☆ 4.6 Article

Quantitation and Mapping of Cerebral Detergent-Insoluble Proteins in the Elderly

BRAIN PATHOLOGY (2009)

期刊

BRAIN PATHOLOGY

卷 19, 期 3, 页码 365-374

出版社

WILEY-BLACKWELL PUBLISHING, INC

DOI: 10.1111/j.1750-3639.2008.00190.x

关键词

-

类别

Clinical Neurology Neurosciences Pathology

资金

Nancy and Buster Alvord Endowment [AG008017, AG23801, AG05136, AG006781, AG 000258]

向作者/读者索取更多资源

Protocol

Reagent

摘要

Accumulation of abnormal protein aggregates, detergent-insoluble (DI) proteins and amyloid in the brain are shared features of many neurodegenerative diseases. Previous studies correlating DI proteins and cognitive performance are limited. We addressed these limitations using two sets of autopsy brains, one selected from our Alzheimer's Disease Research Center and the other an unselected series from Adult Changes in Thought (ACT), a population-based study of brain aging. We observed concentrations of 11 proteins and 6 protein variants that can be grouped into three highly correlated clusters: amyloid (A)beta, tau and alpha-synuclein (alpha-syn). While abnormal proteins from each cluster independently correlated with cognitive performance in ACT participants, only increased soluble A beta oligomers in temporal cortex and increased DI A beta 42 and DI alpha-syn in prefrontal cortex were negatively correlated with cognitive performance. These data underscore the therapeutic imperative to suppress processes leading to accumulation of soluble A beta oligomers, DI A beta 42 and DI alpha-syn, highlight an at least partially independent contribution to cognitive impairment and raise the possibility that the priority for therapeutic targets may vary by brain region in a typical elderly US population.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Chemistry, Multidisciplinary

Expanding the Scope of Polyoxometalates as Artificial Proteases towards Hydrolysis of Insoluble Proteins

Nada D. Savic, David E. Salazar Marcano, Tatjana N. Parac-Vogt

Summary: The study reports the hydrolysis of fully insoluble protein using polyoxometalate complexes as artificial proteases in surfactant solutions for the first time. The results indicate that the hydrolytic selectivity and activity of the POM catalysts strongly depend on the concentration of surfactant.

CHEMISTRY-A EUROPEAN JOURNAL (2022)

添加到收藏夹

Article Chemistry, Medicinal

Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions

Aishi Dasgupta, Shon Gangai, Rishikesh Narayan, Shobhna Kapoor

Summary: The COVID-19 pandemic has generated research interest in identifying robust biomarkers and therapeutic targets. Lipids play a crucial role in SARS-CoV-2 pathogenesis, and targeting lipid-based processes may provide effective strategies for combating COVID-19.

JOURNAL OF MEDICINAL CHEMISTRY (2023)

添加到收藏夹

Article Environmental Sciences

Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts

Gunnar Boysen, Intawat Nookaew

Summary: Formation of DNA adducts is crucial for understanding genotoxicity, and their detection can indicate exposure and link to mutations or gene regulation changes. Current methods can quantify adducts and visualize their location, but they are not compatible with each other. New nanopore technologies originally developed for single-molecule DNA sequencing may enable simultaneous quantification and mapping of DNA adducts across the genome. These emerging technologies are expected to provide a comprehensive view of the exposome and identify gene regions susceptible to DNA adduct formation.

TOXICS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Enhanced recombinant protein capture, purity and yield from crude bacterial cell extracts by N-Lauroylsarcosine-assisted affinity chromatography

Jose Vicente Carratala, Jan Atienza-Garriga, Hector Lopez-Laguna, Esther Vazquez, Antonio Villaverde, Julieta M. Sanchez, Neus Ferrer-Miralles

Summary: To improve the purification yield and purity of difficult proteins, a novel method has been developed using bile salts to supplement crude cell extracts, resulting in a substantial improvement in protein capture by affinity chromatography.

MICROBIAL CELL FACTORIES (2023)

添加到收藏夹

Article Food Science & Technology

Conformational and Structural Changes in Chickpea Proteins Caused by Simulated Salivary Alterations in the Elderly

Ingrid Contardo, Fanny Guzman, Javier Enrione

Summary: This study investigated the impact of simulated salivary alterations on the conformational properties and secondary structure of chickpea protein isolate (CPI) in elderly and adult subjects. The results showed that the ordered secondary protein structure was significantly affected in the elderly population, with a decrease in alpha-helix and an increase in unordered random coil state. These findings could be attributed to an increase in electrolytes in the salivary composition. The study provides meaningful insights into understanding how alterations in the elderly oral system affect protein conformation and may contribute to improving the understanding of plant-based protein digestibility.

