Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Anatomy & Morphology
Shao-Peng Lin, Jingyi Bu, Shan Ye, Qiangda Xie, Jue-Xian Wei, Xiaofang Yin, Fen Mei, Pei-Yi Lin, Xiao-Hui Chen
Summary: This study investigated whether AMPK-induced glucose metabolic and mitochondrial dysfunction were related to glutamate-dependent ROS injury of neurons. The results showed that AMPK phosphorylation promoted glucose uptake, enhanced oxygen consumption rate and intracellular ROS levels. Inhibition of AMPK mitigated glutamate-induced cellular toxicity. These findings suggest that AMPK phosphorylation may be a potential target for treating glutamate-induced neurotoxicity.
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
He Liu, Jinjin Qiao, Jiaolei Shangguan, Jing Zhu
Summary: Nitrogen metabolism can regulate mycelial growth and secondary metabolism in Ganoderma lucidum. Glutamate oxaloacetate transaminase (GOT) isoenzymes, GOT1 and GOT2, were found in G. lucidum, and the silencing of got1 and got2 affects the ROS level and secondary metabolism. The results provide new insights into the effect of GOT on ROS and secondary metabolism in fungi.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Ophthalmology
Daniel T. Hass, Colin J. Barnstable
Summary: Oxidative stress is a crucial factor in major retinal diseases, with mitochondria being a significant source of reactive oxygen species (ROS). UCP2, as a member of the mitochondrial uncoupling protein family, can modulate ROS production and increase neuroprotection in various diseases, making it a promising therapeutic target. Studies on UCP2 have revealed its structural mechanism of action and ways to control its expression and activity for therapeutic use in both acute and chronic conditions, providing new tools to combat serious retinal diseases.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Hulya Gizem Oezkan, Andriy Mokhir
Summary: Hybrid drugs containing ferrocene and phenol residues exhibit potent anticancer activity, but their mode of action, specificity, and metabolism need further investigation. In this study, we synthesized prodrugs of aminoferrocene-phenol hybrids and confirmed their activation in cancer cells while remaining inactive in normal cells. The anticancer activity of the prodrug relies on the generation of reactive oxygen species in cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ivan Menendez-Montes, Salim Abdisalaam, Feng Xiao, Nicholas T. Lam, Shibani Mukherjee, Luke I. Szweda, Aroumougame Asaithamby, Hesham A. Sadek
Summary: Mitochondrial utilization of fatty acids induces a significant increase in ROS detection at the chromatin level, indicating that mitochondrial metabolic perturbations directly alter the nuclear redox status, with chromatin being particularly sensitive to the prooxidant effect of FA utilization by the mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biology
Jules B. L. Devaux, Anthony J. R. Hickey, Gillian M. C. Renshaw
Summary: Anoxia/re-oxygenation (AR) can cause irreversible brain damage due to elevated oxidative stress. Two shark species, the epaulette shark and the grey carpet shark, have adapted to survive AR without significant brain injuries. The epaulette shark shows the capacity to suppress metabolism and depress succinate oxidation, resulting in lower ROS production compared to the grey carpet shark. The research sheds light on potential mechanisms to mitigate brain injury during AR.
Article
Endocrinology & Metabolism
Ibolya Rutkai, Ivan Merdzo, Sanjay V. Wunnava, Genevieve T. Curtin, Prasad V. G. Katakam, David W. Busija
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Endocrinology & Metabolism
Benard O. Ogola, Margaret A. Zimmerman, Venkata N. Sure, Kaylee M. Gentry, Jennifer L. Duong, Gabrielle L. Clark, Kristin S. Miller, Prasad V. G. Katakam, Sarah H. Lindsey
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Virginia Reverte, Venkateswara R. Gogulamudi, Carla B. Rosales, Diego C. Musial, Sabrina R. Gonsalez, Alberto J. Parra-Vitela, Michelle Galeas-Pena, Venkata N. Sure, Bruna Visniauskas, Sarah H. Lindsey, Prasad V. G. Katakam, Minolfa C. Prieto
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Virology
Joseph A. Combs, Elizabeth B. Norton, Zubaida R. Saifudeen, Kerstin Honer Zu Bentrup, Prasad V. Katakam, Cindy A. Morris, Leann Myers, Amitinder Kaur, Deborah E. Sullivan, Kevin J. Zwezdaryk
JOURNAL OF VIROLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Siva S. V. P. Sakamuri, Jared A. Sperling, Wesley R. Evans, Monica H. Dholakia, Aaron L. Albuck, Venkata N. Sure, Ryousuke Satou, Ricardo Mostany, Prasad V. G. Katakam
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Ibolya Rutkai, Wesley R. Evans, Nikita Bess, Tomas Salter-Cid, Sinisa Cikic, Partha K. Chandra, Prasad V. G. Katakam, Ricardo Mostany, David W. Busija
