Article
Biology
Shione Okada, Natsumi Hirano, Toshiki Abe, Toshiki Nagayama
Summary: Aversive learning was used to manipulate the phototactic behavior of marbled crayfish, showing that animals avoided the blue-lit exit in memory tests. Long-term memory formation may require multiple training sessions, while new protein synthesis and the cAMP/PKA/CREB pathway are essential for long-term memory formation.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Psychology, Biological
Jelena M. Wehrli, Yanfang Xia, Samuel Gerster, Dominik R. Bach
Summary: Trace fear conditioning is an important research paradigm for studying aversive learning, but the optimal measurement of memory retention is unclear. This study used psychophysiological measurements to investigate CS+ and CS- differentiation in a recall test, and found that fear-potentiated startle response was the most effective measure.
Article
Chemistry, Multidisciplinary
Mitjan Morr, Jeanine Noell, Daphne Sassin, Jule Daniels, Alexandra Philipsen, Benjamin Becker, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness may contribute to vulnerability to intrusive memories after trauma in healthy men, with altered limbic processing of fear signals being a potential underlying mechanism. Lonely men showed more intrusions and altered amygdala activity, while loneliness did not have the same impact on women.
Article
Pharmacology & Pharmacy
Shihao Huang, Yu Zhou, Feilong Wu, Cuijie Shi, He Yan, Liangpei Chen, Chang Yang, Yixiao Luo
Summary: This study found that berberine combined with extinction training can effectively promote the extinction of fear memories and prevent their reinstatement and spontaneous recovery. This finding provides a new potential avenue for the treatment of fear-related disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Rami El Matine, Judith C. Kreutzmann, Markus Fendt
Summary: By manipulating neural excitability in the amygdala, the specificity of fear learning can be improved, reducing fear generalization and anxiety. The findings suggest that moderate increases in amygdala excitability can be beneficial for fear learning specificity and may have applications for therapeutic interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Yuqi You, Joshua Brown, Wen Li
Summary: Animal data suggest the sensory cortex plays a critical role in the long-term storage of aversive conditioning, post acquisition and consolidation in the amygdala. Through a human aversive conditioning study, it was found that M-biased conditioned stimuli led to stronger effects, especially in anxious individuals, across threat appraisal, physiological arousal, perceptual learning, and cortical plasticity. The long-term retention of conditioning in the basic sensory cortices supports the conserved role of the human sensory cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Aimei Zhao, Nan Liu, Guozhi Jiang, Li Xu, Mingjiang Yao, Yehao Zhang, Bingjie Xue, Bo Ma, Dennis Chang, Yujing Feng, Yunyao Jiang, Jianxun Liu, Guoping Zhou
Summary: This study utilized network analysis and experimental research to explore the potential neuroprotective mechanism of CGGE in treating ischemic stroke. The findings suggest that CGGE may improve neuroinflammation and excitotoxicity by regulating the NLRP3 inflammasome and CAMK4/CREB pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Christian J. Merz, Oliver T. Wolf
Summary: Stress hormones have an impact on the processing of fear, anxiety, and related memory mechanisms. Recent laboratory findings highlight the timing-dependent effects of stress on extinction learning and retrieval. This has implications for clinical intervention approaches, such as exposure therapy, and the administration of stress hormone cortisol.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Konstanze Simbriger, Ines S. Amorim, Gilliard Lach, Kleanthi Chalkiadaki, Stella Kouloulia, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas
Summary: Contextual fear conditioning is a common behavioral paradigm used in neuroscience research to study the mechanisms of learning and memory. Using ribosome profiling, a study demonstrated that an immediate shock in male mice leads to translational and transcriptional changes in Immediate Early Genes in the dorsal hippocampus, an effect often overlooked in research.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Behavioral Sciences
Amy K. Pribadi, Sreekanth H. Chalasani
Summary: Learning to identify and predict threats is a basic skill that allows animals to avoid harm. Studies in invertebrates like Aplysia californica, Drosophila melanogaster, and Caenorhabditis elegans have revealed that the basic mechanisms of learning and memory are conserved.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Cell Biology
Elaheh Soleimanpour, Jorge R. Bergado Acosta, Peter Landgraf, Dana Mayer, Evelyn Dankert, Daniela C. Dieterich, Markus Fendt
Summary: This study aimed to investigate the molecular pathways underlying relief learning and found that relief conditioned rats had higher CREB phosphorylation in the NAC compared to pseudo conditioned rats. The phosphorylation of CREB was mainly induced by dopamine D1 receptor-mediated activation of PKA, with possible contributions from other kinases downstream of the NMDA receptor.