FOODS (2023)

添加到收藏夹

Article Plant Sciences

Unlocking the molecular basis of wheat straw composition and morphological traits through multi-locus GWAS

Salvatore Esposito, Francesca Taranto, Paolo Vitale, Donatella Bianca Maria Ficco, Salvatore Antonio Colecchia, Piergiorgio Stevanato, Pasquale De Vita

Summary: In this study, researchers identified candidate genes controlling biomass composition traits in tetraploid wheat through the analysis of multi-locus genome-wide association models. They also investigated the functions of these genes and validated their effects through molecular methods. The findings provide new insights into the genetic basis of biomass composition traits and contribute to the development of high-yielding wheat varieties for biofuel production.

BMC PLANT BIOLOGY (2022)

添加到收藏夹

Article Microbiology

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo

Shannon L. Kordus, Heather K. Kroh, Ruben Cano Rodriguez, Rebecca A. Shrem, F. Christopher Peritore-Galve, John A. Shupe, Brian E. Wadzinski, D. Borden Lacy, Benjamin W. Spiller

Summary: Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. This article introduces the development of nanobody tools and detection methods for studying the toxins TcdA and TcdB produced by C.difficile. These tools are expected to help researchers understand the production and dynamics of the toxins, as well as the impact of various experimental interventions on toxin production.

PLOS PATHOGENS (2023)

添加到收藏夹

Article Engineering, Biomedical

Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

Aiman Sadaf, Seonghoon Kim, Hyoung Eun Bae, Haoqing Wang, Andreas Nygaard, Yuki Uegaki, Yang Du, Chastine F. Munk, Satoshi Katsube, Hyun Sung Lee, Jungnam Bae, Chul Won Choi, Hee-Jung Choi, Bernadette Byrne, Samuel H. Gellman, Lan Guan, Claus J. Loland, Brian K. Kobilka, Wonpil Im, Pil Seok Chae

Summary: Newly-designed maltoside detergents, GTMs, exhibit different behaviors in terms of detergent self-assembly and protein stabilization efficacy due to the polarity difference between hydrophobic and hydrophilic pendants. The high hydrophobic density in the detergent micelle interior of M-GTMs enhances their efficacy for protein stabilization compared to E-GTMs and a gold standard detergent DDM. This study introduces amphiphiles as biochemical tools in membrane protein studies, advancing protein science and facilitating structure-based drug design.

ACTA BIOMATERIALIA (2021)

添加到收藏夹

Article Biophysics

Lipid packing is disrupted in copolymeric nanodiscs compared with intact membranes

Luis M. Real Hernandez, Ilya Levental

Summary: Synthetic copolymers can form nanodiscs by directly intercalating into intact membranes, but the nanodiscs do not completely retain the physical properties of intact membranes.

BIOPHYSICAL JOURNAL (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Foldable Detergents for Membrane Protein Study: Importance of Detergent Core Flexibility in Protein Stabilization

Lubna Ghani, Seonghoon Kim, Haoqing Wang, Hyun Sung Lee, Jonas S. Mortensen, Satoshi Katsube, Yang Du, Aiman Sadaf, Waqar Ahmed, Bernadette Byrne, Lan Guan, Claus J. Loland, Brian K. Kobilka, Wonpil Im, Pil Seok Chae

Summary: Membrane proteins are difficult to study due to limited chemical tools for stabilization. In this study, a novel detergent was developed and shown to be superior to traditional detergents in stabilizing membrane proteins. This concept of detergent foldability has potential applications in detergent design and membrane protein studies.

CHEMISTRY-A EUROPEAN JOURNAL (2022)

添加到收藏夹

Article Veterinary Sciences

Mapping the branching pattern of the middle cerebral artery in the camel (Camelus dromedarius): a comprehensive anatomical analysis

Ahmad Al Aiyan, Rinsha Balan

Summary: In this study, the branching structure of the middle cerebral artery (MCA) in the dromedary brain was comprehensively analyzed for the first time. Advanced casting techniques were used to create precise renderings of the MCA structure. The findings revealed the main trunk of the MCA and its cortical branches, providing valuable insight into the cerebrovascular system of dromedary camels and opening new avenues for veterinary medicine and neuroscience research.

