Article
Multidisciplinary Sciences
Hongwei Tan, Yifan Zhou, Quanzheng Tao, Johanna Rosen, Sebastiaan van Dijken
Summary: The multisensory neural network integrates and interacts vision, touch, hearing, smell, and taste, enabling crossmodal recognition and imagination, presenting a promising approach for robotic sensing and perception. Tan et al. report an artificial spiking multisensory neural network that mimics the crossmodal perception of biological brains.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Jean-Paul Noel, Renato Paredes, Emily Terrebonne, Jacob I. Feldman, Tiffany Woynaroski, Carissa J. Cascio, Peggy Series, Mark T. Wallace
Summary: This study provides a detailed understanding of the behavioral, electrophysiological, and neural network basis of peripersonal space (PPS) updating in individuals with autism spectrum disorder (ASD) during a social context. The findings suggest that individuals with ASD lack flexibility in perceiving personal space and this inflexibility may be related to excitatory/inhibitory imbalances in neural circuits.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Mathematical
Meike Scheller, Marko Nardini
Summary: Studying how sensory cues are integrated in perception is important for understanding adaptive behavior. Existing studies often overlook or misuse important analysis methods, potentially leading to false positives. Using simulations, we highlight the impact of choosing the wrong contrast in analyzing cue combination and propose an alternate approach. Comparing combined-cue precision to the best single-cue precision at the individual level can enhance the credibility of reported effects. Furthermore, testing for deviations from optimal predictions alone is insufficient for determining cue combination. Careful comparator selection and task design are crucial for accurately testing perceptual precision gains.
BEHAVIOR RESEARCH METHODS
(2023)
Review
Behavioral Sciences
Samuel A. Jones, Uta Noppeney
Summary: The processing of multisensory signals changes with age. Older adults often benefit as much as younger individuals from congruent multisensory stimuli, but are more negatively impacted by intersensory conflict.
Review
Behavioral Sciences
Anne-Laure Rineau, Lionel Bringoux, Jean-Christophe Sarrazin, Bruno Berberian
Summary: Self-motion perception is crucial for guiding pilots' behavior, and impairment in this perception can lead to spatial disorientation, a major cause of accidents. Visuo-vestibular integration is the main process underlying self-motion perception, and it can be modulated by the physical properties of the environment. Additionally, the internal state of an operator and the automation of systems can also influence self-motion perception.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Anne-Laure Rineau, Bruno Berberian, Jean-Christophe Sarrazin, Lionel Bringoux
Summary: Self-motion perception is influenced by visuo-vestibular integration and the reliability of sensory inputs. This study found that being in control of our own action through manual triggers can enhance motion sensitivity, even when the level of ambiguity increases. The results highlight the importance of considering the internal state and agency in self-motion perception.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biology
Robert Mitchell, Shahrzad Shaverdian, Marie Dacke, Barbara Webb
Summary: Ball-rolling dung beetles integrate multiple cues for straight-line orientation. Orientation cues are integrated using vector summation, where compass cues are represented by vectors and summed to give an integrated estimate. Cue weight is set according to cue reliability, consistent with the Bayesian view of cue integration. However, our study suggests an alternative strategy where weighted cues are based on relative contrast rather than reliability.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Itsuki Kanemura, Katsunori Kitano
Summary: Humans perceive the external world by integrating information from different modalities, but the mechanism behind this is still unclear. A model using two reservoir computing systems was able to detect stimulus patterns that repeatedly appear in a time series signal. The model was self-organized and could detect each fluctuation pattern. The original version of the model, which incorporated feedback from appropriately learned sensory modules, performed the best compared to alternative versions.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Mathematical
Phillip M. Newman, Timothy P. McNamara
Summary: Research shows that combining different spatial cues can improve performance in navigation, but different methodological approaches have minimal impact on spatial cue integration in single-cue conditions; performance is better and closer to optimal in dual-cue conditions.
BEHAVIOR RESEARCH METHODS
(2021)
Article
Psychology, Developmental
Erik Verhaar, Wijbrand Pieter Medendorp, Sabine Hunnius, Janny C. Stapel
Summary: The study suggests that information from different sensory modalities can be integrated to improve perceptual precision. Both adults and adolescents tend to bias their localization towards the visual stimulus when presented with visual and tactile stimuli, especially when the stimuli are presented close to each other.
DEVELOPMENTAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Aneesha K. Suresh, Charles M. Greenspon, Qinpu He, Joshua M. Rosenow, Lee E. Miller, Sliman J. Bensmaia
Summary: There are distinct differences in how tactile nerve fibers and cortical neurons process tactile information, with responses in the cuneate nucleus (CN) being more similar to cortical counterparts. The CN plays a key role in processing tactile information, contrary to the traditional view that sensory signals are mainly processed in the cortex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Danish Shaikh
Summary: This article explores the process of multisensory integration and its development in a multisensory environment. It proposes that experience dependent crossmodal synaptic plasticity may be a mechanism underlying the development of multisensory cue integration. The hypothesis is tested using a computational model and simulated experiments.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Neurosciences
Liang Shan, Liu Yuan, Bo Zhang, Jian Ma, Xiao Xu, Fei Gu, Yi Jiang, Ji Dai
Summary: In this study, the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs was systematically investigated. Different response patterns and neural characteristics of bimodal over unimodal modulation were identified. Neurons were further clustered into groups associated with different integrating functions and sub-regions. The study sheds new light on the neural mechanisms of multisensory integration in the primate brain.
