Article
Psychiatry
Yvonne Schroeder, Daniela Michelle Hohmann, Tina Meller, Ulrika Evermann, Julia-Katharina Pfarr, Andreas Jansen, Inge Kamp-Becker, Sarah Grezellschak, Igor Nenadic
Summary: Individuals with higher levels of autism-spectrum-like features show decreased white matter integrity and increased cortical volume, which resemble regional brain structure alterations found in individuals with ASD.
EUROPEAN PSYCHIATRY
(2021)
Article
Psychiatry
Guorui Zhao, Way K. W. Lau, Chanyu Wang, Haifeng Yan, Chichen Zhang, Kangguang Lin, Shijun Qiu, Ruiwang Huang, Ruibin Zhang
Summary: Schizophrenia and bipolar disorder share similarities in terms of brain white matter structure abnormalities, but also have disorder-specific abnormalities. Schizophrenia patients show more extensive white matter alterations compared to bipolar disorder cases, which may be the pathophysiological basis for the clinical continuity of both disorders.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Psychiatry
Zeng Zhang, Liangliang Ping, Ailing Zhai, Cong Zhou
Summary: The meta-analysis found microstructural abnormalities in distributed WM tracts in OCD patients, with heterogeneous results between the VBA and TBSS methods.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Zhixia Cui, Liangliang Meng, Qing Zhang, Jing Lou, Yuan Lin, Yueji Sun
Summary: This study used diffusion-tensor imaging (DTI) and voxel-based morphometry (VBM) to investigate the neurobiological basis of dependent personality disorder (DPD). The results showed differences in neuronal fiber integrity, brain tissue integrity, and gray matter volume between DPD patients and healthy controls. These findings provide new insights into the brain structure alterations in DPD and suggest a potential link between brain structure and the pathophysiology of DPD.
Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Clinical Neurology
Jian Yang, Xiaowei Jiang, Shengnan Wei, Xin Deng, Yue Zhu, Miao Chang, Zhiyang Yin, Haiyang Geng, Yanqing Tang, Xu Dai
Summary: Compared to DTI parameters, DKI parameters showed more sensitivity and stability in probing the local microstructure, especially in exploring cerebral alterations in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Bo Wang, Haotian Wang, Zhidong Cen, Jiachen Yuan, Dehao Yang, Xinhui Chen, Fei Xie, Lebo Wang, Sheng Wu, Zhiyuan Ouyang, Yu-Feng Zang, Wei Luo
Summary: This study investigated white matter structural changes in patients with familial cortical myoclonic tremor with epilepsy (FCMTE) and their relationship with clinical and electrophysiological features. The results showed widespread reductions in white matter values in FCMTE patients, including in the commissural, projection, and association fibers. Increased white matter volume was found in the right cerebellum and sagittal stratum, while decreased values were detected in the sagittal stratum. Furthermore, there was a positive correlation between the volume of the right cerebellum and somatosensory-evoked potential amplitude.
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Giovanni Videtta, Letizia Squarcina, Maria Gloria Rossetti, Paolo Brambilla, Giuseppe Delvecchio, Marcella Bellani
Summary: Recent studies using diffusion tensor imaging (DTI) tractography have revealed significant changes in the white matter fascicles of the corpus callosum (CC) in patients with bipolar disorder (BD). These changes include decreased fractional anisotropy, reduced fiber density, altered fiber tract length, and increased radial and mean diffusivity. These structural modifications in the CC may contribute to the cognitive impairments observed in BD, particularly in executive processing, motor control, and visual memory. However, the limitations of small sample sizes and heterogeneity in research methods and clinical characteristics should be considered.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Mahvash Azarvand Damirichi, Mohammad Karimi Moridani, Seyyed Erfan Mohammadi
Summary: Approximately 2%-3% of the global population has obsessive-compulsive disorder (OCD). The brain volumes in OCD can vary depending on specific OCD symptom dimensions. This study aimed to explore white matter structure changes in specific OCD symptom dimensions. The results showed decreased fractional anisotropy (FA) in the right anterior thalamic radiation, right corticospinal tract, and forceps minor for all OCD patients compared to healthy controls. Furthermore, the contamination subgroup exhibited decreased FA in the forceps minor region, which suggests its central role in the pathophysiology of contamination behaviors in OCD.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Maurizio Bergamino, Elizabeth G. Keeling, Leslie C. Baxter, Nicholas J. Sisco, Ryan R. Walsh, Ashley M. Stokes
Summary: The study investigates the differences in grey matter (GM) volume and white matter (WM) microstructural disorganization between males and females with Alzheimer's disease (AD) using voxel-based morphometry (VBM) and free-water-corrected diffusion tensor imaging (FW-DTI). The results show significant group and sex differences, and post-hoc comparisons reveal that AD is associated with reduced GM volume, reduced FW-FA, and higher FW-RD/FW-index, consistent with neurodegeneration. Females in both groups exhibit higher GM volume than males, while FW-DTI metrics show sex differences only in the AD group.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neuroimaging
Youling Bai, Li Zhang, Chengwei Liu, Xiaobing Cui, Dan Li, Huazhan Yin
Summary: The study investigated the association between white matter volume and sleep quality, finding a negative correlation between global PSQI score and white matter volume in specific brain regions. This suggests that exploring brain white structure in relation to sleep may help to explain the mechanisms underlying the association between sleep quality and brain function, behavior, and cognition, as well as the networks responsible for variations in sleep.
