Article
Medicine, Research & Experimental
Jun Li, Lin Zhang, Chu Xu, Ying-Ying Shen, Yu-Hui Lin, Yu Zhang, Hai-Yin Wu, Lei Chang, Ying-Dong Zhang, Rong Chen, Zheng-Ping Zhang, Chun-Xia Luo, Fei Li, Dong-Ya Zhu
Summary: The study aims to prevent analgesic tolerance by co-targeting NMDAR downstream signaling and GABA(A)Rs. Results show that chronic use of the dual-target compound ZL006-05 can avoid analgesic tolerance and unwanted side effects in treating neuropathic pain.
Article
Neurosciences
Antonella Comitato, Enza Lacivita, Marcello Leopoldo, Rita Bardoni
Summary: The 5-HT7 receptors play an important role in synaptic modulation, particularly in synaptic inhibition, in the dorsal horn of the spinal cord. The stronger impact on synaptic inhibition suggests that these receptors may have an anti-nociceptive role in the spinal cord of naive animals.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Roberto Colangeli, Maria Morena, Allison Werner, Roger J. Thompson, Mario van der Stelt, Quentin J. Pittman, Matthew N. Hill, Campbell Teskey
Summary: Repeated seizures result in persistent alteration of endocannabinoid (eCB) signaling, particularly a deficiency in anandamide signaling in the basolateral amygdala (BLA), leading to abnormal synaptic function and emotional behavior. This study found that repeated seizures reduced tonic and phasic eCB-mediated retrograde signaling in GABA transmission. These effects were not due to changes in CB1 receptor sensitivity or altered baseline 2-AG signaling, but rather impaired stimulus-dependent 2-AG synthesis/release.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Wenshuo Xie, Nianhong Xing, Jicheng Qu, Dongwu Liu, Qiuxiang Pang
Summary: This review summarizes the structure, isoforms, and physiological role of CAPON, as well as its relationship with heart diseases, diabetes, psychiatric disorders, and tumors. The C-terminal PDZ-binding motif of CAPON plays a regulatory role in nitric oxide production and neuronal development. Clarifying the future research directions on the signal pathways related to CAPON will facilitate the study of its regulatory mechanism and provide new ideas for treating human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Junhong Wu, Hui Zhang, Liu Yang, Yuanyuan Chen, Jiyuan Li, Min Yang, Xiaogang Zhang, Changlong He, Xuefeng Wang, Xin Xu
Summary: This study investigates the role of STX7 in epilepsy and finds that reduced expression of STX7 in the epileptic brain is associated with increased susceptibility to epileptic seizures. Overexpression of STX7, on the other hand, decreases susceptibility to seizures and alleviates epileptic activity. It is also found that STX7 affects the release of inhibitory neurotransmitters, but not the intrinsic excitability of neurons.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Immunology
Simone Schilling, Bruno Chausse, Hasan Onur Dikmen, Fadi Almouhanna, Jan-Oliver Hollnagel, Andrea Lewen, Oliver Kann
Summary: Activation of microglia by Toll-like receptors can lead to varying levels of neuronal network dysfunction, with severe dysfunction primarily caused by reactive oxygen and nitrogen species rather than proinflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biology
Charles Ducrot, Gregory de Carvalho, Benoit Delignat-Lavaud, Constantin V. L. Delmas, Priyabrata Halder, Nicolas Giguere, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josee Bourque, Martin Parent, Lulu Y. Chen, Louis-Eric Trudeau
Summary: Midbrain dopamine (DA) neurons play a crucial role in regulating basal ganglia functions, and their connectivity and neurotransmission are influenced by neuroligins, particularly their interaction with neurexins. This study investigated the role of neurexins in DA neuron neurotransmission and found that mice lacking neurexins in DA neurons exhibited impaired locomotor response to amphetamine, decreased levels of DAT, increased levels of VMAT2, and reduced activity-dependent DA release. Electrophysiological recordings also revealed increased GABA co-release from DA neuron axons in these mice.
Article
Neurosciences
Sophia Khom, Larry Rodriguez, Pauravi Gandhi, Dean Kirson, Michal Bajo, Christopher S. Oleata, Leandro F. Vendruscolo, Barbara J. Mason, Marisa Roberto
Summary: This study revealed the regulatory mechanism of glucocorticoid receptors on GABA transmission at synapses in the central nucleus of the amygdala, providing important insights for finding potential drugs for the treatment of alcohol use disorder.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Sana Al Awabdh, Florian Donneger, Marie Goutierre, Martial Seveno, Oana Vigy, Pauline Weinzettl, Marion Russeau, Imane Moutkine, Sabine Levi, Philippe Marin, Jean Christophe Poncer
Summary: KCC2, a neuron-specific chloride extruder, regulates the strength and polarity of GABAA receptor-mediated transmission and also plays a role in spinogenesis and excitatory synaptic function. The study identifies gephyrin as a novel anchoring molecule for KCC2 that stabilizes its plasma membrane expression and promotes its clustering near GABAergic synapses.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N. Simon, Simona Mafrici, Ritu Arya, Esther Rosello-Lleti, Surawee Chuaiphichai, Damian Tyler, Craig A. Lygate, Keith M. Channon, Barbara Casadei
Summary: Myocardial BH4 was found to prevent and reverse left ventricular diastolic and systolic dysfunction associated with diabetes by increasing insulin-independent myocardial glucose uptake and utilization. This mechanism highlights the potential for GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
CIRCULATION RESEARCH
(2021)
Article
Neurosciences
Kyle A. Brown, Panos Zanos, Chris F. Powels, Connor J. Fix, Michael Michaelides, Edna F. R. Pereira, Ruin Moaddel, Todd D. Gould
Summary: Benzethonium chloride (BZT) is an excipient commonly used in ketamine drug formulations, and recent research suggests that BZT has pharmacological activity. This study investigated the affinity of BZT for neurotransmitter receptors and transporters, its effects on synaptic transmission, and its distribution in the body. The results showed that BZT binds to various receptors and transporters, enhances synaptic potentials in the hippocampus, and can be detected in the plasma but not in the brain after administration. These findings suggest that previous studies attributing pharmacological effects to ketamine may be influenced by BZT and warrant further investigation of BZT's functional impact.
