Article
Biology
Benjamin J. Stauch, Alina Peter, Heike Schuler, Pascal Fries
Summary: Stimulus repetition can modulate neuronal-gamma band synchronization and induce plastic changes in activated neuronal circuits. These changes are stimulus-specific and persist even after intervening stimuli. The strongest effects are observed in the early visual cortex, where there is an increase in interareal feedforward influences.
Article
Neurosciences
Jenna N. Adams, Anne Maass, David Berron, Theresa M. Harrison, Suzanne L. Baker, Wesley P. Thomas, Morgan Stanfill, William J. Jagust
Summary: Tau deposition in aging and Alzheimer's disease affects medial temporal lobe (MTL) neural function, impacting repetition suppression. Different levels of tau pathology are associated with activity changes in distinct MTL subregions, with high tau pathology leading to widespread neural dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Eva Berlot, Nicola J. Popp, Scott T. Grafton, Jorn Diedrichsen
Summary: In the context of motor sequence learning, fMRI studies revealed differences in neuronal representations between premotor and parietal regions compared to the primary motor cortex (M1). While M1 showed specific representation of the first finger of each sequence, parietal areas represented the identity of the entire sequence and remained relatively stable during different executions. This suggests that the RS effect in M1 reflects a preparatory signal for movement initiation rather than a trained sequence representation.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Daniel Feuerriegel, Rufin Vogels, Gyula Kovacs
Summary: Recent research has identified confounding factors that may impact the true effects of expectation suppression, casting doubt on its findings across different experimental contexts. However, evidence for genuine expectation suppression was found in specific statistical learning designs.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychology, Clinical
Morgan Szczepaniak, Asadur Chowdury, Paul H. Soloff, Vaibhav A. Diwadkar
Summary: Borderline personality disorder (BPD) is characterized by instability in affective regulation, which can lead to a loss of cognitive control. This study found that BPD patients showed greater neuronal priming for negatively valenced stimuli, while showing less priming for positively valenced stimuli. These results suggest that the familiarity of negative valence may influence neuronal responses in BPD patients.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Yufei Tan, Valerie Chanoine, Eddy Cavalli, Jean-Luc Anton, Johannes C. Ziegler
Summary: The noisy computation hypothesis suggests that developmental dyslexia may be caused by noise in the computational process, leading to less stable word representations. An fMRI experiment tested this hypothesis and found no evidence to support the idea that dyslexic readers have noisier neural representations compared to typical readers.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Alice Pirastru, Sonia Di Tella, Marta Cazzoli, Fabrizio Esposito, Giuseppe Baselli, Francesca Baglio, Valeria Blasi
Summary: The study found that for an emotion-generation task, the reliability of fMRI signals under negative emotional valence conditions was higher than under positive conditions. Neural suppression may not be the primary cause of low signal reliability, with different neural strategies potentially playing a role instead.
Article
Neurosciences
Anila M. D'Mello, Isabelle R. Frosch, Steven L. Meisler, Hannah Grotzinger, Tyler K. Perrachione, John D. E. Gabrieli
Summary: Repeated exposure to a stimulus leads to reduced neural response, known as repetition suppression, in brain regions responsible for processing that stimulus. This is believed to be important for learning and strengthening of perceptual expectations. Reduced sensitivity to repetition has been found in autism spectrum disorder (ASD) and is thought to contribute to sensory hypersensitivities and difficulties in using regularities in the environment for behavior facilitation. In individuals with ASD, there are specific reductions in repetition suppression for face stimuli, which is associated with challenges in social communication. Altered functional connectivity and microstructural differences in related white matter tracts are also observed in ASD, indicating selective alterations in face processing.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Eri Nakagawa, Takahiko Koike, Motofumi Sumiya, Koji Shimada, Kai Makita, Haruyo Yoshida, Hirokazu Yokokawa, Norihiro Sadato
Summary: Japanese English learners find it more difficult to use Double Object (DO) structures than Prepositional Object (PO) structures, and this difficulty may be related to linguistic processing. There is a shared process between DO and PO, but linguistic processing imposes overload in DO.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Camille Heurteloup, Annabelle Merchie, Sylvie Roux, Frederique Bonnet-Brilhault, Carles Escera, Marie Gomot
Summary: This study aimed to explore the effects of the nature (vocal/non-vocal) of the information to be encoded on the establishment of auditory regularities. The results showed that the repetition positivity (RP) was similar between vocal and non-vocal stimuli, suggesting that the repetition suppression phenomena is independent of the nature of the stimulus. However, the P1 amplitude for non-vocal stimuli stabilized faster than for vocal stimuli, indicating different dynamics in the establishment of regularity encoding for non-vocal and vocal stimuli.
Article
Psychology, Mathematical
Amy M. Belfi, Kaelyn Kacirek
Summary: The aim of the study was to create a set of famous musical melodies for assessing cognitive impairments and studying differences between naming and knowing. Participants rated 107 melodies on familiarity, age of acquisition, emotional valence, emotional arousal, and naming ability, confirming that most melodies were highly familiar and easily named.
