Review
Nutrition & Dietetics
Prakash Monika, Mathikere Naganna Chandraprabha, Annapoorni Rangarajan, P. Veena Waiker, Kotamballi N. Chidambara Murthy
Summary: Wound healing is a complicated biological process that is influenced by an individual's health status and other factors. Current treatment options for chronic wounds are limited, and the use of complementary and alternative medicine in wound management is still being explored.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Benedicte Marie Finger, Annika Triller, Ashley M. Bourke, Gert Jan Lammers, Christian Veauthier, Merve Yildizli, Ulf Kallweit
Summary: This study investigated the frequency and characteristics of complementary and alternative medicine (CAM) use in German narcolepsy patients. 15% of patients were using CAM at the time of the survey, and an additional 18% reported past use. The most commonly used CAM treatments were vitamins/trace elements, homeopathy, and meditation. CAM users were more likely to experience side effects from medication and have low adherence to pharmacological treatment.
Review
Pharmacology & Pharmacy
Elvin Peter Chizenga, Heidi Abrahamse
Summary: Good medicine is based on good science, open to new paradigms, and requires a well-structured and multifactorial treatment regime for complex diseases like cancer. Integrative oncology combines CAM therapies with modern medicine, emphasizing the importance of understanding genetic and epigenetic characteristics of individual cancers. Targeting the specific features of tumors at the genetic and epigenetic levels is crucial for successful therapy.
Article
Integrative & Complementary Medicine
Farangis Sharifi, Abbas Heydari, Robab Latifnejad Roudsari
Summary: This study examined infertile women's use of complementary and alternative medicine (CAM) and their experiences of healing. The essence of the experience of CAM use was identified as healing the body and mind, with sub-themes including body salve, harmony with nature, and increasing love in relationships. Integration of CAM into conventional medical therapies for infertility may be beneficial, and fertility centers should consider offering counseling programs based on culturally embedded factors related to CAM use.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Hongmin Chu, Seunghwan Moon, Jeongsu Park, Seongjun Bak, Youme Ko, Bo-Young Youn
Summary: The development of artificial intelligence in complementary and alternative medicine has been rapidly advancing. This systematic scoping review identified three main categories of AI usage in CAM, including acupuncture treatment, tongue and lip diagnoses, and herbal medicine. Future research should focus on verifying and validating these AI models through large-scale clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Jin Young Yoon, Seok-Jae Ko, Jae-Woo Park, Jae Myung Cha
Summary: Many Asian patients with functional dyspepsia (FD) are unsatisfied with conventional medical treatment and are seeking complementary and alternative medicine (CAM) therapies. However, there is limited research on CAM for FD specifically in an Asian context. Traditional herbal formulas, STW-5, peppermint and caraway, FDgard, black seed oil, and psychotherapy have been used in FD patients, but the evidence supporting their effectiveness is weak. Well-planned, large-scale studies are needed to evaluate the efficacy of CAM in treating FD, especially in Asian countries.
Article
Dermatology
Kyla N. Price, Erin K. Collier, Tristan Grogan, Jennifer M. Fernandez, Raed Alhusayen, Afsaneh Alavi, Iltefat H. Hamzavi, Michelle A. Lowes, Martina J. Porter, Jennifer L. Hsiao, Vivian Y. Shi
Summary: Recent studies have shown a widespread use of complementary and alternative medicine (CAM) among patients with HS. Providers vary in their comfort and opinions regarding CAM, with most agreeing that CAM and conventional medicine are more effective together, while citing a lack of scientific evidence as a barrier to recommending CAM.
DERMATOLOGIC THERAPY
(2021)
Article
Public, Environmental & Occupational Health
Seyed Hamdollah Mosavat, Mehdi Pasalar, Hassan Joulaei, Vira Ameli, Seyed Taghi Heydari, Ali Mirzazadeh, Mohammad Hashem Hashempur
Summary: This study examines the frequency and reasons behind the use of complementary and alternative medicine (CAM) among people living with HIV in Shiraz, Iran. The results show that the majority of participants use CAM, and there is no significant difference in quality of life between those who use CAM and those who do not.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Clinical Neurology
Panagiotis Kerezoudis, Evangelia N. Kerezoudi, Abdurehman Choudhry, Benjamin T. Himes, Ian F. Parney
Summary: Many patients and caregivers of glioma seek CAM methods to comfort themselves and cope with cancer medication side effects. This study summarizes the existing evidence on the safety and efficacy of CAM treatments for gliomas.
