Review
Geriatrics & Gerontology
Sam Asher, Ruth Stephen, Paivi Mantyla, Anna Liisa Suominen, Alina Solomon
Summary: This review found that poor periodontal health, including periodontitis and tooth loss, is associated with cognitive decline and dementia. Tooth loss, in particular, is found to independently increase the risk of cognitive decline and dementia. However, the overall evidence quality is low, with associations potentially influenced by reverse causality. Further well-designed studies are needed to establish more robust conclusions.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Medicine, General & Internal
Pia Lopez-Jornet, Carmen Zamora Lavella, Eduardo Pons-Fuster Lopez, Asta Tvarijonaviciute
Summary: Dementia patients have poorer oral health, are more likely to have fewer teeth, oral issues, and a higher risk of cognitive decline.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Tomohisa Nakamura, Kun Zou, Yasuyuki Shibuya, Makoto Michikawa
Summary: As the global aging population continues to rise, the prevalence of dementia is increasing, posing a significant social issue. Studies have shown a strong association between oral disorders and systemic diseases, linking poor oral health and tooth loss with dementia in patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Edwin C. K. Tan, Duangjai Lexomboon, Henrike Habel, Johan Fastbom, Maria Eriksdotter, Kristina Johnell, Gunilla Sandborgh-Englund
Summary: This study externally validated a model for medication-related dental outcomes in older adults with and without dementia using population-based data from Swedish national registers. The results showed that certain medication types were associated with tooth extraction and restorative procedures in both dementia and non-dementia cohorts, indicating consistent performance of the model across different groups.
Article
Dentistry, Oral Surgery & Medicine
J. A. Jones, K. Moss, T. L. Finlayson, J. S. Preisser, J. A. Weintraub
Summary: This longitudinal cohort study found that older birth cohorts had greater cognitive decline compared to younger cohorts. Additionally, edentulism and irregular dental care were identified as important predictors of cognitive decline.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Y. -S. Lin, Q. Wang, Z. -K. Shen, H. -X. Sun, C. Wu, H. He, G. -Q. Zou, F. Xu, Y. -L. Bu, J. -W. Li, C. Zhao, M. Hong, X. Lu, Jin-Shui Xu, Wei Gao
Summary: This study found that the loss of occlusal pairs of teeth is associated with an increased risk of sarcopenia in the elderly population in China, particularly in females and older individuals.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Geriatrics & Gerontology
Sachiko Takehara, Vasant Hirani, F. A. Clive Wright, Vasi Naganathan, Fiona M. Blyth, David G. Le Couteur, Louise M. Waite, Markus J. Seibel, David J. Handelsman, Robert G. Cumming
Summary: This study investigated the relationship between oral health, appetite, and weight loss in elderly Australian men. The findings suggest that the number of natural teeth and appetite are independently associated with weight change.
Review
Clinical Neurology
Liqing Li, Qi Zhang, Di Yang, Sule Yang, Yulan Zhao, Min Jiang, Xiaofang Wang, Ling Zhao, Qi Liu, Zuxun Lu, Xiaogang Zhou, Yong Gan, Chunmei Wu
Summary: Epidemiological studies have shown that tooth loss may be associated with an increased risk of cognitive decline and dementia. However, some results do not show a significant association. Therefore, we performed a meta-analysis to evaluate this association.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Tobias Mollers, Hannah Stocker, Laura Perna, Dan Rujescu, Bernd Holleczek, Ben Schoettker, Hermann Brenner
Summary: Short-term memory difficulties are associated with both vascular and all-cause dementia, and can predict the risk of developing these types of dementia in the intermediate and long term. This emphasizes the importance of cardiovascular disease prevention in late middle-age for preserving cognitive health.
Article
Medicine, General & Internal
Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu, Yamei Tang
Summary: This study found that shift work is associated with an increased risk of dementia, but night shift work is not significantly associated with dementia risk. The increased incidence of dementia in shift workers does not differ between participants with different genetic susceptibility to dementia.
Article
Geriatrics & Gerontology
Wakana Ito, Takamasa Komiyama, Takashi Ohi, Takako Hiratsuka, Sanae Matsuyama, Toshimasa Sone, Ichiro Tsuji, Makoto Watanabe, Yoshinori Hattori
Summary: The study involving 937 older Japanese individuals aged 70 years or older found a significant relationship between poor oral health status and the incidence of fall-related fractures. Individuals with unilateral or no posterior occlusal support, fewer remaining teeth, and edentulous individuals were found to have a higher risk of fall-related fractures compared to those with better oral health indicators.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychology, Clinical
Terry E. Goldberg, Jongwoo Choi, Seonjoo Lee, Barry Gurland, Davangere P. Devanand
Summary: Social and emotional isolation, as well as restriction of physical and instrumental activities, were found to be associated with cognitive decline and incident dementia in a longitudinal study. Notably, restriction had a more significant impact on memory decline, indicating potential warning signs of future cognitive deterioration and dementia.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Clinical Neurology
Shahram Oveisgharan, Ana W. Capuano, Sukriti Nag, Sonal Agrawal, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis, Julie A. Schneider
Summary: The study found that in older adults, higher A1C levels were associated with less TDP-43 proteinopathy, while the relationship between diabetes mellitus and TDP-43 pathology needs further investigation.
Article
Clinical Neurology
Satoshi Yamaguchi, Takahisa Murakami, Michihiro Satoh, Takamasa Komiyama, Takashi Ohi, Yoshitada Miyoshi, Kosei Endo, Takako Hiratsuka, Azusa Hara, Yukako Tatsumi, Tomoko Totsune, Kei Asayama, Masahiro Kikuya, Kyoko Nomura, Atsushi Hozawa, Hirohito Metoki, Yutaka Imai, Makoto Watanabe, Takayoshi Ohkubo, Yoshinori Hattori
Summary: This study aimed to investigate the association between the number of teeth present (NTP) and hippocampal atrophy, based on the severity of periodontitis. The results showed that individuals with fewer teeth experienced faster left hippocampal atrophy in patients with mild periodontitis, while individuals with more teeth experienced faster atrophy in those with severe periodontitis.
Article
Medicine, General & Internal
Kyung-A Ko, Jin-Young Park, Jung-Seok Lee, Byoung Seok Ye, Ui-Won Jung, Seong-Ho Choi, Jae-Kook Cha
Summary: This study investigated the association between changes in masticatory function and cognitive impairment. The results suggest a potential causative relationship between neglected missing teeth and the onset of dementia.
YONSEI MEDICAL JOURNAL
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.