Article
Biochemistry & Molecular Biology
Francesca Felicia Caputi, Serena Stopponi, Laura Rullo, Martina Palmisano, Massimo Ubaldi, Sanzio Candeletti, Roberto Ciccocioppo, Patrizia Romualdi
Summary: The genetically selected Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate up-regulation of the CRF system for negative mood and stress responses, as well as inherent up-regulation of the N/OFQ system for anti-stress responses. Alcohol consumption dampens N/OFQ and results in a complex reorganization of neuropeptidergic systems in the extended amygdala of msP rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lucia Carboni, Luisa Ponzoni, Daniela Braida, Mariaelvina Sala, Cecilia Gotti, Michele Zoli
Summary: This study found that long-term nicotine withdrawal-induced affective and cognitive symptoms are associated with lasting molecular alterations in peptidergic signaling, which may determine impaired neuroplasticity in the hippocampal and striatal circuitry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lei An, Mengxue Li, Cunen Zou, Ke Wang, Wei Zhang, Xiaolong Huang, Yousheng Wang
Summary: Accumulating evidence suggests that walnut polyphenols (WP) and their metabolites urolithins have protective effects on oxidative stress-induced damage in human neuroblastoma cells. The activation of cAMP-response element binding protein (CREB)-mediated signaling pathway, as well as the up-regulation of brain-derived neurotrophic factor (BDNF), is involved in the neuroprotective effects of WP and urolithin A (UroA). This study provides new insights into the beneficial effects of WP and UroA on brain function.
Article
Pharmacology & Pharmacy
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi
Summary: Fisetin has been found to improve cognitive function in mice with PTZ-induced kindling through modulation of oxidative stress markers, gene expressions, and neurotransmitter levels. These findings suggest a therapeutic potential of fisetin against cognitive dysfunction associated with PTZ-induced kindling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin Wu
Summary: Stress can promote the establishment of propofol addiction in rats, while CRF1R antagonist may inhibit it, suggesting a potential therapeutic approach for propofol addiction treatment. The study highlights the role of CRF1R in mediating central reward processing through D1R in the NAc.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Review
Pharmacology & Pharmacy
Claire Leconte, Raymond Mongeau, Florence Noble
Summary: Substance use disorders and traumatic stress-related pathologies often coexist. The KOR and DYN play a crucial role in this comorbidity, regulating the effects of stress and drug use. The DYN/KOR system is involved in anxiety, depressive symptoms, conditioned fear response, and negative reinforcement after drug use. KOR activation leads to drug-seeking behavior and cross-regulates with corticotropin-releasing factor. The sexual dimorphism of the DYN/KOR system may contribute to gender differences in patients with SUD or/and traumatic stress-related pathologies. Antagonists targeting KOR could be a promising pharmacological strategy for treating this comorbidity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Badrah S. Alghamdi, Fahad S. Alshehri
Summary: The study revealed the potential of melatonin in modulating morphine addiction by affecting gene expression levels such as GLT-1, BDNF, NF-kappa B, and CREB.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Markus Heilig
Summary: Alcohol use has significant negative consequences, especially for individuals with alcohol addiction. Current pharmacotherapies for alcohol addiction are limited in effectiveness and usage. However, research suggests that targeting neuropeptide systems, such as corticotropin-releasing factor type 1 and neurokinin 1/substance P receptors, may offer potential therapeutic options. This paper explores the findings and future prospects of these mechanisms as novel medications for alcohol addiction.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopra
Summary: TMP treatment can improve learning and memory deficits, alleviate hyperglycemia and dyslipidemia, suppress inflammation and apoptosis, and restore cholinergic dysfunction in diabetic rats.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Eli-Eelika Esvald, Jurgen Tuvikene, Andra Moistus, Kathy Rannaste, Susann Koomagi, Tonis Timmusk
Summary: In this study, the regulation of BDNF expression in different brain regions was investigated using neuronal populations from rat cerebral cortices and hippocampi. It was found that the expression of BDNF is region-specific and depends on different transcription factors. Additionally, several neurodevelopmentally important transcription factors were identified as brain region-specific regulators of BDNF expression.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Plant Sciences
En-Yu Liu, Chao-Lin Yang, Jen-Chieh Tsai, Hao-Yuan Cheng, Wen-Huang Peng
Summary: The anti-depressive effects of Uncaria rhynchophylla were investigated in CUMS-induced depressive mice. RH increased the levels of 5-HT and the expressions of BDNF and CREB in the cortex and hippocampus, leading to improved depressive symptoms. The findings suggest that RH can be a potential therapeutic agent for depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Ying Zhang, Qian Zhou, Lu Lu, Yu Su, Wei Shi, Hu Zhang, Ran Liu, Yuepu Pu, Lihong Yin
Summary: It has been reported that disordered Cu metabolism is associated with neurodegenerative diseases. This study investigated the effects of Cu on cognitive functions in mice and the potential mechanisms. The results showed that Cu exacerbates learning and memory impairment, induces neuronal degeneration and oxidative damage, and affects synaptic regulation and the CREB/BDNF pathway.
Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Neurosciences
Hiroaki Matsushita, Yuya Sasaki, Aya Yunoki, Ayuka Matsuji, Hein Min Latt, Kazunari Onishi, Kazuhito Tomizawa, Hideki Matsui
Summary: Male sexual activity reduces depression through oxytocin (OT)-induced CREB signaling in the hippocampus.
NEUROSCIENCE RESEARCH
(2022)
Article
Cell & Tissue Engineering
Xuyu Qian, Yijing Su, Christopher D. Adam, Andre U. Deutschmann, Sarshan R. Pather, Ethan M. Goldberg, Kenong Su, Shiying Li, Lu Lu, Fadi Jacob, Phuong T T Nguyen, Sooyoung Huh, Ahmet Hoke, Sarah E. Swinford-Jackson, Zhexing Wen, Xiaosong Gu, R. Christopher Pierce, Hao Wu, Lisa A. Briand, H. Isaac Chen, John A. Wolf, Hongjun Song, Guo-Ii Ming
Review
Pharmacology & Pharmacy
D. Eacret, S. C. Veasey, J. A. Blendy
MOLECULAR PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Marco D. Carpenter, Melissa T. Manners, Elizabeth A. Heller, Julie A. Blendy
Summary: Prescription opioid misuse is a significant public health issue among children and adolescents in the United States. Studies have shown that adolescent exposure to oxycodone can have long-term epigenetic consequences in the brain, affecting dopamine-related gene expression.
Article
Multidisciplinary Sciences
Evelyn Ordones Sanchez, Charlotte C. Bavley, Andre U. Deutschmann, Rachel Carpenter, Drew R. Peterson, Reza Karbalaei, James Flowers, Charleanne M. Rogers, Miranda G. Langrehr, Cory S. Ardekani, Sydney T. Famularo, Angela R. Bongiovanni, Melissa C. Knouse, Stan B. Floresco, Lisa A. Briand, Mathieu E. Wimmer, Debra A. Bangasser
Summary: This study investigated the stress inoculation effect of early adversity using the LBN model, focusing on addiction-related phenotypes in adulthood. Results showed that LBN reduced impulsive choice, morphine self-administration, and AMPA/NMDA ratio in males, indicating a male-specific stress inoculation effect against addiction-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Megan M. Wickens, Julia M. Kirkland, Melissa C. Knouse, Anna G. McGrath, Lisa A. Briand
Summary: Disruption of prefrontal glutamate receptor interacting protein (GRIP) enhances cue-induced cocaine seeking in both males and females, while protein interacting with C kinase 1 (PICK1) plays an opposing role. Deletion of PICK1 in the prefrontal cortex reduces cue-induced cocaine seeking in male mice but increases it in females, with androgens potentially influencing the compensatory effects of PICK1 knockdown.
Article
Biochemistry & Molecular Biology
Andre U. Deutschmann, Julia M. Kirkland, Lisa A. Briand
Summary: Exposure to adversity during early childhood and adolescence increases vulnerability to substance use disorder, with excitatory afferents to the nucleus accumbens mediating responses to stress and reward. Social isolation rearing alters presynaptic glutamatergic transmission in the NAc, with projections from the ventral hippocampus potentially being a target for reversing stress-induced plasticity.