FRONTIERS IN VETERINARY SCIENCE (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Biomimetic Recognition-Driven Plasmonic Nanogap-Enhanced Raman Scattering for Ultrasensitive Protein Fingerprinting and Quantitation

Hui He, Lingli Zhou, Zhanchen Guo, Pengfei Li, Song Gao, Zhen Liu

Summary: A novel dual biomimetic recognition-driven plasmonic nanogap-enhanced Raman scattering strategy was reported for ultrasensitive protein fingerprinting and quantitation. By trapping target proteins into plasmonic nanogaps, ultra-high Raman signal amplification was achieved, along with a ratiometric assay for robust quantitation.

NANO LETTERS (2022)

添加到收藏夹

Review Multidisciplinary Sciences

Mapping the molecular and cellular complexity of cortical malformations

Esther Klingler, Fiona Francis, Denis Jabaudon, Silvia Cappello

Summary: This article discusses the composition of the cerebral cortex, the causes of neurodevelopmental disorders, and the importance of a multilevel assessment of disease processes for developing therapeutic strategies.

SCIENCE (2021)

添加到收藏夹

Article Agronomy

The Effect of Tytanit on Fibre Fraction Content in Medicago x varia T. Martyn and Trifolium pratense L. Cell Walls

Milena Truba, Jacek Sosnowski

Summary: The aim of this experiment was to investigate the effect of the titanium-based stimulator Tytanit on the fibrous fractions, cellulose, and hemicellulose content of alfalfa and clover cell walls. The results showed that the stimulator altered the fibrous fractions content in plant cell walls, but had no significant effect on Relative Feed Value.

AGRICULTURE-BASEL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

CryoEM reconstructions of membrane proteins solved in several amphipathic solvents, nanodisc, amphipol and detergents, yield amphipathic belts of similar sizes corresponding to a common ordered solvent layer

Veronica Zampieri, Alexia Gobet, Xavier Robert, Pierre Falson, Vincent Chaptal

Summary: Researchers have found that amphipathic belts surrounding membrane proteins can be visualized in 3D reconstructions using cryo-EM, and the nature of the amphipathic compound does not influence the size of the belt. These observations illustrate that the observed belt corresponds to the minimum ordered layer around membrane proteins in 3D reconstructions.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

添加到收藏夹

Article Clinical Neurology

The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery

Dolly Reyes-Dumeyer, Kelley Faber, Badri Vardarajan, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak-Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux

Summary: The NIA-LOAD FBS is the largest collection of familial Alzheimer's disease worldwide, and it focuses on studying the genetic etiology of the disease. The study has identified the association between APOE genotype and age-at-onset, and it has also found novel and known variants associated with early- and late-onset Alzheimer's disease and frontotemporal dementia.

ALZHEIMERS & DEMENTIA (2022)

添加到收藏夹

Article Clinical Neurology

18F-MK-6240 tau-PET in genetic frontotemporal dementia

Jake P. Levy, Gleb Bezgin, Melissa Savard, Tharick A. Pascoal, Elizabeth Finger, Robert Laforce, Joshua A. Sonnen, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto, Simon Ducharme

Summary: This study demonstrates promising potential for F-18-MK-6240 PET tracer in detecting tau in genetic frontotemporal dementia, with significant binding in P301L and R406W MAPT mutation subjects and no non-specific binding observed. The results suggest that a positive F-18-MK-6240 tau-PET does not necessarily indicate Alzheimer's disease diagnosis and may have applications in tauopathies beyond Alzheimer's.

BRAIN (2022)

添加到收藏夹

Article Immunology

MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes

Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy

Summary: This study investigated the expression levels of miR-210 in astrocytes under ischemic stroke and in vitro stress conditions, and found its association with the astrocytic response to disease and neuroprotection.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Article Medicine, General & Internal

Association of Antihypertensives That Stimulate vs Inhibit Types 2 and 4 Angiotensin II Receptors With Cognitive Impairment

Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress

Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.

