Article
Oncology
Matthew R. Trendowski, Jaclyn M. Kyko, Christine M. Lusk, Julie J. Ruterbusch, Theresa A. Hastert, Felicity W. K. Harper, Hayley Thompson, Jennifer L. Beebe-Dimmer, Ann G. Schwartz
Summary: This study characterized cancer survivorship in younger African American survivors, using the Detroit Research on Cancer Survivors (ROCS) study, to assess health behaviors and quality of life. The findings showed that younger adult African American cancer survivors who report experiencing discrimination and suffer from multiple comorbid conditions have poorer mental and overall health.
Article
Oncology
Linda Koehler, Lauren Elyse Penz, Florence John, Ashley Stenzel, Patricia Jewett, Deanna Teoh, Anne Blaes, Colleen Rivard, Rachel Vogel
Summary: The aim of this study was to compare the differences in function, quality of life, body image, and distress levels between gynecologic cancer survivors with and without lymphedema symptoms, and determine the number of individuals who received rehabilitation treatment following treatment for gynecological malignancy. The findings showed that participants in the symptomatic group had lower quality of life, lower function scores, and greater cancer-related distress, with higher rates of clinically significant levels of distress. These results remained largely consistent in multivariable models.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
I. Vaz-Luis, M. Masiero, G. Cavaletti, A. Cervantes, R. T. Chlebowski, G. Curigliano, E. Felip, A. R. Ferreira, P. A. Ganz, J. Hegarty, J. Jeon, C. Johansen, F. Joly, K. Jordan, B. Koczwara, P. Lagergren, M. Lambertini, D. Lenihan, H. Linardou, C. Loprinzi, A. H. Partridge, S. Rauh, K. Steindorf, W. van der Graaf, L. van de Poll-Franse, G. Pentheroudakis, S. Peters, G. Pravettoni
Summary: Survivorship care consists of five main components and can be delivered through structured care models, focusing on coordinated care and educational programs.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Jessica L. Krok-Schoen, Janell Pisegna, Elizabeth Arthur, Emily Ridgway, Christian Stephens, Ashley E. Rosko
Summary: Older female cancer survivors have poor diet quality, high rates of overweight or obesity, and low levels of physical activity, impacting their health-related quality of life. Tailored health coaching focusing on lifestyle behaviors is needed to improve prognosis and HRQoL for this population.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
K. Banning, J. Fucinari, A. Fielder, J. J. Ruterbusch, J. L. Beebe-Dimmer, A. G. Schwartz, J. J. Wallbillich, M. L. Cote
Summary: This study examined the quality of life (QOL) in endometrial cancer (EC) survivors, and found that survivors with high-grade disease had lower QOL, particularly in physical and functional aspects. Interestingly, the EC-specific QOL did not differ by grade. These findings highlight the importance of comprehensive assessment and interventions for EC survivors.
Article
Oncology
Elisavet Moschopoulou, Jennifer Deane, Morvwen Duncan, Sharif A. Ismail, Sophie Moriarty, Shah-Jalal Sarker, Peter White, Ania Korszun
Summary: This study aimed to identify the most appropriate measure of quality of life for cancer patients living with and beyond cancer. Measures including FACT-G, EORTC QLQ-C30, IOCv2 (positive and negative subscales) and WEMWBS were completed by 182 patients in Central London, showing significant correlations between different scales. The study concluded that FACT-G, EORTC, and the negative IOC scales can all be used to measure QoL, with the unique aspects of QoL being captured by the two IOCv2 subscales. Participants rated all measures similarly in terms of relevance and ease of use.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Allen Hodge, Patricia Sheean, Paula O'Connor, Kiley Tyler, Abigail Kerschner, Alexis Williams, Kathleen Jensik, Alexis Visotcky, Anita D'Souza, Parameswaran Hari, Binod Dhakal, Saurabh Chhabra, Kathryn E. Flynn, Patrick Hagen, Melinda Stolley
Summary: This study explores the lifestyle behaviors and supportive care needs of a racially diverse sample of MM survivors. The results demonstrate the need for and interest in lifestyle change support among these survivors. Interventions that are group-based, target knowledge gaps, social connections, accountability, and provide a structured framework with professional instruction will best address the needs of this survivor population.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Adriaan Penson, Iris Walraven, Ewald Bronkhorst, Heleen Maurice-Stam, Martha A. Grootenhuis, Margriet Van der Heiden-van der Loo, Wim J. E. Tissing, Helena J. H. Van der Pal, Andrica C. H. De Vries, Dorine Bresters, Cecile Ronckers, Marry M. Van den Heuvel, Sebastian J. C. M. M. Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Saskia M. F. Pluijm, Leontien C. M. Kremer, Nicole Blijlevens, Eline Van Dulmen-den Broeder, Hans Knoop, Jacqueline Loonen
Summary: The study found that fatigue in childhood cancer survivors can negatively impact vitality, general health, and role limitations. Therefore, timely treatment of fatigue is crucial for the quality of life of survivors.
