Article
Behavioral Sciences
Shir Shalom-Sperber, Aihua Chen, Adam Zaidel
Summary: This study investigated cross-sensory (visual-vestibular) adaptation of self-motion perception. The results showed that even several short-duration stimuli can lead to functional adaptation of perception, suggesting that the brain monitors and adapts to supra-modal statistics of events in the environment.
Article
Engineering, Mechanical
Mitchell Wall, Matthew S. Allen, Robert J. Kuether
Summary: This paper presents measurements from a benchmark structure with two bolted joints to predict damping and model nonlinear coupling between elastic modes. Nonlinearities introduced by the bolted joints cause challenges in characterizing the structure's response to varying load amplitudes, with differences in response correlating with the strength of excited modes. The findings highlight the importance of understanding mode coupling in predicting structural behavior.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2022)
Article
Psychology, Multidisciplinary
Kennis S. T. Ma, Jan W. H. Schnupp
Summary: This study investigates whether factors such as beliefs and prior experience modulate multisensory integration. The results show that incongruence between male/female faces and voices does not disrupt the McGurk illusion, but familiarization and priming with appropriate pairings can significantly reduce the illusion.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Sreetosh Goswami, Rajib Pramanick, Abhijeet Patra, Santi Prasad Rath, Martin Foltin, A. Ariando, Damien Thompson, T. Venkatesan, Sreebrata Goswami, R. Stanley Williams
Summary: The profuse dendritic-synaptic interconnections among neurons in the neocortex enable sophisticated decision-making abilities that vastly outperform any artificial electronic analogues. The brain's dynamically reconfigurable network provides flexibility and adaptability to changing environments, in contrast to the hard-wired threshold switches of state-of-the-art semiconductor logic circuits. By re-imagining fundamental electronic circuit elements and expressing complex logic in nanometre-scale material properties, the study demonstrates voltage-driven conditional logic interconnectivity among distinct molecular redox states to embed decision trees within a single memristor, allowing for non-volatile switching transitions between conductance levels in a single sweep cycle. Multiple redox transitions in a molecular memristor can be utilized to undertake complex and reconfigurable logic operations in a single time step.
Article
Neurosciences
Naomi L. Bean, Scott A. Smyre, Barry E. Stein, Benjamin A. Rowland
Summary: The responses of individual superior colliculus (SC) neurons are enhanced by concordant visual-auditory stimuli. This ability for multisensory integration is acquired through cross-modal experience. Raising animals in omnidirectional sound prevents them from obtaining this experience and disrupts the normal multisensory transform in the SC, resulting in decreased responses to concordant visual-auditory stimuli. Behavioral experiments show that noise-reared animals do not exhibit multisensory performance benefits in simple detection/localization tasks, indicating a parallel between behavior and single neuron physiology.
Article
Neurosciences
Scott A. Smyre, Naomi L. Bean, Barry E. Stein, Benjamin A. Rowland
Summary: The deep layers of the superior colliculus (SC) are important for detecting and guiding responses to salient events in the environment. Neurons in the SC can enhance their responses to events detected by multiple sensory modalities. Modulatory dynamics induced by stimulus repetition are specific to sensory modalities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Xiao Han, Jinghong Xu, Song Chang, Les Keniston, Liping Yu
Summary: This study investigates how sensory processing in sensory cortices is modulated by cross-modal interaction during perceptual tasks. The researchers recorded neural responses in the primary auditory cortex of rats performing discrimination tasks with audiovisual or unisensory cues. They found that cross-modal representation in auditory cortices varies with task contexts, with a significant increase in visually evoked responses during tasks with an audiovisual cue associated with reward. Additionally, associative learning seemed to have a plastic effect on multisensory enhancement in the auditory cortex. These findings suggest that multisensory processing in sensory cortices is not static and can be substantially enhanced by cross-modal interaction.
Article
Biology
Ryan J. Morrill, James Bigelow, Jefferson DeKloe, Andrea R. Hasenstaub
Summary: In everyday behavior, sensory systems compete for attentional resources. This study investigated the cellular and circuit-level mechanisms of modality-selective attention in the mouse auditory cortex. Results showed that attending to sound elements reduced neuronal activity and improved sound encoding efficiency. Attention also filtered out sound-irrelevant background activity and facilitated sound discrimination.
