Article
Geriatrics & Gerontology
Amanda T. Calcetas, Kelsey R. Thomas, Emily C. Edmonds, Sophia L. Holmqvist, Lauren Edwards, Maria Bordyug, Lisa Delano-Wood, Adam M. Brickman, Mark W. Bondi, Katherine J. Bangen, Alzheimers Dis Neuroimaging Initiative
Summary: White matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, increase the risk of developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). This study found that individuals with objectively-defined subtle cognitive decline (Obj-SCD) had greater WMH in the temporal, occipital, and frontal regions compared to cognitively unimpaired individuals (CU). Those with MCI had higher WMH volume across all regions. The findings support the use of Obj-SCD criteria to capture biologically-based cognitive changes.
NEUROBIOLOGY OF AGING
(2022)
Article
Neuroimaging
Lingyan Liang, Zaili Chen, Yichen Wei, Fei Tang, Xiucheng Nong, Chong Li, Bihan Yu, Gaoxiong Duan, Jiahui Su, Wei Mai, Lihua Zhao, Zhiguo Zhang, Demao Deng
Summary: This study conducted fusion analysis of structural MRI and DTI using mCCA-jICA, revealing joint-discriminative independent components of GM and FA in SCD and MCI patients. The findings showed shared abnormalities in specific brain regions, confirming the simultaneous GM and WM changes underlying cognitive decline, suggesting that multimodal fusion analysis provides a more comprehensive understanding of the neuropathological mechanism in SCD and MCI.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Haichao Zhao, Jian Cheng, Tao Liu, Jiyang Jiang, Forrest Koch, Perminder S. Sachdev, Peter J. Basser, Wei Wen
Summary: White matter abnormalities, such as orientational changes in specific fiber tracts, were found to be prominent in Alzheimer's disease patients compared to cognitively normal individuals. In contrast, individuals with amnestic mild cognitive impairment showed subtle changes in specific fiber tracts that were associated with cognitive performance. These findings suggest that white matter fiber orientation information could offer valuable insights into the pathology of neurodegenerative diseases like Alzheimer's disease.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Kentaro Hirao, Fumio Yamashita, Akito Tsugawa, Rieko Haime, Raita Fukasawa, Tomohiko Sato, Hidekazu Kanetaka, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu, Soichiro Shimizu
Summary: The study investigated the association between WMH progression and cognitive decline in amnestic MCI patients. Results showed that an increase in DWMH volume was significantly correlated with a decline in frontal lobe function and semantic memory, suggesting that WMH progression might affect some AD pathophysiologies in amnestic MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Jingwen Jiang, Kanmin Yao, Xiaojun Huang, Yu Zhang, Fanxia Shen, Suiqing Weng
Summary: This study aimed to investigate the factors associated with changes in white matter hyperintensity (WMH) volume and cognitive decline in patients with minor stroke. Through a 2-year longitudinal observation of a group of patients, it was found that WMH volume changes were associated with the use of antihypertensive medications and the presence of lacunes at the initial visit. The progression of WMH volume was also found to be a significant risk factor for cognitive decline.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Neurosciences
Chang Li, Rongbing Jin, Kaijun Liu, Yang Li, Zhiwei Zuo, Haipeng Tong, Jingna Zhang, Junfeng Zhang, Yu Guo, Yuqi Lai, Jinju Sun, Jian Wang, Kunlin Xiong, Xiao Chen
Summary: The study revealed that T2DM-MCI patients exhibited significant reduction in white matter volume compared to T2DM-NC patients, mainly in regions such as the temporal lobe, frontal lobe, and limbic system. The white matter volume of the left posterior cingulate, precuneus, insula, and right rostral middle frontal gyrus showed high diagnostic value for detecting cognitive impairment in T2DM patients, serving as independent imaging biomarkers for early identification.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Hematology
F. Hannan, J. Hamilton, C. J. Patriquin, K. Pavenski, M. T. Jurkiewicz, L. Tristao, A. M. Owen, P. K. Kosalka, S. C. L. Deoni, J. Theberge, J. Mandzia, S. H. S. Huang, J. D. Thiessen
Summary: This study investigated brain changes in iTTP patients during remission using advanced MRI techniques and found persistent white matter damage in key regions such as the frontal lobe and cingulate cortex. These changes were associated with cognitive impairment and depression. The findings highlight the importance of re-evaluating treatment approaches for iTTP.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Neuroimaging
Cassandra Morrison, Mahsa Dadar, Sylvia Villeneuve, Louis Collins
