Article
Immunology
Zhiqi Huang, Peng Yang, Fan Wang
Summary: The research identified a novel hemocyte activation factor in shrimp plasma, known as CREG protein, which induces cell activation and maturation in hemolymph. This protein is likely a conserved myeloid cell lineage activation factor from invertebrates to vertebrates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Ricardo Perez-Velasco, Marlenne Manzano-Sarabia, Miguel Angel Hurtado-Oliva
Summary: Salinity changes in the oceans due to climate change affect the biology and immune responses of oysters like C. corteziensis. High salinity stress conditions pose a greater challenge to the oysters compared to low salinity stress conditions, potentially increasing vulnerability to other environmental stressors and diseases.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Zoology
Shaohua Li, Fanghua Liu, Zhiwei Kang, Xiangdong Li, Yang Lu, Qiyun Li, Yunshun Pang, Fangqiang Zheng, Xiangchu Yin
Summary: This study identified five types of circulating hemocytes in the yellow peach moth larvae and analyzed their alterations and functions in immune responses against Beauveria bassiana infection. The results showed significant decreases in hemocyte counts over time after infection, and observed hemocyte-mediated phagocytosis and nodulation. Additionally, the study found that the introduction of DEAE-Sepharose Fast Flow beads induced a strong encapsulation response. These observations provide insights into the immune system of the yellow peach moth.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2022)
Review
Fisheries
Wei Yang, Ngoc Tuan Tran, Chun-Hua Zhu, De-Fu Yao, Jude Juventus Aweya, Yi Gong, Hong-Yu Ma, Yue-Ling Zhang, Guang-Li Li, Sheng-Kang Li
Summary: Immune priming has been demonstrated as a form of immune memory in invertebrates without acquired immune systems, with implications for vaccinating economically valuable shellfish. Research on priming responses and mechanisms is necessary for the development of prophylactic strategies. Both humoral and cellular factors are involved in priming protection, but cellular immunity appears to be more important in pathogen clearance and survival.
Article
Fisheries
He Zhang, An-Ran Tan, Peng-Ju Li, Sheng-Ping Lu, Qing-Chen Jia, Shu-Ning Huang, Juan Bai, You-Ming Hou
Summary: Red palm weevil larvae possess a strong immune priming response that enhances their protection against pathogens. This response is correlated with hemocyte proliferation and phagocytic ability, as well as the continuous synthesis of serotonin.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Zoology
John T. Sullivan
Summary: During the development of Biomphalaria glabrata, embryos and larvae possess passive immune protection through parentally-derived antimicrobial proteins. This study observed hemocyte-like cells in late trochophores and veligers of the BS-90 strain, suggesting the formation of the internal defense system (IDS). These cells showed various cellular functions and increased in number during larval development.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gang Xu, Yuan-Yuan Zhang, Gui-Xiang Gu, Guo-Qing Yang, Gong-Yin Ye
Summary: Octopamine is structurally and functionally similar to adrenaline/noradrenaline in vertebrates, but it modulates diverse physiological and behavioral processes in invertebrates. The study cloned beta-adrenergic-like octopamine receptors (CcOct beta Rs) from Cotesia chilonis, revealing varied transcript levels in different tissues and activation by OA and other agonists in heterologous expression. These findings offer important insights into the molecular and pharmacological properties of the receptors in parasitoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Li-Sha Zheng, Xiao-Qiang Liu, Ge-Ge Liu, Qian-Qiao Huang, Jin-Jun Wang, Hong-Bo Jiang
Summary: The study cloned a beta-adrenergic-like octopamine receptor cDNA and demonstrated its functional role in regulating behavior and physiology in the red flour beetle. RNAi assay showed that TcOct beta 2R affects beetle locomotion, mating duration, and fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yazhuo Zhang, Xinning Liu, Jun Zhao, Jie Wang, Qiaoling Song, Chenyang Zhao
Summary: In this review, we summarize the physicochemical properties and specific processes involved in 13-glucan induced phagocytosis, as well as the cascade events triggered by 13-glucan at the cellular and molecular levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Zoology
Daniella-Mari White, Michail-Aggelos Valsamidis, Vasileios Bakopoulos
Summary: This study aimed to investigate the sensitivity of common octopus to bacterial infection, assess the activation of hemocytes and their phagocytic activity after infection, and examine the relationship between sensitivity, phagocytic activity, and temperature, route of infection, and pathogen.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2022)
Article
Ecology
A. Y. Andreyeva, E. S. Kladchenko, T. A. Kukhareva
Summary: The study found that 72 hours of hypoxia significantly affected the hemocyte functional parameters of Pacific oysters, including changes in hemolymph cellular composition and cell diameter, but did not weaken their immune capacity.
REGIONAL STUDIES IN MARINE SCIENCE
(2021)
Article
Agronomy
Ping Cai, Yuanyuan Zhang, Mu Yang, Chenghao Zhang, Mingxia Li, Wei Xiao, Zhifeng Xu, Yongqiang Zhang
Summary: This study identified TcOct beta 2R as the main target gene of amitraz in Tetranychus cinnabarinus and revealed that the difference in acaricidal activity between amitraz and DPMF was due to the divergence of target binding. These results revealed the physiological and pharmacological functions of octopamine receptors in T. cinnabarinus and could provide a basis for the design of new acaricides, with octopamine receptors as a special target.
