Article
Biochemistry & Molecular Biology
Irene Soffritti, Sabine Gravelsina, Maria D'Accolti, Francesca Bini, Eleonora Mazziga, Anda Vilmane, Santa Rasa-Dzelzkaleja, Zaiga Nora-Krukle, Angelika Krumina, Modra Murovska, Elisabetta Caselli
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease without diagnostic biomarkers, but there is evidence supporting a role of herpesviruses and microRNAs in its development. This study found that six out of eight selected microRNAs were differently expressed in ME/CFS patients compared to healthy controls. The levels of these microRNAs correlated with disease severity but not with pro-inflammatory cytokines or HHV-6A/6B genome levels. These results suggest that microRNAs could serve as potential biomarkers and provide insights into ME/CFS pathogenic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Shinya Yamaguchi, Kazuhiro Watanabe, Naotaka Sugimura, Inaho Shishido, Issei Konya, Tomoko Fujita, Yuichi Yoshimitsu, Shintaro Kato, Yoichi M. Ito, Rika Yano
Summary: This study explored the salivary biomarkers associated with nurses' chronic fatigue and found that cortisol and secretory immunoglobulin A (s-IgA) levels were related to the severity of chronic fatigue. Specifically, low cortisol levels and high s-IgA levels were associated with higher levels of irritability and unwillingness to work. Combining cortisol and s-IgA levels further revealed different profiles that influenced nurses' chronic fatigue.
Article
Cell Biology
Xiujie Gao, Kefeng Ma, Honglian Yang, Kun Wang, Bo Fu, Yingwen Zhu, Xiaojun She, Bo Cui
Summary: In this study, a fatigue model based on speech was constructed by collecting physiological indicators and speech features under different fatigue conditions. The method can rapidly judge the degree of fatigue and has the advantages of real-time operation, non-invasiveness, and high efficiency.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrej Rusin, Colin Seymour, Alan Cocchetto, Carmel Mothersill
Summary: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) have overlapping symptoms and their etiologies may be linked. Studies suggest that multiple stressors including HPA-axis dysfunction, the serotonergic system, cytokines and inflammation, metabolic insufficiency and mitochondrial dysfunction, and genetic changes are involved in both CRF and CFS/ME. There may be a continuum of potential biological effects occurring in response to stress, influenced by factors such as genetic background. Future research should focus on identifying common biomarkers in CFS/ME and CRF patients to further understand their commonalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Qinrui Fu, Leilei Yu, Yin Wang, Peifeng Li, Jibin Song
Summary: Chronic diseases claim millions of lives every year, and it is important to develop advanced drugs for better treatment. Nanotheranostics, which integrate diagnosis and treatment into a single nanosystem, have shown great potential. However, their applications in nanomedicine are still in the early stages.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Virology
Jessica Binetti, Monica Real, Marcela Renzulli, Laia Bertran, David Riesco, Carles Perpinan, Alba Mohedano, Rosa San Segundo, Marta Ortiz, Jose Antonio Porras, Daniela Rosanna Pineda, Teresa Auguet
Summary: Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. Fatigue is the most frequently associated symptom. This study aims to analyze the impact of a supervised exercise program on the clinical evolution of LC patients with fatigue and to identify potential predictive biomarkers for rehabilitation response.
Review
Chemistry, Analytical
Sariye Irem Kaya, Ahmet Cetinkaya, Goksu Ozcelikay, Seyda Nur Samanci, Sibel A. Ozkan
Summary: Heart failure is a cardiovascular disease characterized by symptoms resulting from inadequate blood supply to the tissues. It is a significant public health concern and is associated with high healthcare costs. Biomarkers associated with myocardial and vascular stretch, neurohormonal pathways, and myocardial fibrosis and hypertrophy have been used for diagnosis and prognosis. There is a growing need for fast, portable, and low-cost biosensing devices for these biomarkers. This review discusses the latest applications of biosensors for acute and chronic heart failure.
