Article
Chemistry, Analytical
Mengjie Li, Yang Chen, You Zhou, Jiapeng Wang, Ying Wu
Summary: A sensitive photoelectrochemical biosensor was developed for the detection of potential heavy metal pollutant mercury ion. The biosensor, based on Nb.BtsI-assisted Hg2+ cycle strategy and MB-dsDNA intercalation complex, exhibited low background noise, high sensitivity, and excellent accuracy.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Xingxing Guan, Xunxun Deng, Jie Song, Xiuyun Wang, Shuo Wu
Summary: A highly sensitive PEC immunoassay sensor was constructed using two forms of polydopamine (PDA) as the photoelectrode-modified material and signal reporting label, showing potential application prospects for point-of-care assay of various tumor markers. The PDA film extended light absorption range and amplified photocurrent response, while the PDA nanospheres exhibited multiple quenching effects, resulting in decreased photocurrent signal.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Qingyu Wang, Jingliang Liu, Shuaibing Yu, Haobo Sun, Lei Wang, Lianzhi Li, Jinming Kong, Xueji Zhang
Summary: A peptide-based biosensor was developed for sensitive and selective analysis of matrix metalloproteinase 2 (MMP-2) using a signal amplification strategy. The biosensor showed good performance in determining MMP-2 in human serum samples and has great potential in clinical analysis applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jiao Yang, Shilan Fu, Fang Luo, Longhua Guo, Bin Qiu, Zhenyu Lin
Summary: A novel homogeneous PEC biosensor based on target-responsive hydrogels has been developed for sensitive detection of miRNA-155. By utilizing a cascade amplification strategy, the biosensor exhibits high sensitivity with a low detection limit of 0.41 fM and a wide linear range from 1.0 fM to 100 pM. The simplicity, reproducibility, and storage stability of the prepared hydrogels make this biosensing platform versatile for diverse target detection.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Multidisciplinary
Wang He, Bin Qiao, Fengzhen Li, Lisha Pan, Delun Chen, Yang Cao, Jinchun Tu, Xiaohong Wang, Chuanzhu Lv, Qiang Wu
Summary: A novel electrochemical biosensor was developed for ultrasensitive Hg2+ detection using a triple signal amplification strategy involving DNA dual cycle, organic-inorganic hybrid nanoflowers, and gold nanoparticle probe. The biosensor exhibited high stability, sensitivity, and specificity, with detection levels improved by up to seven orders of magnitude compared to WHO standards. This versatile strategy could be easily adapted for detecting other hazardous heavy metals and nucleic acids.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Jun Yao, Xiang Zeng
Summary: Nanosheets of anatase TiO2 and CdS quantum dots modified with thioglycolic acid were used to prepare a heterojunction photoelectrochemical biosensor, which showed improved light capture ability and carrier migration, leading to enhanced sensitivity and selectivity for the detection of chloramphenicol. The biosensor exhibited good reproducibility and stability under optimal conditions, with a linear response range of 10-10,000 pM and a low limit of detection (LOD) of 0.23 pM.
Article
Chemistry, Analytical
Danli Hu, Haiyan Cui, Xinyang Wang, Fang Luo, Bin Qiu, Weicheng Cai, Hui Huang, Jian Wang, Zhenyu Lin
Summary: An innovative photo-electrochemical aptasensor based on Au/GaN photoelectrode has been developed for cancer biomarker detection. The sensor combines the characteristics of Au promoting charge transfer and aptamer high selectivity, showing high sensitivity and selectivity in detecting AFP concentration ranging from 1.0-150 ng/mL.
ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Yuecan Zhao, Junzhu Xiang, Hao Cheng, Xiaojuan Liu, Feng Li
Summary: The development of a novel flexible photoelectrochemical biosensor for miRNA determination showed promising potential for ultrasensitive disease diagnosis. The biosensor exhibited excellent analytical performance, selectivity, stability, flexibility, and practical applicability, making it a valuable tool for bioassays and early disease detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Linfei Xiong, Zhaohui Li, Guangming Li, Huangxian Ju
Summary: This study developed a DNA dendrimer for loading signal molecules and constructing an amplified electrochemical immunosensing method. The DNA dendrimer was self-assembled by hybridizing complementary oligonucleotides, enabling signal amplification. The method showed excellent performance in analyzing prostate specific antigen as a model analyte.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Chenxin Fang, Yuxing Yang, Shuhao Zou, Ping Ouyang, Yang Qing, Jialun Han, Haiyu Li, Zhencui Wang, Jie Du
Summary: This study aims to develop a label-free sensing strategy for highly sensitive detection of miRNA-21. The co-action of DNAzymes and double-hairpin molecular beacons is utilized to enhance the fluorescence signal and detect miRNA-21.
