Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki
Summary: EAAT2 plays crucial roles in glutamate homeostasis in the brain and therapy resistance of cancer cells. This study presents the cryo-EM structures of EAAT2 and the inhibitory mechanisms of selective inhibitor WAY213613. The structures reveal the binding sites and disruption of EAAT2 by WAY213613, providing insights for structure-based drug design targeting EAAT2.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mariko Kato Hayashi, Kaoru Sato, Yuko Sekino
Summary: Neurons induce astrocyte branches and make them avoid each other, potentially contributing to the tiling of astrocytes' territories.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Stefan Passlick, Christine R. Rose, Gabor C. Petzold, Christian Henneberger
Summary: High-affinity, Na+-dependent glutamate transporters play a crucial role in removing synaptically released glutamate, thus increasing spatial precision of synaptic communication. Dysfunction of these transporters can lead to elevated glutamate concentration, enhanced spread, and potentially neuronal death.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Nils Pape, Christine R. R. Rose
Summary: The vertebrate brain has a high energy requirement, and ischemia can cause a rapid decline in intracellular ATP concentration, leading to cellular damage. In this study, the pathways driving ATP loss during transient metabolic inhibition were analyzed in mouse neocortex neurons and astrocytes using a nanosensor. It was found that brief chemical ischemia resulted in a temporary decrease in intracellular ATP, with neurons being more affected than astrocytes. Inhibition of voltage-gated Na+ channels, NMDA receptors, or transient receptor potential vanilloid 4 (TRPV4) channels reduced the ATP decline, suggesting the involvement of excitatory neuronal activity and TRPV4 channels in cellular energy loss during ischemia.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Bronac Flanagan, Liam McDaid, John Joseph Wade, Marinus Toman, KongFatt Wong-Lin, Jim Harkin
Summary: Neurotransmitter dynamics in neuronal synapses can be controlled by astrocytes, with key contributions to neuronal activity. Glutamate released by neurons is primarily removed by the astrocytic transporter EAAT-2, while co-localization of GABA transporter GAT-3 with EAAT-2 demonstrates reversed transport of GAT-3, influencing synaptic neuronal excitability. Astrocytic mechanisms, such as efflux of GABA from astrocytes to the synaptic space, play a crucial role in modulating hyperexcitability and synaptic neuronal excitation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jun An, Yan He, Jun-Jun Yin, Zhi-Bin Ding, Qing-Xian Han, Yang-Yang Chen, Qing Wang, Zhi Chai, Jie-Zhong Yu, Li-Juan Song, Bao-Guo Xiao, Cun-Gen Ma
Summary: In the CPZ-induced mouse model, significant reduction of axons and neurons occurs 4-6 weeks after feeding, leading to neuronal death and loss of glutamate neurons. Astrocyte-mediated glutamate reuptake plays a protective role against excitotoxicity in the CNS.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Sidoryk-Wegrzynowicz, Beata Dabrowska-Bouta, Grzegorz Sulkowski, Lidia Struzynska
Summary: Tau-dependent neurodegeneration in a transgenic mouse model is accompanied by astrocytosis, indicating the critical role of astrocytes in the disease development. Alterations in glutamine transport and recycling affect the neuronal-astrocytic integrity, suggesting potential mechanisms operating in Tau pathology.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Neurosciences
Xing Liu, Jun Ying, Xifeng Wang, Qingcui Zheng, Tiancheng Zhao, Sungtae Yoon, Wen Yu, Danying Yang, Yang Fang, Fuzhou Hua
Summary: Astrocytes are major glial cells in the brain, playing a supporting role in the energy and nutritional supply of neurons. They actively regulate synaptic transmission, formation, and plasticity, and any negative changes in their structure or function can impact neuronal activity, leading to neurodevelopmental disorders. Understanding the roles of astrocytes in regulating synaptic development and neural circuit plasticity could lead to new treatments for various neurological and psychiatric disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Developmental Biology
Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Takai
Summary: We demonstrated that co-cultured neurons induced astrocyte ramifications and formation of tripartite synapses in an in vitro system. The induction of astrocyte ramifications was dependent on neuronal activity and likely involved synaptically-released glutamate and activation of astrocytic mGluR5. Moreover, the Necl2/3 trans-interaction recruited glutamate transporters and K+ channels to the perisynaptic astrocyte processes, enhancing synapse formation and astrocyte functional polarization.