Article
Oncology
Nazi Nejat, Amir Rahbarian, Fatemeh Mehrabi, Fatemeh Rafiei
Summary: This study investigated the prevalence of complementary and alternative medicine (CAM) use among cancer patients in Iran. The findings showed that 44.3% of the 320 participants were using CAM. Most patients used CAM to improve their physical condition and used it alongside conventional medical treatments. Common CAM treatments included visiting holy places, practicing yoga, engaging in prayer therapy, and using medicinal plants and special diets.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Integrative & Complementary Medicine
Bo -Young Youn, Seunghwan Moon, Kyungyul Mok, Chunhoo Cheon, Youme Ko, Sunju Park, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko
Summary: This study conducted a multinational survey to explore the experience, attitude, and promotion of TC&AM in nine countries. The results showed that the participants favored TC&AM treatments and therapies, with a preference for herbal medicine over acupuncture. They also indicated a focus on promoting metabolism rather than treating musculoskeletal diseases. Furthermore, participants suggested the use of Facebook as a channel for promoting TC&AM, and expressed the potential application of TC&AM in treating infectious diseases such as COVID-19.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Jussi Valtonen, Ville-Juhani Ilmarinen, Jan-Erik Lonnqvist
Summary: The study found that individual political orientation is associated with the use of conventional medicine (CM) and complementary/alternative medicine (CAM). People with an anti-corruption political orientation are less likely to use CM but more likely to use CAM. People with a Green/alternative/libertarian political orientation are more likely to use CAM. Poor health status moderates the association between anti-corruption political orientation and CM use, but not between political orientation and CAM use.
SOCIAL SCIENCE & MEDICINE
(2023)
Review
Nutrition & Dietetics
Adamasco Cupisti, Domenico Giannese, Claudia D'Alessandro, Alessia Benedetti, Vincenzo Panichi, Carlo Alfieri, Giuseppe Castellano, Piergiorgio Messa
Summary: Complementary and alternative medicine (CAM), including herbal remedies, probiotics, and vitamins, is often used in the treatment of kidney stone patients. However, most dietary supplements claiming to treat or prevent kidney stones lack scientific evidence. Clinicians should inform patients that the effects of these supplements are largely unknown and that absence of evidence does not mean lack of potential harm. Despite the popularity of CAM products among kidney stone patients, the lack of knowledge in this field prevents their recommendation in daily clinical practice, with only a weak suggestion for their use being reasonable.
Review
Dermatology
Elizabeth Tkachenko, Jean-Phillip Okhovat, Priya Manjaly, Kathie P. Huang, Maryanne M. Senna, Arash Mostaghimi
Summary: This study identified various complementary and alternative medicine (CAM) therapies for the treatment of alopecia areata (AA), including essential oil aromatherapy, topical garlic, and oral glucosides of peony with compound glycyrrhizin. Hypnosis and mindfulness psychotherapy showed low-quality evidence for improvement of psychologic and quality of life outcomes. Adverse events were rare and mild for all therapies evaluated.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Doga uenlueyol, Hueseyin Goekcekus, Youssef Kassem, Murat Tezer, Filiz Mericli, Dudu Ozkum Yavuz
Summary: This study aims to investigate the use of herbal medicines in Northern Cyprus, focusing on the targets, disease types, reasons, and sources of information. The findings indicate that most respondents learned about herbal products and complementary and alternative medicine (CAM) from other patients, the Internet, friends, and family. The commonly used herbal medicines include fennel, ginger, and echinacea, mainly for treating common illnesses such as the common cold. Furthermore, nearly 50% of the participants believe that herbal medicines are safe, have fewer side effects, and are effective for treating minor health conditions.