NEUROSCIENCE BULLETIN
(2023)
Article
Multidisciplinary Sciences
Reuben Rideaux, Katherine R. Storrs, Guido Maiello, Andrew E. Welchman
Summary: The brain faces the challenge of determining whether sensations of motion have a single cause or multiple causes, integrating vestibular and visual cues for more precise estimation of self-motion. The macaque medial superior temporal area contains neurons that encode combinations of vestibular and visual motion cues, with some responding to congruent cues and others to opposite cues. A neural network model trained for causal inference in motion estimation exhibits both congruent and opposite units, showing the importance of the balance between their activities in determining whether cues should be integrated or separated.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Andrea Pavan, Seyma Koc Yilmaz, Hulusi Kafaligonul, Luca Battaglini, Steven P. Blurton
Summary: This study investigated the effects of transient exogenous cues on the perception of briefly presented drifting Gabor patches. The results showed that neutral cues improved performance in a motion direction discrimination task compared to valid spatial cues. The findings suggest that transient attention prolongs the internal response to the attended stimulus, thus reducing the temporal segregation of visual events.
Review
Neurosciences
Adam Kohn, Ruben Coen-Cagli, Ingmar Kanitscheider, Alexandre Pouget
ANNUAL REVIEW OF NEUROSCIENCE, VOL 39
(2016)
Editorial Material
Multidisciplinary Sciences
Zachary F. Mainen, Michael Hausser, Alexandre Pouget
Article
Neurosciences
Agnieszka Grabska-Barwinska, Simon Barthelme, Jeff Beck, Zachary F. Mainen, Alexandre Pouget, Peter E. Latham
NATURE NEUROSCIENCE
(2017)
Article
Neurosciences
Alexandre Pouget, Jan Drugowitsch, Adam Kepecs
NATURE NEUROSCIENCE
(2016)
Article
Ophthalmology
Jielei Emma Zhu, Wei Ji Ma
Article
Ophthalmology
Andra Mihali, Bas van Opheusden, Wei Ji Ma
Editorial Material
Neurosciences
Larry F. Abbott, Dora E. Angelaki, Matteo Carandini, Anne K. Churchland, Yang Dan, Peter Dayan, Sophie Deneve, Ila Fiete, Surya Ganguli, Kenneth D. Harris, Michael Hausser, Sonja Hofer, Peter E. Latham, Zachary F. Mainen, Thomas Mrsic-Flogel, Liam Paninski, Jonathan W. Pillow, Alexandre Pouget, Karel Svoboda, Ilana B. Witten, Anthony M. Zador
Article
Neurosciences
Yoshiyuki Yamada, Khaleel Bhaukaurally, Tamas J. Madarasz, Alexandre Pouget, Ivan Rodriguez, Alan Carleton
Article
Psychology
Ronald van den Berg, Aspen H. Yoo, Wei Ji Ma
PSYCHOLOGICAL REVIEW
(2017)
Article
Biochemical Research Methods
Joel Zylberberg, Alexandre Pouget, Peter E. Latham, Eric Shea-Brown
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Biochemical Research Methods
Kaushik J. Lakshminarasimhan, Alexandre Pouget, Gregory C. Deangelis, Dora E. Angelaki, Xaq Pitkow
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Neurosciences
Satohiro Tajima, Jan Drugowitsch, Nisheet Patel, Alexandre Pouget
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Jan Drugowitsch, Andre G. Mendonca, Zachary F. Mainen, Alexandre Pouget
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Han Hou, Qihao Zheng, Yuchen Zhao, Alexandre Pouget, Yong Gu
Editorial Material
Neurosciences
Amy Adams, Jan G. Bjaalie, James O. Deshler, Yves De Koninck, Gary Egan, Judy Illes, Sung-Jin Jeong, Caroline Montojo, Shigeo Okabe, Gang Pei, Linda J. Richards, Pann-Ghill Suh, Xu Zhang, Jialin Zheng, Stephanie Albin, Katrin Amunts, Tasia Asakawa, Amy Bernard, Khaled Chakli, Christoph J. Ebell, Melina Hale, Michael Hausser, Linda Lanyon, Yan Li, Pierre Magistretti, Agnes McMahon, Hideyuki Okano, Toshihisa Ohtsuka, Alexandre Pouget, Karen S. Rommelfanger, Jason Reindorp, Paul Sajda, Kimberly N. Scobie, Keiji Tanaka, Edda Thiels, Pedro A. Valdes-Sosa, Andrew E. Welchman, Samantha White, Gary Wilson, Rafael Yuste
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.