Article
Neurosciences
Duo Li, Sihui Li, Min Pan, Qiang Li, Jiangling Song, Rui Zhang
Summary: This study proposed a novel neuron-astrocyte computational model to investigate the impact of extracellular glutamate homeostasis dysregulation on neuronal epileptic discharges. The results demonstrated that downregulation of EAAT2 expression, aberrant activation of mGluRs, and elevated glutamate levels can aggravate neuronal epileptic discharges and transition between different discharge states. These factors can also alter the bifurcation threshold for the generation and transition of epileptic discharges.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neurosciences
Li Wang, Quan Lei, Shuai Zhao, WenJuan Xu, Wei Dong, JiHua Ran, QingHai Shi, JianFeng Fu
Summary: Ginkgolide B shows protective effects in neuronal cells subjected to hypoxia by regulating neuronal Ca2+ homeostasis and suppressing increases in cytoplasmic Ca2+ levels. This compound can also inhibit actions of hypoxia on spontaneous discharge frequency, action potential frequency, and calcium current magnitude, suggesting its potential as a neuroprotective agent against hypoxic injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hagar Bauminger, Inna Gaisler-Salomon
Summary: This study discusses the role of glutamate homeostasis in schizophrenia-related cognitive dysfunction. They focus on cognitive domains that can be measured in humans and rodents, and discuss the relevance of glutamate alterations in these domains. They find that the interaction between astrocytes and neurons is crucial for cognition, and that presynaptic and postsynaptic components play a critical role in maintaining glutamate homeostasis and cognitive well-being.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Tianyou Wang, Yingqi Sun, Ulf Dettmer
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons. This review highlights the roles of astrocytes in PD and how their properties can be utilized to increase neuron survivability. Astrocytes normally have protective functions but can become dysfunctional and contribute to neurotoxicity in PD. Restoring healthy astrocyte function and maximizing their beneficial effects represent promising therapeutic approaches.
Review
Cell Biology
Sung-Min Hwang, Ji Yeon Lee, Chul-Kyu Park, Yong Ho Kim
Summary: Neurodegenerative diseases (NDs) primarily affect neurons and glial cells in the brain, with risk factors and pathophysiological mechanisms not fully understood. Homeostasis of intracellular Ca2+ concentration and pH is crucial for cell function, with TRP channels and PMCA playing vital roles in modulating ionic homeostasis. Dysfunctions of TRP channels and PMCA disrupt neuronal homeostasis under pathological conditions, resulting in various NDs. This review highlights their potential as novel targets for treating NDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Jean-Yves Chatton, Pierre J. Magistretti, L. Felipe Barros
Article
Neurosciences
C. R. Rose, J. -Y. Chatton
Article
Neurosciences
Joel Wellbourne-Wood, Theresa S. Rimmele, Jean-Yves Chattona
Article
Multidisciplinary Sciences
Sandro Lecci, Laura M. J. Fernandez, Frederik D. Weber, Romain Cardis, Jean-Yves Chatton, Jan Born, Anita Luthi
Article
Biochemistry & Molecular Biology
Theresa S. Rimmele, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Sylvain Lengacher, Jean-Yves Chatton
ACS CHEMICAL NEUROSCIENCE
(2018)
Review
Biochemistry & Molecular Biology
Joel Wellboume-Wood, Jean-Yves Chatton
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Cell Biology
Christophe M. Lamy, Hitomi Sanno, Gwenael Labouebe, Alexandre Picard, Christophe Magnan, Jean-Yves Chatton, Bernard Thorens
Article
Biochemistry & Molecular Biology
Helene Perreten Lambert, Manuel Zenger, Guillaume Azarias, Jean-Yves Chatton, Pierre J. Magistretti, Sylvain Lengacher
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
David Vallois, Guy Niederhaeuser, Mark Ibberson, Vini Nagaray, Lorella Marselli, Piero Marchetti, Jean-Yves Chatton, Bernard Thorens
Article
Multidisciplinary Sciences
Theresa S. Rimmele, Jean-Yves Chatton
Article
Cell Biology
Nicolas Merienne, Cecile Meunier, Anne Schneider, Jonathan Seguin, Satish S. Nair, Anne B. Rocher, Stephanie Le Gras, Celine Keime, Richard Faull, Luc Pellerin, Jean-Yves Chatton, Christian Neri, Karine Merienne, Nicole Deglon
Article
Neurosciences
Haissa de Castro Abrantes, Marc Briquet, Celine Schmuziger, GLeonardo Restivo, Julien Puyal, Nadia Rosenberg, Anne-Berengere Rocker, Stefan Offermanns, Jean-Yves Chatton
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Lara Buscemi, Melanie Price, Julia Castillo-Gonzalez, Jean-Yves Chatton, Lorenz Hirt
Summary: Lactate has a protective effect against acute brain injuries, but this effect does not appear to be dependent on HCAR1 activation. Other signaling pathways or metabolic effects may be responsible for the beneficial effects of lactate. Therefore, HCAR1 activation should not be considered as a therapeutic strategy for stroke patients.
Article
Chemistry, Analytical
Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton
Summary: The status of lactate has evolved from being considered a waste product to a signaling molecule. Evaluation of lactate levels within tissues is crucial with high spatial and temporal resolution. HCAR1 shows promise as a building block for a lactate biosensor, but is sensitive to structural perturbations.
Article
Neurosciences
Theresa S. Rimmele, Anne-Berengere Rocher, Joel Wellbourne-Wood, Jean-Yves Chatton
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.