Article
Physiology
Xueshu Tao, Xin Luo, Tianhe Zhang, Brad Hershey, Rosana Esteller, Ru-Rong Ji
Summary: The study suggests that 1 kHz spinal cord stimulation can reduce neuropathic pain by decreasing IL-1 beta levels and increasing RvD1 levels in the CSF. Additionally, the stimulation alone did not significantly affect cold allodynia induced by nerve injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Zhi-Ling Zhang, Zhi-Tong Wang, Jing Shi, Xiao-Ping Pu, Suo-Di Zhai
Summary: This study aimed to investigate the potential anti-neuropathic pain effects of Tetrandrine (TET) and the involvement of Chemokine-like factor 1 (CKLF1) in the action of TET. The results showed that TET improved mechanical allodynia in mice with neuropathic pain by inhibiting CKLF1 and neuroinflammation.
Article
Clinical Neurology
John E. Gilbert, Tianhe Zhang, Rosana Esteller, Warren M. Grill
Summary: Temporal patterns of spinal cord stimulation designed using a computational model could effectively inhibit pain-related neuronal activity and potentially increase the efficacy of spinal cord stimulation.
Article
Neurosciences
Eric Brown, Ayma F. Malik, Elizabeth R. Moese, Abigail F. McElroy, Angelo C. Lepore
Summary: Neuropathic pain (NP) is a common and debilitating comorbidity of spinal cord injury (SCI). This study investigates the neural activity changes in the pain circuitry following cervical spinal cord injury. The findings reveal complex changes in neuronal activation, with increased activation in some neurons and decreased activation in inhibitory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jia Sun, Ya-qun Zhou, Bing-yang Xu, Jia-yan Li, Long-qing Zhang, Dan-yang Li, Shuang Zhang, Jia-yi Wu, Shao-jie Gao, Da-wei Ye, Wei Mei
Summary: The study demonstrated that dsDNA mediated activation of microglial STING signaling pathway, promoting hyperalgesia initiation in the spinal cord dorsal horn of SNI model. Pharmacological blockade of STING may be a promising target in the treatment of initiation of neuropathic pain.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Immunology
Hai-Ming Guo, Yu Zhang, Yan Zhang, Peng-Fei Jiao, Xiao-Chong Fan, Cun-Long Kong, Tao Wang, Xin-Xin Li, Hong-Wei Zhang, Li-Rong Zhang, Min-Yu Ma, Hui-Lian Bu
Summary: NINJ2 is involved in the development of nerve injury-induced neuropathic pain by activating neuroinflammation in the spinal cord via the NF-Kappa B pathway. The study suggests that reducing NINJ2 levels can partially block the development of pain in SNI rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jan Willem Kallewaard, Jose Francisco Paz-Solis, Pasquale De Negri, Maria Angeles Canos-Verdecho, Hayat Belaid, Simon J. Thomson, David Abejon, Jan Vesper, Vivek Mehta, Philippe Rigoard, Paolo Maino, Sarah Love-Jones, Isaac F. Pena, Simon Bayerl, Christophe Perruchoud, Renaud Bougeard, Cleo Mertz, Yu Pei, Roshini Jain
Summary: The study evaluated the use of an SCS device capable of delivering sub-perception and supra-perception stimulation simultaneously or sequentially, and found that this combination therapy could significantly reduce pain and improve quality of life in patients with chronic back and/or leg pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Peng
Summary: Neuropathic pain caused by spinal cord injury is a long-term disturbance for patients, and the underlying mechanisms are still unclear. This study found that the abnormal expression of Nav1.7 in SDH is associated with NP. Pharmacological studies demonstrated that the blood-brain-barrier permeable Nav1.7 inhibitor GNE-0439 has a significant analgesic effect on NP in SCI mice.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jinhong Jiang, Lingfei Xu, Long Yang, Su Liu, Zhe Wang
Summary: MOTS-c, a mitochondrial-derived peptide, plays an important role in physiological and pathological functions through AMPK activation. This study found that MOTS-c levels were lower in mice with neuropathic pain compared to control mice. MOTS-c treatment dose-dependently reduced pain sensitivity in these mice via the activation of AMPK and inhibition of proinflammatory cytokine production and microglia activation.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Anesthesiology
Eric J. Wang, Lauren E. Berninger, Olga Komargodski, Thomas J. Smith
Summary: The evidence for neuromodulation devices for the treatment of painful diabetic neuropathy (PDN) mainly consists of open-label prospective trials or case reports. Spinal cord stimulators (SCS) have the most evidence for efficacy, while studies on transcutaneous electrical nerve stimulators (TENS) show mixed results. Peripheral nerve stimulators (PNS) and scrambler therapy devices (ST) may hold promise but require further prospective controlled trials.
