Article
Agriculture, Dairy & Animal Science
Fuminori Kawabata, Yuta Yoshida, Yuki Inoue, Yuko Kawabata, Shotaro Nishimura, Shoji Tabata
Summary: The study shows that chickens have a functional fatty acid taste receptor, GPR120, in their oral tissues, but they do not prefer oleic acid solution. Chickens are able to perceive the taste of oleic acid solution, but do not selectively ingest it.
Article
Agriculture, Dairy & Animal Science
Ivonne Cassaigne, Ron Thompson, Richard McKenna, Rodrigo A. Medellin, William Given, Francisco Remolina, Rodrigo Nunez, Diego Woolrich, Fernando Luna
Summary: This study successfully induced conditioned taste aversion in six captive jaguars using Thiabendazole (TBZ), providing an important tool to reduce livestock predation and protect this endangered species.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Ayano Katagiri, Takafumi Kato, Hajime Sato
Summary: Intranasal administration of rotenone impairs conditioned taste aversion memory in mice by decreasing GABAergic synaptic transmission and causing LTD impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jianfeng Liu, Ruyan Wu, Bernard Johnson, Yanan Zhang, Qing Zhu, Jun-Xu Li
Summary: This study found that selective TAAR1 agonists can induce conditioned taste aversion, highlighting the need for careful evaluation before their clinical use in the treatment of mental disorders.
PSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Sarah A. Stern, Estefania P. Azevedo, Lisa E. Pomeranz, Katherine R. Doerig, Violet J. Ivan, Jeffrey M. Friedman
Summary: The insular cortex plays a crucial role in regulating conditioned overconsumption in response to learned cues by controlling a specific circuit, which is active during feeding and suppresses satiety signals in the central amygdala.
Article
Psychology, Biological
Shaoyi Su, Zimo Wei, Helai Huang, Tomohiko Yoshizawa, Tadashi Inui, Makoto Funahashi
Summary: This study aims to investigate the effects of cisplatin and emetine on conditioned taste aversion and demonstrates it using a taste reactivity test in rats. It is found that the readministration of saccharin after gustatory conditioning with cisplatin or emetine induces gaping reactions. The study shows that cisplatin and emetine can induce taste aversion, and it is also observed that gaping reactions almost never occur with intraperitoneal injections of emetine alone.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Antonio D. R. Aguera, Clara Candido, Rocio Donaire, Mauricio R. Papini, Carmen Torres
Summary: This study investigated the behavioral effects of ketamine in animals and found that it increased consummatory suppression and induced conditioned taste aversion to sucrose.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Fubing Han, Fenghua Xu, Qianqian Zhu, Peng Sun, Yu Zhou, Ming Yu
Summary: This study investigates the effect of virus-mediated overexpression of ghrelin receptor GHS-R1a in the basolateral amygdala (BLA) on conditioned taste aversion (CTA) memory processes. The findings reveal that upregulation of GHS-R1a expression in BLA pyramidal neurons represses CTA extinction while it has no effect on CTA acquisition. Additionally, the study shows that local infusion of the endogenous GHS-R1a antagonist LEAP2 abolishes the inhibitory effect of increased GHS-R1a on CTA memory extinction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Jean-Pascal Morin, Emmanuel Rodriguez-Nava, Victor Manuel Torres-Garcia, Omar Alejandro Contreras-Vazquez, Cesar Armando Castellanos-Perez, Jorge Tovar-Diaz, Gabriel Roldan-Roldan
Summary: The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible through a combination of innate and learned taste preferences. Recent evidence suggests a role of cholinergic muscarinic signaling in the amygdala for the learning and storage of emotional memories, particularly in conditioned taste aversion.
NEUROSCIENCE LETTERS
(2021)
Article
Immunology
Minhong Huang, Emir Malovic, Alyssa Ealy, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Summary: Epigenetic reprogramming allows innate immune cells to form memories of environmental stimuli, enhancing their response to subsequent stressors. In this study, microglial cells were primed with LPS and showed augmented inflammatory responses to the secondary stressor Mn. The deposition of H3K27ac was found to be involved in the immune memory formation, and inhibition of H3K27ac deposition attenuated the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biodiversity Conservation
Tim Andrewartha, Maldwyn Evans, Anton Blencowe, Kyle Brewer, Iain J. Gordon, Adrian D. Manning
Summary: Predation by invasive mammalian species is a major threat to native species. The current management approach focuses on removing invasive species, but this is challenging and may not be completely effective. This study tested the use of conditioned taste aversion (CTA) as a tactic to reduce predation. By associating nausea with a specific food source, the study successfully reduced bait consumption by red foxes in a wild context. The results suggest that CTA could be a promising tool for managing the impacts of invasive mammalian predators.
CONSERVATION SCIENCE AND PRACTICE
(2023)
Article
Behavioral Sciences
Hayley N. Manke, Samuel S. Nunn, Robert A. Jones, Kenner C. Rice, Anthony L. Riley
Summary: This study examined the response of mice to synthetic cathinones, and found that mice displayed significant aversive and rewarding effects, similar to previous studies in rats. The results of this study are important for predicting abuse potential and understanding the impact of various factors on drug abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biodiversity Conservation
J. Tobajas, E. Descalzo, R. Villafuerte, J. Jimenez, R. Mateo, P. Ferreras
Summary: The study found that conditioned odor aversion can reduce predation on rabbits by foxes and has a positive impact on rabbit population growth after translocation. This non-lethal method could be used for the recovery of key prey during programs involving the reintroduction of endangered predators or vulnerable species requiring translocations.