Article
Pharmacology & Pharmacy
Yu-Chen Yan, Zhi-Heng Xu, Jian Wang, Wen-Bo Yu
Summary: This study utilized single-nuclei RNA sequencing data for network pharmacology analysis and employed a deep learning algorithm for high-throughput screening of effective drug-target interactions. The strongest interactions between ginkgolides and MAPK14 were validated by molecular docking. This work overcomes the limitations of conventional research, enhances our understanding of the mechanisms of GBE in treating PD, and provides a theoretical foundation for future drug development in PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Sanja Klein, Onno Kruse, Isabell Tapia Leon, Lukas Van Oudenhove, Sophie R. van 't Hof, Tim Klucken, Tor D. Wager, Rudolf Stark
Summary: Sharing and comparing imaging data across psychological tasks is becoming more feasible with the advancement of open science movement. This study validates the commonalities between aversive and appetitive classical conditioning through a multivariate approach, providing an empirical method to integrate fMRI findings across paradigms.
Article
Neurosciences
Ana Oliveira, Marcia Azevedo, Rafaela Seixas, Raquel Martinho, Paula Serrao, Monica Moreira-Rodrigues
Summary: Adrenaline and glucose released during stress may strengthen contextual fear memory. Glucose can enhance contextual fear memory independently of adrenaline in Ad-deficient mice, possibly through increased gene expression in the hippocampus. Additionally, adrenaline and glucose may act synergistically to strengthen contextual fear memory.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yi-Han Liao, Li-Han Sun, Ya-Hsuan Chan, Chienfang G. Cherng, Yi-Chi Su, Wei-Jen Yao, Lung Yu
Summary: Vicarious learning is crucial for the survival of social animals, and adrenal hormones play a key role in this type of learning. Mice that observe fear conditioning in others exhibit greater fear responses. Adrenalectomy in observers results in lower fear responses.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Renata Mancini Banin, Meira Maria Forcelini Machado, Iracema Senna de Andrade, Lorenza Oliveira Testa Carvalho, Bruna Kelly Sousa Hirata, Heider Mendonca de Andrade, Viviane da Silva Julio, Jessica de Souza Figueiredo Borges Ribeiro, Suzete Maria Cerutti, Lila Missae Oyama, Eliane Beraldi Ribeiro, Monica Marques Telles
Summary: The study demonstrated that GbE treatment improved ovariectomy-related obesity and anxious/depressive-like behaviors in female rats, including changes in body composition, adiponectin levels, blood lipid profile, anxiety index, and latency to immobility. Further research is needed to fully understand the therapeutic potential of GbE in menopause.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Vitor Rodrigues da Costa, Larissa Valdemarin Bim, Luiza Dornelles Penteado e Silva, Gabriel Avelar Colloza-Gama, Andre Uchimura Bastos, Rosana Delcelo, Gisele Oler, Janete Maria Cerutti
Summary: This study compared three different strategies to detect TERT promoter mutations in PTC, finding good concordance among the methodologies when a high percentage of mutated alleles was present. Sanger sequencing showed a limitation in detection of mutated alleles, indicating that the prevalence of TERT promoter mutations in PTC may be higher than previously reported.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose Miguel Dora, Rosa Paula Mello Biscolla, Gustavo Caldas, Janete Cerutti, Hans Graf, Ana O. Hoff, Glaucia M. F. S. Mazeto, Patricia Kunzle Ribeiro Magalhaes, Cleo Otaviano Mesa Junior, Rafael Selbach Scheffel, Patricia de Fatima dos Santos Teixeira, Fernanda Vaisman, Danilo Villagelin, Ana Luiza Maia
Summary: The study aims to develop evidence-based recommendations for thyroid conditions through the Choosing Wisely (CW) initiative. After extensive discussions and voting, 5 final thyroid CW recommendations were determined. These recommendations are designed to avoid unnecessary medical tests, treatments, or procedures, promoting shared decision-making between physicians and patients.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Biology
Luiza Sisdelli, Maria Isabel V. Cordioli, Fernanda Vaisman, Osmar Monte, Carlos A. Longui, Adriano N. Cury, Monique O. Freitas, Aline Rangel-Pozzo, Sabine Mai, Janete M. Cerutti
Summary: Genetic alterations such as RET/PTC and AGK-BRAF fusions are common in pediatric papillary thyroid carcinoma (PTC), but their role as prognostic markers is still being investigated. AGK-BRAF fusion may affect nuclear architecture, leading to a more aggressive disease outcome.
Article
Oncology
Thaise Nayane Ribeiro Carneiro, Larissa Valdemarin Bim, Vanessa Candiotti Buzatto, Vanessa Galdeno, Paula Fontes Asprino, Eunjung Alice Lee, Pedro Alexandre Favoretto Galante, Janete Maria Cerutti
Summary: RAS mutations have been found in various types of thyroid tumors, indicating a cooperation with other driver mutations in tumorigenesis. The study identified dysregulation of the Hippo pathway in RAS-positive thyroid carcinomas, suggesting a potential crosstalk with other signaling pathways.