Article
Anesthesiology
Qi-Yuan Bao, Pei-Ching Chang, Maria Virginia Centeno, Melissa A. Farmer, Marwan Baliki, Daniel Procissi, Weibin Zhang, A. Vania Apkarian
Summary: Following surgical repair after peripheral nerve injury, neuropathic pain diminishes in most patients but can persist in a small proportion of cases, the mechanism of which remains poorly understood. A rat nerve repair model was used to study the role of brain circuitry in the reversal of neuropathic pain.
Review
Biochemistry & Molecular Biology
Vinicius Tieppo Francio, Keith F. Polston, Micheal T. Murphy, Jonathan M. Hagedorn, Dawood Sayed
Summary: Since 1967, spinal cord stimulation (SCS) technology has evolved significantly, with the introduction of the 10 kHz SCS system that selectively activates inhibitory interneurons in the dorsal horn. This high-frequency stimulation pattern has demonstrated significant pain control superiority in patients with chronic back pain and neuropathic pain.
Review
Biochemistry & Molecular Biology
Bryan C. Hoelzer, Deborah Edgar, Shiao-Ping Lu, Rod S. Taylor
Summary: This study systematically reviewed the application of spinal cord stimulation (SCS) in patients with painful diabetic neuropathy (PDN) and compared the high-frequency and low-frequency modalities. The results showed that 10 kHz SCS treatment provided superior pain relief and responder rate compared to low-frequency SCS in PDN patients.
Article
Clinical Neurology
Tomas Hoikkanen, Mette Nissen, Tiina-Mari Ikaheimo, Henna-Kaisa Jyrkkanen, Jukka Huttunen, Mikael von Und Zu Fraunberg
Summary: A retrospective study on 35 consecutive CRPS patients undergoing SCS treatment found that 70% continued using the SCS device over an 8-year follow-up period, but some patients experienced device explantation or complications, with no significant change in medication use.
Review
Medicine, Research & Experimental
Oskar Puk, Magdalena Jablonska, Pawel Sokal
Summary: This systematic review consolidates findings on the immunological and endocrine effects of Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS), revealing that both these neurostimulation techniques have anti-inflammatory effects by modulating local immune responses. These findings provide a foundation for future research in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Josefa Belen Alarcon, Priscila Belen Chuhuaicura, Kathleen Anne Sluka, Carol G. T. Vance, Valeria Paula Sasoli Fazan, Karina Alejandra Godoy, Ramon Eduardo Fuentes, Fernando Jose Dias
Summary: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy that can accelerate nerve regeneration and increase axon quantity and diameter. Low-frequency TENS application can promote normal myelination, while high-frequency TENS application can stimulate motor regeneration but may increase the risk of neuropathic pain. Although further research is needed, TENS seems to be a promising treatment for nerve injury.
Article
Anesthesiology
Muath A. Shraim, Kathleen A. Sluka, Michele Sterling, Lars Arendt-Nielsen, Charles Argoff, Karl S. Bagraith, Ralf Baron, Helena Brisby, Daniel B. Carr, Ruth L. Chimenti, Carol A. Courtney, Michele Curatolo, Beth D. Darnall, Jon J. Ford, Thomas Graven-Nielsen, Melissa C. Kolski, Eva Kosek, Richard E. Liebano, Shannon L. Merkle, Romy Parker, Felipe J. J. Reis, Keith Smart, Rob J. E. M. Smeets, Peter Svensson, Bronwyn L. Thompson, Rolf-Detlef Treede, Takahiro Ushida, Owen D. Williamson, Paul W. Hodges
Summary: This study used the Delphi expert consensus method to identify classification features and generated a list of candidate features that could aid in discrimination between types of musculoskeletal pain.
Article
Clinical Neurology
Dana L. Dailey, Carol G. T. Vance, Ruth Chimenti, Barbara A. Rakel, Miriam Bridget Zimmerman, Jon M. Williams, Kathleen A. Sluka, Leslie J. Crofford
Summary: This study found that regular use of opioid medications does not diminish the effectiveness of transcutaneous electrical nerve stimulation (TENS) for movement-evoked pain. However, women with fibromyalgia regularly taking opioids did experience greater bodily pain and fatigue compared to those not regularly taking opioids. These differences, while statistically significant, may not have clear clinical significance.