Summary: The study found that cerebral small vessel disease (CSVD), amyloid, and pTau are related to age-related cognitive decline. Specifically, there was an inverse correlation between white matter lesions (WMLs) and amyloid AB42, but no correlation between WMLs and pTau. Additionally, baseline AB42 was associated with executive function, while baseline pTau did not have any association with cognitive measures.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Zili Zhu, Qingze Zeng, Ruiting Zhang, Xiao Luo, Kaicheng Li, Xiaopei Xu, Minming Zhang, Yunjun Yang, Peiyu Huang
Summary: This study found that white matter free water (FW) is associated with baseline cognition and can predict the decline of executive and language functions in patients with mild cognitive impairment (MCI). However, no association was found between total cerebral small vessel disease (CSVD) score and cognitive declines.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Zhenrong Fu, Mingyan Zhao, Yirong He, Xuetong Wang, Jiadong Lu, Shaoxian Li, Xin Li, Guixia Kang, Ying Han, Shuyu Li
Summary: The study revealed that structural covariance and connectivity strength are decreased in individuals with subjective cognitive decline (SCD) compared to normal controls (NC), and structural covariance patterns in specific large-scale brain networks show divergent changes at the early Alzheimer's disease (aMCI) stage and dementia (AD) stage.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Zahinoor Ismail, Alexander McGirr, Sascha Gill, Sophie Hu, Nils D. Forkert, Eric E. Smith
Summary: The study showed that individuals with both MBI and SCD had the highest risk of cognitive and functional decline, suggesting that these two conditions combined can serve as a simple and scalable method to identify high-risk patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Ashwati Vipin, Benjamin Yi Xin Wong, Dilip Kumar, Audrey Low, Kok Pin Ng, Nagaendran Kandiah
Summary: This study investigated the relationship between small-vessel cerebrovascular disease and grey matter volume (GMV) alterations in Alzheimer's disease patients. The results showed differential effects of WMH burden on GMV in Mild Cognitive Impairment (MCI), with both negative and positive associations observed at different WMH loads. Additionally, the association between WMH and cognitive functions such as memory and executive function was moderated by regional GMV in MCI patients.
Article
Geriatrics & Gerontology
Yage Qiu, Ling Yu, Xin Ge, Yawen Sun, Yao Wang, Xiaowei Wu, Qun Xu, Yan Zhou, Jianrong Xu
Summary: The study revealed significantly higher WMH burden in specific brain regions in the svMCI group compared to the control group, and the WMH burden was negatively correlated with composite Z-scores. Among diffusion parameters, mean FA values of WMH and WMH-P of the BCC were correlated with composite Z-scores in svMCI patients. These findings suggest that microstructural changes in the WMH penumbra, especially in the corpus callosum, may contribute to cognitive deficits in SIVD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
An-Ming Hu, Yan-Ling Ma, Yue-Xiu Li, Zai-Zhu Han, Nan Yan, Yu-Mei Zhang
Summary: This study investigated the characteristics of cognitive impairment in patients with white matter lesions caused by cerebral small vessel disease and the corresponding changes in WM microstructures. The results showed that these patients had abnormal diffusion tensor imaging metrics, which were significantly correlated with cognitive assessment results, indicating that these changes could serve as biomarkers of white matter lesions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qian-Qian Li, Ke Wu, Jia-Li Xu, Liang Yin
Summary: This study found that patients with PD experience early cognitive impairment, and the MoCA scale can be used for early screening, while DTI of white matter can highlight early white matter damage. There is a significant positive correlation between MoCA score and white matter of the right parietal and left occipital lobes in the PD-MCI group.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Letter
Rehabilitation
Christelle Nguyen, Isabelle Boutron, Alexandra Roren, Gabriel Baron, Charlotte Pauwels, Marie-Martine Lefevre-Colau, Serge Poiraudeau, Arnaud Dupeyron, Emmanuel Coudeyre, Francois Rannou
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Review
Health Care Sciences & Services
Alexander Perlmutter, Mehdi Benchoufi, Philippe Ravaud, Viet-Thi Tran
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Medicine, General & Internal
Olivier Hermine, Xavier Mariette, Pierre-Louis Tharaux, Matthieu Resche-Rigon, Raphael Porcher, Philippe Ravaud
Summary: In this clinical trial of COVID-19 patients with pneumonia requiring oxygen support but not in the ICU, tocilizumab did not reduce WHO-CPS scores below 5 by day 4 but may have reduced the risk of needing noninvasive ventilation, mechanical ventilation, or death by day 14. There was no difference in mortality by day 28. Further studies are needed to confirm these preliminary results.
