Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Emma Barinas-Mitchell, Yuefang Chang, Howard Aizenstein, Carol A. Derby, Pauline M. Maki
Summary: This study examined the association between carotid atherosclerosis and brain white matter hyperintensities in midlife women, and found that higher carotid intima media thickness is associated with greater WMH volume. The association is stronger among APOE ε4-positive women, indicating the importance of vascular risk for midlife brain health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Hui Shi, Mei-Ling Ge, Birong Dong, Qian-Li Xue
Summary: Higher Framingham CVD risk score was associated with a greater risk of incident frailty among Chinese older adults in this study. However, this association was no longer significant after adjusting for chronological age.
Article
Clinical Neurology
Michelle C. Johansen, Rebecca F. Gottesman, Brian G. Kral, Dhananjay Vaidya, Lisa R. Yanek, Lewis C. Becker, Diane M. Becker, Paul Nyquist
Summary: In healthy high-risk individuals, the presence and volume of coronary artery plaque are associated with larger WMH volumes, appearing the strongest for periventricular WMH. These findings in high-risk families suggest a disease relationship in 2 different vascular beds, possibly due to genetic predisposition.
Article
Clinical Neurology
Hui Jin, Xue Qin, Fanfan Zhao, Yuting Yan, Yu Meng, Zhenyu Shu, Xiangyang Gong
Summary: This study investigated the relationship between coronary artery calcium (CAC) and white matter hyperintensity (WMH) for diagnostic purposes. The findings indicate that patients with CAC have larger WMH volumes compared to those without calcium, and the volume of WMH significantly increases with higher CAC scores.
Article
Multidisciplinary Sciences
Sergio Grosu, Susanne Rospleszcz, Felix Hartmann, Mohamad Habes, Fabian Bamberg, Christopher L. Schlett, Franziska Galie, Roberto Lorbeer, Sigrid Auweter, Sonja Selder, Robin Buelow, Margit Heier, Wolfgang Rathmann, Katharina Mueller-Peltzer, Karl-Heinz Ladwig, Hans J. Grabe, Annette Peters, Birgit B. Ertl-Wagner, Sophia Stoecklein
Summary: By analyzing two independent population-based cohorts using machine learning methods, it was found that besides age and hypertension, prediabetes and social environmental factors may also play important roles in the development of cerebral white matter hyperintensities.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Nader Saki, Hossein Babaahmadi-Rezaei, Zahra Rahimi, Maedeh Raeisizadeh, Fateme Jorfi, Faeze Seif, Bahman Cheraghian, Hossien Ghaderi-Zefrehi, Maryam Rezaei
Summary: This cohort study examined the association between modifiable risk factors and Framingham risk score in the prediction of 10-year risk of cardiovascular diseases in an Arab community in Iran. Results showed that hypertension, smoking, physical activity, diabetes, cholesterol, and HDL were independently associated with the CVD risk in both genders. Hypertension and diabetes had the largest AUC values in men, while physical activity had the highest AUC value in women.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
X. Chen, Q. Tu, D. Wang, J. Liu, Y. Qin, Y. Zhang, Q. Xiang
Summary: The objective of this study was to evaluate the effectiveness of the China-PAR and Framingham risk score in predicting the 10-year risk of CVD in Chinese hypertensive patients. The study found that both models tended to overestimate the risk of CVD, and performed better in males in terms of calibration.