Article
Anesthesiology
Joseph B. Lesnak, Alexis Fahrion, Amber Helton, Lynn Rasmussen, Megan Andrew, Stefanie Cunard, Michaela Huey, Austin Kreber, Joseph Landon, Travis Siwiec, Kenan Todd, Laura A. Frey-Law, Kathleen A. Sluka
Summary: Resistance training can prevent the development of muscle pain through the activation of androgen receptors. It acutely increases lactate and testosterone, and increases strength over time.
Article
Medicine, General & Internal
Giovanni Berardi, Laura Frey-Law, Kathleen A. Sluka, Emine O. Bayman, Christopher S. Coffey, Dixie Ecklund, Carol G. T. Vance, Dana L. Dailey, John Burns, Asokumar Buvanendran, Robert J. McCarthy, Joshua Jacobs, Xiaohong Joe Zhou, Richard Wixson, Tessa Balach, Chad M. Brummett, Daniel Clauw, Douglas Colquhoun, Steven E. Harte, Richard E. Harris, David A. Williams, Andrew C. Chang, Jennifer Waljee, Kathleen M. Fisch, Kristen Jepsen, Louise C. Laurent, Michael Olivier, Carl D. Langefeld, Timothy D. Howard, Oliver Fiehn, Jon M. Jacobs, Panshak Dakup, Wei-Jun Qian, Adam C. Swensen, Anna Lokshin, Martin Lindquist, Brian S. Caffo, Ciprian Crainiceanu, Scott Zeger, Ari Kahn, Tor Wager, Margaret Taub, James Ford, Stephani P. Sutherland, Laura D. Wandner
Summary: Chronic pain is a global health problem that reduces quality of life, but its clinical management has been hindered by incomplete understanding of risk factors and molecular mechanisms. The A2CPS Program aims to predict chronic pain development following surgery using biomarkers. This study collects standardized data from multiple clinical sites to advance understanding of the transition from acute to chronic postsurgical pain.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Saman Haider, Adam J. Janowski, Joseph B. Lesnak, Kazuhiro Hayashi, Dana L. Dailey, Ruth Chimenti, Laura A. Frey-Law, Kathleen A. Sluka, Giovanni Berardi
Summary: An increasing number of individuals experience prolonged symptoms after having COVID-19, known as post-COVID-19 condition. This study aimed to compare the symptom profiles of individuals with post-COVID-19, fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS). The study found that all three conditions had elevated levels of pain, fatigue, anxiety, depression, catastrophizing, and kinesiophobia. Physical and cognitive function were similarly affected in post-COVID-19, FMS, and CFS, but post-COVID-19 individuals reported lower levels of pain and fatigue compared to FMS and CFS. The comorbidity of post-COVID-19 with FMS and/or CFS worsened pain, fatigue, and psychological aspects. These findings suggest the importance of a biopsychosocial approach in managing post-COVID-19 symptoms.
Article
Anesthesiology
Ruth L. Chimenti, Andrew A. Post, Ebonie K. Rio, G. Lorimer Moseley, Megan Dao, Hadley Mosby, Mederic Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Emine O. Bayman, Kathleen A. Sluka
Summary: Exercise is the standard treatment for Achilles tendinopathy (AT), but a significant number of patients still experience pain after rehabilitation. Adding pain science education (PSE) to an exercise program may improve clinical outcomes, but this has not been studied in AT patients. Moreover, we have limited knowledge about how AT rehabilitation affects fear of movement and central nervous system nociceptive processing.
Article
Orthopedics
Andrew A. Post, Dana L. Dailey, Emine O. Bayman, Ruth L. Chimenti, Michele Costigan, Carla Franck, Trevis Huff, Elizabeth Johnson, Maxine Koepp, David-Erick Lafontant, Megan E. McCabe, Tina Neill-Hudson, Carol G. T. Vance, Barb Van Gorp, Bridget M. Zimmerman, Dixie Ecklund, Leslie J. Crofford, Kathleen A. Sluka
Summary: This study aims to examine if adding TENS to routine physical therapy improves movement-evoked pain in individuals with fibromyalgia. The study will enroll 600 participants and utilize a randomized cluster design. The findings of this study will provide important data for healthcare policymakers, clinicians, and insurers.
Article
Orthopedics
Andrew A. Post, Ebonie K. Rio, Kathleen A. Sluka, G. Lorimer Moseley, Emine O. Bayman, Mederic M. Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Ruth L. Chimenti
Summary: The study compared the efficacy of physical therapy delivered via telehealth or hybrid format with in-person format for individuals with chronic Achilles tendinopathy (AT). The results showed that there was no significant difference in pain outcomes between the telehealth/hybrid groups and the in-person group. This suggests that telehealth-based physical therapy can improve accessibility to AT rehabilitation and prioritize patient preferences for treatment format.