Article
Chemistry, Analytical
Cuizhong Zhang, Liya Zhou, Jinyun Peng
Summary: A photoelectrochemical (PEC) KAN aptasensor was developed based on a Schottky junction and sensitization strategy, using a CuO/Pd nanocomposite as the substrate and aptamer immobilization to improve response. This sensor exhibited a low detection limit of 20 pM and a wide linear range of 0.1-500 nM, showing great potential for various applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yajuan Liu, Simin Ai, Ruo Yuan, Hongyan Liu
Summary: In this study, a photoelectrochemical biosensor based on defective Se-doped In2S3 nanostructure was designed for the ultrasensitive detection of chloramphenicol. Se doping improved the separation of photocarriers and the absorption of light, resulting in enhanced photocurrent. Additionally, a target-triggered recycling signal amplification procedure further improved the detection sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yuting Yan, Fangfang Zhou, Qian Wang, Yue Huang
Summary: A sensitive electrochemical biosensor is developed using Cu2+-modulated signal amplification for the detection of quinolones. The presence of target quinolones inhibits the activity of Cu2+-specific DNAzyme, resulting in the amplification of electrochemical signal positively correlated with the concentration of quinolones. The biosensor exhibits a good linear relationship and low limit of detection, making it suitable for the detection of quinolones in foodstuff samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Ruiwen Shu, Weijie Li, Xian Zhou, Dongdong Tian, Gengyuan Zhang, Ying Gan, Jianjun Shi, Jie He
JOURNAL OF ALLOYS AND COMPOUNDS
(2018)
Article
Materials Science, Multidisciplinary
Ruiwen Shu, Gengyuan Zhang, Jiabin Zhang, Xin Wang, Meng Wang, Ying Gan, Jianjun Shi, Jie He
Article
Nanoscience & Nanotechnology
Jian-Jun Shi, Yan Wang, Li-Rong Meng, Jing-Chun Zhu, Rui-Wen Shu, Jie He
Article
Chemistry, Analytical
Jian-Jun Shi, Jing-Chun Zhu, Ming Zhao, Yan Wang, Ping Yang, Jie He
Article
Materials Science, Multidisciplinary
Gengyuan Zhang, Ruiwen Shu, Yan Xie, Haitao Xia, Ying Gan, Jianjun Shi, Jie He
Article
Electrochemistry
Ping Yang, Lina Feng, Jun Hu, Wenqin Ling, Shaohua Wang, Jianjun Shi, Zhangfu Yang, Fengwu Wang
Article
Cell Biology
Miriam Hernandez-Morales, Trisha Shang, Jingjia Chen, Victor Han, Chunlei Liu
Article
Environmental Sciences
Jianjun Shi, Xinyi Zhang, Qianqian Zhang, Ping Yang
Summary: This work developed a magnetic molecularly imprinted polymer-based quantum dots electrochemiluminescent probe for the ultrasensitive detection of bisphenol A. The sensor showed high sensitivity, a wide linear range, and a low detection limit, performing well in the detection of BPA in actual water samples with high recovery rates.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steven Cao, Hongjiang Wei, Jingjia Chen, Chunlei Liu
Summary: The study investigates the symmetry constraint in susceptibility tensor imaging, finding that relaxing the constraint can improve tensor estimation, especially in suppressing noise and artifacts.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Jingjia Chen, Nan-Jie Gong, Khallil Taverna Chaim, Maria Concepcion Garcia Otaduy, Chunlei Liu
Summary: DECOMPOSE-QSM method is developed to decompose bulk susceptibility measured with QSM into sub-voxel paramagnetic and diamagnetic components based on a three-pool complex signal model. By solving for linear and nonlinear parameters in the model, Paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS) maps are constructed to represent the sub-voxel compartments, showing visually enhanced contrast between brain structures comparing to threshold QSM in initial in vivo investigation of human brain images.
Article
Nanoscience & Nanotechnology
Jian-Jun Shi, Zhe Wang, Yan Wang, Rui-Wen Shu, Ping Yang
Summary: A photoelectrochemical sensor has been developed for the detection of the polycyclic aromatic hydrocarbon pollutant benzo[a]pyrene (BaP). The sensor demonstrates high sensitivity and selectivity and utilizes a nanocomposite material to enhance the photocurrent signal.
MICRO & NANO LETTERS
(2022)
Article
Biochemical Research Methods
Victor Han, Jianshu Chi, Tanya Deniz Ipek, Jingjia Chen, Chunlei Liu
Summary: Excitation in MRI can occur through traditional single-photon excitation or multiphoton excitation when multiple radiofrequencies are employed. Although multiphoton excitation has been known in NMR, its exploration in MRI has been limited. This study presents and demonstrates the principles of multiphoton selective RF pulse design in imaging, specifically considering radiofrequency fields in both the traditional xy-direction and nontraditional z-direction. The use of multiphoton excitation allows for simultaneous multislice excitation with lower tissue heating compared to traditional methods.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Neurosciences
Maruf Ahmed, Jingjia Chen, Arvin Arani, Matthew L. Senjem, Petrice M. Cogswell, Clifford R. Jack, Chunlei Liu
Summary: A compartmentalized susceptibility MRI imaging technique has the potential to track pathological neurodegeneration in Alzheimer's Disease. This technique provides comprehensive information about the disease mechanism and can be used to track pathological changes in different tissue types and regions of the brain.
Article
Neurosciences
Dimitrios G. Gkotsoulias, Roland Mueller, Carsten Jaeger, Torsten Schlumm, Toralf Mildner, Cornelius Eichner, Andre Pampel, Jennifer Jaffe, Tobias Graessle, Niklas Alsleben, Jingjia Chen, Catherine Crockford, Roman Wittig, Chunlei Liu, Harald E. Moeller
Summary: Uncovering brain-tissue microstructure, including axonal characteristics, is a major focus in neuroimaging research. This study proposes a novel phase-based methodology, called high angular resolution susceptibility imaging (HARSI), to estimate orientation distribution functions (ODFs). Results show that HARSI can provide information on whole-brain fiber architecture and potentially offer complementary microstructural information compared to high angular resolution diffusion imaging (HARDI) techniques.
Article
Physics, Fluids & Plasmas
Liu-Suo Wang, Ning-Xi Li, Jing-Jia Chen, Xiao-Peng Zhang, Feng Liu, Wei Wang