BEHAVIOR RESEARCH METHODS
(2021)
Article
Neurosciences
Sara D. Beach, Ola Ozernov-Palchik, Sidney C. May, Tracy M. Centanni, Tyler K. Perrachione, Dimitrios Pantazis, John D. E. Gabrieli
Summary: In this study, the neural responses of individuals with and without dyslexia to speech stimuli were recorded using magnetoencephalography (MEG). The results showed that individuals with dyslexia had similar sensitivity to repetition as those without dyslexia, but only the control group showed an increasing difference between standard and deviant stimuli with repetition.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Hayden J. Peel, Philippe A. Chouinard
Summary: Research findings on fMRI adaptation to the form, orientation, and size of visual stimuli in different brain areas are mixed. Some brain regions show adaptation to form and size, but not to orientation. These results are important for understanding how the brain processes different visual features.
Article
Biology
Stephen J. Gotts, Shawn C. Milleville, Alex Martin
Summary: In the study, Gotts et al. tested different theoretical model predictions for repetition-associated alterations in functional and/or effective brain connectivity using fMRI. They found that the data was most consistent with a Synchrony model-based prediction, leading to refinements of all tested models. While some support for the Facilitation and Sharpening models was found, the data primarily supported the Synchrony model with increased coupling between specific brain regions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vahid Mehrpour, Travis Meyer, Eero P. Simoncelli, Nicole C. Rust
Summary: Contrast modulation was found to have a significant effect on IT neural responses, leading to a discussion on repetition suppression and sensory referenced suppression and their impact on visual recognition memory behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Chen, Anja Soldan, Kenichi Oishi, Andreia Faria, Yuxin Zhu, Marilyn Albert, Peter C. M. van Zijl, Xu Li
Summary: The study found that elevated brain iron content, together with beta-amyloid, is associated with lower cognitive functioning in cognitively normal older adults, particularly in the hippocampus. In the PET subgroup, iron content in the hippocampus was negatively correlated with episodic memory and visuospatial score, independent of beta-amyloid burden.Clusters showing negative and positive correlations between brain iron and beta-amyloid were observed, particularly in the frontal cortex, where iron content negatively correlated with both beta-amyloid and global cognitive scores.
Article
Clinical Neurology
Gabriela T. Gomez, Rebecca F. Gottesman, Kelley Pettee Gabriel, Priya Palta, Alden L. Gross, Anja Soldan, Marilyn S. Albert, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, B. Gwen Windham, Keenan A. Walker
Summary: The ARIC study found that participants with MCR and MCI status both demonstrated an increased risk for dementia. The pattern of brain structural abnormalities associated with MCR+ differed from that of MCI+, with MCI+ linked to smaller volumes in brain regions vulnerable to Alzheimer's disease pathology, while MCR+ status was associated with smaller volumes in frontoparietal regions and greater white matter abnormalities.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neuroimaging
Corinne Pettigrew, Anja Soldan, Rostislav Brichko, Yuxin Zhu, Mei-Cheng Wang, Kwame Kutten, Murat Bilgel, Susumu Mori, Michael Miller, Marilyn Albert
Summary: The research suggests that performance on the PAL task may be more sensitive to amyloid positivity than standard neuropsychological tests, and individuals with mild cognitive impairment generally perform worse than cognitively normal participants in cognitive tasks.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Angeliki Tsapanou, Niki Mourtzi, Sokratis Charisis, Alex Hatzimanolis, Eva Ntanasi, Mary H. Kosmidis, Mary Yannakoulia, Georgios Hadjigeorgiou, Efthimios Dardiotis, Paraskevi Sakka, Yaakov Stern, Nikolaos Scarmeas
Summary: Sleep problems are associated with cognition, and specific genes are associated with sleep regulation and cognition. This study validates the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and finds an association between Sleep PRS and cognitive changes related to visuo-spatial ability in older non-demented adults.
Article
Neurosciences
Carol K. Chan, Corinne Pettigrew, Anja Soldan, Yuxin Zhu, Mei-Cheng Wang, Marilyn Albert, Paul B. Rosenberg
Summary: This study found that neuropsychiatric symptoms were associated with executive function decline in cognitively normal older adults. However, there was no relationship between these symptoms and global cognitive function or episodic memory. Additionally, the association between neuropsychiatric symptoms and cognitive decline was not modified by amyloid or cerebrovascular disease burden.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hualu Han, Zixuan Lin, Anja Soldan, Corinne Pettigrew, Joshua F. Betz, Kumiko Oishi, Yang Li, Peiying Liu, Marilyn Albert, Hanzhang Lu
Summary: The study aims to evaluate short-term longitudinal changes in global cerebral blood flow (CBF) in cognitively normal older adults and finds that the rate of CBF reduction is associated with increased white matter damage with age.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Kumiko Oishi, Anja Soldan, Corinne Pettigrew, Johnny Hsu, Susumu Mori, Marilyn Albert, Kenichi Oishi
Summary: The study demonstrates an association between measured and predicted changes in cognitive performance in older adults who are cognitively normal. By analyzing changes in pairwise functional connectivity between 80 gray matter regions, the study identifies 11 pairs of functional connections associated with the default mode network as features related to changes in cognitive performance. Linear and elastic net regression models allow the use of these 11 features to predict changes in cognitive performance over two years.
