Review
Immunology
Shahram Solaymani-Mohammadi
Summary: Human giardiasis is a common parasitic disease that can lead to malnutrition and developmental disorders. Understanding the interaction between the parasite and the intestinal epithelial cells may provide insights into the pathology and help identify new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Agriculture, Multidisciplinary
Qi Yang, Siwen Lyu, Menglei Xu, Shengrao Li, Zhiyang Du, Xuanting Liu, Xiaomin Shang, Zhipeng Yu, Jingbo Liu, Ting Zhang
Summary: The study aims to review the effects of egg white protein (EWP) and its bioactive peptides on intestinal structural repair. The potential modulation mechanisms by which EWP and their peptides regulate the gut microbiota and intestinal barrier include restoring the structure of the intestinal barrier, enhancing the intestinal immune system, alleviating inflammation and oxidative damage, and increasing the abundance of beneficial bacteria and metabolites. Further research is needed to understand the coregulation of multiple signaling pathways and evaluate the combined effects of these mechanisms in experimental models. Human trials can provide new directions for development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Immunology
Jingyan Guan, Congxiao Wu, Yunfan He, Feng Lu
Summary: The skin acts as a critical barrier tissue against external pathogens, with its uppermost epidermal layer and skin barrier immunity playing a vital role in maintaining its barrier function. The integrity and effectiveness of skin barrier immunity depend on the close interaction and communication between immune cells and the skin environment. Skin-associated adipocytes have been found to modulate skin immune responses and infection through the secretion of cytokines, adipokines, and antimicrobial peptides. This review summarizes recent research on the interactions between skin-associated adipocytes and other skin cells in maintaining the integrity and effectiveness of skin barrier immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Robert L. Beverly, Prajna Woonnimani, Brian P. Scottoline, Jiraporn Lueangsakulthai, David C. Dallas
Summary: The study identified antimicrobial and bifidogenic peptides in infant intestinal samples, narrowing down a list of 6645 milk peptides to 11 candidate peptides for synthesis. Six of these peptides fully inhibited the growth of E. coli and S. aureus at certain concentrations, providing evidence for the potential bioactivity of milk peptides in the infant intestinal tract.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Qianqian Xu, Huafeng Jian, Wenyan Zhao, Jiankui Li, Xiaoting Zou, Xinyang Dong
Summary: This study evaluated the effects of early weaning stress on intestinal functions in squabs. The results showed that weaning stress had negative effects on the growth performance and intestinal barrier functions of squabs. It also caused disturbance in intestinal microbiota and activation of inflammation cell responses.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Connie Fung, Lisa M. Fraser, Gabriel M. Barron, Matthew B. Gologorsky, Samantha N. Atkinson, Elias R. Gerrick, Michael Hayward, Jennifer Ziegelbauer, Jessica A. Li, Katherine F. Nico, Miles D. W. Tyner, Leila B. DeSchepper, Amy Pan, Nita H. Salzman, Michael R. Howitt
Summary: Succinate produced by commensal protist T. mu stimulates tuft cells, leading to type 2 immunity. Microbial-derived succinate increases Paneth cell numbers and alters the AMP landscape in the small intestine. Tuft cells utilize SUCNR1 and succinate sensing to modulate bacterial homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Chunru Liu, Stoffel Matjeke Radebe, Hang Zhang, Junpeng Jia, Shuang Xie, Miaolei Shi, Qinghua Yu
Summary: This study found that Bacillus coagulans can maintain the intestinal mucosal barrier by improving the intestinal flora, enhancing innate immunity, and promoting intestinal epithelial proliferation.
VETERINARY MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Ting You, Jiayong Tang, Shenggang Yin, Gang Jia, Guangmang Liu, Gang Tian, Xiaoling Chen, Jingyi Cai, Bo Kang, Hua Zhao
Summary: This study investigated the effects of licorice flavonoids powder (LFP) on the growth performance and intestinal health of piglets. The results showed that dietary LFP supplementation improved the growth performance of weaning piglets, reduced the incidence of diarrhea, and enhanced intestinal morphological structure, barrier function, immune function, and development. The addition of 150 mg/kg LFP was found to be the most effective.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Immunology
Julia Beisner, Louisa Filipe Rosa, Valentina Kaden-Volynets, Iris Stolzer, Claudia Guenther, Stephan C. Bischoff
Summary: This study showed that supplementation with inulin or sodium butyrate improved diet-induced liver steatosis in obese mice, reduced weight gain, liver weight, plasma and hepatic triglyceride levels. The supplementation also induced expression of Paneth cell antimicrobials, contributing to improved intestinal barrier function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Lijing Huang, Fang He, Bangyuan Wu
Summary: Nickel is an important metal that widely exists in nature and is necessary for human beings and animals as a trace element. Excessive nickel exposure can induce excessive free radicals in the body, causing damage to cells and negatively affecting overall health, particularly in the intestine.
Article
Cell Biology
Takashi Nakanishi, Hirokazu Fukui, Xuan Wang, Shin Nishiumi, Haruka Yokota, Yutaka Makizaki, Yoshiki Tanaka, Hiroshi Ohno, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa
Summary: High-fat diet-induced dysbiosis in the small intestine leads to pathological changes in the luminal environment, disruption of small-intestinal mucosal integrity, and minimal inflammation in the gut-liver axis, ultimately resulting in the development of steatohepatitis in mice.