Article
Clinical Neurology
Brooke G. Rogers, Sierra A. Bainter, Rosana Smith-Alvarez, William K. Wohlgemuth, Michael H. Antoni, Alan E. Rodriguez, Steven A. Safren
Summary: Insomnia is prevalent and interfering comorbidity of HIV infection, affecting nearly 70% of people living with HIV/AIDS. The study found that insomnia symptoms were associated with poorer health-related quality of life, greater depressive symptoms, poorer medication adherence, and worse health status in PLWHA. These findings suggest that insomnia treatment could improve overall health and well-being in this population.
BEHAVIORAL SLEEP MEDICINE
(2021)
Article
Oncology
Molly E. Ream, Mollie S. Pester, Zachary T. Goodman, Sierra A. Bainter, Michael H. Antoni
Summary: Hispanic women with breast cancer in later stages experience greater emotional distress and poorer emotional states compared to non-Hispanic white women, potentially impacting their quality of life. However, the impact of later-stage disease on quality of life did not significantly differ between the two ethnic groups.
Article
Psychiatry
Youngmee Kim, Steve W. Cole, Charles S. Carver, Michael H. Antoni, Frank J. Penedo
Summary: Findings suggest that caregiving-related transcriptional effects seem to be most pronounced when caregivers experience low social support and loneliness, as well as little meaning or purpose in their caregiving. These findings suggest that the development of new intervention strategies that prioritize reductions in caregiver loneliness may favorably impact biological mechanisms related to caregiver health.
PSYCHOSOMATIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jennifer L. Steel, Vincent Reyes, Dan P. Zandberg, Marci Nilsen, Lauren Terhorst, Geena Richards, Bhanu Pappu, Gauri Kiefer, Jonas Johnson, Michael Antoni, Yoram Vodovotz, Michael Spring, Jon Walker, David A. Geller
Summary: The study aims to test the effectiveness of a web-based stepped collaborative care intervention for cancer patients and caregivers through a randomized controlled trial. Preliminary analysis suggests that the intervention delivered via telemedicine can reduce post-operative complications and healthcare costs.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Immunology
Antonio Chahine, Tulay Koru-Sengul, Daniel J. Feaster, Samantha E. Dilworth, Michael H. Antoni, Nichole Klatt, Margaret E. Roach, Suresh Pallikkuth, Mark Sharkey, Jessica Salinas, Mario Stevenson, Savita Pahwa, Dietmar Fuchs, Adam W. Carrico
Summary: This study found that ongoing stimulant use and HIV persistence independently predicted dysregulated metabolism of amino acid precursors for catecholamines, but this did not explain amplified risk for depression.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Endocrinology & Metabolism
Alain Diaz, Chloe J. Taub, Marc E. Lippman, Michael H. Antoni, Bonnie B. Blomberg
Summary: The study found that brief cognitive behavioral therapy (CBT) or relaxation training (RT) stress management interventions can mitigate increases in pro-inflammatory leukocyte NF-kappa B binding over 12 months of primary treatment in highly distressed breast cancer patients. These effects are likely brought about by improved stress management skills.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Adaixa Padron, Christina S. McCrae, Michael E. Robinson, Lori B. Waxenberg, Michael H. Antoni, Richard B. Berry, Jacqueline Castagno, Gregory Schultz, Elizabeth L. Kacel, Chantel Ulfig, Stephanie Garey, Seema Patidar, Timothy Sannes, Laura Trinastic, Shan Wong, Deidre B. Pereira
Summary: Cognitive Behavioral Therapy (CBT) shows significant improvement in the sleep outcomes of insomnia and pain patients, including subjective sleep efficiency, sleep quality, and sleep onset latency. Compared to psychoeducation, CBT has a more pronounced effect on sleep in patients with gynecologic cancers.
