes the existing research findings of different MNDs, such as ALS, SMA, SBMA, and HSP, in relation to their complex genetic architecture.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
Summary: This study found that salbutamol can alleviate muscle atrophy and has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Mujeeba Rehman, Rishabh Chaudhary, Sonu Rajput, Vipul Agarwal, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Rohit Singh, Irfan Aziz, Sanjay Singh, Vikas Mishra
Summary: Chronic stress is a major risk factor for cardiovascular diseases due to the release of pro-inflammatory cytokines. This study validated a mouse model of chronic unpredictable stress and evaluated the characteristic features of atherosclerosis. The study also found that Butein can offer protection against chronic stress-induced atherosclerosis.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Immunology
Rishabh Chaudhary, Ajay Prasad, Vipul Agarwal, Mujeeba Rehman, Anand Kumar, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Vikas Mishra
Summary: This study validates the role of chronic stress in the aggravation of rheumatoid arthritis and psoriasis. The findings suggest that a prolonged 8-week exposure to unpredictable stress leads to worsened symptoms and increased inflammatory response in rats, which are associated with these autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Kanika Sharma, Piyush Kalakoti, Miriam Henry, Vikas Mishra, Rosario Maria Riel-Romero, Christina Notarianni, Anil Nanda, Hai Sun
CLINICAL NEUROLOGY AND NEUROSURGERY
(2017)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
