期刊
BRAIN RESEARCH
卷 1352, 期 -, 页码 214-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.06.065
关键词
parkin knockout mice; Dopamine release; In vivo voltammetry; Medial forebrain bundle
资金
- Strategic Research Program for Brain Sciences (SRPBS)
- Japanese Ministry of Education, Culture, Sports, Science and Technology
parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellular dopamine (DA) overflow in the striatum with in vivo voltammetry. The amplitude of evoked DA overflow was low in PKO mice. The half-life time of evoked DA overflow was long in PKO mice suggesting lower release and uptake of dopamine. Facilitation of DA overflow by repetitive stimulation enhanced in the older PKO mice. Decreased dopamine release and uptake in young PKO mice suggest early pre-symptomatic changes in dopamine neurotransmission, while the enhanced facilitation in the older PKO mice may reflect a compensatory adaptation in dopamine function during the late pre-symptomatic phase of Parkinson's disease. Our results showed parkin deficiency may affect DA release in PKO mice, although it does not cause massive nigral degeneration or parkinsonian symptoms as in humans. (C) 2010 Elsevier B.V. All rights reserved.
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