Editorial Material
Public, Environmental & Occupational Health
Maaike van Gerwen, Janete M. Cerutti, Joseph Rapp, Eric Genden, Gregory J. Riggins, Emanuela Taioli
Summary: While there is debate about potential explanations for the increased risk of thyroid cancer in World Trade Center dust exposed cohorts, further investigation into the causal link is necessary. Future studies will help better understand the potential consequences on the thyroid gland.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Beatriz G. Muratori, Claudia R. Zamberlam, Thais B. Mendes, Bruno H. N. Nozima, Janete M. Cerutti, Suzete M. Cerutti
Summary: The study demonstrates that EGb treatment before acquisition of object recognition memory promotes the persistence of long-term memory by upregulating BDNF expression in a dose- and session-dependent manner, leading to improved performance of animals in memory tests.
Article
Multidisciplinary Sciences
Gabriel A. Colozza-Gama, Fabiano Callegari, Nikola Besic, Ana C. de J. Paviza, Janete M. Cerutti
Summary: Somatic mutations in cancer driver genes play a key role in diagnosis, prognosis, and treatment decisions. This study compared pyrosequencing and ddPCR for the detection of BRAF V600E mutation in FFPE-derived DNA, finding that while ddPCR has higher sensitivity than Sanger sequencing, it is less consistent than pyrosequencing due to droplet classification bias. Algorithms for automated droplet classification, particularly Machine learning k-NN, showed promise for improving ddPCR analysis and have potential applications in clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Larissa Valdemarin Bim, Thaise Nayane Ribeiro Carneiro, Vanessa Candiotti Buzatto, Gabriel Avelar Colozza-Gama, Fernanda C. Koyama, Debora Mota Dias Thomaz, Ana Carolina de Jesus Paniza, Eunjung Alice Lee, Pedro Alexandre Favoretto Galante, Janete Maria Cerutti
Summary: Thyroid cancer is the most common endocrine malignancy, but cytological diagnosis of certain malignant thyroid tumors and their benign counterparts poses a challenge for preoperative diagnosis. This study identified novel gene variants through RNA-sequencing of driver-negative samples and described distinct expression signatures in these samples.
Article
Neurosciences
Meira M. F. Machado, Janilda P. Pereira, Bruna K. S. Hirata, Viviane S. Julio, Renata M. Banin, Heider M. Andrade, Eliane B. Ribeiro, Suzete M. Cerutti, Monica M. Telles
Summary: The study found that a single acute dose of GbE can rapidly stimulate key hypothalamic anorexigenic pathways, but failed to modify orexigenic effectors. No changes in food intake, body weight, and hypothalamic protein levels were observed.
Article
Biochemistry & Molecular Biology
Myrcea A. de S. Tilger, Renan B. Gaiardo, Suzete M. Cerutti
Summary: Despite progress in understanding the role of the hippocampus in memory and anxiety, further research is needed to identify plastic changes within the intra- and extrahippocampal circuits. This study investigated the effects of reversible inactivation of the dorsal CA1 subfield (dCA1) on memory formation and anxiety-like behaviors. The results showed that the dCA1 is required for discriminative avoidance consolidation and that CREB-1 expression plays a role in long-term memory and retrieval of aversive memory and anxiety.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Behavioral Sciences
Renan Barretta Gaiardo, Amanda Paula Pedroso, Eliane Beraldi Ribeiro, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti
Summary: Our study investigated the role of the dorsal hippocampal formation (dHF) in recent and remote memory of conditioned lick suppression using proteomic analysis. The results showed changes in the expression of various proteins on postconditioning Day 2 and Day 40, suggesting their involvement in conditioning memory. Integrated pathway analysis revealed alterations in myelin sheath, neuron generation and differentiation, regulation of neurogenesis and synaptic vesicle transport, axonal development, and the growth cone. These findings support the importance of the dHF in conditioned lick suppression memory and provide insights into the molecular changes associated with recent and remote memory in the dHF, which could be targeted for cognitive enhancers.
BEHAVIORAL NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Maria Sharmila Alina de Sousa, Isabela Nogueira Nunes, Yasmin Paz Christiano, Luiza Sisdelli, Janete Maria Cerutti
Summary: Differentiated thyroid cancer (DTC) is a rare disease in the pediatric population, but the incidence is increasing. Pediatric DTC has a better prognosis compared to adults. Individualized management based on clinical presentation and genetic findings is recommended by European and American guidelines. A systematic review was conducted to identify the epidemiology of genetic alterations in pediatric populations affected by thyroid tumors and/or DTC, and three key recommendations were outlined to improve precision health approaches globally.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Neurosciences
Carla Vitor de Andrade, Andressa Gabriela Soliani, Suzete Maria Cerutti
Summary: Long-term memory formation depends on neurochemical changes that ensure the persistence of short-term memory through consolidation. A standardized extract of Ginkgo biloba (EGb) combined with novelty was found to enhance the consolidation and persistence of object location memory (OLM) in both young adult and aged rats. The treatment resulted in short-term memory lasting for 1 hour and persisting for 24 hours, with a robust long-term OLM observed in aged rats.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
