Article
Cell Biology
Sarah A. Stern, Estefania P. Azevedo, Lisa E. Pomeranz, Katherine R. Doerig, Violet J. Ivan, Jeffrey M. Friedman
Summary: The insular cortex plays a crucial role in regulating conditioned overconsumption in response to learned cues by controlling a specific circuit, which is active during feeding and suppresses satiety signals in the central amygdala.
Article
Biochemistry & Molecular Biology
Fubing Han, Fenghua Xu, Qianqian Zhu, Peng Sun, Yu Zhou, Ming Yu
Summary: This study investigates the effect of virus-mediated overexpression of ghrelin receptor GHS-R1a in the basolateral amygdala (BLA) on conditioned taste aversion (CTA) memory processes. The findings reveal that upregulation of GHS-R1a expression in BLA pyramidal neurons represses CTA extinction while it has no effect on CTA acquisition. Additionally, the study shows that local infusion of the endogenous GHS-R1a antagonist LEAP2 abolishes the inhibitory effect of increased GHS-R1a on CTA memory extinction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Jean-Pascal Morin, Emmanuel Rodriguez-Nava, Victor Manuel Torres-Garcia, Omar Alejandro Contreras-Vazquez, Cesar Armando Castellanos-Perez, Jorge Tovar-Diaz, Gabriel Roldan-Roldan
Summary: The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible through a combination of innate and learned taste preferences. Recent evidence suggests a role of cholinergic muscarinic signaling in the amygdala for the learning and storage of emotional memories, particularly in conditioned taste aversion.
NEUROSCIENCE LETTERS
(2021)
Article
Agriculture, Dairy & Animal Science
Fuminori Kawabata, Yuta Yoshida, Yuki Inoue, Yuko Kawabata, Shotaro Nishimura, Shoji Tabata
Summary: The study shows that chickens have a functional fatty acid taste receptor, GPR120, in their oral tissues, but they do not prefer oleic acid solution. Chickens are able to perceive the taste of oleic acid solution, but do not selectively ingest it.
Article
Agriculture, Dairy & Animal Science
Ivonne Cassaigne, Ron Thompson, Richard McKenna, Rodrigo A. Medellin, William Given, Francisco Remolina, Rodrigo Nunez, Diego Woolrich, Fernando Luna
Summary: This study successfully induced conditioned taste aversion in six captive jaguars using Thiabendazole (TBZ), providing an important tool to reduce livestock predation and protect this endangered species.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Kozlowska, Bai-Chung Shyu, Andrew Chih Wei Huang
Summary: The study aimed to re-examine the paradoxical effect hypothesis of abused drugs by investigating the impact of different doses of morphine on neuronal activity and connectivity between subareas of the medial prefrontal cortex (mPFC), subregions of the nucleus accumbens (NAc), and the basolateral amygdala (BLA) after conditioned taste aversion (CTA) and conditioned place preference (CPP) tests. The results revealed differential effects of morphine doses on c-Fos expression in various brain regions. Furthermore, correlation analysis demonstrated distinct patterns of neural connectivity between different doses of morphine and the CTA and CPP tests. These findings expand our understanding of the paradoxical effects of abused drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Signe Schultz Pedersen, Lars Roed Ingerslev, Mathias Olsen, Michala Prause, Nils Billestrup
Summary: Butyrate can prevent pancreatic islet dysfunction by modifying histone acetylation levels, which may have potential therapeutic effects on type 2 diabetes.
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Ayano Katagiri, Takafumi Kato, Hajime Sato
Summary: Intranasal administration of rotenone impairs conditioned taste aversion memory in mice by decreasing GABAergic synaptic transmission and causing LTD impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Saira R. Ali, Ayla Orang, Shashikanth Marri, Ross A. McKinnon, Robyn Meech, Michael Z. Michael
Summary: High-fiber diets with butyrate can prevent colorectal cancer by modulating gene and microRNA expression, providing insights into potential novel drug targets for cancer prevention and treatment.
Article
Environmental Sciences
Jingmiao Yang, Shuai Yang, Yongshan Liao, Yuewen Deng, Yu Jiao
Summary: To produce cultured pearls, a mantle graft with a nucleus is transplanted into a host pearl oyster. The immune response of pearl oyster after transplantation is a major factor causing nucleus rejection and death. Butyrate, an HDAC inhibitor, was used to treat pearl oysters before transplantation. The results showed that butyrate treatment increased histone H3 acetylation, activated lysosome and intracellular immune recognition response, and increased the activity of immune-related enzymes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Neurosciences
Zhi-Yue Gao, Chung Ming Huang, Cai-N Cheng, Andrew Chih-Wei Huang
Summary: Cancer patients often experience nausea and vomiting during chemotherapy, and this study used lithium chloride to induce conditioned taste aversion as an animal model of chemotherapy-induced symptoms. The basolateral amygdala (BLA) was found to mediate the learning of conditioned taste aversion induced by lithium chloride. Lidocaine microinjections into the BLA attenuated the aversive response, while haloperidol blunted the learning. These findings suggest that the BLA, through sodium chloride ion channels and D2 receptors, regulates the suppression of conditioned saccharin solution intake induced by lithium chloride, and can contribute to identifying strategies to prevent chemotherapy side effects.