BRAIN IMAGING AND BEHAVIOR
(2022)
Review
Neuroimaging
Maryam Haghshomar, Seyed Peyman Mirghaderi, Parnian Shobeiri, Anthony James, Mojtaba Zarei
Summary: Microstructural alterations in white matter are evident in paediatric OCD, with changes reported in various brain regions. These alterations are associated with symptoms and specific genetic polymorphisms are linked to white matter changes in the cerebellum.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Chemistry, Analytical
Yi Qiao, Wenli Liu, Na Lu, Zheyun Xu, Jing Tu, Zuhong Lu
Summary: The concept of cyclical concentration adjusting can accelerate MDA and improve reaction efficiency, with the rapid droplet MDA method saving over half of the total reaction time and exhibiting higher accuracy compared to the conventional method.
ANALYTICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Haoxiang Tang, Mingtao Li, Xiangyu Yan, Zuhong Lu, Zhongwei Jia
Summary: The article proposed a drug epidemic model and predicted the drug epidemic in China from 2020 to 2030. The results showed that strengthening the investigation and rehabilitation admission of hidden drug users is the most effective intervention strategy to eliminate drug epidemics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Chemistry, Multidisciplinary
Xin Tan, Liqin Ge, Tianzhu Zhang, Zuhong Lu
Summary: This review explores the significance of DNA preservation and the diverse requirements in different fields, introduces the emerging research of DNA data storage and its connection to DNA integrity, analyzes the factors influencing long-term DNA storage and the advantages and disadvantages of various preservation methods. The aim is to promote further research through these preservation suggestions.
RUSSIAN CHEMICAL REVIEWS
(2021)
Article
Engineering, Environmental
Congmin Zhu, Junyi Zhang, Xin Wang, Yuqing Yang, Ning Chen, Zuhong Lu, Qinyu Ge, Rui Jiang, Xuegong Zhang, Yunfeng Yang, Ting Chen
Summary: Freshwater lakes are threatened by harmful cyanobacterial blooms, in which Cyanobacterial Aggregates (CA) and associated bacteria play significant roles with variation in taxonomic and functional structure across different blooming stages. Environmental factors and internal metabolism influence the dynamics of microbial structure in CA, with total nitrogen and total phosphorus identified as key drivers of taxonomic and functional variations. Genomic analysis revealed diverse energy pathways in cyanobacteria strains and highlighted co-nitrogen and co-phosphorus pathways with bacteria, suggesting a potential for controlling blooms through disruption of critical microbes.
Article
Biotechnology & Applied Microbiology
Ai-Ping Pang, Haiyan Wang, Funing Zhang, Xin Hu, Fu-Gen Wu, Zhihua Zhou, Wei Wang, Zuhong Lu, Fengming Lin
Summary: The study demonstrates that only high-concentration rapamycin induced a transient impact on T. reesei RUT-C30 at its early cultivation stage, indicating that T. reesei RUT-C30 is highly resistant to rapamycin possibly due to insensitivity of trTOR and its related signaling pathways to rapamycin. This temporary influence of rapamycin was mediated by gene trFKBP12, adding to our understanding of the roles rapamycin and the TOR signaling pathways play in T. reesei.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Environmental Sciences
Na Li, Honglin Zhang, Zhimao Bai, Haitao Jiang, Fan Yang, Xiao Sun, Zuhong Lu, Dongrui Zhou
Summary: This study found that exposure to low cleanliness helps prevent allergic diseases and increase the diversity of intestinal microbiota. Dust exposure after antibiotic treatment can prevent reduction in gut microbiota diversity and accelerate its recovery.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2021)
Article
Biodiversity Conservation
Yixin Li, Xin Liao, Chunpeng He, Zuhong Lu
Summary: This study used high resolution micro-computed tomography to investigate morphological changes in Acropora corallites, revealing patterns of calcium carbonate deposition during new branch formation and truncated tip repair. The results showed that the volume ratio of calcareous deposits in the axial canal of truncated branches significantly increased within the first three weeks, then returned to initial levels in the following week. These findings demonstrate the temporary storage and remobilization of calcium carbonate for rapid growth in Acropora.
