Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Fei Ding, Yunpeng Bai, Qiong Cheng, Shu Yu, Mengchun Cheng, Yulin Wu, Xiaozhe Zhang, Xinmiao Liang, Xiaosong Gu
Summary: The study identified a peptide from Achyranthes bidentata Blume, named bidentatide, as an NMDA receptor subtype 2B (NR2B) antagonist with neuroprotective effects. It showed that bidentatide prevented NMDA-induced cell death and apoptosis through multiple mechanisms, suggesting its potential in developing neuroprotective agents with high selectivity and safety profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon
Summary: In this study, divergently modified peptide analogs derived from EPO showed potent neuroprotective effects against oxidative stress without inducing cell proliferation. One of the peptides, ML1-h3, exhibited unique binding potency to EPOR and inhibited neuronal death and brain injury under hypoxic stress.
Review
Neurosciences
Sam A. Booker, David J. A. Wyllie
Summary: NMDARs are essential for synaptic information transfer and plasticity in the majority of brain circuits. Inhibitory GABAergic interneurons exhibit diverse NMDAR expression and function, controlling cellular excitation in a synapse-specific manner. Further research is needed to fully understand the role of NMDARs in modulating GABAergic synaptic and circuit function.
Article
Biochemistry & Molecular Biology
Caroline Lahogue, Jean-Marie Billard, Thomas Freret, Valentine Bouet
Summary: The 5-HT6 receptors antagonist SB-271046 increases excitatory synaptic transmission and NMDAR activation at the CA3/CA1 hippocampal connections in mice. In male mice, this improvement is related to GABAAR antagonism, while in female mice it is not. Furthermore, the 5-HT6 receptors blockade has no significant effect on synaptic plasticity.
Article
Pharmacology & Pharmacy
Cristina Cosi, Jean-Claude Martel, Agnes L. Auclair, Ginetta Collo, Laura Cavalleri, Peter Heusler, Ludovic Leriche, Florence Gaudoux, Pierre Sokoloff, Paul C. Moser, Silvia Gatti-McArthur
Summary: F17464 is a new potential antipsychotic with a unique profile, showing high affinity for dopamine receptor subtype 3 and serotonin receptor subtype 1a, while having lower affinity for dopamine receptor subtype 2. It has demonstrated various neurochemistry and behavioral effects, suggesting therapeutic potential for schizophrenia and autism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Diego Pichardo-Rojas, Pavel Salvador Pichardo-Rojas, Jose Manuel Cornejo-Bravo, Aracely Serrano-Medina
Summary: The primary mechanism for neuron death after an ischemic stroke is excessive depolarization leading to NMDA-mediated calcium entry and subsequent cellular death. Memantine, a non-competitive NMDA receptor antagonist, has shown promising preclinical and clinical evidence as a neuroprotective drug for ischemic stroke. Clinical trials have found that high-dose memantine can improve neurological function and aphasia in poststroke patients, but limitations such as small sample sizes limit the impact of these findings. Further research is needed to conclusively determine if memantine improves outcomes in patients post-ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Samuel S. Newton, Monica Sathyanesan
Summary: Cognitive deficits are common in psychiatric disorders, such as major depression and schizophrenia, and play a significant role in functional impairment. Targeted treatments for cognitive deficits are limited, with a need for more efficacious treatments. Erythropoietin (Epo) shows promising procognitive effects in psychiatric disorders, supporting a neurotrophic drug development approach.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Xinxin Jiang, Peirong Liang, Ke Wang, Jun Jia, Xiaomin Wang
Summary: This study suggests that the 5-HT1A receptor agonist 8-OH-DPAT improves motor activity and modulates oscillations in the motor cortex of parkinsonian rats. Unlike L-dopa, 8-OH-DPAT ameliorates motor symptoms of PD through the glutamatergic pathway instead of the dopaminergic pathway.
Review
Pharmacology & Pharmacy
Yuanyuan Li, Xiaokun Cheng, Xinying Liu, Le Wang, Jing Ha, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun
Summary: This article reviews the role of NMDA receptors in cerebral ischemia, especially the role of metabotropic signaling. Studies have shown that ion flow interacts with metabotropic signaling to regulate ischemic injury. NMDA receptor antagonists may have important implications for the treatment of cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Hongliang Liu, Bo Chen, Bianqin Guo, Xiaoyuan Deng, Bin Wang, Xiaoyun Dou
Summary: The study found that postconditioning with sevoflurane could reverse the cognitive deficits induced by neuroinflammation and provide reliable neuroprotection. On the other hand, postconditioning with propofol, while also anti-neuroinflammatory like sevoflurane, caused neurotoxicity leading to impairments in spatial recognition memory.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
Article
Neurosciences
Li-Juan Zhu, Yan-Qiu Sun, Shuang Wang, Hu-Jiang Shi, Na Li
Summary: The involvement of 5-HT1A receptor and histone acetylation in depressive behaviors suggests a potential role in the pathophysiology and treatment of depression.
Article
Biochemistry & Molecular Biology
Kayla Farrell, Madeline Musaus, Aubrey Auerbach, Shaghayegh Navabpour, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Summary: Females have higher levels of proteasome-independent K63-polyubiquitination in the amygdala following fear conditioning, which is involved in regulating ATP synthesis and proteasome activity. Knockdown of K63-polyubiquitination impairs fear memory and reduces ATP levels and proteasome activity in female rats, but not in males. These findings provide the first evidence linking proteasome-independent and proteasome-dependent UPS functions in fear memory formation and may contribute to understanding the sex differences in PTSD development.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Luis Escribano, Ana-Maria Simon, Alberto Perez-Mediavilla, Pablo Salazaf-Colocho, Joaquin Del Rio, Diana Frechilla
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Oncology
Raul Catena, Diego Luis-Ravelo, Iker Anton, Carolina Zandueta, Pablo Salazar-Colocho, Leyre Larzabal, Alfonso Calvo, Fernando Lecanda
Article
Developmental Biology
Pablo Salazar-Colocho, Joaquin Del Rio, Diana Frechilla
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2008)
Article
Neurosciences
Ana-Maria Simon, Lucio Schiapparelli, Pablo Salazar-Colocho, Mar Cuadrado-Tejedor, Luis Escribano, Rakel Lopez de Maturana, Joaquin Del Rio, Alberto Perez-Mediavilla, Diana Frechilla
NEUROBIOLOGY OF DISEASE
(2009)
Article
Neurosciences
Pablo Salazar-Colocho, Jose L. Lanciego, Joaquin Del Rio, Diana Frechilla
NEUROSCIENCE RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
P. Salazar-Colocho, J. Del Rio, D. Frechilla
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2007)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.