Review
Cardiac & Cardiovascular Systems
Hao Jin, Jianfeng Xu, Zheng Sui, Lili Wang
Summary: This meta-analysis evaluates the association between risk factors in the Framingham risk score (FRS) and anthracycline-induced cardiotoxicity in breast cancer patients. The study finds that hypertension, hyperlipidemia, diabetes, smoking, and obesity are associated with an increased risk of cardiac events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, Research & Experimental
Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei, Dagfinn Aune
Summary: This study aims to investigate the agreement and correlation between laboratory-based and office-based Framingham models for cardiovascular disease risk assessment. The results showed substantial agreement and strong correlation between the two models in both the overall population and different subgroups. The office-based model is more practical and reliable in countries with limited resources.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lin Jin, Jianxiong Chen, Lingheng Wu, Mengjiao Zhang, Jiali Sun, Cuiqin Shen, Lianfang Du, Dingqian Wang, Zhaojun Li
Summary: The relative importance of arterial stiffness in different cardiovascular disease (CVD) risk scores was verified in a large sample of Chinese women. Arterial stiffness showed significant positive correlations with CVD risk scores and exhibited higher importance in predicting risk scores compared to traditional risk factors. These findings suggest the potential use of arterial stiffness measurements in CVD risk assessment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Sazzli Shahlan Kasim, Nurulain Ibrahim, Sorayya Malek, Khairul Shafiq Ibrahim, Muhammad Firdaus Aziz, Cheen Song, Yook Chin Chia, Anis Safura Ramli, Kazuaki Negishi, Nafiza Mat Nasir
Summary: This study validated and compared the performance of four cardiovascular disease risk prediction models in an Asian population. The FRS and RPCE models showed good discrimination but poor calibration in predicting CVD risk. SCORE2 and RPCE outperformed their previous versions, SCORE and PCE, respectively.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Neurosciences
Liangqi Wang, Huandong Lin, Zehua Zhao, Lingyan Chen, Li Wu, Ting Liu, Jing Li, Chu-Chung Huang, Yifeng Peng, Chun-Yi Zac Lo, Xin Gao
Summary: White matter hyperintensity (WMH) is associated with vascular hemodynamic alterations and reflects white matter injury. This study investigated the sex difference in tract-specific WMH and the relationship between high blood pressure (BP) and WMH in a Chinese population. The results showed that men had higher WMH in most white matter tracts compared to women. High systolic blood pressure (SBP) and pulse pressure (PP) were associated with lower WMH burden in women, while high diastolic blood pressure (DBP) were associated with higher WMH burden in men.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Jasmin A. Keller, Ilse M. J. Kant, Arjen J. C. Slooter, Simone J. T. van Montfort, Mark A. van Buchem, Matthias J. P. van Osch, Jeroen Hendrikse, Jeroen de Bresser
Summary: This study investigated the association between cardiovascular risk factors and WMH markers in non-demented older adults. The results showed that hypertension was associated with irregular WMH shape, while diabetes was associated with WMH volume. Different cardiovascular risk factors may lead to different WMH MRI phenotypes.
NEUROIMAGE-CLINICAL
(2022)
Article
Multidisciplinary Sciences
Jong-Ho Park, Sun U. Kwon, Hyuk Sung Kwon, Sung Hyuk Heo
Summary: Prior ICH is associated with WMH severity, increasing the risk of both ischemic and hemorrhagic stroke. In patients with ICH, advanced WMH is linked to higher risk of ischemic stroke, while mild WMH is associated with increased risk of hemorrhagic stroke.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Sanjay M. Sisodiya, Christopher D. Whelan, Sean N. Hatton, Khoa Huynh, Andre Altmann, Mina Ryten, Annamaria Vezzani, Maria Eugenia Caligiuri, Angelo Labate, Antonio Gambardella, Victoria Ives-Deliperi, Stefano Meletti, Brent C. Munsell, Leonardo Bonilha, Manuela Tondelli, Michael Rebsamen, Christian Rummel, Anna Elisabetta Vaudano, Roland Wiest, Akshara R. Balachandra, Nuria Bargallo, Emanuele Bartolini, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Benoit Caldairou, Sarah J. A. Carr, Gianpiero L. Cavalleri, Fernando Cendes, Luis Concha, Patricia M. Desmond, Martin Domin, John S. Duncan, Niels K. Focke, Renzo Guerrini, Khalid Hamandi, Graeme D. Jackson, Neda Jahanshad, Reetta Kalviainen, Simon S. Keller, Peter Kochunov, Magdalena A. Kowalczyk, Barbara A. K. Kreilkamp, Patrick Kwan, Sara Lariviere, Matteo Lenge, Seymour M. Lopez, Pascal Martin, Mario Mascalchi, Jose C. V. Moreira, Marcia E. Morita-Sherman, Heath R. Pardoe, Jose C. Pariente, Kotikalapudi Raviteja, Cristiane S. Rocha, Raul Rodriguez-Cruces, Margitta Seeck, Mira K. H. G. Semmelroch, Benjamin Sinclair, Hamid Soltanian-Zadeh, Dan J. Stein, Pasquale Striano, Peter N. Taylor, Rhys H. Thomas, Sophia I. Thomopoulos, Dennis Velakoulis, Lucy Vivash, Bernd Weber, Clarissa Lin Yasuda, Junsong Zhang, Paul M. Thompson, Carrie R. McDonald
Summary: Epilepsy is a common and serious neurological disorder. MRI has been instrumental in advancing our understanding of epilepsy, and the ENIGMA-Epilepsy project aims to strengthen epilepsy research by increasing sample sizes and collaborating with scientists and clinicians.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Joosup Kim, Damien Easton, Henry Zhao, Skye Coote, Garveeta Sookram, Karen Smith, Michael Stephenson, Stephen Bernard, Mark W. Parsons, Bernard Yan, Patricia M. Desmond, Peter J. Mitchell, Bruce C. Campbell, Geoffrey A. Donnan, Stephen M. Davis, Dominique A. Cadilhac
Summary: The Melbourne Mobile Stroke Unit (MSU) provided prehospital acute stroke treatment including thrombolysis and endovascular thrombectomy. The cost-effectiveness analysis showed that MSU was estimated to cost an additional $30,982 per DALY avoided compared to standard care, but was considered cost-effective due to the earlier provision of reperfusion therapies.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Geriatrics & Gerontology
Catherine M. Said, Jennifer L. McGinley, Cassandra Szoeke, Barbara Workman, Keith D. Hill, Joanne E. Wittwer, Michael Woodward, Danny Liew, Leonid Churilov, Julie Bernhardt, Meg E. Morris
Summary: This study found that better cognition and a longer stay in rehabilitation were associated with a positive improvement in walking speed in older people. This suggests that in older individuals with complex health problems or multiple morbidities, cognitive ability and longer rehabilitation periods play a significant role in rehabilitation outcomes.
