Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M. A. Garcia-Perez, Pedro Bekinschtein, Noelia Weisstaub, Pablo Fuentealba
Summary: Memory systems store and discriminate representations of similar experiences through pattern separation to guide future decisions efficiently. Somatostatin cells in the dentate gyrus play a crucial role in the acquisition of contextual and spatial overlapping memories.
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Neurosciences
Seong-Beom Park, Heung-Yeol Lim, Eun-Young Lee, Seung-Woo Yoo, Hyun-Suk Jung, Eunsoo Lee, Woong Sun, Inah Lee
Summary: The fasciola cinereum (FC) is a subregion of the hippocampus that shows clear anatomical borders with the CA1 and receives inputs from the lateral entorhinal cortex and perirhinal cortex while projecting exclusively to the crest of the DG. Neurotoxic lesions in the FC impair visual contextual memory acquisition and place recognition in rats, suggesting a critical role in contextual pattern separation in the hippocampus.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Anatomy & Morphology
Hajnalka Abraham, Hisae Kojima, Katalin Gotzer, Abigel Molnar, Tamas Tornoczky, Laszlo Seress
Summary: In this study, the maturation process of PV-immunoreactive interneurons in the human hippocampal formation was investigated. The results showed that no PV-immunoreactive neurons could be detected in the human hippocampus before birth. The number of PV-immunoreactive cells and their dendritic and axonal arborization gradually increased with age, indicating the long-lasting functional maturation of the human cortex.
FRONTIERS IN NEUROANATOMY
(2023)
Review
Biochemistry & Molecular Biology
Timothy J. Schoenfeld, Chance Swanson
Summary: Physical exercise has wide-ranging benefits to cognitive functioning and mental state, with effects resembling enhancements to hippocampal functioning. Beta-endorphins released during exercise are a potential candidate for moderating increases in neurogenesis and related behavioral benefits. Further exploration of beta-endorphin as a key mediator of hippocampal neurogenesis could provide insights into how exercise promotes adult neurogenesis and overall brain health.
Article
Geriatrics & Gerontology
Kubra Gulmez Karaca, David V. C. Brito, Janina Kupke, Benjamin Zeuch, Ana M. M. Oliveira
Summary: The study found that in aged mice, impaired individuals showed disrupted reactivation of memory-encoding neuronal ensembles during long-term memory recall, while unimpaired individuals were unaffected. Memory performance in the aged population correlated with the degree of engram reactivation during long-term memory recall. These findings suggest impairments in neuronal ensemble stabilization and/or reactivation as underlying mechanisms in age-dependent cognitive decline.
NEUROBIOLOGY OF AGING
(2021)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yasuyuki Fujii, Jun Sakata, Fumitaka Sato, Kurumi Onishi, Yuki Yamato, Kazuki Sakata, Shu Taira, Hiroki Sato, Naomi Osakabe
Summary: Recent studies suggest that consumption of polyphenol-rich plant foods may reduce the risk of cognitive decline. A short-term administration of A2 may enhance spatial memory by promoting neurogenesis in the dentate gyrus of adult mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Anne Albrecht, Elhanan Ben-Yishay, Gal Richter-Levin
Summary: Behavioral profiling is introduced as a translational approach to distinguish trauma-affected animals from resilient ones, utilizing multiple behavioral tests. Enhanced local inhibition in specific circuits of the dorsal dentate gyrus may be associated with observed symptoms.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Cassidy T. Burke, Iuliia Vitko, Justyna Straub, Elsa O. Nylund, Agnieszka Gawda, Kathryn Blair, Kyle A. Sullivan, Lara Ergun, Matteo Ottolini, Manoj K. Patel, Edward Perez-Reyes
Summary: Epileptogenesis involves changes in neuronal firing and gene transcription networks, which can be targeted by the activity-dependent transcription factor EpiPro. The study successfully validated the effectiveness of EpiPro in multiple rodent models of epilepsy, highlighting its potential as a gene therapy driver for epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kelsey D. McDermott, M. Agustina Frechou, Jake T. Jordan, Sunaina S. Martin, J. Tiago Goncalves
Summary: Aging is associated with cognitive deficits, especially in spatial memory. The hippocampal dentate gyrus (DG) is important for processing spatial information but is vulnerable to aging. Using two-photon calcium imaging, researchers found that neuronal activity and spatial representations in the DG were impaired in aged mice. However, with repeated exposure to the same environment, spatial tuning and information levels in aged mice improved, while activity remained elevated.