Article
Oncology
Elizabeth S. Ver Hoeve, Leila Ali-Akbarian, Sarah N. Price, Nurhyikmah M. Lothfi, Heidi A. Hamann
Summary: Financial toxicity (FT) was reported by approximately 18% of cancer survivors, with significant associations found between FT and various components of health-related quality of life (HRQOL), but not with adherence to survivorship health behaviors. Financial burden remains a concern for a minority of cancer survivors and further research is needed to understand the impact of FT on underinsured survivors and those treated in community oncology settings.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
L. M. E. van Erp, H. Maurice-Stam, L. C. M. Kremer, W. J. E. Tissing, H. J. H. van der Pal, A. C. H. de Vries, M. M. van den Heuvel-Eibrink, B. A. B. Versluys, J. J. Loonen, D. Bresters, M. Louwerens, M. van der Heiden-van der Loo, M. H. van den Berg, C. M. Ronckers, A. L. L. F. van der Kooi, M. van Gorp, E. van Dulmen-den Broeder, M. A. Grootenhuis
Summary: The study found that Dutch adult childhood cancer survivors generally have worse health-related quality of life, especially in vitality and general health perceptions. Low educational attainment and lack of a partner are significant risk factors for impaired physical and mental health.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Chiara Papini, Ameera A. Fayad, Mingjuan Wang, Fiona S. M. Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M. Howell, Deokumar Srivastava, Wendy M. Leisenring, Gregory T. Armstrong, Todd M. Gibson, Leslie L. Robison, Kevin C. Oeffinger, Kevin R. Krull, Tara M. Brinkman
Summary: Young adult survivors of childhood cancer have an increased risk of loneliness, which can lead to physical and mental health issues in the future.
Article
Oncology
Jahyun Choi, Sanghee Kim, Mona Choi, Woo Jin Hyung
Summary: This study investigated the factors affecting the quality of life of gastric cancer survivors and provided basic data for effective interventions. The results showed that gastric cancer-specific symptoms, spiritual well-being, self-efficacy, and functional status are important factors influencing the quality of life.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Maureen Rigney, Eleni Rapsomaniki, Lisa Carter-Harris, Jennifer C. King
Summary: This study found that awareness of lung cancer has increased among the general public in 2018 compared to 2008, but there has been no shift in the perception of whether patients should be blamed for their illness. Furthermore, lung cancer patients reported a higher level of stigma associated with the disease in 2018, indicating that stigma continues to be a significant issue.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
J. L. Vardy, A. Liew, J. Turner, K. Kerin-Ayres, Sue Butler, C. Deguchi, S. Khatri, C. Wildbore, C. Mo, M. Hamayun, H. M. Dhillon, A. Malalasekera, S. Y. Tan
Summary: The study found that survivors attending SCSC increased their exercise levels after 3 months of treatment, and sustained the increase at 1 year. Most overweight or obese survivors were able to avoid further weight gain. Survivors had relatively good quality of life at 1 year, with improvements in many symptoms and lifestyle factors.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Anthony J. Cannon, Mehmet E. Dokucu, Fausto R. Loberiza
Summary: This study found that spirituality has a positive impact on the physical and mental quality of life of cancer survivors, while religiosity may have some influence on physical quality of life. Clinicians incorporating spirituality into cancer treatment can help improve patients' quality of life during the often challenging and uncertain treatment process.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Rosie Shrout, Annelise A. Madison, Megan E. Renna, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, Doreen M. Agnese, William E. Carson, William B. Malarkey, Michael T. Bailey, Janice K. Kiecolt-Glaser
Summary: Satisfying relationships among breast cancer survivors are associated with lower gut permeability and inflammation levels, leading to improved physiological health. This type of relationship can help reduce disease risks and enhance quality of life.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Endocrinology & Metabolism
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Jeanette M. Bennett, William B. Malarkey, Charles F. Emery, Janice K. Kiecolt-Glaser
Summary: Breast cancer survivors with a distress disorder history have lower HRV during and after an experimental stressor, and experience higher levels of anxiety compared to those without such a history.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychology, Multidisciplinary
Annelise A. Madison, Rebecca Andridge, M. Rosie Shrout, Megan E. Renna, Jeanette M. Bennett, Lisa M. Jaremka, Christopher P. Fagundes, Martha A. Belury, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: The social-signal-transduction theory of depression suggests that individuals who experience ongoing interpersonal stress and have a greater inflammatory response to social stressors are more likely to develop depression. This was confirmed in two adult samples, where heightened depressive symptoms were observed in those with more frequent interpersonal tension and greater inflammatory reactivity to social stress. Lonelier and less socially supported individuals, particularly those with higher inflammatory response to social-evaluative stressors, showed increased depressive symptoms.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Communication
Stephanie J. Wilson, Lisa M. Jaremka, Christopher P. Fagundes, Rebecca Andridge, Janice K. Kiecolt-Glaser
Summary: Research shows that the use of "we" in couples' discussions can predict better relationship quality and well-being. However, prior studies have not differentiated "we" talk based on its context. Additionally, the consistency of "we" talk during conflicts is high, but its effects may vary depending on the context in which it is used.
JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS
(2022)
Article
Immunology
Janice K. Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Rebecca Andridge
Summary: This study investigated the inflammatory responses of breast cancer survivors to a typhoid vaccine as an indicator of their innate immune response to new pathogens. The results showed that chemotherapy and central obesity were associated with smaller vaccine responses. Women with lower fitness levels also had reduced vaccine responses.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Geriatrics & Gerontology
Stephanie J. Wilson, Janice K. Kiecolt-Glaser
Summary: This study compares the differences in language use and emotional reactions during relationship history discussions between older and younger couples. The study found that compared to younger couples, older couples used more positive words and less immediacy during the discussion, which was associated with less negative mood and more positive appraisals among husbands. However, partners' language use in older couples was more similar but unrelated to mood and appraisals.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Oncology
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, William E. Carson, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study found that colorectal cancer patients with higher levels of depressive and anxiety symptoms experienced greater pain, fatigue, and inflammation. These results emphasize the negative impact that anxiety and depression can have on the physical and biological side effects of colorectal cancer.
Article
Endocrinology & Metabolism
Annelise A. Madison, Janice K. Kiecolt-Glaser
Summary: This article assesses the relationship between inflammation and impulsivity and presents three challenges: vague definition of impulsivity, reverse causality, and lack of causal evidence. Future research can explore the relationship between inflammation and impulsivity by improving study design.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Ruchika Shaurya Prakash, Stephanie Fountain-Zaragoza, Megan Fisher, Oyetunde Gbadeyan, Rebecca Andridge, Janice Kiecolt-Glaser, Heena R. Manglani, Elizabeth J. Duraney, Anita Shankar, Michael R. McKenna, James Teng, Madhura Phansikar, Rosie Canter
Summary: This study aims to examine the benefits of a manualized mindfulness-based stress reduction program in improving attentional control and reducing mind-wandering in older adults. The study design includes randomized controlled trial with behavioral and neuroimaging assessments, as well as long-term follow-up. The primary outcomes are behavioral measures of attentional control and mind-wandering.
Article
Psychology, Clinical
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Maryam Lustberg, Stephen P. Povoski, Doreen M. Agnese, Raquel E. Reinbolt, Robert Wesolowski, Nicole O. Williams, Bhuvaneswari Ramaswamy, Sagar D. Sardesai, Anne M. Noonan, Jeffrey B. VanDeusen, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Michael Di Gregorio, Janice K. Kiecolt-Glaser
Summary: Psychological disorders can worsen physical symptoms associated with breast cancer diagnosis and treatment, and a distress disorder history may increase the risk of pain, fatigue, sleep difficulties, and lower self-rated health in breast cancer survivors both before and after adjuvant treatment.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Felix Tretter, Eva M. J. Peters, Joachim Sturmberg, Jeanette Bennett, Eberhard Voit, Johannes W. Dietrich, Gary Smith, Wolfram Weckwerth, Zvi Grossman, Olaf Wolkenhauer, James A. Marcum
Summary: This paper argues that data-driven analysis alone is insufficient for understanding the COVID-19 pandemic and for justifying public health regulations. It emphasizes the need for over-arching hypothesis-related and/or theory-based rationales to conduct effective research on SARS-CoV2/COVID-19.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Psychology, Experimental
Lydia G. Roos, Jeanette M. Bennett
Summary: Inadequate emotion regulation can lead to the development of psychopathology and worsened physical health. Cognitive reappraisal is considered an adaptive strategy to manage negative emotions, but its effectiveness depends on contextual and individual differences. The interactive effects of habitual reappraisal, reappraisal ability, and exposure to stressful life events on mental health were examined. Habitual reappraisal may protect against elevated depressive symptoms and worsened physical health for individuals facing more stressful life events.
Article
Immunology
Annelise A. Madison, Baldwin Way, Kyle G. Ratner, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study examined whether a typhoid vaccine would increase social disconnection and avoidance behavior, and found that mild inflammatory stimuli did not affect social processes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Nicole L. Stott Bond, Didier Dreau, Ian Marriott, Jeanette. M. M. Bennett, Michael. J. J. Turner, Susan. T. T. Arthur, Joseph. S. S. Marino
Summary: This study discovered that metformin can reduce the proliferation of non-small cell lung cancer cells and downregulate certain genes related to cell cycle regulation and apoptosis. These findings support further research on the use of metformin as an anti-cancer agent or adjunctive therapy.
Article
Oncology
Annelise A. Madison, Rebecca Andridge, Anthony H. Kantaras, Megan E. Renna, Jeanette M. Bennett, Catherine M. Alfano, Stephen P. Povoski, Doreen M. Agnese, Maryam Lustberg, Robert Wesolowski, William E. Carson III, Nicole O. Williams, Raquel E. Reinbolt, Sagar D. Sardesai, Anne M. Noonan, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Depression combined with inflammation or intestinal permeability may contribute to poorer subjective and objective cognitive function in breast cancer survivors. These findings suggest that survivors with depression accompanied by immune dysregulation may be more aware of depression-related cognitive deficits compared to other depressed survivors.
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)