PEST MANAGEMENT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Seegehalli M. Anil, Nurit Shalev, Ajjampura C. Vinayaka, Stalin Nadarajan, Dvora Namdar, Eduard Belausov, Irit Shoval, Karthik Ananth Mani, Guy Mechrez, Hinanit Koltai
Summary: Cannabis extract shows anti-inflammatory activity by reducing immune response markers associated with COVID-19 inflammation. It induces polarization and phagocytosis of macrophages, while also reducing pro-inflammatory cytokine secretion. Additional caution is needed when considering cannabis as a treatment for COVID-19.
SCIENTIFIC REPORTS
(2021)
Article
Entomology
Hang Zhu, Zheming Liu, Haihao Ma, Wei Zheng, Jia Liu, Yong Zhou, Yilong Man, Xiaoao Zhou, Aiping Zeng
Summary: In this study, researchers identified and analyzed the molecular characteristics and expression patterns of an octopamine receptor gene PxOct beta 3 in the diamondback moth. They found that PxOct beta 3 plays an important role in the physiological processes of the moth and demonstrated its pharmacological properties. This study provides a theoretical basis for the development of new pesticides targeting octopamine receptors.
Article
Biochemistry & Molecular Biology
Isma Gul, Saima Kausar, Qiuxiang You, Wei Sun, Zekun Li, Muhammad Nadeem Abbas, Hongjuan Cui
Summary: The Nimrod family genes play a crucial role in host defense by positively regulating the antibacterial immune response in silkworm B. mori. Knockdown of BmDraper decreased bacterial clearance and increased replication, contributing to increased mortality rates, while knockdown of BmNimrod-B had no significant effect on these outcomes. The genes did not significantly affect the production of antimicrobial peptides following E. coli infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agronomy
Fen Mao, Lei Guo, Miao Jin, Xiao-mu Qiao, Gong-yin Ye, Jia Huang
PEST MANAGEMENT SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
X. Bai, T. Zeng, X-Y Ni, H-A Su, J. Huang, G-Y Ye, Y-Y Lu, Y-X Qi
INSECT MOLECULAR BIOLOGY
(2019)
Article
Biology
Shelley A. Adamo, Laura E. McMillan
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Xu-yang Ni, Zhen-dong Zhou, Jia Huang, Xiaomu Qiao
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gang Xu, Xue-Fei Chang, Gui-Xiang Gu, Wen-Xi Jia, Lei Guo, Jia Huang, Gong-Yin Ye
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Entomology
Fen Mao, Wan-Jun Lu, Yi Yang, Xiaomu Qiao, Gong-Yin Ye, Jia Huang
Article
Biochemistry & Molecular Biology
L. Guo, Z. -D. Zhou, F. Mao, X. -Y. Fan, G. -Y. Liu, J. Huang, X. -M. Qiao
INSECT MOLECULAR BIOLOGY
(2020)
Review
Physiology
Shelley A. Adamo
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2020)
Article
Biology
Laura E. McMillan, Shelley A. Adamo
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
X. -y. Ni, W. -j. Lu, X. Qiao, J. Huang
Summary: The study found that all four promoters could be used with variable efficiency to drive mutagenesis of the white gene in Drosophila suzukii. Among the four DsU6 promoters tested, DsU6-3 had the highest genome editing efficiency. In comparison, the DmU6:3 promoter showed lower efficiency. These findings expand the options for promoters to express gRNAs in D. suzukii, facilitating both basic and applied research on this important pest.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Biology
Lei Guo, Xin-yu Fan, Xiaomu Qiao, Craig Montell, Jia Huang
Summary: The study revealed that amitraz activates octopamine receptors in Varroa mites, with bees being relatively insensitive to it. Bees resist amitraz through their insensitive receptors, which has implications for resistance management and the development of safer insecticides targeting pests while being less toxic to non-target pollinators.
Article
Genetics & Heredity
Wanjun Lu, Zhihan Liu, Xinyu Fan, Xinzhong Zhang, Xiaomu Qiao, Jia Huang
Summary: This study systematically examined the susceptibility of fruit fly nAChR subunit mutants to eleven insecticides and found that different subtypes of nAChRs are responsible for the toxicity of different insecticides. Three subtypes were identified as the major molecular targets of neonicotinoids. Spinosyns were found to exclusively act on one specific subtype of nAChRs. The results further confirmed that neonicotinoids exert their insecticidal effects through receptor activation rather than inhibition. These findings have important implications for resistance management and the development of novel insecticides.
Editorial Material
Neurosciences
Takaaki Sokabe, Youngseok Lee, Jia Huang
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Xiaomu Qiao, Xiaoyu Zhang, Zhendong Zhou, Lei Guo, Weiping Wu, Suhan Ma, Xinzhong Zhang, Craig Montell, Jia Huang
Summary: This study identified nicotinamidase (Naam) as a previously unknown molecular target for the insecticide flonicamid. Inhibition of Naam by a metabolite of flonicamid led to defects in gravity sensing in flies. The resistance of bees to flonicamid was due to a gene duplication.
Article
Ecology
Lei Guo, Xiaomu Qiao, Diler Haji, Tianhao Zhou, Zhihan Liu, Noah K. Whiteman, Jia Huang
Summary: This study reveals the convergent evolution of a gene encoding the GABA receptor in herbivorous insects and their predators. It also suggests that the evolution of resistant GABA receptors is linked to the diversification of insects. The molecular mechanisms of coevolution between plants and insects remain elusive.
NATURE ECOLOGY & EVOLUTION
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)