期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 25, 期 1, 页码 120-126出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2010.09.004
关键词
Autoimmunity; T lymphocytes; EAE; Regulatory T cells
资金
- Gemeinnutzige Hertie Stiftung [1.01.1/04/006]
- Deutsche Forschungsgemeinschaft [BI 603/5-1]
- Interdisciplinary Clinical Research Center (IZKF) Tubingen, Germany
- University of Tubingen
- Boehringer Ingelheim Funds
The role of regulatory T cell populations within the CNS in the regulation of CNS-autoimmunity is controversial. We show that during recovery from relapsing remitting experimental autoimmune encephalomyelitis, regulatory T cells accumulate within the CNS that express high levels of CD62L. These CD62L(high) Treg cells express increased amounts of CTLA-4, ICOS and TGF-beta and are more potent than CD62L(low) Treg cells in suppressing proliferation and inducing apoptosis in effector T cells. CD62L(high) Treg cells thus represent a population of Treg cells that display superior immunosuppressive properties and accumulate in the CNS during recovery from CNS-autoimmunity. (C) 2010 Elsevier Inc. All rights reserved.
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