Review
Orthopedics
Kazuhiro Hayashi, Adam Janowski, Joseph B. Lesnak, Kathleen A. Sluka
Summary: Preoperative exercise can reduce postoperative pain and improve function, as well as decrease the risk of complications. This systematic review found that preoperative exercise in joint replacement surgery can significantly reduce pain within 2-5 months after surgery and improve quality of life and function within the first 2 months. However, the effect on pain and function after 6 months is not significant, and the impact on other surgery types is inconclusive.
Article
Anesthesiology
Kazuhiro Hayashi, Joseph B. B. Lesnak, Ashley N. N. Plumb, Lynn A. A. Rasmussen, Kathleen A. A. Sluka
Summary: We developed an animal model of activity-induced muscle pain that relies on the activation of macrophages and the release of interleukin-1 β. The P2X7/NLRP3/Caspase-1 pathway plays a crucial role in the initiation and early maintenance phases of muscle pain in male mice. However, this pathway does not contribute to late maintenance phases in male mice or to muscle pain in female mice.
Review
Anesthesiology
Kathleen A. Sluka, Tor D. Wager, Stephani P. Sutherland, Patricia A. Labosky, Tessa Balach, Emine O. Bayman, Giovanni Berardi, Chad M. Brummett, John Burns, Asokumar Buvanendran, Brian Caffo, Vince D. Calhoun, Daniel Clauw, Andrew Chang, Christopher S. Coffey, Dana L. Dailey, Dixie Ecklund, Oliver Fiehn, Kathleen M. Fisch, Laura A. Frey Law, Richard E. Harris, Steven E. Harte, Timothy D. Howard, Joshua Jacobs, Jon M. Jacobs, Kristen Jepsen, Nicolas Johnston, Carl D. Langefeld, Louise C. Laurent, Rebecca Lenzi, Martin A. Lindquist, Anna Lokshin, Ari Kahn, Robert J. McCarthy, Michael Olivier, Linda Porter, Wei-Jun Qian, Cheryse A. Sankar, John Satterlee, Adam C. Swensen, Carol G. T. Vance, Jennifer Waljee, Laura D. Wandner, David A. Williams, Richard L. Wixson, Xiaohong Joe Zhou
Summary: Chronic pain affects a large number of Americans and there is a lack of understanding of the underlying mechanisms. Biomarkers have the potential to identify and measure changes caused by pain, provide treatment targets, and identify at-risk patients. The A2CPS program aims to evaluate and develop biomarkers for chronic pain after surgery, including genomic, proteomic, metabolomic, and neuroimaging measures.
Article
Engineering, Biomedical
Adam J. Janowski, Andrew A. Post, Alberto M. Heredia-Rizo, Hadley Mosby, Megan Dao, Laura Frey Law, Emine O. Bayman, Jason M. Wilken, Kathleen A. Sluka, Ruth L. Chimenti
Summary: This study characterized movement-evoked pain in individuals with Achilles tendinopathy during tendon loading and stretching tasks, and found associations between movement-evoked pain and biomechanical and psychological variables.
CLINICAL BIOMECHANICS
(2023)
Review
Medicine, General & Internal
Carol G. T. Vance, Dana L. Dailey, Ruth L. Chimenti, Barbara J. Van Gorp, Leslie J. Crofford, Kathleen A. Sluka
Summary: TENS is a non-pharmacological intervention used for acute and chronic pain conditions. Research has improved understanding of TENS efficacy mechanisms, but uncertainty remains regarding clinical effectiveness, requiring further high-quality studies to evaluate the therapeutic potential.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Nathan Augeard, Geoff Bostick, Jordan Miller, David Walton, Yannick Tousignant-Laflamme, Anne Hudon, Andre Bussieres, Lynn Cooper, Nicol McNiven, Aliki Thomas, Lesley Singer, Scott M. Fishman, Marie H. Bement, Julia M. Hush, Kathleen A. Sluka, Judy Watt-Watson, Lisa C. Carlesso, Sinead Dufour, Roland Fletcher, Katherine Harman, Judith Hunter, Suzy Ngomo, Neil Pearson, Kadija Perreault, Barbara Shay, Peter Stilwell, Susan Tupper, Timothy H. Wideman
Summary: This study aimed to create a consensus-based competency profile for pain management specific to the Canadian context of physiotherapy. Through a modified Delphi design, a total of 15 competencies reached consensus, and the majority of participants reported being very satisfied with the process. This study contributes to the field of integrated research in pain management.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.