Article
Chemistry, Physical
Liqin Ge, Chenxi Luo, Dan You, Ning Yang, Qianli Zhang, Renqiang Yuan, Jieran Wang, Zuhong Lu
Summary: A new strategy for preparing stable coatings on alloy substrates using layer-by-layer self-assembly technique with hydrogen peroxide, chitosan, and dialdehyde starch was reported. The resulting coating showed good cellular compatibility and promoted cell adhesion, demonstrating promising application for high adhesive properties on iron-contained alloy substrates.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Multidisciplinary Sciences
Jing Tu, Mengqin Duan, Wenli Liu, Na Lu, Yue Zhou, Xiao Sun, Zuhong Lu
Summary: The study introduces a method to detect G-quadruplex structures in DNA by utilizing fluctuations in sequencing quality, identifying a high percentage of canonical G4 structures in the human genome. The method is transferable across different species with detection rates ranging from 32% to 58%.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jing Tu, Zengyan Yang, Na Lu, Zuhong Lu
Summary: This study presents an efficient method for analyzing copy number variation (CNV) in single cells using overlapping pooling and branch and bound algorithm. By overlapping pooling, the number of required libraries is reduced, resulting in lower costs. Computer simulations showed high accuracy in classifying cells based on CNV pattern, with significantly fewer sequencing libraries required. This method is expected to improve the efficiency of single-cell genome sequencing.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Multidisciplinary Sciences
Cheng Zhang, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang, Hao Yan
Summary: A general and programmable strategy for allosteric DNA regulations was developed, allowing precise control through varying the dimensions, positions, and number of conformational signals. This strategy enables the creation of fan-out/fan-in DNA gates, multiple-layer DNA cascading networks, and long-range allosteric signal transmission. It has significant implications for nano-engineering, chemical, and biomedical applications.
Article
Pharmacology & Pharmacy
Xiaohui Zhai, Yulin Kang, Xiuxia Yuan, Yaping Wang, Sifen Lu, Zuhong Lu
Summary: The study investigated the potential impact of oxidative stress on cognitive deficits in schizophrenia. Findings revealed that oxidative parameters and inflammatory markers were higher in FES patients compared to controls, while antioxidant levels were lower. Additionally, significant differences in hemogram and T cell subtype were observed between FES and control groups.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Na Lu, Yi Qiao, Zuhong Lu, Jing Tu
Summary: Multiple displacement amplification (MDA) using isothermal random priming and high fidelity phi29 DNA polymerase has revolutionized whole genome amplification by enabling amplification of DNA from single cells. However, MDA faces challenges, such as the formation of chimeric sequences, which disrupt downstream analysis. This review provides a comprehensive overview of current research on MDA chimeras, including the mechanisms of formation, detection methods, characteristics, and methods for processing chimeric sequences.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Mathematical & Computational Biology
Yunqing Liu, Yunchi Zhu, Chunpeng He, Zuhong Lu
Summary: Y BENviewer is a brand-new online gene interaction network visualization server based on graph embedding models. It provides human-friendly 2D visualization based on over 2000 biological pathways, showing genes involved and interaction tightness. This unique visualization server is expected to help researchers gain deeper insights into biological networks, with simplified operation flow and URL optimization for batch data acquisition.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Chemistry, Multidisciplinary
Jing Tu, Yi Qiao, Yuhan Luo, Naiyun Long, Zuhong Lu
Summary: DNA quantification is crucial in life sciences research, and real-time MDA technology can provide template amount information during whole-genome amplification with a very low detection limit, offering a promising tool to quantify entire DNA without sacrificing sample completeness or introducing redundant steps.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