JAMA NETWORK OPEN (2022)

添加到收藏夹

Article Neurosciences

Correlates of Conversion from Mild Cognitive Impairment to Dementia with Lewy Bodies: Data from the National Alzheimer's Coordinating Center

Sarah Payne, Jane B. Shofer, Andrew Shutes-David, Ge Li, Adrienne Jankowski, Pamela Dean, Debby Tsuang

Summary: This study aims to identify baseline characteristics in individuals with mild cognitive impairment (MCI) that correlate with eventual conversion to DLB or AD. The strongest predictors of conversion to DLB were nonamnestic MCI, multidomain MCI, male sex, and presence of nighttime behaviors.

JOURNAL OF ALZHEIMERS DISEASE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy, Antonio F. Pardinas, Ting Qi, Georgia Panagiotaropoulou, Swapnil Awasthi, Tim B. Bigdeli, Julien Bryois, Chia-Yen Chen, Charlotte A. Dennison, Lynsey S. Hall, Max Lam, Kyoko Watanabe, Oleksandr Frei, Tian Ge, Janet C. Harwood, Frank Koopmans, Sigurdur Magnusson, Alexander L. Richards, Julia Sidorenko, Yang Wu, Jian Zeng, Jakob Grove, Minsoo Kim, Zhiqiang Li, Georgios Voloudakis, Wen Zhang, Mark Adams, Ingrid Agartz, Elizabeth G. Atkinson, Esben Agerbo, Mariam Al Eissa, Margot Albus, Madeline Alexander, Behrooz Z. Alizadeh, Koksal Alptekin, Thomas D. Als, Farooq Amin, Volker Arolt, Manuel Arrojo, Lavinia Athanasiu, Maria Helena Azevedo, Silviu A. Bacanu, Nicholas J. Bass, Martin Begemann, Richard A. Belliveau, Judit Bene, Beben Benyamin, Sarah E. Bergen, Giuseppe Blasi, Julio Bobes, Stefano Bonassi, Alice Braun, Rodrigo Affonseca Bressan, Evelyn J. Bromet, Richard Bruggeman, Peter F. Buckley, Randy L. Buckner, Jonas Bybjerg-Grauholm, Wiepke Cahn, Murray J. Cairns, Monica E. Calkins, Vaughan J. Carr, David Castle, Stanley Catts, Kimberley D. Chambert, Raymond C. K. Chan, Boris Chaumette, Wei Cheng, Eric F. C. Cheung, Siow Ann Chong, David Cohen, Angele Consoli, Quirino Cordeiro, Javier Costas, Charles Curtis, Michael Davidson, Kenneth L. Davis, Lieuwe de Haan, Franziska Degenhardt, Lynn E. DeLisi, Ditte Demontis, Faith Dickerson, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Jubao Duan, Giuseppe Ducci, Frank Dudbridge, Johan G. Eriksson, Lourdes Fananas, Stephen Faraone, Alessia Fiorentino, Andreas Forstner, Josef Frank, Nelson B. Freimer, Menachem Fromer, Alessandra Frustaci, Ary Gadelha, Giulio Genovese, Elliot S. Gershon, Marianna Giannitelli, Ina Giegling, Paola Giusti-Rodriguez, Stephanie Godard, Jacqueline Goldstein, Javier Gonzalez Penas, Ana Gonzalez-Pinto, Srihari Gopal, Jacob Gratten, Michael F. Green, Tiffany A. Greenwood, Olivier Guillin, Sinan Guloksuz, Raquel E. Gur, Ruben C. Gur, Blanca Gutierrez, Eric Hahn, Hakon Hakonarson, Vahram Haroutunian, Annette M. Hartmann, Carol Harvey, Caroline Hayward, Frans A. Henskens, Stefan Herms, Per Hoffmann, Daniel P. Howrigan, Masashi Ikeda, Conrad Iyegbe, Inge Joa, Antonio Julia, Anna K. Kahler, Tony Kam-Thong, Yoichiro Kamatani, Sena Karachanak-Yankova, Oussama Kebir, Matthew C. Keller, Brian J. Kelly, Andrey Khrunin, Sung-Wan Kim, Janis Klovins, Nikolay Kondratiev, Bettina Konte, Julia Kraft, Michiaki Kubo, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Agung Kusumawardhani, Hana Kuzelov A-Ptackova, Stefano Landi, Laura C. Lazzeroni, Phil H. Lee, Sophie E. Legge, Douglas S. Lehrer, Rebecca Lencer, Bernard Lerer, Miaoxin Li, Jeffrey Lieberman, Gregory A. Light, Svetlana Limborska, Chih-Min Liu, Jouko Lonnqvist, Carmel M. Loughland, Jan Lubinski, Jurjen J. Luykx, Amy Lynham, Milan Macek, Andrew Mackinnon, Patrik K. E. Magnusson, Brion S. Maher, Wolfgang Maier, Dolores Malaspina, Jacques Mallet, Stephen R. Marder, Sara Marsal, Alicia R. Martin, Lourdes Martorell, Manuel Mattheisen, Robert W. McCarley, Colm McDonald, John J. McGrath, Helena Medeiros, Sandra Meier, Bela Melegh, Ingrid Melle, Raquelle Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Marina Mitjans, Espen Molden, Esther Molina, Maria Dolores Molto, Valeria Mondelli, Carmen Moreno, Christopher P. Morley, Gerard Muntane, Kieran