期刊
BRAIN RESEARCH
卷 1221, 期 -, 页码 93-97出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.05.019
关键词
Parkinson's disease; serotonin; dorsal raphe nucleus; subthalamic nucleus
资金
- Medical Research Council Funding Source: Medline
- Parkinson's UK [G-0716] Funding Source: Medline
- Parkinson's UK [G-0716] Funding Source: researchfish
Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据