Article
Neurosciences
Max Rudolph, Christian W. Schmeer, Madlen Guenther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W. Witte, Christoph Redecker, Silke Keiner
Summary: After stroke, there is a transient increase in apoptotic cells in the dentate gyrus of the hippocampus, with impaired removal by microglia. However, phagocytosis of newly generated precursor cells is not affected. This disturbed phagocytosis in the hippocampus after a prefrontal stroke lesion may contribute to inflammatory processes and cognitive impairment, warranting further investigation.
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Ting Feng, Christian Alicea, Vincent Pham, Amanda Kirk, Simon Pieraut
Summary: The study found that using an enriched environment during the preweaning period affects the circuit plasticity of inhibitory cell types in the hippocampus, with CCK+ basket cells showing a significant increase in somatic inhibition and PV+ cells showing no changes. The change in somatic inhibition from CCK+ neurons increases CB1R-mediated inhibition in the circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Milad Afrasiabi, Akshay Gupta, Huaying Xu, Bogumila Swietek, Vijayalakshmi Santhakumar
Summary: This study reveals that fast-spiking parvalbumin interneurons (PV-INs) contribute minimally to basal synaptic inhibition but selectively mediate sustained feedback inhibition in a subtype of dentate projection neurons called semilunar granule cells (SGCs). The blunting of activity-driven sustained inhibitory gating in SGCs may play a crucial role in their preferential and persistent recruitment during behavioral tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: In this study, it was found that repeated BKM120 treatment induced anxiety- and depression-like behaviors in mice and these behaviors were positively correlated with the extent of DCX-positive cell migration. The treatment also affected the activity of Akt, JNK, DCX, and RhoA.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ana R. A. A. Quadros, Rocio Diez Arazola, Andrea Romaguera Alvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen
Summary: FBXO41 plays a critical role in synaptic transmission and brain development, and its loss can lead to deficits in these processes.
Article
Neurosciences
Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M. A. Garcia-Perez, Pedro Bekinschtein, Noelia Weisstaub, Pablo Fuentealba
Summary: Memory systems store and discriminate representations of similar experiences through pattern separation to guide future decisions efficiently. Somatostatin cells in the dentate gyrus play a crucial role in the acquisition of contextual and spatial overlapping memories.
Review
Neurosciences
Chuanqi Liu, Jiayin Liu, Hong Gong, Tianyao Liu, Xin Li, Xiaotang Fan
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical social communication and repetitive sensory-motor behaviors. Emerging evidence suggests that deficits in hippocampal neurogenesis may play a significant role in the abnormal behaviors observed in ASD. This review summarizes pre-clinical and clinical studies supporting the importance of hippocampal neurogenesis in the pathogenesis of ASD, discusses the potential of enhancing hippocampal neurogenesis as a new therapeutic strategy for ASD, and highlights the prospects of pro-neurogenic therapies for ASD.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Cell Biology
Joshua D. Rieskamp, Patricia Sarchet, Bryon M. Smith, Elizabeth D. Kirby
Summary: The study estimated the cell density of neural stem/progenitor cells in the dentate gyrus of adult mice using immunohistochemical methods and found that they had similar density as other cell types with secretory functions. These findings contribute to refining hypotheses about the roles of these cell types in regulating hippocampal function and their potential therapeutic uses.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Correction
Biochemistry & Molecular Biology
Jasper O. Nuninga, Rene C. W. Mandl, Iris E. C. Sommer
Summary: The amended version of the paper has been published and is accessible via a link at the top of the paper.
MOLECULAR PSYCHIATRY
(2021)
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Paul J. Lamothe-Molina, Andreas Franzelin, Lennart Beck, Dong Li, Lea Auksutat, Tim Fieblinger, Laura Laprell, Joachim Alhbeck, Christine E. Gee, Matthias Kneussel, Andreas K. Engel, Claus C. Hilgetag, Fabio Morellini, Thomas G. Oertner
Summary: Research shows that cFos expression patterns in the mouse dentate gyrus change dramatically from day to day, suggesting that this clock-like selection mechanism may aid in encoding episodic memories.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Yoshihide Sehara, Yuka Hayashi, Kenji Ohba, Ryosuke Uchibori, Masashi Urabe, Ayumu Inutsuka, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami
Summary: This study compared the transduction efficiency of AAV2, 5, and rh10 in the hippocampal DG, finding that AAV5 exhibited a higher efficiency in neural stem cells and precursor cells, while AAVrh10 showed a greater efficiency in mature neurons.
HUMAN GENE THERAPY
(2022)
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rohit Seth, Rikki S. Corniola, Shannon D. Gower-Winter, Thomas J. Morgan, Brian Bishop, Cathy W. Leyenson
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2015)
Article
Neurosciences
Elise C. Cope, Deborah R. Morris, Shannon D. Gower-Winter, Naomi C. Brownstein, Cathy W. Levenson
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Ali Darkazalli, Abdol Aziz Ould Ismail, Nastaren Abad, Samuel C. Grant, Cathy W. Levenson
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2016)
Article
Critical Care Medicine
Ali Darkazalli, Cynthia Vied, Crystal-Dawn Badger, Cathy W. Levenson
JOURNAL OF NEUROTRAUMA
(2017)
Article
Biochemical Research Methods
Kate J. F. Carnevale, Megan E. Muroski, Parth N. Vakil, Megan E. Foley, Geoffry Laufersky, Rachael Kenworthy, Diego A. R. Zorio, Thomas J. Morgan, Cathy W. Levenson, Geoffrey F. Strouse
BIOCONJUGATE CHEMISTRY
(2018)
Review
Endocrinology & Metabolism
Deborah R. Morris, Cathy W. Levenson
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2013)
Article
Chemistry, Inorganic & Nuclear
J. Tyler Simmons, John R. Allen, Deborah R. Morris, Ronald J. Clark, Cathy W. Levenson, Michael W. Davidson, Lei Zhu
INORGANIC CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Deborah R. Morris, Cathy W. Levenson
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Article
Chemistry, Multidisciplinary
Megan E. Muroski, Thomas J. Morgan, Cathy W. Levenson, Geoffrey F. Strouse
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Review
Nutrition & Dietetics
Elise C. Cope, Deborah R. Morris, Cathy W. Levenson
Article
Neurosciences
Shannon D. Gower-Winter, Rikki S. Corniola, Thomas J. Morgan, Cathy W. Levenson
NUTRITIONAL NEUROSCIENCE
(2013)
Article
Biochemical Research Methods
Prabu Sellappan, Jason Cote, Phillip A. Kreth, Victor D. Schepkin, Ali Darkazalli, Deborah R. Morris, Farrukh S. Alvi, Cathy W. Levenson
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Nutrition & Dietetics
Katrina A. Hall, Maria T. Spicer, Jasminka Z. Ilich, Cathy W. Levenson
TOPICS IN CLINICAL NUTRITION
(2019)
Review
Cell Biology
Ali Darkazalli, Cathy W. Levenson
HISTOLOGY AND HISTOPATHOLOGY
(2012)
Article
Clinical Neurology
Elise C. Cope, Deborah R. Morris, Angus G. Scrimgeour, Cathy W. Levenson
NEUROREHABILITATION AND NEURAL REPAIR
(2012)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.