Article
Orthopedics
A. C. van Berkel, W. E. van Spil, D. Schiphof, J. Runhaar, J. M. van Ochten, P. J. E. Bindels, S. M. A. Bierma-Zeinstra
Summary: This study on biomarkers in patients with hip and/or knee pain suggests that inflammation and cartilage matrix degeneration play a role in pain, but not in fatigue.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Medicine, General & Internal
Anouk W. Vaes, Yvonne M. J. Goertz, Maarten van Herck, Rosanne J. H. C. G. Beijers, Martijn van Beers, Chris Burtin, Daisy J. A. Janssen, Annemie M. W. J. Schols, Martijn A. Spruit
Summary: The study found that both physical and mental fatigue are frequently experienced simultaneously in people with non-communicable chronic diseases, but can also occur separately. There is a lack of discussion and treatment for fatigue among healthcare professionals, highlighting the need for increased awareness.
ANNALS OF MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Zhonghong Yan, Guanran Wang, Xingyang Shi
Summary: Chronic kidney disease (CKD) poses a serious public health concern globally, with issues including inaccurate diagnosis, dependency on biopsies, and multifactorial prognosis challenges in clinical treatment and management. Developing effective biomarkers is crucial for improving CKD prognosis and clinical management.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Jun Ren, Tianxiang He, Xin Zhou, Zhiwei Wu, Lingjun Kong
Summary: This study aims to investigate the effects of Tuina in the management of Chronic Fatigue Syndrome through a systematic review and meta-analysis, providing evidence for the treatment of CFS in the future. The conclusions drawn from this review are expected to benefit patients, clinical practitioners, and policy makers.
Article
Clinical Neurology
Inge Kirchberger, Christa Meisinger, Dennis Freuer, Vincenza Leone, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen
Summary: This study aimed to identify specific biomarkers associated with fatigue in post-stroke patients and replicate the findings in a population-based study. The results showed an association between the growth factor SCF and fatigue. Future research should focus on a longitudinal design and include a sufficient number of participants to test associations between certain cytokines and sub-groups of chronic fatigue.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amer Alhaideri, Michael Maes
Summary: Physiosomatic symptoms play an important role in the phenomenology of schizophrenia. Higher scores of physiosomatic symptoms in schizophrenia patients are associated with increased levels of psychosis, hostility, excitement, formal thought disorders, psychomotor retardation, and negative symptoms. The variance in physiosomatic symptoms score is influenced by cognitive tasks, IL-10, IL-6, and other markers. Neural network analysis identified top predictors of physiosomatic symptoms including IL-6, HMGB1, education level, MOR, KOR, and IL-10. Immune pathways, neural markers, and alterations in the endogenous opioid system appear to contribute to the physiosomatic symptoms in schizophrenia.
METABOLIC BRAIN DISEASE
(2021)
Review
Clinical Neurology
Zhengwu Zhang, Jennifer S. Gewandter, Paul Geha
Summary: The prevalence of chronic pain has become an epidemic, and this manuscript provides evidence that the understanding of the role of the brain in chronic pain is about to change. The focus is on the concept of learning in chronic pain emergence and the latest brain imaging findings.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Analytical
Gioele Visconti, Miguel de Figueiredo, Oriane Strassel, Julien Boccard, Nicolas Vuilleumier, David Jaques, Belen Ponte, Serge Rudaz
Summary: Accurate quantitative analysis in liquid chromatography-mass spectrometry (LC-MS) can be achieved by generating calibration curves in the same matrix as the study sample. The multitargeted internal calibration (MTIC) approach, which utilizes stable isotope labeled (SIL) standards as internal calibrants, is a promising method for the quantification of endogenous compounds. A study using MTIC workflow was conducted to quantify metabolites related to chronic kidney disease (CKD) in serum or plasma samples. The results demonstrated the feasibility of this approach for absolute quantification of endogenous biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
