Article
Multidisciplinary Sciences
Na Li, Qiong Liu, Yimu Zhang, Zhongyi Yang, Xuefeng Shi, Yu Gu
Summary: In mouse dorsal lateral geniculate nucleus (dLGN), a critical period for ocular dominance (OD) plasticity has been identified from eye opening to puberty. There is an innate process of OD formation from contralateral to equal bias in dLGN binocular neurons. Inactivation of primary visual cortex (V1) has different effects on OD bias and plasticity in dLGN, with short-term inactivation reversing the formation of equal OD bias and long-term inactivation retaining dLGN development to an immature stage.
Article
Neurosciences
Rachana D. Somaiya, Natalie A. Huebschman, Lata Chaunsali, Ubadah Sabbagh, Gabriela L. Carrillo, Bhanu P. Tewari, Michael A. Fox
Summary: The study investigated the transcriptional identity and development of astrocytes in the mouse visual thalamus, revealing that these cells have acquired adult-like morphology and functional characteristics before eye-opening. The results also showed that thalamic astrocytes ensheathe retinogeniculate synapses and are capable of efficient uptake of glutamate by eye-opening.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Yao Q. Wang, Yanhua H. Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J. Nestler, Oliver M. Schluter, Yan Dong
Summary: This study elucidates the dynamic interactions between AMPARs and NMDARs during the generation and maturation of silent synapses in the NAc after cocaine experience. The findings provide a mechanistic basis for manipulating new synaptic contacts and potentially new neural network patterns created by these synapses for therapeutic benefit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
R. Re, D. Messenio, G. Marano, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, P. Boracchi, E. Biganzoli, R. Cubeddu, A. Torricelli
Summary: This study used TD-fNIRS to evaluate the hemodynamic response function in glaucomatous eyes compared to healthy eyes. The amplitudes of hemodynamic parameters showed significant association with pathology, while latencies did not show significant results. The ease of use and noninvasiveness of TD-NIRS make it a promising tool for evaluating glaucoma pathology.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Maxim Nikolaev, Daniil M. Strashkov, Mikhail N. Ryazantsev, Denis B. Tikhonov
Summary: NMDA receptors are crucial in various physiological and pathological processes in the CNS, and photoswitchable compounds have proven to be valuable for studying receptor contributions. In this study, light-sensitive compounds based on the DENAQ structure were developed and their effects on glutamate receptors were investigated. The compound PyrAQ showed the most activity in inhibiting NMDA receptors and can be used as a useful tool for photo-pharmacological studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Psychiatry
Kangkang Xue, Jingli Chen, Yarui Wei, Yuan Chen, Shaoqiang Han, Caihong Wang, Yong Zhang, Xueqin Song, Jingliang Cheng
Summary: This research used resting state functional magnetic resonance imaging (rs-fMRI) to study schizophrenia patients and found that those with auditory verbal hallucination (AVH) showed abnormal dynamic functional connectivity (dFC) in auditory related regions, mainly involving the occipital lobe, default mode network (DMN), and middle temporal lobe. These findings provide insights into the neurological mechanism of AVH in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Guela Sokhadze, Peter W. Campbell, Naomi Charalambakis, Gubbi Govindaiah, William Guido, Aaron W. McGee
Summary: Researchers characterized three Cre driver lines targeting the nuclei of the dorsal thalamus in mice, each showing unique expression patterns specifically in TC neurons. These Cre driver lines are useful for developmental studies and investigating sensory TC circuitry. Optogenetic activation of TC afferents in the primary visual cortex proved to be effective in measuring frequency-dependent depression.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Qianli Meng, Keith A. Schneider
Summary: This study found that there is a magnocellular division in the auditory relay in the thalamus, analogous to the magnocellular layers in the visual system. This division shows a strong preference for transient sounds, consistently across individuals, and constitutes an information stream specialized for encoding auditory dynamics.
Article
Neurosciences
Chia-Chi Liao, Mariana Gabi, Hui-Xin Qi, Jon H. Kaas
Summary: This article describes the postnatal development of retinal projections in galagos, and reveals unique features and potential roles of these projections in the visual system of primates.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Francisco Ros-Bernal, Isis Gil-Miravet, Jorge Luceron, Monica Navarro-Sanchez, Esther Castillo-Gomez, Andrew L. Gundlach, Francisco E. Olucha-Bordonau
Summary: This study investigated the neurodevelopmental consequences of RLN3 innervation in the septal area during postnatal development in rats. The results showed that RLN3 network development in the septal area began between P17 and P20 and was correlated with the onset of hippocampal theta rhythm and associated learning processes.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Bing Zhang, Xili Yang, Luyu Ye, Rui Liu, Binglu Ye, Weijia Du, Fuyi Shen, Qian Li, Fan Guo, Jinqi Liu, Fei Guo, Yang Li, Zhendong Xu, Zhiqiang Liu
Summary: Ketamine demonstrates rapid antidepressant effects at subanaesthetic doses, but the understanding of its mechanism is still limited. By increasing the excitability of the mPFC, ketamine exerts its antidepressant effects, with a critical role played by the GABAergic system in the mPFC.
Article
Biochemistry & Molecular Biology
Kristin M. Barry, Donald Robertson, Wilhelmina H. A. M. Mulders
Summary: This study examines the impact of peripheral deafferentation on the central nervous system in the adult auditory system, focusing on the functional connectivity between the prefrontal cortex and MGN. Results suggest a compensatory mechanism after cochlear trauma to increase sensory gating and prevent altered activity from reaching the cortex.
Article
Behavioral Sciences
Sara Sabihi, Caitlin Goodpaster, Skyler Maurer, Benedetta Leuner
Summary: Mother-offspring interactions reduce postpartum anxiety-like behavior through GABAA neurotransmission in the mPFC. Activation of GABAA receptors in the mPFC restores anxiolysis in mothers separated from their pups, while an increased anxiety-like behavior in pup-separated mothers is associated with a lower number and percentage of activated GABAergic neurons in the mPFC.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Summary: Individuals with substance use disorder are at a higher risk of contracting HIV and progressing to AIDS. Neurotoxicity and neurodegeneration are characteristic of HIV-1-associated neurocognitive disorders. Studies have found that cocaine potentiates the neurotoxic effects of HIV-associated proteins. The NMDA antagonist drug memantine shows potential in attenuating the neurotoxicity caused by cocaine and HIV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Anna Pankowska, Sylwester Matwiejczuk, Paulina Koziol, Tomasz Zarnowski, Radoslaw Pietura, Ewa Kosior-Jarecka
Summary: The aim of this study was to evaluate changes in the central visual pathways during different stages of bilateral normal-tension glaucoma. The results showed that the grey matter thickness increased in the V1 region with more-advanced glaucoma stages, which may indicate compensatory hypertrophy. Additionally, the early affected regions in glaucoma included the right lateral occipital gyrus and left lingual gyrus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.