期刊
BRAIN RESEARCH
卷 1261, 期 -, 页码 20-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.12.073
关键词
Ventrolateral prefrontal cortex; Stop-signal task; Cognitive control; Insula cortex; Visually-guided response control
资金
- State University of New York at Stony Brook, a Drescher Award
- NIH [DA023044]
It has been suggested that the right inferior frontal gyrus (IFG) plays a critical role in manual response inhibition, although neuroimaging studies of healthy adults have also reported widespread activations in other cortical regions during a variety of response inhibition tasks. We conducted a functional magnetic resonance imaging (fMRI) experiment to examine whether the activation of the IFG is dependent on the type of visuo-motor associations during response inhibition by varying the feature of the stop signal (color vs. orientation) in the stop-signal task. Results from 12 subjects showed that the bilateral ventral posterior IFG, anterior insula, inferior frontal junction (IFJ), middle temporal gyrus (MTG) and fusiform gyrus (FG) are active during response inhibition cued by both color and orientation stop signals. While only the MTG showed differential activity to the two stop signals, both MTG and FG showed significantly stronger activity during successful than unsuccessful stopping of unwanted responses cued by orientation and color, respectively. Our findings suggest that the right ventral posterior IFG may play a more general role in response inhibition regardless of the feature of the visual signal, while successful inhibition may depend on efficient processing of the signal. (C) 2009 Elsevier B.V. All rights reserved.
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