Article
Engineering, Multidisciplinary
Mahmoud Al Ahmad, Lillian Joyce Among Olule
Summary: A short-range mmWave radar is proposed for non-contact, non-invasive, and high-accuracy measurements of vital signs. The system extracts heart rate, respiration rate, and blood pressure using a compact radar sensing unit operating at 122 GHz. Algorithms were developed for blood pressure extraction, and the measured values were consistent with reference values. The system shows feasibility for low-cost, highly accurate, and continuous patient monitoring.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Physiology
Jun Kaminosono, Yuki Kambe, Akihide Tanimoto, Tomoyuki Kuwaki, Akira Yamashita
Summary: The optogenetic-based cardiac pacing method allows non-invasive stimulation of the cardiac muscle, producing blood flow and indirectly affecting respiration rhythm. This method is feasible in awake, freely moving mice and can be used to study the relationship between heartbeat state and animal behavior.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Psychology, Biological
Caitlin M. DuPont, Aidan G. C. Wright, Stephen B. Manuck, Matthew F. Muldoon, J. Richard Jennings, Peter J. Gianaros
Summary: Negative emotionality is marginally associated with CA-IMT and lower blood pressure reactivity, while heightened blood pressure reactivity is related to greater CA-IMT. Positive emotionality is not correlated with cardiovascular reactivity or CA-IMT.
Article
Multidisciplinary Sciences
Hooseok Lee, Hoon Ko, Heewon Chung, Yunyoung Nam, Sangjin Hong, Jinseok Lee
Summary: In this study, PPGI sensors were mounted on a robot for active and autonomous HR estimation. A proposed algorithm simplified the extraction of facial skin images and selected pixels based on the most frequent saturation value to achieve accurate HR assessment. The algorithm was validated on two datasets, demonstrating high accuracy and processing efficiency.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Alice C. Haynes, Annie Lywood, Emily M. Crowe, Jessica L. Fielding, Jonathan M. Rossiter, Christopher Kent
Summary: Anxiety disorders are a significant global issue, often treated with therapy and medication. However, these methods have limitations, leading researchers to propose a non-pharmacological intervention that utilizes haptic technology to alleviate anxiety. By developing a huggable haptic interface that simulates slow breathing, this study demonstrates the effectiveness of such an approach.
Article
Peripheral Vascular Disease
Thomas Weber, Athanase D. Protogerou, Mohsen Agharazii, Antonis Argyris, Sola Aoun Bahous, Jose R. Banegas, Ronald K. Binder, Jacques Blacher, Andrea Araujo Brandao, Juan J. Cruz, Kathrin Danninger, Cristina Giannatasio, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Yan Li, Alessandro Maloberti, Christopher C. Mayer, Barry J. McDonnell, Carmel M. McEniery, Marco Antonio Mota Gomes, Annelise Machado Gomes, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Aletta E. Schutte, Petros P. Sfikakis, Dimitrios Terentes-Printzios, Alexandre Vallee, Charalambos Vlachopoulos, Lisa Ware, Ian Wilkinson, Robert Zweiker, James E. Sharman, Siegfried Wassertheurer
Summary: Central systolic blood pressure (cSBP) is more closely associated with hypertension-mediated organ damage and prognosis than brachial systolic blood pressure. This study investigated the 24-hour profiles of brachial and central SBP in untreated adults, providing reference values and analyzing daytime-nighttime variability. The findings have potential implications for refining hypertension diagnosis and management.
Article
Multidisciplinary Sciences
Andy Schumann, Karl-Juergen Baer
Summary: This study provides a database of high-resolution biological signals to describe the effect of healthy aging on cardiovascular regulation, demonstrating the decline of heart rate variability with increasing age.
