期刊
BRAIN PATHOLOGY
卷 20, 期 4, 页码 763-770出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1750-3639.2009.00357.x
关键词
astrocytoma; endothelial cell; ependymoma; KIT; pediatric brain tumor; pilocytic astrocytoma; receptor tyrosine kinase
资金
- Helsinki Biomedical Graduate School
- Finnish Cultural Foundation
- Ida Montin Foundation
- Biomedicum Foundation
- Orion-Farmos Research Foundation
- Emil Aaltonen Foundation
- Helsinki University Central Hospital
- Helsinki University
- Sigrid Juselius Foundation
- Cancer Society of Finland
- Academy of Finland
KIT receptor tyrosine kinase is expressed in tumor endothelial cells of adult glioblastomas, but its expression in pediatric brain tumor endothelial cells is unknown. We assessed expression of KIT, phosphorylated KIT, stem cell factor (SCF) and vascular endothelial growth factor receptor-2 (VEGFR-2) in 35 juvenile pilocytic astrocytomas and 49 other pediatric brain tumors using immunohistochemistry, and KIT messenger RNA (mRNA) using in situ hybridization. KIT and phospho-KIT were moderately or strongly expressed in tumor endothelia of 37% and 35% of pilocytic astrocytomas, respectively, whereas marked SCF and VEGFR-2 expression was uncommon. KIT mRNA was detected in tumor endothelial cells. Tumor endothelial cell KIT expression was strongly (P < 0.01) associated with endothelial cell phospho-KIT and SCF expression, and with tumor KIT (P = 0.0011) and VEGFR-2 expression (P = 0.022). KIT and phospho-KIT were present in endothelia of other pediatric brain tumors, notably ependymomas. Endothelial cell KIT expression was associated with a young age at diagnosis of pilocytic astrocytoma or ependymoma, and it was occasionally present in histologically normal tissue of the fetus and children. We conclude that KIT is commonly present in endothelial cells of juvenile brain tumors and thus may play a role in angiogenesis in these neoplasms.
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