C. Murphy, Inez Myin-Germeys, Igor Nenadic, Gerald Nestadt, Liene Nikitina-Zake, Cristiano Noto, Keith H. Nuechterlein, Niamh Louise O'Brien, F. Anthony O'Neill, Sang-Yun Oh, Ann Olincy, Vanessa Kiyomi Ota, Christos Pantelis, George N. Papadimitriou, Mara Parellada, Tiina Paunio, Renata Pellegrino, Sathish Periyasamy, Diana O. Perkins, Bruno Pfuhlmann, Olli Pietilainen, Jonathan Pimm, David Porteous, John Powell, Diego Quattrone, Digby Quested, Allen D. Radant, Antonio Rampino, Mark H. Rapaport, Anna Rautanen, Abraham Reichenberg, Cheryl Roe, Joshua L. Roffman, Julian Roth, Matthias Rothermundt, Bart P. F. Rutten, Safaa Saker-Delye, Veikko Salomaa, Julio Sanjuan, Marcos Leite Santoro, Adam Savitz, Ulrich Schall, Rodney J. Scott, Larry J. Seidman, Sally Isabel Sharp, Jianxin Shi, Larry J. Siever, Engilbert Sigurdsson, Kang Sim, Nora Skarabis, Petr Slominsky, Hon-Cheong So, Janet L. Sobell, Erik Soderman, Helen J. Stain, Nils Eiel Steen, Agnes A. Steixner-Kumar, Elisabeth Stogmann, William S. Stone, Richard E. Straub, Fabian Streit, Eric Strengman, T. Scott Stroup, Mythily Subramaniam, Catherine A. Sugar, Jaana Suvisaari, Dragan M. Svrakic, Neal R. Swerdlow, Jin P. Szatkiewicz, Thi Minh Tam Ta, Atsushi Takahashi, Chikashi Terao, Florence Thibaut, Draga Toncheva, Paul A. Tooney, Silvia Torretta, Sarah Tosato, Gian Battista Tura, Bruce Turetsky, Alp Ucok, Arne Vaaler, Therese van Amelsvoort, Ruud van Winkel, Juha Veijola, John Waddington, Henrik Walter, Anna Waterreus, Bradley T. Webb, Mark Weiser, Nigel M. Williams, Stephanie H. Witt, Brandon K. Wormley, Jing Qin Wu, Zhida Xu, Robert Yolken, Clement C. Zai, Wei Zhou, Feng Zhu, Fritz Zimprich, Muhammad Ayub, Christian Benner, Alessandro Bertolino, Donald W. Black, Nicholas J. Bray, Gerome Breen, Nancy G. Buccola, William F. Byerley, Wei J. Chen, C. Robert Cloninger, Benedicto Crespo-Facorro, Gary Donohoe, Robert Freedman, Cherrie Galletly, Michael J. Gandal, Massimo Gennarelli, David M. Hougaard, Hai-Gwo Hwu, Assen Jablensky, Steven A. McCarroll, Jennifer L. Moran, Ole Mors, Preben B. Mortensen, Bertram Muller-Myhsok, Amanda L. Neil, Merete Nordentoft, Michele T. Pato, Tracey L. Petryshen, Matti Pirinen, Ann E. Pulver, Thomas G. Schulze, Jeremy M. Silverman, Jordan W. Smoller, Eli A. Stahl, Debby W. Tsuang, Elisabet Vilella, Shi-Heng Wang, Shuhua Xu, Rolf Adolfsson, Celso Arango, Bernhard T. Baune, Sintia Iole Belangero, Anders D. Borglum, David Braff, Elvira Bramon, Joseph D. Buxbaum, Dominique Campion, Jorge A. Cervilla, Sven Cichon, David A. Collier, Aiden Corvin, David Curtis, Marta Di Forti, Enrico Domenici, Hannelore Ehrenreich, Valentina Escott-Price, Tonu Esko, Ayman H. Fanous, Anna Gareeva, Micha Gawlik, Pablo Gejman, Michael Gill, Stephen J. Glatt, Vera Golimbet, Kyung Sue Hong, Christina M. Hultman, Steven E. Hyman, Nakao Iwata, Erik G. Jonsson, Rene S. Kahn, James L. Kennedy, Elza Khusnutdinova, George Kirov, James A. Knowles, Marie-Odile Krebs, Claudine Laurent-Levinson, Jimmy Lee, Todd Lencz, Douglas F. Levinson, Qingqin S. Li, Jianjun Liu, Anil K. Malhotra, Dheeraj Malhotra, Andrew McIntosh, Andrew McQuillin, Paulo R. Menezes, Vera A. Morgan, Derek W. Morris, Bryan J. Mowry, Robin M. Murray, Vishwajit Nimgaonkar, Markus M. Nothen, Roel A. Ophoff, Sara A. Paciga, Aarno Palotie, Carlos N. Pato, Shengying Qin, Marcella Rietschel, Brien P. Riley, Margarita Rivera, Dan Rujescu, Meram C. Saka, Alan R. Sanders, Sibylle G. Schwab, Alessandro Serretti, Pak C. Sham, Yongyong Shi, David St Clair, Hreinn Stefansson, Kari Stefansson, Ming T. Tsuang, Jim van Os, Marquis P. Vawter, Daniel R. Weinberger, Thomas Werge, Dieter B. Wildenauer, Xin Yu, Weihua Yue, Peter A. Holmans, Andrew J. Pocklington, Panos Roussos, Evangelos Vassos, Matthijs Verhage, Peter M. Visscher, Jian Yang, Danielle Posthuma, Ole A. Andreassen, Kenneth S. Kendler, Michael J. Owen, Naomi R. Wray, Mark J. Daly, Hailiang Huang, Benjamin M. Neale, Patrick F. Sullivan, Stephan Ripke, James T. R. Walters, Michael C. O'Donovan