Review
Cell Biology
Anna G. M. Rojer, Keenan A. Ramsey, Elvira S. Amaral Gomes, Luke D'Andrea, Christopher Chen, Cassandra Szoeke, Carel G. M. Meskers, Esmee M. Reijnierse, Andrea B. Maier
Summary: The study revealed that higher levels of physical activity and lower levels of sedentary behavior are associated with better global cognitive function in older adults, especially moderate-to-vigorous activity and total physical activity are most beneficial for cognitive function.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Clinical Neurology
Vignan Yogendrakumar, Leonid Churilov, Peter J. Mitchell, Timothy J. Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Felix C. Ng, Helen M. Dewey, Tissa Wijeratne, Bernard Yan, Patricia M. Desmond, Mark W. Parsons, Geoffrey Alan Donnan, Stephen M. Davis, Bruce C. Campbell
Summary: In patients over 80 years old, TNK 0.25 mg/kg is associated with improved 90-day mRS and reduced mortality, while no significant differences were observed among different doses in patients under 80 years old.
Article
Clinical Neurology
Tina Kaffenberger, Vijay Venkatraman, Chris Steward, Vincent N. Thijs, Julie Bernhardt, Patricia M. Desmond, Bruce C. Campbell, Nawaf Yassi
Summary: A freely available stroke population-specific anatomical CT/MRI atlas has been developed, along with a reliable normalisation pipeline for clinical CT. The atlas can standardise stroke lesion segmentation and, together with the automated normalisation pipeline, can improve prediction tools for stroke patients based on analysis of existing and new datasets.
Article
Clinical Neurology
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Gargan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Richard Leigh, Bruce C. Campbell
Summary: This study investigates the relationship between BBB integrity, cerebral blood flow, and cerebral edema in patients who received acute reperfusion therapy. The results show that increased BBB permeability and reduced cerebral blood flow are significantly associated with cerebral edema.
Article
Clinical Neurology
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Richard Leigh, Bruce C. Campbell
Summary: This study found that the severity of tissue injury within the infarct, as determined by assessing the integrity of the blood-brain barrier (BBB), is independently associated with improved functional outcome in patients with ischemic stroke. In addition to reducing infarct volume, reperfusion may also improve clinical outcome by reducing tissue injury severity within the infarct.
Article
Psychiatry
Kai Sin Chin, Sanuji Gajamange, Patricia M. Desmond, Victor L. Villemagne, Christopher C. Rowe, Leonid Churilov, Nawaf Yassi, Rosie Watson
Summary: Amyloid-beta deposition in dementia with Lewy bodies is associated with early cortical thinning, but not hippocampal volume, which may represent an early Alzheimer's disease-related neurodegenerative process.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Benjamin Sinclair, Varduhi Cahill, Jarrel Seah, Andy Kitchen, Lucy E. Vivash, Zhibin Chen, Charles B. Malpas, Marie F. O'Shea, Patricia M. Desmond, Rodney J. Hicks, Andrew P. Morokoff, James A. King, Gavin C. Fabinyi, Andrew H. Kaye, Patrick Kwan, Samuel F. Berkovic, Meng Law, Terence J. O'Brien
Summary: Around 30% of drug-resistant MTLE patients do not achieve seizure freedom after surgery, and the success of surgery depends on careful patient selection and neuroimaging data. Machine learning techniques show potential in predicting surgical outcomes with acceptable to good accuracy.