Article
Psychology, Multidisciplinary
Anna Exner, Miriam Kampa, Johannes B. Finke, Tobias Stalder, Holger Klapperich, Marc Hassenzahl, Kristian Kleinke, Tim Klucken
Summary: Contrary to previous research, no differential stress reactivity pattern was observed between coping groups in this study, possibly due to the non-social nature of the stressor used. The novel finding of physiological baseline differences between fluctuating and non-defensive individuals is of interest and should be further explored in different types of stressors in future research.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Biological
Melody M. Moore, Alexandra T. Tyra, Danielle A. Young, Annie T. Ginty
Summary: The relationship between adiposity and cardiovascular disease morbidity and mortality is complex. The current study aimed to examine the association between two metrics of adiposity and two indices of cardiovascular stress responses. The results showed that there were no statistically significant associations between adiposity and cardiovascular stress reactivity or habituation.
Article
Endocrinology & Metabolism
Paula C. Bianchi, Lucas Gomes-de-Souza, Willian Costa-Ferreira, Paola Palombo, Paulo E. Carneiro de Oliveira, Sheila A. Engi, Rodrigo M. Leao, Cleopatra S. Planeta, Carlos C. Crestani, Fabio C. Cruz
Summary: The study found that prolonged ethanol vapor exposure increased cardiovascular reactivity to stress in male rats, but had no significant effect on female rats.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Peripheral Vascular Disease
Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Zhongyun Wang, Ursa Bezan Petric, Ming Chang Hu, Scott A. Smith, Masaki Mizuno, Wanpen Vongpatanasin
Summary: This study found that SGLT2i can reduce blood pressure in hypertensive patients and attenuate renal sympathetic nerve activity and skeletal muscle reflex activity. Additionally, the study found that SGLT2i has no impact on glycemic control. These findings have important clinical implications for preventing hypertension and hypertensive heart disease in young prehypertensive individuals.
Article
Medicine, General & Internal
Piotr Sobieraj, Maciej Sinski, Jacek Lewandowski
Summary: The study found that elevated resting heart rate remains an important independent cardiovascular risk factor that is unrelated to the reduction of systolic blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Cosimo Aliani, Eva Rossi, Marco Luchini, Italo Calamai, Rossella Deodati, Rosario Spina, Piergiorgio Francia, Antonio Lanata, Leonardo Bocchi
Summary: In this study, a methodological approach based on RF and SVM classifiers was proposed to assess the presence and severity of COVID-19. The results showed that the RF and SVM classifiers achieved high accuracy in discriminating between healthy subjects and COVID-19 patients, as well as differentiating the severity of COVID-19.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Julia Werner, Anna M. Saller, Judith Reiser, Steffanie Senf, Pauline Deffner, Nora Abendschoen, Johannes Fischer, Andrea Grott, Regina Miller, Yury Zablotski, Katja Steiger, Shana Bergmann, Michael H. Erhard, Mathias Ritzmann, Susanne Zoels, Christine Baumgartner
Summary: This study developed a feasible and effective method for local anesthesia in piglet castration, using two different injection techniques in combination with lidocaine or mepivacaine. Both injection techniques significantly reduced the nociceptive parameters during piglet castration, but the one-step fenestrated method was faster and easier.
Article
Physiology
Gessynger Morais-Silva, Lucas Gomes-de-Souza, Willian Costa-Ferreira, Jacqueline C. Pavan, Carlos C. Crestani, Marcelo T. Marin
Summary: Prolonged and heightened responses to stress can affect the development of mood disorders and cardiovascular diseases. This study aimed to investigate how susceptible and resilient rats respond to a new stressor after exposure to social defeat stress. The results showed that susceptible rats had increased cardiovascular reactivity, indicating a higher risk for cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Multidisciplinary Sciences
Jingyang Su, Zhi Li, Akira Yamashita, Ikue Kusumoto-Yoshida, Takuto Isomichi, Liying Hao, Tomoyuki Kuwaki
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Biochemistry & Molecular Biology
Shuichi Matsuda, Jun-Dal Kim, Fumihiro Sugiyama, Yuji Matsuo, Junji Ishida, Kazuya Murata, Kanako Nakamura, Kana Namiki, Tatsuhiko Sudo, Tomoyuki Kuwaki, Masahiko Hatano, Koichiro Tatsumi, Akiyoshi Fukamizu, Yoshitoshi Kasuya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physiology
Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biology
Tomoyuki Kuwaki, Kouta Kanno
Summary: The study examined courtship behavior in orexin neuron-ablated mice (ORX-AB), a model of narcolepsy/cataplexy, and found that these mice displayed cataplexy-like behavior in response to female encounter, with a predominant presence during dark periods when exposed to chocolate. Studying cataplexy-like behavior in narcoleptic mice is useful for understanding mechanisms behind positive emotions, such as those associated with chocolate and courtship.