Article
Behavioral Sciences
Melissa C. Knouse, Lisa A. Briand
Summary: Females exhibit stronger behavioral responses than males to drugs like cocaine and opioids, possibly driven by ovarian hormones. While there are overlapping neural mechanisms underlying cocaine and opioid abuse, they have divergent effects on synaptic plasticity. This suggests that behavioral sex differences in substance use disorder may be driven by different mechanisms depending on the drug class.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Anna G. McGrath, Lisa A. Briand
Summary: Post-weaning social isolation stress affects addiction-like behavior in adulthood. Long-term changes in behavior may be due to lasting structural changes in reward-related brain regions. Previous studies have shown that stress alters dendritic spine density in these regions, but many studies only focus on short-term effects and mainly involve male subjects. There is growing evidence of sex differences in stress responses and plasticity. This study examines the long-lasting, sex-specific alterations in spine density following post-weaning social isolation in mice.
Article
Neurosciences
Julia K. Brynildsen, Kechun Yang, Crystal Lemchi, John A. Dani, Mariella De Biasi, Julie A. Blendy
Summary: The SNP D398N in the CHRNA5 gene has been associated with nicotine and opiate dependence. By using CRISPR/Cas9 genome editing, mice with the risk-associated allele were generated and it was found that this genotype may enhance opioid reward specifically in females. The response of DA neurons to morphine was altered in Chrna5 A/A mice, and increased opiate reward was observed two weeks after conditioning.
Article
Endocrinology & Metabolism
Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Summary: This article investigates the sex differences in glutamatergic transmission within the medial prefrontal cortex, finding higher levels of glutamatergic transmission in females. This provides important evidence for the development of sex-specific pharmacotherapies for psychiatric diseases.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Psychiatry
Darrell Eacret, Elisabetta Manduchi, Julia Noreck, Emma Tyner, Polina Fenik, Amelia D. Dunn, Jonathan Schug, Sigrid C. Veasey, Julie A. Blendy
Summary: Disrupted sleep is a common symptom in psychiatric disorders, including substance use disorders. This study focuses on the impact of morphine, an opioid drug, on sleep. The researchers found that chronic morphine exposure significantly disrupts sleep, particularly during the dark cycle, and this effect is associated with increased neural activity in the Paraventricular Nucleus of the Thalamus (PVT). This suggests that PVT neurons expressing Mu Opioid Receptors (MORs) play an important role in mediating morphine-induced sleep disturbance.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Melissa C. Knouse, Andre U. Deutschmann, Miroslav N. Nenov, Mathieu E. Wimmer, Lisa A. Briand
Summary: In this study, potential sex differences in synaptic plasticity and excitatory transmission within the nucleus accumbens core were examined. The results showed that female mice and rats have higher AMPA/NMDA ratios, a larger readily releasable pool of glutamate, and lower release probability compared to males. These sex differences should be considered in the development of pharmacotherapies for treating depression and substance use disorder.
BIOLOGY OF SEX DIFFERENCES
(2023)
Correction
Multidisciplinary Sciences
Evelyn Ordones Sanchez, Charlotte C. Bavley, Andre U. Deutschmann, Rachel Carpenter, Drew R. Peterson, Reza Karbalaei, James Flowers, Charleanne M. Rogers, Miranda G. Langrehr, Cory S. Ardekani, Sydney T. Famularo, Angela R. Bongiovanni, Melissa C. Knouse, Stan B. Floresco, Lisa A. Briand, Mathieu E. Wimmer, Debra A. Bangasser
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Meeting Abstract
Neurosciences
Debra Bangasser, Evelyn Ordones Sanchez, Charlotte Bavley, Andre Deutschmann, Drew Peterson, Rachel Carpenter, Reza Karbalaei, James Flowers, Charleanne Rogers, Miranda Langrehr, Cory Ardekani, Sydney Famularo, Angela Bongiovanni, Melissa Knouse, Stan Floresco, Benjamin Garcia, Lisa Briand, Mathieu Wimmer
BIOLOGICAL PSYCHIATRY
(2021)
Meeting Abstract
Neurosciences
Evelyn Ordones Sanchez, Charlotte Bavley, Rachel Carpenter, Drew Peterson, Reza Karbalaei, James Flowers, Charleanne Rogers, Miranda Langrehr, Cory Ardekani, Sydney Famularo, Angela Bongiovanni, Stan Floresco, Benjamin Garcia, Lisa Briand, Mathieu Wimmer, Debra Bangasser
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.