Article
Neurosciences
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The microstructural differences in the hippocampal subfields are associated with age-related memory loss, and the submillimeter resolution diffusion weighted MRI sequence can accurately measure these differences, providing new insights into the mechanisms of age-related memory loss.
Article
Neurosciences
Andres Benitez-Rosendo, Patricia Lagos, Karina Cal, Laura Colman, Carlos Escande, Aldo Calliari
Summary: DBC1 plays a crucial role in energy metabolism, cell cycle progression, and cancer cell regulation. This study reveals the impact of DBC1 on cell cycle and neurogenesis, suggesting its involvement in neuroblast generation and neural differentiation, as well as its association with cognitive functions such as learning and memory formation.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Ehsan Mohammadi, Bahador Makkiabadi, Mohammad Bagher Shamsollahi, Parham Reisi, Saeed Kermani
Summary: This article investigates signal analysis methods for sleep detection and proposes a new feature, Wbiph, which combines wavelet and bispectrum. A convolutional neural network is applied for classification, achieving high accuracy.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Neurosciences
Zahra Rezaei, Hojjatallah Alaei, Parham Reisi
Summary: This study examined the role of the basolateral amygdala (BLA) in morphine addiction. The results showed that electrical stimulation of the BLA induced conditioned place preference (CPP), while inactivation of the BLA inhibited morphine-induced CPP.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Neda Hasanpour Razmanjani, Parham Reisi
Summary: Tramadol is commonly used for pain control, but its mechanisms of action are not well understood. This study found that orexins and endocannabinoids may play a crucial role in the effects of tramadol, and there may be an interaction between the two systems through OX2 and CB1 receptors.
Article
Neurosciences
Elham Kalantarzadeh, Maryam Radahmadi, Parham Reisi
Summary: This study investigated the effects of different dark chocolate dietary patterns on brain functions in rats under chronic isolation stress. The results showed that the compulsory and restricted dark chocolate diets reversed the harmful effects of stress on brain functions and reduced food intake and body weight.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Elahe Amohashemi, Parham Reisi, Hojjatallah Alaei
Summary: The role of GABA(A) receptors in LHb on morphine-induced conditioned place preference (CPP) was investigated in this study. The results revealed that GABA(A) receptors in LHb play a critical role in morphine reward, and microinjections of bicuculline/muscimol may alter the morphine response through the GABAergic system.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Neurosciences
Somayeh Shahidani, Zahra Jokar, Hojjatallah Alaei, Parham Reisi
Summary: This study aimed to investigate the effects of chronic stress and treadmill running on anxiety-like behavior, neuronal activity, oxidative stress markers, and total thiol levels in the basolateral amygdala of morphine-treated rats. The results showed that chronic stress and exercise reduced anxiety-like behaviors in morphine-treated rats, and treadmill running prevented the increase in oxidative stress caused by morphine. Moreover, morphine treatment decreased neuronal activity, but acute morphine application decreased GABAergic neuronal activities in the morphine-exercise-stress group.
Article
Neurosciences
Elahe Amohashemi, Parham Reisi, Hojjatallah Alaei
Summary: This study investigated the effects of AMPARs agonist and antagonist in the LHb on the acquisition and expression phases of CPP in male rats. The results showed that NBQX, the antagonist, in combination with morphine, increased CPP scores during the acquisition phase. AMPA, the agonist, significantly reduced conditioning scores in the acquisition phase. Pre-treatment with NBQX reversed the inhibitory effect of AMPA on morphine-induced CPP in the acquisition phase. The antagonist increased the effect of a high dose of the agonist on CPP. NBQX also increased CPP scores during the expression phase.