Article
Neurosciences
Caroline Biojone, Plinio Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodriguez, Angelina Lesnikova, Mikko Voipio, Eero Castren
Summary: A recent study has identified the nitration of TRKB receptors as a new molecular brake on plasticity, demonstrating the inhibitory effect of nitric oxide on neural plasticity.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
David Perez-Boyero, Carlos Hernandez-Perez, Jorge Valero, Valeria Lorena Cabedo, Jose Ramon Alonso, David Diaz, Eduardo Weruaga
Summary: The main olfactory bulb (MOB) is a neural structure that processes olfactory information. Nitric oxide (NO), produced mainly by neuronal nitric oxide synthase (nNOS), plays a crucial role in the plasticity and functioning of the MOB. The absence of nNOS expression in nNOS-KO mice leads to a reduced olfactory capacity, while an increase in the expression of endothelial nitric oxide synthase (eNOS) is observed. However, the level of NO generated in the MOB does not appear to change significantly. These findings suggest that nNOS is essential for the proper functioning of the olfactory system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Christian Arias-Reyes, Sofien Laouafa, Natalia Zubieta-DeUrioste, Vincent Joseph, Aida Bairam, Edith M. Schneider Gasser, Jorge Soliz
Summary: The study reveals that EPO stimulates CSN activity under hypoxic conditions at lower concentrations, but inhibits it at higher concentrations. The inhibitory effect of high-dose EPO on CSN activity may be attributed to an increase in nitric oxide production.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carolina Nunes da Silva, Kenia Nunes Pedrosa, Grazielle Caroline da Silva, Pricila da Silva Cunha, Thiago F. Diniz, Luisa Michette S. Maia, Flavia De Marco Almeida, Ricardo Santiago Gomez, Virginia S. Lemos, Dawidson Assis Gomes, Maria Elena de Lima
Summary: PnPP-19 peptide potentiates erectile function through nitric oxide activation, with a key role of endothelial nitric oxide synthase, and inducible nitric oxide synthase enhancing its effect on erectile function.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Cell Biology
Guangfu Wang, Genrieta Bochorishvili, Yucai Chen, Kathryn A. Salvati, Peng Zhang, Steve J. Dubel, Edward Perez-Reyes, Terrance P. Snutch, Ruth L. Stornetta, Karl Deisseroth, Alev Erisir, Slobodan M. Todorovic, Jian-Hong Luo, Jaideep Kapur, Mark P. Beenhakker, J. Julius Zhu
GENES & DEVELOPMENT
(2015)
Article
Clinical Neurology
Ewa Lewczuk, Suchitra Joshi, John Williamson, Mouna Penmetsa, Sarah Shan, Jaideep Kapur
Article
Clinical Neurology
Suchitra Joshi, Karthik Rajasekaran, John Williamson, Jaideep Kapur
Article
Neurosciences
Suchitra Joshi, Karthik Rajasekaran, Huayu Sun, John Williamson, Jaideep Kapur
NEUROBIOLOGY OF DISEASE
(2017)
Editorial Material
Clinical Neurology
Thomas Wychowski, Jaideep Kapur
Editorial Material
Clinical Neurology
Barbara A. Dworetzky, Jaideep Kapur
Article
Clinical Neurology
Terry Zhang, Marko S. Todorovic, John Williamson, Jaideep Kapur
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2017)
Review
Neurosciences
Suchitra Joshi, Jaideep Kapur
Article
Neurosciences
Suchitra Joshi, Huayu Sun, Karthik Rajasekaran, John Williamson, Edward Perez-Reyes, Jaideep Kapur
NEUROBIOLOGY OF DISEASE
(2018)
Article
Computer Science, Interdisciplinary Applications
Haoyi Liang, Natalia Dabrowska, Jaideep Kapur, Daniel S. Weller
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2019)
Review
Behavioral Sciences
John Williamson, Tanveer Singh, Jaideep Kapur
EPILEPSY & BEHAVIOR
(2019)
Article
Behavioral Sciences
Hannah R. Cock, Lisa D. Coles, Jordan Elm, Robert Silbergleit, James M. Chamberlain, James C. Cloyd, Nathan Fountain, Shlomo Shinnar, Dan Lowenstein, Robin Conwit, Thomas P. Bleck, Jaideep Kapur
EPILEPSY & BEHAVIOR
(2019)
Article
Medicine, General & Internal
James M. Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm, Maija Holsti, Lynn Babcock, Alex Rogers, William Barsan, James Cloyd, Daniel Lowenstein, Thomas P. Bleck, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan B. Fountain, Ellen Underwood, Jason T. Connor, Robert Silbergleit
Article
Oncology
Andrew C. Schomer, Jaideep Kapur
ANNALS OF TRANSLATIONAL MEDICINE
(2016)
Article
Clinical Neurology
Suchitra Joshi, Jaideep Kapur
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