Article
Clinical Neurology
Seymour M. Lopez, Leon M. Aksman, Neil P. Oxtoby, Sjoerd B. Vos, Jun Rao, Erik Kaestner, Saud Alhusaini, Marina Alvim, Benjamin Bender, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Leonardo Bonilha, Lorenzo Caciagli, Benoit Caldairou, Maria Eugenia Caligiuri, Angels Calvet, Fernando Cendes, Luis Concha, Estefania Conde-Blanco, Esmaeil Davoodi-Bojd, Christophe de Bezenac, Norman Delanty, Patricia M. Desmond, Orrin Devinsky, Martin Domin, John S. Duncan, Niels K. Focke, Sonya Foley, Francesco Fortunato, Marian Galovic, Antonio Gambardella, Ezequiel Gleichgerrcht, Renzo Guerrini, Khalid Hamandi, Victoria Ives-Deliperi, Graeme D. Jackson, Neda Jahanshad, Simon S. Keller, Peter Kochunov, Raviteja Kotikalapudi, Barbara A. K. Kreilkamp, Angelo Labate, Sara Lariviere, Matteo Lenge, Elaine Lui, Charles Malpas, Pascal Martin, Mario Mascalchi, Sarah E. Medland, Stefano Meletti, Marcia E. Morita-Sherman, Thomas W. Owen, Mark Richardson, Antonella Riva, Theodor Ruber, Ben Sinclair, Hamid Soltanian-Zadeh, Dan J. Stein, Pasquale Striano, Peter N. Taylor, Sophia I. Thomopoulos, Paul M. Thompson, Manuela Tondelli, Anna Elisabetta Vaudano, Lucy Vivash, Yujiang Wang, Bernd Weber, Christopher D. Whelan, Roland Wiest, Gavin P. Winston, Clarissa Lin Yasuda, Carrie R. McDonald, Daniel C. Alexander, Sanjay M. Sisodiya, Andre Altmann
Summary: Using data from a large multicenter cross-sectional cohort, this study found a sequential regional morphometric changes pattern in patients with mesial temporal lobe epilepsy and hippocampal sclerosis, which is correlated with clinical features. A disease progression model was reconstructed from cross-sectional MRI data, highlighting a sequence of MRI changes consistent with previous longitudinal studies.
Article
Clinical Neurology
Vignan Yogendrakumar, James Beharry, Leonid Churilov, Khairunnisa Alidin, Melissa Ugalde, Lauren Pesavento, Louise Weir, Peter J. Mitchell, Timothy J. Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Tissa Wijeratne, Bernard Yan, Patricia M. Desmond, Gagan Sharma, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Bruce C. Campbell
Summary: This study found that tenecteplase is more effective than alteplase in improving reperfusion in patients with large vessel occlusions. Importantly, this improvement is consistent across different thrombolytic to reperfusion assessment times.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
P. Ravanfar, W. T. Syeda, R. J. Rushmore, B. Moffat, A. E. Lyall, A. H. Merritt, G. A. Devenyi, M. M. Chakravarty, P. Desmond, V. L. Cropley, N. Makris, M. E. Shenton, A. I. Bush, D. Velakoulis, C. Pantelis, M. Walterfang
Summary: This study compared individuals with Niemann-Pick type C disease and healthy controls using quantitative susceptibility mapping MR imaging, and found that brain iron deposition in patients with Niemann-Pick type C disease led to thalamic atrophy and increased disease severity.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Bo-yong Park, Sara Lariviere, Raul Rodriguez-Cruces, Jessica Royer, Shahin Tavakol, Yezhou Wang, Lorenzo Caciagli, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Marina K. M. Alvim, Clarissa Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Barbara A. K. Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Michael Rebsamen, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J. O'Brien, Meng Law, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M. Desmond, Charles B. Malpas, Elaine Lui, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kalviainen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Costanza Parodi, Domenico Tortora, Sean N. Hatton, Sjoerd B. Vos, John S. Duncan, Marian Galovic, Christopher D. Whelan, Nuria Bargallo, Jose Pariente, Estefania Conde-Blanco, Anna Elisabetta Vaudano, Manuela Tondelli, Stefano Meletti, Xiang-Zhen Kong, Clyde Francks, Simon E. Fisher, Benoit Caldairou, Mina Ryten, Angelo Labate, Sanjay M. Sisodiya, Paul M. Thompson, Carrie R. McDonald, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt
Summary: This study compared the spatial distribution of grey matter asymmetry and atrophy in temporal lobe epilepsy using the ENIGMA-Epilepsy dataset. The results showed marked differences between the two measures, with asymmetry revealing anomalies in ipsilateral limbic circuits and atrophy displaying diffuse and bilateral patterns. Additionally, cortical atrophy was correlated with disease duration and age at seizure onset.
Review
Criminology & Penology
Anita Stubbs, Cassandra Szoeke
Summary: Research shows that intimate partner violence has negative effects on women's physical health, including worsening menopausal symptoms, increasing the risk of diabetes, contracting sexually transmitted infections, engaging in risky behaviors, developing chronic diseases and pain. It also impacts HIV outcomes. Further long-term studies are needed in this field to better inform healthcare for women who have experienced IPV.
TRAUMA VIOLENCE & ABUSE
(2022)