期刊
BRAIN RESEARCH
卷 1259, 期 -, 页码 68-73出版社
ELSEVIER
DOI: 10.1016/j.brainres.2008.12.058
关键词
Conditioned taste aversion; Latent inhibition; Taste neophobia; Insular cortex; Rat
资金
- NIDCD NIH HHS [R01 DC006456, R01 DC004341, R01 DC004341-05, R56 DC006456, DC04341, R01 DC006456-03, DC06456] Funding Source: Medline
Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar and as a result show a latent inhibition-like retardation of learning. This account anticipates that ICX rats should acquire CTAs at the same slow rate as normal rats that are familiar with the taste stimulus. The present experiment confirmed this hypothesis in a design that compared CTA acquisition in normal and ICX rats following either extensive taste familiarization or no taste familiarization prior to conditioning. (C) 2008 Elsevier B.V. All rights reserved.
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