Article
Clinical Neurology
Zixuan Lin, Chantelle Lim, Dengrong Jiang, Anja Soldan, Corinne Pettigrew, Kumiko Oishi, Yuxin Zhu, Abhay Moghekar, Peiying Liu, Marilyn Albert, Hanzhang Lu
Summary: The longitudinal change in oxygen extraction fraction (OEF) in older adults is primarily associated with vascular pathology, but not with markers of Alzheimer's disease (AD) pathology.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Anja Soldan, Alfonso Alfini, Corinne Pettigrew, Andreia Faria, Xirui Hou, Chantelle Lim, Hanzhang Lu, Adam P. Spira, Vadim Zipunnikov, Marilyn Albert
Summary: This cross-sectional study examined the relationship between physical activity levels and brain connectivity among older adults. The findings suggest that higher physical activity is associated with better functional and structural connectivity in the brain, independent of vascular risk, genotype, cognitive reserve, and white matter hyperintensities volume.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Kylie H. Alm, Anja Soldan, Corinne Pettigrew, Andreia V. Faria, Xirui Hou, Hanzhang Lu, Abhay Moghekar, Susumu Mori, Marilyn Albert, Arnold Bakker
Summary: In this study, the independent contributions of structural and functional connectivity markers to individual differences in episodic memory performance in cognitively normal older adults were examined. The results showed that fornix RD, hippocampal cingulum RD, and salience network functional connectivity were significant predictors of memory performance. These findings demonstrated that a combination of structural and functional connectivity markers best accounted for individual variability in episodic memory function in cognitively normal older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Rostislav Brichko, Anja Soldan, Yuxin Zhu, Mei-Cheng Wang, Andreia Faria, Marilyn Albert, Corinne Pettigrew
Summary: This study found that lifetime experiences are associated with white matter microstructure, and their relationship is influenced by participant age, APOE-ε4 genetic status, and level of vascular risk. Higher cognitive reserve (CR) composite scores are associated with lower RD values and higher FA values, but the relationship differs in different age groups.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Barry D. Greenberg, Corinne Pettigrew, Anja Soldan, Jiangxia Wang, Mei-Cheng Wang, Jacqueline A. Darrow, Marilyn S. Albert, Abhay Moghekar
Summary: This study examined the association between baseline CSF measures of Alzheimer's disease-related pathology and the time to onset of mild cognitive impairment (MCI). The study also investigated whether these associations differed based on age, sex, Apolipoprotein E (ApoE4) status, and the time to symptom onset. The findings suggest that elevated levels of ptau181 and t-tau were associated with earlier onset of MCI within 7 years of baseline, while a lower A beta 42/A beta 40 ratio was associated with later onset if it occurred more than 7 years from baseline. The study also found significant interactions between CSF levels and age, sex, and A beta 42/A beta 40 ratio.
Article
Clinical Neurology
Anja Soldan, Sungtaek Oh, Taekyung Ryu, Corinne Pettigrew, Yuxin Zhu, Abhay Moghekar, Mei-Fang Xiao, Gregory M. M. Pontone, Marilyn Albert, Chan-Hyun Na, Paul Worley
Summary: This study found that lower baseline levels of the synaptic protein NPTX2 are associated with earlier onset of symptoms of mild cognitive impairment (MCI). Furthermore, baseline NPTX2 levels can improve the prediction of MCI onset even when accounting for traditional CSF AD biomarkers.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Feng Xu, Dapeng Liu, Dan Zhu, Argye E. Hillis, Arnold Bakker, Anja Soldan, Marilyn S. Albert, Doris D. M. Lin, Qin Qin
Summary: This MRI study evaluated the test-retest reliability of VSI-prepared 3D VSASL protocol to measure baseline CBF variations in different brain regions among cognitively normal participants. The study found that both absolute and relative CBF showed higher variability, but could still detect normal variations using VSASL.
Article
Genetics & Heredity
Angeliki Tsapanou, Margaret Gacheru, Seonjoo Lee, Niki Mourtzi, Yunglin Gazes, Christian Habeck, Daniel W. Belsky, Yaakov Stern
Summary: This study analyzed the relationship between genetics and cognitive performance, and found that genetics play a moderating role in cognitive aging. The results suggest that genetics have a stronger association with cognitive performance in young and midlife older adults.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.