Article
Neurosciences
Moa G. Peter, Gustav Martensson, Elbrich M. Postma, Love Engstrom Nordin, Eric Westman, Sanne Boesveldt, Johan N. Lundstrom
Summary: Individuals with congenital anosmia showed enhanced multisensory integration performance, suggesting potential reorganization of multisensory processing in the brain. However, no significant group differences were found in olfactory associated regions compared to controls. The results tentatively suggest enhanced processing of audio-visual stimuli in individuals with congenital anosmia may be mediated by multisensory, and not primary sensory, cerebral regions.
Article
Biology
Jasenko Zivanov, Joaquin Oton, Zunlong Ke, Andriko von Kuegelgen, Euan Pyle, Kun Qu, Dustin Morado, Daniel Castano-Diez, Giulia Zanetti, Tanmay A. M. Bharat, John A. G. Briggs, Sjors H. W. Scheres
Summary: We propose a new approach for determining macromolecular structures from cryo-ET data. Unlike existing methods, our approach optimizes a regularized likelihood target that approximates a function of the 2D experimental images. Additionally, we optimize tilt-series alignments, beam-induced motions, defoci, and higher-order optical aberrations using the increased signal-to-noise ratio in the averaged structure.
Review
Neurosciences
Yuhui Chai, Tina T. Liu, Sean Marrett, Linqing Li, Arman Khojandi, Daniel A. Handwerker, Arjen Alink, Lars Muckli, Peter A. Bandettini
Summary: The study examines laminar activity patterns in different topographical subfields of human PT under unimodal and multisensory stimuli, revealing a division of function between visual and auditory processing in PT and distinct feedback mechanisms in different subareas.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Giulia L. L. Poerio, Manami Ueda, Hirohito M. M. Kondo
Summary: This study found that synesthesia is up to four times as common among ASMR-responders compared to non-responders, with over half of synesthetes also experiencing ASMR. The prevalence rate for ASMR was approximately 20%. These findings provide empirical support for the idea that ASMR may be driven by synesthetic mechanisms.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Meike Scheller, Michael J. Proulx, Michelle de Haan, Annegret Dahlmann-Noor, Karin Petrini
Summary: The study shows that in individuals with normal vision, adult-like audio-haptic integration develops at around 13-15 years of age and remains stable until late adulthood. Early-blind individuals integrate audio-haptic information optimally even at young ages, while late-blind individuals do not. Optimal integration in low-vision individuals follows a similar development trajectory as in sighted individuals.
DEVELOPMENTAL SCIENCE
(2021)
Article
Neurosciences
Miro Grundei, Pia Schroeder, Sam Gijsen, Felix Blankenburg
Summary: The study investigates the neural mechanisms underlying probabilistic inference in the human brain using EEG. The researchers found modality-specific signatures of mismatch responses and a common cross-modal signature in the P3a time range. The observed dynamics were best explained by Bayesian learning models.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Ryan L. Miller, David L. Sheinberg
Summary: This study explores the differences in visual and haptic object recognition and finds that there may be differences in the features used for comparing shapes in different contexts, suggesting that object recognition may not solely occur in a single region.
Article
Neurosciences
Barry E. Stein, Terrence R. Stanford, Benjamin A. Rowland
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Clara M. Poveda, Maria L. Valero, Marianny Pernia, Juan C. Alvarado, David K. Ryugo, Miguel A. Merchan, Jose M. Juiz
Review
Neurosciences
Juan Carlos Alvarado, Veronica Fuentes-Santamaria, Jose M. Juiz
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Juan C. Alvarado, Veronica Fuentes-Santamaria, Pedro Melgar-Rojas, Maria C. Gabaldon-Ull, Jose J. Cabanes-Sanchis, Jose M. Juiz
Article
Neurosciences
Scott A. Smyre, Zhengyang Wang, Barry E. Stein, Benjamin A. Rowland
Summary: Neurons in the superior colliculus require cross-modal experience to develop their characteristic multisensory capability. Dysfunction in these neurons leads to impairments in behavioral capabilities such as detection and localization. Animals raised in darkness showed defects in multisensory detection and localization performance compared to normally reared animals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Huai Jiang, Terrence R. Stanford, Benjamin A. Rowland, Barry E. Stein
Summary: The study found that in cats with unilateral hemianopia, there were no signs of visual recovery even after providing additional training sessions with ipsilesional AES deactivated. However, subsequent training under the same conditions but with active AES reversed the hemianopia within the normal timeframe. These results suggest that the corticotectal circuit involving multisensory plasticity in the SC needs to be operational for the brain to use visual-auditory experience to resolve hemianopia.