JAMA INTERNAL MEDICINE
(2021)
Article
Critical Care Medicine
Xavier Mariette, Olivier Hermine, Pierre Louis Tharaux, Matthieu Resche-Rigon, Raphael Porcher, Philippe Ravaud, Serge Bureau, Maxime Dougados, Annick Tibi
Summary: The study aimed to determine the effectiveness of anakinra in improving outcomes of patients with mild-to-moderate COVID-19 pneumonia, but the results showed that anakinra did not show improvement in patient outcomes. Further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Christelle Nguyen, Isabelle Boutron, Rafael Zegarra-Parodi, Gabriel Baron, Sophie Alami, Katherine Sanchez, Camille Daste, Margaux Boisson, Laurent Fabre, Peggy Krief, Guillaume Krief, Marie-Martine Lefevre-Colau, Francois Rannou
Summary: This study compared the efficacy of standard osteopathic manipulative treatment (OMT) with sham OMT in reducing low back pain (LBP) specific activity limitations in patients with nonspecific subacute or chronic LBP. Results showed that standard OMT had a small effect on reducing LBP-specific activity limitations compared to sham OMT, but the clinical relevance of this effect is questionable.
JAMA INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Manu Shankar-Hari, Claire L. Vale, Peter J. Godolphin, David Fisher, Julian P. T. Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S. Benbenishty, Lindsay R. Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L. De Buyser, Lennie P. G. Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C. Gordon, Richard Haynes, Olivier Hermine, Peter W. Horby, Nora K. Horick, Kuldeep Kumar, Bart N. Lambrecht, Martin J. Landray, Lorna Leal, David J. Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini Mohan, Michael C. Nivens, Jarmo Oksi, Jose A. Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet Ramanan, Philippe Ravaud, Pankti D. Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B. Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H. Stone, Garth W. Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W. Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E. Westerweel, Srinivas Murthy, Janet Diaz, John C. Marshall, Jonathan A. C. Sterne
Summary: This study identified 27 clinical trials and found that the use of IL-6 antagonists was associated with lower 28-day all-cause mortality in patients hospitalized for COVID-19 compared to usual care or placebo. Different risk effects were observed between tocilizumab and sarilumab, increasing understanding of the treatment with these drugs.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Dominique Berton, Anne Floquet, Willy Lescaut, Gabriel Baron, Marie-Christine Kaminsky, Philippe Toussaint, Remy Largillier, Aude-Marie Savoye, Jerome Alexandre, Catherine Delbaldo, Emmanuelle Malaurie, Hugues Barletta, Claire Bosacki, Claire Garnier-Tixidre, Philippe Follana, Hortense Laharie-Mineur, Charles Briac Levache, Bruno Valenza, Agnes Dechartres, Delphine Mollon-Grange, Frederic Selle
Summary: The study assessed the safety and clinical application of bevacizumab therapy in real-world setting in France, showing consistent results with randomized trials, despite differences in patient population and treatment schedule.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Respiratory System
Olivier Hermine, Xavier Mariette, Raphael Porcher, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Philippe Ravaud
Summary: This study aimed to determine whether anti-interleukin (IL)-6 receptors improve outcomes in critically ill patients with COVID-19 pneumonia. The results showed that anti-IL-6 receptor treatment did not significantly increase the number of patients alive without the need for noninvasive ventilation (NIV) or mechanical ventilation (MV) by day 14.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Health Care Sciences & Services
Astrid Chevance, Axel Fortel, Adeline Jouannin, Faustine Denis, Marie-France Mamzer, Philippe Ravaud, Stephanie Sidorkiewicz
Summary: Digital pills face limitations in prospective acceptability and willingness to use, primarily due to clinical and ethical concerns. Results indicate that willingness to take digital pills is associated with gender and the current use of connected devices to record health settings.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Health Care Sciences & Services