Article
Chemistry, Medicinal
Elahe Amohashemi, Hojjatallah Alaei, Parham Reisi
Summary: This study found that blockade of GABAB receptors can significantly attenuate the inhibitory effects of morphine on neuronal activity in the lateral habenula (LHb).
RESEARCH IN PHARMACEUTICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Parastou Naghibi Rad, Farzaneh Behzadi, Seyed Abbas Yazdanfar, Hessam Ghamari, Erfan Zabeh, Reza Lashgari
Summary: This article is a systematic review that aims to strengthen the relationship between architecture and neuroscience by classifying data measurement techniques in the field of neuroarchitecture with a focus on the most practical and common methodological approaches. It provides a summary of techniques and methodological approaches applied in the field to help scholars carry out more practical research in designing built environments more efficiently.
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2023)
Article
Neurosciences
Elahe Amohashemi, Parham Reisi, Hojjatallah Alaei
Summary: This study investigated the involvement of N-methyl-d-aspartate (NMDA) receptors in the lateral habenula (LHb) in the expression and acquisition phases of morphine-induced conditioned place preference (CPP) in male rats. The results showed that different doses of NMDA plus morphine reduced CPP scores during the acquisition phase, while MK-801 significantly increased conditioning scores during this phase. In the expression phase, agonists and antagonists of NMDA receptors in the LHb had no significant effect on CPP scores and locomotion, but motor activity in the acquisition phase was affected by the drugs.
Review
Chemistry, Medicinal
Arash Salehi, Mustafa Ghanadian, Behzad Zolfaghari, Amir Reza Jassbi, Maryam Fattahian, Parham Reisi, Dezso Csupor, Ikhlas A. Khan, Zulfiqar Ali
Summary: This study provides a narrative review of diterpenoid alkaloids (DAs), a family of extremely important natural products found predominantly in some species of Aconitum and Delphinium (Ranunculaceae). DAs have long been a focus of research attention due to their numerous intricate structures and diverse biological activities, especially in the central nervous system (CNS). Although the role of tertiary nitrogen in ring A and the polycyclic complex structure are of great importance in drug-receptor affinity, recent advances in developing new drugs from DAs were insignificant due to their neurotoxicity.
Article
Medicine, Research & Experimental
Mahshid Zamani, Maryam Radahmadi, Parham Reisi
Summary: This study compared the therapeutic effects of different doses of escitalopram, exercise, and exercise-accompanied escitalopram on synaptic potency and long-term plasticity in rats under chronic stress. Results showed that exercise, escitalopram, and combined treatment could effectively reverse the impairments caused by chronic stress. The combination of exercise and escitalopram had additive effects.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Neda Hasanpour Razmanjani, Parham Reisi
Summary: The acute effects of tramadol on neuronal activity in the medial prefrontal cortex (mPFC) were investigated using electrophysiological methods. The results showed that tramadol did not have a rapid effect on neural activity in the mPFC. These findings suggest that abuse of tramadol may be due to delayed responses or chronic use.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Vajihe Imanpour, Parham Reisi
Summary: This study aimed to evaluate the modulatory effects of orexin-2 (OX2R) and endocannabinoid-1 (CB1R) receptors on neuronal activity in CA1, in response to tramadol. The findings suggest that neural activity in CA1 is rapidly affected by acute use of tramadol, and some of these effects may be induced through the endocannabinoid and orexin systems. Therefore, the function of endocannabinoid and orexin systems in CA1 may play a role in tramadol addiction.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zahra Rezaei, Hojjatallah Alaei, Parham Reisi
Summary: The present study investigated the effects of dopamine D1 receptor blockade in the basolateral amygdala (BLA) on morphine-induced conditioned place preference (CPP). The results showed that D1 receptor antagonist significantly suppressed CPP formation and induced aversion even at high doses of morphine. Additionally, D1 receptor blockade effectively prevented CPP expression and reduced locomotor activity.
ADVANCED BIOMEDICAL RESEARCH
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.