Article
Neurosciences
Jianfeng Liu, Ruyan Wu, Bernard Johnson, Yanan Zhang, Qing Zhu, Jun-Xu Li
Summary: This study found that selective TAAR1 agonists can induce conditioned taste aversion, highlighting the need for careful evaluation before their clinical use in the treatment of mental disorders.
PSYCHOPHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Qiufang Zong, Huan Qu, Yahui Zhao, Haoyu Liu, Shenglong Wu, Shuai Wang, Wenbin Bao, Demin Cai
Summary: This study aims to investigate whether a histone deacetylase inhibitor, sodium butyrate (NaBu), can protect the porcine liver from deoxynivalenol (DON) exposure by modulating cholesterol metabolism. The results showed that NaBu effectively restored parameters associated with liver injury, cholesterol content, and key genes involved in the cholesterol biosynthesis pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Psychology, Biological
Shaoyi Su, Zimo Wei, Helai Huang, Tomohiko Yoshizawa, Tadashi Inui, Makoto Funahashi
Summary: This study aims to investigate the effects of cisplatin and emetine on conditioned taste aversion and demonstrates it using a taste reactivity test in rats. It is found that the readministration of saccharin after gustatory conditioning with cisplatin or emetine induces gaping reactions. The study shows that cisplatin and emetine can induce taste aversion, and it is also observed that gaping reactions almost never occur with intraperitoneal injections of emetine alone.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biology
Mahsa Moaddab, Madelyn H. Ray, Michael A. McDannald
Summary: The ventral pallidum (VP) is anatomically poised to contribute to threat behavior as recent studies have shown VP neurons dynamically respond to threat, decreasing firing to uncertain cues and increasing firing to rewards. This dynamic response suggests the VP serves as a neural basis for threat behaviors, with specific signals for relative threat identified in two distinct neuronal populations.
COMMUNICATIONS BIOLOGY
(2021)
Article
Physiology
Thomas A. Houpt, Bumsup Kwon, Charles E. Houpt, Bryan Neth, James C. Smith
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2013)
Article
Neurosciences
Angie M. Cason, Bumsup Kwon, James C. Smith, Thomas A. Houpt
Article
Neurosciences
Denesa L. Oberbeck, Stefanie McCormack, Thomas A. Houpt
Article
Behavioral Sciences
Ann-Marie Torregrossa, Michelle B. Bales, Joseph M. Breza, Thomas A. Houpt, James C. Smith, Robert J. Contreras
Article
Biochemical Research Methods
Bumsup Kwon, Thomas A. Houpt
JOURNAL OF NEUROSCIENCE METHODS
(2010)
Article
Neurosciences
Adam Kimbrough, Bumsup Kwon, Lisa A. Eckel, Thomas A. Houpt
Article
Behavioral Sciences
Bumsup Kwon, Thomas A. Houpt
NEUROBIOLOGY OF LEARNING AND MEMORY
(2012)
Article
Psychology, Biological
Patrick L. Smith, James C. Smith, Thomas A. Houpt
PHYSIOLOGY & BEHAVIOR
(2010)
Article
Psychology, Biological
Thomas A. Houpt, Charles E. Houpt
PHYSIOLOGY & BEHAVIOR
(2010)
Article
Psychology, Biological
Thomas A. Houpt, Jennifer A. Cassell, Alison Hood, Megan DenBleyker, Ilana Janowitz, Kathleen Mueller, Breyda Ortega, James C. Smith
PHYSIOLOGY & BEHAVIOR
(2010)
Article
Psychology, Biological
Thomas A. Houpt, Lee Carella, Dani Gonzalez, Ilana Janowitz, Anthony Mueller, Kathleen Mueller, Bryan Neth, James C. Smith
PHYSIOLOGY & BEHAVIOR
(2011)
Article
Psychology, Biological
Corinne M. Spencer, Lisa A. Eckel, Rahel Nardos, Thomas A. Houpt
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Psychology, Biological
Thomas A. Houpt, Jennifer Cassell, Lee Carella, Bryan Neth, James C. Smith
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Physiology
Jason M. Cote, Alison Hood, Bumsup Kwon, James C. Smith, Thomas A. Houpt
Summary: Static high magnetic fields interact with the vestibular system, causing various perturbations in rats and mice, such as head movements, circular locomotion, suppressed rearing, nystagmus, and conditioned taste aversion acquisition. Mutant mice lacking otoconia in the utricle and saccule showed no response to the magnetic field, while mice with a mutation affecting the semicircular canals exhibited significant locomotor circling and suppressed rearing. These findings demonstrate the importance of otoconia for the effects of high magnetic fields and suggest a contribution from the semicircular canals.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.