ANIMAL CONSERVATION
(2021)
Article
Neurosciences
Yueqing Su, Jiamei Lian, Shiyan Chen, Wenchang Zhang, Chao Deng
Summary: This study investigated the regulation of histone acetylation in neuroinflammation and neurotransmission using a prenatal Poly I:C exposure model. The results showed global changes in histone acetylation in the prefrontal cortex of offspring rats exposed to Poly I:C. Enhanced histone acetylation on the promoter region of Rela and increased binding of histone deacetylase 6 (HDAC6) on the promoter region of Nlrp3 were observed. However, no specific changes were found in histone acetylation on the promoter region of neurotransmitter receptor genes. These findings suggest that epigenetic modulation contributes to neuroinflammation and neurodevelopmental disturbances associated with maternal immune activation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Christopher L. Cunningham, Lee Bakner, Lindsey M. Schuette, Emily A. Young
Summary: Opioid receptor antagonists can alter the expression or extinction of ethanol's conditioned motivational effects, but their effects are likely not mediated by opioid receptors. Morphine enhances ethanol-induced conditioned place preference, while ethanol itself reduces this preference. Neither drug affects the extinction process.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Maria Pascual, Rosa Lopez-Hidalgo, Sandra Montagud-Romero, Juan R. Urena-Peralta, Marta Rodriguez-Arias, Consuelo Guerri
Summary: The study investigates the effects of binge alcohol drinking during adolescence on synaptic plasticity and cognitive function in mice, as well as the potential of mTOR inhibitor rapamycin to restore these effects.
Article
Neurosciences
S. Montagud-Romero, M. D. Reguilon, M. Pascual, M. C. Blanco-Gandia, C. Guerri, J. Minarro, M. Rodriguez-Arias
Summary: This study aimed to assess the role of the immune TLR4 and its signaling response in the increased contextual reinforcing effects of cocaine and ethanol induced by social stress. Results suggest that TLR4 receptors mediate the neuroinflammatory response underlying the increase in rewarding effects of cocaine and ethanol induced by social stress.
Article
Nanoscience & Nanotechnology
Carlos Manuel Cuesta, Francisco Ibanez, Rosa Lopez-Hidalgo, Juan Urena, Aroa Duro-Castano, Ana Arminan, Maria Jesus Vicent, Maria Pascual, Consuelo Guerri
Summary: An optimized and targeted polypeptide-based nanoconjugate of a curcuminoid shows potential in attenuating alcohol-induced neuroinflammation and protecting against neural damage.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Carlos M. Cuesta, Consuelo Guerri, Juan Urena, Maria Pascual
Summary: This study discusses the critical role of bacterial extracellular vesicles (EVs) from the gut in the neuropathology of brain dysfunctions by modulating the immune response, leading to neuroinflammatory immune response activation. These vesicles, containing harmful bacterial contents, can cross tissue barriers and interact with immune receptors to produce cytokines and inflammatory mediators, ultimately causing brain impairment and behavioral dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Francisco Rodenas-Gonzalez, Maria del Carmen Blanco-Gandia, Maria Pascual, Irene Molari, Consuelo Guerri, Jose Minarro Lopez, Marta Rodriguez-Arias
Summary: Studies suggest that consuming high-fat foods may decrease vulnerability to drug abuse, and limiting exposure to high-fat diets during extinction and reinstatement processes can be beneficial in reducing cocaine-induced reinstatement. Additionally, gender differences may exist in the effects of fat consumption on drug-related memories.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francesc Ibanez, Jorge Montesinos, Estela Area-Gomez, Consuelo Guerri, Maria Pascual
Summary: Recent evidence suggests that ethanol-induced EV secretion is closely related to MAMs and SMase activity. Ethanol increases EV release and inflammatory molecule concentration, while also altering lipid metabolism in microglia cells. Inhibiting SMase or MAM activity effectively prevents ethanol-induced increase in EV secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Macarena Gonzalez-Portilla, Susana Mellado, Sandra Montagud-Romero, Fernando Rodriguez de Fonseca, Maria Pascual, Marta Rodriguez-Arias
Summary: This study evaluated the effects of oleoylethanolamide (OEA) on the rewarding properties of cocaine and relapse-related gene expression in the striatum and hippocampus. The results showed that OEA did not affect cocaine-induced conditioned place preference acquisition, but it blocked drug-induced reinstatement and inhibited the expression of dopamine receptor gene D1, dopamine receptor gene D2, and cannabinoid receptor 1 in the striatum and hippocampus. These findings suggest that OEA may be a promising pharmacological agent in the treatment of cocaine use disorder.
BEHAVIORAL AND BRAIN FUNCTIONS
(2023)
Article
Endocrinology & Metabolism
Carla Perpina-Clerigues, Susana Mellado, Jose F. Catala-Senent, Francesc Ibanez, Pilar Costa, Miguel Marcos, Consuelo Guerri, Francisco Garcia-Garcia, Maria Pascual
Summary: The study shows that drinking alcohol leads to the enrichment of plasma EV lipid species in female adolescents, which is associated with the propagation of neuroinflammatory responses. Gender differences in lipid abundance were also observed in wild-type mice and Toll-like receptor 4 deficient mice. These findings support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Neurosciences
Susana Mellado, Carlos M. Cuesta, Sandra Montagud, Marta Rodriguez-Arias, Victoria Moreno-Manzano, Consuelo Guerri, Maria Pascual
Summary: This study demonstrates the therapeutic potential of MSC-derived EVs in reducing neuroinflammation, myelin and synaptic damage, and cognitive dysfunction induced by adolescent alcohol consumption. The results provide evidence for the use of MSC-derived EVs in the treatment of alcohol-related neurological disorders.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)