期刊
BRAIN RESEARCH
卷 1277, 期 -, 页码 90-103出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.02.047
关键词
Otitis media; Immunology; Mice; Genetic predisposition to disease; Etiology
资金
- NIDCD NIH HHS [R01 DC007392-04, R21 DC007443, DC005846, DC007443, P30 DC005983, R01 DC008165, R21 DC005846, R01 DC007392, R01 DC009246, R21 DC007443-02, R01 DC008165-02, DC007392, R01 DC009246-01A2, R21 DC005846-04, DC008165] Funding Source: Medline
Otitis media (OM) remains the most common childhood disease and its annual costs exceed $5 billion. Its potential for permanent hearing impairment also emphasizes the need to better understand and manage this disease. The pathogenesis of OM is multifactorial and includes infectious pathogens, anatomy, immunologic status, genetic predisposition, and environment. Recent progress in mouse model development is helping to elucidate the respective roles of these factors and to significantly contribute toward efforts of OM prevention and control. Genetic predisposition is recognized as an important factor in OM and increasing numbers of mouse models are helping to uncover the potential genetic bases for human OM. Furthermore, the completion of the mouse genome sequence has offered a powerful set of tools for investigating gene function and is generating a rich resource of mouse mutants for studying the genetic factors underlying OM. Published by Elsevier B.V.
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