Review
Neurosciences
Terrence R. Stanford, Emilio Salinas
Summary: Addressing temporal uncertainty through urgent visuomotor tasks, a novel behavioral metric describing the evolution of subjective perceptual judgments has been established, clarifying the neural distinction between perceptual evaluation and motor selection processes.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Article
Neurosciences
Emilio Salinas, Terrence R. Stanford
Summary: This study reveals that the choice of where to look next is influenced by both exogenous and endogenous factors, with their interaction details and unique contributions to target selection becoming clearer. Exogenous modulations associated with stimulus detection quickly and briefly interrupt ongoing motor plans according to spatial congruence rules, explaining characteristic features of various saccadic tasks. These low-level visuomotor interactions contribute to diverse oculomotor phenomena traditionally attributed to different neural mechanisms.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Review
Neurosciences
Juan Carlos Alvarado, Veronica Fuentes-Santamaria, Jose M. Juiz
Summary: This review summarizes the etiology of neurodegenerative diseases, particularly Alzheimer's disease (AD) and presbycusis, and emphasizes the possible interplay among oxidative stress, frailty syndrome, AD, and presbycusis. The knowledge gained from this review may contribute to the development of new therapeutic strategies and improve the quality of life for patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Naomi L. Bean, Scott A. Smyre, Barry E. Stein, Benjamin A. Rowland
Summary: The responses of individual superior colliculus (SC) neurons are enhanced by concordant visual-auditory stimuli. This ability for multisensory integration is acquired through cross-modal experience. Raising animals in omnidirectional sound prevents them from obtaining this experience and disrupts the normal multisensory transform in the SC, resulting in decreased responses to concordant visual-auditory stimuli. Behavioral experiments show that noise-reared animals do not exhibit multisensory performance benefits in simple detection/localization tasks, indicating a parallel between behavior and single neuron physiology.
Article
Geriatrics & Gerontology
Veronica Fuentes-Santamaria, Juan Carlos Alvarado, Susana Mellado, Pedro Melgar-Rojas, Maria Cruz Gabaldon-Ull, Jose J. Cabanes-Sanchis, Jose M. Juiz
Summary: This study found that noise exposure accelerated age-related hearing loss in young rats by causing progressive dysfunction and early degeneration of cochlear cells and structures. The findings provide functional, structural, and molecular evidence of the interaction between age and noise in exacerbating presbycusis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Allison T. Goldstein, Terrence R. Stanford, Emilio Salinas
Summary: Oculomotor circuits take into consideration exogenous and endogenous influences to complete target selection. In high urgency conditions, the exogenous signal arrives approximately -80 ms after the cue onset, accelerating the incorrect plan towards the cue, while the informed endogenous signal arrives slightly later, favoring the correct plan away from the cue. The exogenous response is largely unaffected by task instructions.
Article
Biochemistry & Molecular Biology
Alejandro Gibaja, Juan C. Alvarado, Verena Scheper, Liliana Carles, Jose M. Juiz
Summary: Kanamycin and cisplatin are ototoxic drugs with unclear mechanisms of cochlear damage. Kanamycin causes auditory threshold shifts and outer hair cell loss, as well as apoptosis and oxidative stress. In contrast, cisplatin induces different injuries in different regions of the cochlea, with more outer hair cells surviving in the apical region compared to kanamycin, despite the absence of evoked auditory activity. Additionally, there are differential regulations of antioxidant enzyme levels between the two drugs.
Article
Neurosciences
Naomi L. Bean, Barry E. Stein, Benjamin A. Rowland
Summary: Hemianopia can be improved through noninvasive cross-modal stimulation, which is related to the ability of multisensory integration. However, multisensory integration is not a prerequisite for visual recovery in hemianopia.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.