Van Thu Nguyen, Philippe Ravaud, Viet Thi Tran, Bridget Young, Isabelle Boutron
Summary: The study investigates patients' preferences for the organization of randomized controlled trials (RCTs) and finds that most patients prefer a hybrid model involving both on-site and remote visits. Patients are more likely to participate in a trial organized according to their preferences.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Health Care Sciences & Services
Gloria A. Aguayo, Catherine Goetzinger, Renza Scibilia, Aurelie Fischer, Till Seuring, Viet-Thi Tran, Philippe Ravaud, Tamas Bereczky, Laetitia Huiart, Guy Fagherazzi
Summary: Patient and public involvement (PPI) in research is important for improving the quality and relevance of studies. Various methods, including workshops, surveys, and focus groups, are commonly used for PPI in epidemiological research. Recommendations include early integration of PPI, combining methods for idea generation, and utilizing digital tools for e-cohorts.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Rheumatology
France X. Mariette, O. Hermine, P-L Tharaux, M. Resche-Rigon, R. Porcher, P. Ravaud
Summary: Treatment with sarilumab did not improve early outcomes in patients with moderate-to-severe COVID-19 pneumonia. Further studies are warranted to evaluate the effect of sarilumab on long-term survival.
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Raphaele Seror, Gabriel Baron, Marine Camus, Divi Cornec, Elodie Perrodeau, Simon J. Bowman, Michele Bombardieri, Hendrika Bootsma, Jacques-Eric Gottenberg, Benjamin Fisher, Wolfgang Hueber, Joel A. van Roon, Valerie Devauchelle-Pensec, Peter Gergely, Xavier Mariette, Raphael Porcher
Summary: An composite responder index, called Sjogren's Tool for Assessing Response (STAR), was developed in this study to evaluate the treatment response in primary Sjogren's syndrome (pSS). Through data analysis and consensus techniques, the researchers identified five core domains and developed 227 STAR options for sensitivity testing. The candidate STAR showed good sensitivity to change and will be further validated in a dedicated randomized controlled trial.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Dermatology
Laura Fertitta, Kavita Y. Sarin, Christina Bergqvist, Ekshika Patel, Bastien Peiffer, Sabine Moryousef, Marie-Laure Armand, Arnaud Jannic, Salah Ferkal, Philippe Ravaud, Viet-Thi Tran, Jaishri O. Blakeley, Carlos G. Romo, Khaled Ezzedine, Pierre Wolkenstein
Summary: This study first defined severity strata for cutaneous neurofibromas using an anchoring approach. After validation in French and United States populations, the cNF-Skindex and the strata showed a strong correlation in interpreting cutaneous neurofibromas in daily practice and clinical trials.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Olivier Hermine, Xavier Mariette, Raphael Porcher, Felix Djossou, Yann Nguyen, Jean-Benoit Arlet, Laurent Savale, Jean Luc Diehl, Sophie Georgin-Lavialle, Jacques Cadranel, Gilles Pialoux, Karine Lacombe, Arsene Mekinian, Helene Gros, Xavier Lescure, Jade Ghosn, Elisabeth Coupez, Kevin Grapin, Christophe Rapp, Marc Michel, Anne Lise Lecapitaine, Jean Marie Michot, Nathalie Costedoat-Chalumeau, Liem Binh Luong Nguyen, Luca Semerano, Francois Raffi, Claire Aguillar, Claire Rouzaud, Jacques Eric Gottenberg, Yves Hansmann, Boris Bienvenu, Jonathan London, Franklin Samou Fantchou, Felix Ackermann, Antoine Gros, Alexandre Morel, Nicolas Gambier, Damien Sene, Bruno Megarbane, Elie Azoulay, Serge Bureau, Maxime Dougados, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Mathieu Mahevas, Frederic Pene, Frederic Schlemmer, Valerie Pourcher-Martinez, Annick Tibi, Gabriel Baron, Elodie Perrodeau, Stephanie Baron, Gabriel Steg, Yazdan Yazdapanah, Tabassome Simon, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Philippe Ravaud
Summary: The combination of dexamethasone and tocilizumab did not improve the need for mechanical ventilation and mortality in patients with moderate-to-severe COVID-19 pneumonia. The safety of both treatments was similar.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.