Summary: In this study, a two-stage genome-wide association study was conducted to identify common variants associated with schizophrenia. The results revealed 287 distinct genomic loci and 120 genes likely to be involved in the development of schizophrenia. This research provides valuable insights into the pathophysiology of schizophrenia and offers a resource for further mechanistic studies.

NATURE (2022)

添加到收藏夹

Article Genetics & Heredity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez, Fahri Kucukali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar De Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo Garcia-Gonzalez, Carla Abdelnour, Emilio Alarcon-Martin, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Victoria Alvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antunez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belen Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Celine Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merce Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossu, Geir Brathen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Burger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Genevieve Chene, Jaeyoon Chung, Michael L. Cuccaro, Roberta Cecchetti, Laura Cervera-Carles, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anais Corma-Gomez, Emanuele Costantini, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean-Francois Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes, Lot D. De Witte, Stephanie Debette, Jurgen Deckert, Teodoro del Ser, Nicola Denning, Anita Destefano, Martin Dichgans, Janine Diehl-Schmid, Monica Diez-Fairen, Paolo Dionigi Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Duzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Tagliavini Fabrizio, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernandez-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fliessbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macias, Maria J. Bullido, Ana Frank-Garcia, Lutz Froelich, Brian Fulton-Howard, Daniela Galimberti, Jose Maria Garcia-Alberca, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M. Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio Gonzalez-Perez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grunblatt, Michelle Grunin, Vilmundur Gudnason, Tamar Guetta-Baranes, Annakaisa Haapasalo, Georgios Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann-Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernandez, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah R. Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Stahlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda B. Kuzma, Carmen Lage, Erika J. Laukka, Lenore Launer, Alessandra Lauria, Chien-Yueh Lee, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleo, William Longstreth, Oscar Lopez, Adolfo Lopez de Munain, Seth Love, Malin Lowemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macias, Catherine A. Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquie, Rachel Marshall, Eden R. Martin, Angel Martin Montes, Carmen Martinez Rodriguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menendez-Gonzalez, Pablo Mir, Susanne Moebus, Merel Mol, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan, Thomas Mosley, Markus M. Nothen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gael Nicolas, Borge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Gina Peloso, Alba Perez-Cordon, Jordi Perez-Tur, Pierre Pericard, Oliver Peters, Yolande A. L. Pijnenburg, Juan A. Pineda, Gerard Pinol-Ripoll, Laudia Pisanu, Thomas Polak, Julius Popp, Danielle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Ines Quintela, Jesper Qvist Thomassen, Alberto Rabano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M. Real, Marcel J. T. Reinders, Christiane Reitz, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez, Arvid Rongve, Irene Rosas Allende, Maitee Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, Maria Eugenia Saez, Paraskevi Sakka, Ingvild Saltvedt, Maria Bernal Sanchez-Arjona, Florentino Sanchez-Garcia, Pascual Sanchez Juan, Raquel Sanchez-Valle, Sigrid B. Sando, Chloe Sarnowski, Claudia L. Satizabal, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott, Geir Selbaek, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A. Shadrin, Olivia Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Yeunjoo Song, Sandro Sorbi, Oscar Sotolongo-Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluis Tarraga, Niccolo Tesi, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjaerg-Hansen, Andre Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares, Christine Van Broeckhoven, Jeffery Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sebastien Vidal, Jonathan Vogelgsang, Martin Vyhnalek, Michael Wagner, David Wallon, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, Miren Zulaica, Lindsay A. Farrer, Bruce M. Psaty, Mohsen Ghanbari, Towfique Raj, Perminder Sachdev, Karen Mather, Frank Jessen, M. Arfan Ikram, Alexandre de Mendonca, Jakub Hort, Magda Tsolaki, Margaret A. Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimon, Jean-Francois Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustin Ruiz, Alfredo Ramirez, Jean-Charles Lambert

Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.

NATURE GENETICS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam C. Naj, Nilufer Ertekin-Taner, Todd E. Golde, Leroy Hood, Nathan D. Price

Summary: This study investigated the phenotypic associations of late-onset Alzheimer's Disease (AD) genetic variants using a large-scale GWAS meta-analysis dataset. The results revealed significant associations between the genetic variants and blood markers, lipid metabolism, and immune response systems, suggesting their potential involvement in early-stage biological pathways to AD.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Neurosciences

Regional and age-related diversity of human mature oligodendrocytes

Moein Yaqubi, Julia Xiao Xuan Luo, Salma Baig, Qiao-Ling Cui, Kevin Petrecca, Haritha Desu, Catherine Larochelle, Elia Afanasiev, Jeffery A. Hall, Roy Dudley, Myriam Srour, Lisbet Haglund, Jean Ouellet, Miltiadis Georgiopoulos, Carlo Santaguida, Joshua A. Sonnen, Luke M. Healy, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel

Summary: Morphological and molecular studies have shown that there is heterogeneity within the oligodendrocyte population in the human central nervous system. Through single-cell RNA sequencing, this study identified transcriptionally distinct subpopulations of mature oligodendrocytes in different regions and at different ages. The findings suggest that the heterogeneity of oligodendrocyte populations may be influenced by developmental and environmental factors.

GLIA (2022)

添加到收藏夹

Article Neurosciences

Sex Modifies the Associations of APOE ε4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease

Andrew S. Dissanayake, Yu Bin Tan, Christopher R. Bowie, Meryl A. Butters, Alastair J. Flint, Damien Gallagher, Angela C. Golas, Nathan Herrmann, Zahinoor Ismail, James L. Kennedy, Sanjeev Kumar, Krista L. Lanctot, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji, Michael Tau, Anika Maraj, Nathan W. Churchill, Debby Tsuang, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer

Summary: This study suggests that the gene APOE ε4 may be more strongly associated with neuropsychiatric symptom burden in females with Alzheimer's disease, especially in APOE ε4/4 females. This finding provides insights for further investigation into the underlying mechanisms of this association.