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Sinisa Cikic, Partha K. Chandra, Jarrod C. Harman, Ibolya Rutkai, Prasad V. G. Katakam, Jessie J. Guidry, Jeffrey M. Gidday, David W. Busija
Summary: The study identified sexual dimorphism in mitochondrial metabolic protein profiles of cerebral microvessels, with females expressing more proteins involved in energy production, antioxidant defense, and fatty acid oxidation, while males had higher expression levels of mitochondria-destructive proteins. These differences may contribute to sex-dependent cerebrovascular and neurological pathologies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Fengming Liu, Shen Dai, Dechun Feng, Zhongnan Qin, Xiao Peng, Siva S. V. P. Sakamuri, Mi Ren, Li Huang, Min Cheng, Kabir E. Mohammad, Ping Qu, Yong Chen, Chunling Zhao, Faliang Zhu, Shujian Liang, Bertal H. Aktas, Xiaofeng Yang, Hong Wang, Prasad V. G. Katakam, David W. Busija, Tracy Fischer, Prasun K. Datta, Jay Rappaportl, Bin Gao, Xuebin Qin
NATURE COMMUNICATIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Aaron L. Albuck, Siva S. V. P. Sakamuri, Jared A. Sperling, Wesley R. Evans, Lahari Kolli, Venkata N. Sure, Ricardo Mostany, Prasad V. G. Katakam
Summary: This study demonstrates the generation of functionally significant PN in isolated brain mitochondria and its pathological relevance in eNOS-deficient mice. Exogenous PN and a PN donor (SIN-1) were found to decrease respiratory function in brain mitochondria, while a PN scavenger (FeTMPyP) enhanced mitochondrial respiration. Neither SIN-1 nor FeTMPyP depolarized the mitochondria, indicating potential therapeutic benefits.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Partha K. Chandra, Sinisa Cikic, Melody C. Baddoo, Ibolya Rutkai, Jessie J. Guidry, Erik K. Flemington, Prasad V. G. Katakam, David W. Busija
Summary: This study reveals significant sex disparities in gene expression and canonical pathways of brain microvessels, with male microvessels showing differential expression in genes related to glycosylphosphatidylinositol and steroid synthesis, while female microvessels mainly involve respiratory chain and ribosome pathways.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Geriatrics & Gerontology
Rakesh Gurrala, Isabella M. Kilanowski-Doroh, Dillion D. Hutson, Benard O. Ogola, Margaret A. Zimmerman, Prasad V. G. Katakam, Ryousuke Satou, Ricardo Mostany, Sarah H. Lindsey
Summary: This study investigated the role of estrogen receptors in the cardiovascular system, finding that vasodilation to estrogen and GPER agonist decreased with age in female mice, along with downregulation of GPER protein. However, ER alpha and GPER were the primary receptors in all tissues, while ERss was predominantly detectable in the kidney.
Article
Geriatrics & Gerontology
Partha K. Chandra, Sinisa Cikic, Ibolya Rutkai, Jessie J. Guidry, Prasad V. G. Katakam, Ricardo Mostany, David W. Busija
Summary: The study found that the differentially expressed proteins in the cortical microvessels of aged mice showed significant changes with aging, particularly in oxidative stress response, mRNA/protein stability, basement membrane composition, glycolysis, and mitochondrial function. This suggests that increased oxidative stress during aging leads to adverse changes in protein profile of brain cortical microvessels, affecting mRNA/protein stability, basement membrane integrity, and ATP synthesis capacity.
Editorial Material
Cardiac & Cardiovascular Systems
Siva S. V. P. Sakamuri, Venkata N. Sure, Prasad V. G. Katakam
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Behavioral Sciences
D. Parker Kelley, Lucas Albrechet-Souza, Shealan Cruise, Rajani Maiya, Aspasia Destouni, Siva S. V. P. Sakamuri, Alexander Duplooy, Meghan Hibicke, Charles Nichols, Prasad V. G. Katakam, Nicholas W. Gilpin, Joseph Francis
Summary: Stress is associated with contextual memory deficits, which may lead to avoidance of trauma-associated contexts in posttraumatic stress disorder. These deficits may result from impaired pattern separation in the brain, which affects the ability to distinguish similar experiences. The production of reactive oxygen species in the hippocampus has been found to be related to pattern separation and may play a role in the effects of stress on memory.
GENES BRAIN AND BEHAVIOR
(2023)
Review
Clinical Neurology
Yinghua Jiang, Ning Liu, Jinrui Han, Yadan Li, Pierce Spencer, Samuel J. Vodovoz, Ming-Ming Ning, Gregory Bix, Prasad V. G. Katakam, Aaron S. Dumont, Xiaoying Wang
Summary: This review summarizes the potential mechanisms underlying the exacerbation of outcomes in diabetic stroke patients after IV tPA therapy, including factors influencing tPA recanalization and hemorrhagic transformation, as well as various factors contributing to the exacerbation of HT.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