Article
Veterinary Sciences
Wanling Yao, Yahui Zhang, Wangdong Zhang, Yanqiao Wen, Rong Yang, Jiaqi Dong, Xiaosong Zhang, Yongli Hua, Peng Ji, Yanming Wei
Summary: This study aimed to explore the pathological mechanism of intestinal mucosal barrier injury in large intestine dampness-heat syndrome (LIDHS) and the protective effect of Yujin powder (YJP). The LIDHS rat model was established and treated with YJP. The results showed that the intestinal mucosal barrier was damaged in LIDHS rats, and certain genes and proteins were abnormally expressed. After treatment with YJP, the mucosal integrity was restored, and the expression levels of related indicators and genes and proteins were regulated.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Fisheries
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: The paper discusses the issue of intestinal mucosa immunity in teleost fish. The organization and functional properties of the elements that determine this immunity are reviewed according to current data. The knowledge of intestinal mucosal immunity in teleost fish has great potential for practical applications in the field of epidemiological safety.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Microbiology
Fabiola Puertolas-Balint, Bjoern O. O. Schroeder
Summary: Diet has a stronger impact on shaping the gut microbial community composition than defensins. However, defensins can modulate specific microbial taxa and protect the host from diet-induced metabolic dysfunction.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Yun Ji, Xiaoxiao Fan, Yunchang Zhang, Ju Li, Zhaolai Dai, Zhenlong Wu
Summary: This study showed that dietary supplementation with 2% glycine can improve the growth performance of weaned piglets by enhancing the intestinal immunological barrier function and altering the microbial composition.
Review
Hospitality, Leisure, Sport & Tourism
David C. Nieman, Brandt D. Pence
JOURNAL OF SPORT AND HEALTH SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Jana F. Schader, Mark Haid, Alexander Cecil, Julia Schoenfeld, Martin Halle, Arne Pfeufer, Cornelia Prehn, Jerzy Adamski, David C. Nieman, Johannes Scherr
Review
Hospitality, Leisure, Sport & Tourism
David C. Nieman
JOURNAL OF SPORT AND HEALTH SCIENCE
(2020)
Article
Physiology
Amy M. Knab, David C. Nieman, Laura M. Zingaretti, Arnoud J. Groen, Artyom Pugachev
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Immunology
Yue Shi, Tingting Liu, David C. Nieman, Yanqiu Cui, Fei Li, Luyu Yang, Hui Shi, Peijie Chen
FRONTIERS IN IMMUNOLOGY
(2020)
Editorial Material
Nutrition & Dietetics
Niels Ortenblad, Joachim Nielsen, Kasper D. Gejl, Harry E. Routledge, James P. Morton, Graeme L. Close, David C. Niemann, Julia L. Bone, Louise M. Burke
Article
Nutrition & Dietetics
David C. Nieman, Kevin A. Zwetsloot, Andrew J. Simonson, Andrew T. Hoyle, Xintang Wang, Heather K. Nelson, Catherine Lefranc-Millot, Laetitia Guerin-Deremaux
Review
Biochemistry & Molecular Biology
Etore F. Signini, David C. Nieman, Claudio D. Silva, Camila A. Sakaguchi, Aparecida M. Catai
Article
Nutrition & Dietetics
David C. Nieman, Nicholas D. Gillitt, Guan-Yuan Chen, Qibin Zhang, Wei Sha, Colin D. Kay, Preeti Chandra, Kristine L. Kay, Mary Ann Lila
FRONTIERS IN NUTRITION
(2020)
Article
Environmental Sciences
Marcus M. Lawrence, Kevin A. Zwetsloot, Susan T. Arthur, Chase A. Sherman, Joshua R. Huot, Vladimir Badmaev, Mary Grace, Mary Ann Lila, David C. Nieman, R. Andrew Shanely
Summary: The study showed that phytoecdysteroid treatment does not affect muscle mass or fiber type, nor does it activate protein synthesis signaling in sedentary aging mice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Josep Bassaganya-Riera, Elliot M. Berry, Ellen E. Blaak, Barbara Burlingame, Johannes le Coutre, Willem van Eden, Ahmed El-Sohemy, J. Bruce German, Dietrich Knorr, Christophe Lacroix, Maurizio Muscaritoli, David C. Nieman, Michael Rychlik, Andrew Scholey, Mauro Serafini
Summary: In the past five years, significant progress has been made in nutrition science, such as the integration of Sustainable Development Goals and nutritional science, as well as research on the Human Microbiome. Looking ahead to the next five years, emphasis on health and sustainability will be the main focus of nutrition science.
FRONTIERS IN NUTRITION
(2021)
Editorial Material
Nutrition & Dietetics
David C. Nieman
Article
Biochemistry & Molecular Biology
Martin Osswald, Dario Kohlbrenner, Nora Nowak, Jorg Sporri, Pablo Sinues, David Nieman, Noriane Andrina Sievi, Johannes Scherr, Malcolm Kohler
Summary: This study utilized SESI-HRMS to continuously monitor metabolites in exhaled breath during a graded cycle ergometry cardiopulmonary exercise test, revealing significant changes in various metabolic pathways. Real-time monitoring enabled high-resolution data collection on metabolite shifts from rest to voluntary exhaustion, providing insights into metabolite changes during exercise.
Review
Nutrition & Dietetics
David C. Nieman
Summary: Precision nutrition for athletes aims to improve individualization of nutrition practices to optimize long-term performance and health, involving the acquisition of individual-specific information and the delivery of science-based nutrition advice.
FRONTIERS IN NUTRITION
(2021)
Review
Sport Sciences
David C. Nieman
Summary: Regular physical activity can improve immune surveillance, reduce the risk of COVID-19 infection, and potentially enhance the efficacy of COVID-19 vaccines. Additionally, physical training and rehabilitation can help improve physical fitness, quality of life, and immune health in patients with sustained morbidity from COVID-19.
CURRENT SPORTS MEDICINE REPORTS
(2021)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)