COMMUNICATIONS BIOLOGY
(2021)
Article
Behavioral Sciences
Hideki Kashiwadani, Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The study found that linalool odor exposure still triggered analgesic effects even in TRPA1-deficient mice, and intranasal application of TRPA1 selective antagonist did not alter the analgesic effects of linalool odor, indicating that linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Biochemistry & Molecular Biology
Tomoyuki Kuwaki
Summary: This article summarizes the recent research findings of the author's research group on the role of orexin in the state-dependent adjustment of central autonomic regulation, as well as new discoveries using optogenetic manipulation of the orexin system. The study suggests that the orexin system may play a crucial role in coordinating circuits controlling autonomic functions and behaviors.
Article
Multidisciplinary Sciences
Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The exposure to Linalool odor induces analgesic effects in mice, which are triggered by olfactory input and involve hypothalamic orexinergic neurons. Specifically, the activation of the orexinergic descending pathway by Linalool odor exposure suppresses neuronal activity in the spinal cord, leading to reduced nociceptive information flow and pain relief.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Akira Yamashita, Shunpei Moriya, Ryusei Nishi, Jun Kaminosono, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: Orexin neurons in the perifornical area of the hypothalamus play a critical role in the defense response, as shown by rapid increase in neuronal activity just prior to changes in heart rate. The memory of aversive stimulus can activate orexin neurons and increase heart rate. Targeting orexin neurons may enable treatment of psychiatric disorders associated with chronic stress and traumatic memories.
Article
Cell Biology
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Junichi Sakaguchi, Yoko Ikoma, Yoshimune Sameshima, Yuki Kambe, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study reveals that acute nociceptive stimuli rapidly increase the activities of AS/A7 NA or B2 5-HT neurons in awake mice, while non-noxious stimuli do not have this effect. This suggests that AS/A7 NA or B2 5-HT neurons play important roles in nociceptive processing in the central nervous system.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study found that the activity of orexin-deficient mice's neurons increased before the onset of cataplexy-like behavior but decreased during the episode. This suggests that orexin neurons are moderately inhibited during cataplexy, providing insights for better understanding and treatment of cataplexy in narcolepsy patients.
Article
Physiology
Tatsuroh Kaneko, Tomoyuki Kuwaki, Hideki Kashiwadani
Summary: The study reveals that orexin neurons in the lateral hypothalamus modulate pain and itch in an opposite way, with pain relief and itch exacerbation. Most of these neurons respond to both pain and itch input.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki
Summary: This study investigated the relationship between cataplexy and positive emotions in narcolepsy mice. The researchers found that narcolepsy mice could remember the chocolate-associated chamber and exhibited more cataplexy-like behaviors in that chamber. The activation patterns of the nucleus accumbens during spontaneous and chocolate-induced cataplexy were similar. These findings support the hypothesis that some spontaneous cataplexy in narcolepsy mice might indicate the remembering of happy moments.
Review
Neurosciences
Tomoyuki Kuwaki, Nobuaki Takahashi
Summary: TRPA1 is a member of the TRP superfamily of cation channels and is widely expressed in sensory neural pathways. It detects irritant chemicals, hypoxia, and hyperoxia. Its role in respiratory and behavioral modulation has been studied using Trpa1 knockout mice. The results show that TRPA1 is necessary for protective responses in respiration and behavior, suggesting that TRPA1 channels in the airway may play a sentinel role for environmental threats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.