JOURNAL OF ALZHEIMERS DISEASE (2022)

添加到收藏夹

Article Clinical Neurology

Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots

Oswaldo Lorenzo-Betancor, Livio Galosi, Laura Bonfili, Anna Maria Eleuteri, Valentina Cecarini, Ranieri Verin, Fabrizio Dini, Anna-Rita Attili, Sara Berardi, Lucia Biagini, Patrizia Robino, Maria Cristina Stella, Dora Yearout, Michael O. Dorschner, Debby W. Tsuang, Giacomo Rossi, Cyrus P. Zabetian

Summary: This study described the genetic and pathological findings of three Yellow-crowned parrot siblings with a severe neurodegenerative phenotype. The brains of these parrots exhibited Lewy body-like pathology and a homozygous missense mutation in the CADPS2 gene was identified. Further investigation of this gene may provide important insights into the pathophysiology of Lewy body disorders.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci

Richard Sherva, Rui Zhang, Nathan Sahelijo, Gyungah Jun, Tori Anglin, Catherine Chanfreau, Kelly Cho, Jennifer R. R. Fonda, J. Michael Gaziano, Kelly M. M. Harrington, Yuk-Lam Ho, William S. S. Kremen, Elizabeth Litkowski, Julie Lynch, Zoe Neale, Panos Roussos, David Marra, Jesse Mez, Mark W. W. Miller, David H. H. Salat, Debby Tsuang, Erika Wolf, Qing Zeng, Matthew S. S. Panizzon, Victoria C. C. Merritt, Lindsay A. A. Farrer, Richard L. L. Hauger, Mark W. W. Logue

Summary: This study examined the genetics of dementia in an African descent cohort using data from the Million Veteran Program, and identified significant genetic variants associated with Alzheimer's Disease and related dementias in this population. The findings highlight the importance of including diverse populations in genetic studies to improve our understanding of AD pathophysiology and reduce health disparities.

MOLECULAR PSYCHIATRY (2023)

添加到收藏夹

Article Psychology, Clinical

Linking Self-Perceived Cognitive Functioning Questionnaires Using Item Response Theory: The Subjective Cognitive Decline Initiative

Laura A. Rabin, Sietske A. M. Sikkes, Douglas Tommet, Richard N. Jones, Paul K. Crane, Milushka M. Elbulok-Charcape, Mark A. Dubbelman, Rebecca Koscik, Rebecca E. Amariglio, Rachel F. Buckley, Merce Boada, Gael Chetelat, Bruno Dubois, Kathryn A. Ellis, Katherine A. Gifford, Angela L. Jefferson, Frank Jessen, Sterling Johnson, Mindy J. Katz, Richard B. Lipton, Tobias Luck, Eleni Margioti, Paul Maruff, Jose Luis Molinuevo, Audrey Perrotin, Ronald C. Petersen, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Steffi G. Riedel-Heller, Shannon L. Risacher, Octavio Rodriguez-Gomez, Perminder S. Sachdev, Andrew J. Saykin, Nikolaos Scarmeas, Colette Smart, Beth E. Snitz, Reisa A. Sperling, Vanessa Taler, Wiesje M. van der Flier, Argonde C. van Harten, Michael Wagner, Steffen Wolfsgruber

Summary: This study aimed to link self-perceived cognitive functioning data from international aging studies using item response theory. The results demonstrated that a single-factor structure was reasonable for the latent trait, and identified top items that made the greatest contribution to measurement precision. This allows for joint or pooled analyses across international studies and may lead to the development of new self-perceived cognitive functioning questionnaires.

NEUROPSYCHOLOGY (2023)

添加到收藏夹

Article Psychology, Clinical

Measurement Precision Across Cognitive Domains in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Data Set

Paul K. Crane, Seo-Eun Choi, Michael Lee, Phoebe Scollard, R. Elizabeth Sanders, Brandon Klinedinst, Connie Nakano, Emily H. Trittschuh, Jesse Mez, Andrew J. Saykin, Laura E. Gibbons, Chun Wang, Dan Mungas, Ruoyi Zhu, Nancy S. Foldi, Melissa Lamar, Roos Jutten, Sietske A. M. Sikkes, Evan Grandoit, Laura A. Rabin, Richard N. Jones, Doug Tommet, Shubhabrata Mukherjee

Summary: Objective of this study is to demonstrate measurement precision of cognitive domains in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set. The study used data from participants with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) to calibrate scores for memory, executive function, language, and visuospatial functioning. The results showed variations in measurement precision across cognitive domains in ADNI, with memory having the highest standard error of measurement and visuospatial having the lowest.

NEUROPSYCHOLOGY (2023)

添加到收藏夹

Meeting Abstract Geriatrics & Gerontology

REMOTE ASSESSMENT OF COGNITIVE AGING AND MENTAL HEALTH IN OLDER BLACK AMERICANS

Debby Tsuang, Ciara DeGraff, Sarah Payne, Adrienne Jankowski, Karl Brown, Katie Wilson, Andrew Shutes-David

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2022)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.