BEHAVIORAL SLEEP MEDICINE
(2022)
Article
Psychology, Clinical
Taghrid Asfar, Tulay Koru-Sengul, Michael A. Antoni, Asha Dorsey, Estefania C. Ruano Herreria, David J. Lee, Monica Webb Hooper
Summary: This study described lessons learned from recruiting a diverse sample of African American, White, and Hispanic/Latinx smokers in a smoking cessation trial. Word-of-mouth, flyers, newspaper, and online ads were more successful among racial/ethnic minorities. Flyers and newspaper ads were found to be the most economic methods for recruitment.
ADDICTIVE BEHAVIORS
(2022)
Article
Oncology
Jennifer L. Steel, Aarshati Amin, Tristen Peyser, Donna Olejniczak, Michael Antoni, Maureen Carney, Emily Tillman, Carol Lynn Hecht, Niva Pandya, Jessica Miceli, Vincent Reyes, Marci Nilsen, Jonas Johnson, Gauri Kiefer, Bhanu Pappu, Dan P. Zandberg, David A. Geller
Summary: This study examined the impact of the COVID-19 pandemic on patients diagnosed with cancer and their family caregivers. The results showed that while psychological functioning remained similar to pre-pandemic levels, there was a notable decrease in healthcare utilization due to fear of COVID-19. Additionally, a majority of participants reported some benefits from the pandemic, despite its negative effects.
Article
Oncology
Charmaine L. Blanchard, Keletso Mmoledi, Michael H. Antoni, Georgia Demetriou, Maureen Joffe, Gilberto Lopes, Paul Ruff, Daniel S. O'Neil
Summary: Questionnaires that allow patients to directly report chemotherapy side effects can improve their quality of life and clinical outcomes. This study aimed to design and validate a paper-based tool, the PRS-SA survey, for assessing patient-reported symptoms and chemotherapy-related symptoms in South African oncology clinics.
Article
Oncology
Patrick Bou-Samra, Paul Scott, Hannah Cheng, Cramer Kallem, Ritambhara Pathak, David A. Geller, Wallis Marsh, Yisi Wang, Michael Antoni, Frank Penedo, Allan Tsung, Jennifer L. Steel
Summary: The study found that older age and lower perceived social support were significantly associated with poorer survival in gastrointestinal cancer patients.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Oncology
Jamie M. Jacobs, Kathryn Post, Katina Massad, Nora K. Horick, Emily A. Walsh, Julia Cohn, Chelsea S. Rapoport, Amy J. Clara, Michael H. Antoni, Steven A. Safren, Ann H. Partridge, Jeffrey M. Peppercorn, Elyse R. Park, Jennifer S. Temel, Joseph A. Greer
Summary: The study found that the telehealth intervention STRIDE showed promising results in reducing symptom distress and improving self-management, coping, quality of life, and mood among patients taking AET after breast cancer. The intervention was well-received by patients and should be further tested in larger trials.
Article
Geriatrics & Gerontology
Amie Zarling, Joseph Kim, Dan Russell, Carolyn Cutrona
Summary: This study examined the effectiveness of an online acceptance and commitment therapy (ACT) program in reducing loneliness among older adults in the community. The results showed significant improvements in loneliness, especially for individuals who were lonely at the beginning of the intervention.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Health Care Sciences & Services
Kate Loveys, Michael Antoni, Liesje Donkin, Mark Sagar, Elizabeth Broadbent
Summary: This study compared the feasibility and acceptability of virtual humans, teletherapy, and self-guided e-manuals in delivering stress management interventions. Results showed that all three technologies were feasible and acceptable for delivering one module of cognitive behavioral stress management to distressed adult women. The technologies had unique strengths and limitations that may depend on individual characteristics and specific circumstances.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Clinical
Ruth G. St Fleur, Sara M. St George, Daniel J. Feaster, Tae Kyoung Lee, Michael H. Antoni
Summary: The study examined the effects of cognitive behavioral therapy (CBT)-based group interventions on the quality of life (QoL) in breast cancer patients. It found that the intervention improved emotional and functional QoL by increasing benefit finding. This effect was particularly significant among patients with low optimism levels before surgery.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
