期刊
BRAIN RESEARCH
卷 1258, 期 -, 页码 43-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.12.021
关键词
Radial glia; Vimentin; Neural stem cell; Neuronal migration; Subventricular zone
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Coordenaqdo de Aperfeiqoamento de Pessoal de Nivel Superior
- Fundacao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de Janeiro (FAPERJ)
During development, radial glia cells contribute to neuronal migration and neurogenesis, and differentiate into astrocytes by the end of the developmental period. Recently, it was demonstrated that during development, radial glia cells, in addition to their role in migration, also give rise to neuroblasts. Furthermore, radial glial cells remain in the adult brain as adult neural stem cells (NSC) in the subventricular zone (SVZ) around the lateral ventricles (LVs), and generate new neurons continuously throughout adulthood. In this study, we used immunohistochemical and morphological methods to investigate the presence of radial glia-like cells around the LVs during the postnatal development period until adulthood in rats. In all ages of rats studied, we identified cells with morphological and immunocytochemical features that are similar to the radial glia cells found in the embryonic brain. Similarly to the radial glia, these cells express nestin and vimentin, and have a radial morphology, extending perpendicularly as processes from the ventricle wall. These cells also express GFAP, GLAST, and Pax6, and proliferate. In the brains of adult rats, we identified cells with relatively long processes (up to 600 mu m) in close apposition with migrating neuroblasts. Our results showed that the radial glia-like cells present in the adult rat brain share several morphological and functional characteristics with the embryonic radial glia. We suggest that the embryonic radial glia cells located around the LV walls do not complete their transformation into astrocytes, but rather persist in adulthood. (C) 2008 Elsevier B.V. All rights reserved.
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