Article
Biochemistry & Molecular Biology
Eman I. Sobeh, Gamal El-ghannam, Reda M. S. Korany, H. M. Saleh, Souad A. Elfeky
Summary: This study reports the preparation of CUR/HA nanocomposite and its application in protecting male Wistar rats from the carcinogenic consequences of gamma irradiation. TEM and XRD analysis provided information on the morphology and structure of the nanosized HA nanoparticles and CUR/HA nanocomposite. Biochemical analysis and histological examinations demonstrated that CUR/HA nanocomposite injection did not significantly affect non-irradiation rats, but controlled the changes in pro-inflammatory cytokines, kidney function, and liver function when injected pre-irradiation. This research introduces a novel effective protection modality for the gamma irradiation hazard.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Li Wang, Xiangning Li, Fengming Chen, Qing Liu, Fuqiang Xu
Summary: Centrifugal projections in the olfactory system play a critical role in olfactory processing and behavior. This study identified the main inputs to mitral/tufted cells (M/TCs) in the olfactory bulb (OB) from the anterior olfactory nucleus (AON), piriform cortex (PC), and basal forebrain (BF). These inputs were differentially organized compared to the inputs to granule cells (GCs), with M/TCs receiving less input from primary olfactory cortical areas and more input from the BF and contralateral brain regions. Furthermore, cholinergic neurons in the BF innervated multiple layers of the OB, affecting both M/TCs and GCs. These findings suggest that centrifugal projections contribute to complementary and coordinated strategies in olfactory processing and behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Kristina Tekavec, Tanja Svara, Tanja Knific, Jernej Mlakar, Mitja Gombac, Carlo Cantile
Summary: Nerve sheath tumors (NSTs) are characterized by abnormal cell growth in various types of cells. Loss of H3K27me3 expression in a subset of MNSTs has been identified as a potential diagnostic marker. In a study of 68 canine tumors previously diagnosed as NST, 25% showed loss of H3K27me3 expression, 49% had mosaic loss of expression, and 26% retained expression. However, there were no significant correlations between H3K27me3 expression and histopathological features or other markers. More research is needed to evaluate the diagnostic value of H3K27me3 loss in canine NST.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sedat Giray Kandemirli, Aytug Altundag, Duzgun Yildirim, Deniz Esin Tekcan Sanli, Ozlem Saatci
Summary: This study evaluated 23 patients with persistent COVID-19 olfactory dysfunction, finding olfactory cleft and olfactory bulb abnormalities to be common in cases of COVID-19 anosmia. The study also revealed a relatively high percentage of olfactory bulb degeneration, indicating a need for further longitudinal imaging studies to better understand the mechanism of olfactory neuronal pathway injury in COVID-19 anosmia.
ACADEMIC RADIOLOGY
(2021)
Review
Clinical Neurology
Karina A. Lenartowicz, Anshit Goyal, Michelle L. Mauermann, Thomas J. Wilson, Robert J. Spinner
Summary: Intraneural perineurioma is a rare peripheral nerve sheath tumor characterized by localized proliferation of perineurial cells. It mainly affects major peripheral nerves and their branches, typically presenting in adolescents and young adults. Most cases are managed conservatively, while surgical treatment strategies vary.
WORLD NEUROSURGERY
(2021)
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Richard L. Doty
Summary: Decreased smell function is associated with brain health, mortality, and quality of life. Most COVID-19 patients experience some degree of smell dysfunction during the acute phase, with many being unaware of the loss. Long-term olfactory deficits occur in up to 30% of cases, but total anosmia is relatively rare. This review examines the nature and pathophysiology of olfactory dysfunction caused by the SARS-CoV-2 virus, including reversible inflammation in the olfactory cleft, downregulation of olfactory receptor proteins, and persistent damage to olfactory structures. It also addresses whether long-term smell loss may increase the risk of future cognitive and neurological deficits.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Mateo Torres, Irene Ortiz-Leal, Andrea Ferreiro, Jose Luis Rois, Pablo Sanchez-Quinteiro
Summary: Chemical senses play a crucial role in the survival of wild mammals. This study focuses on the neuroanatomical basis of the olfactory and accessory olfactory bulbs in meerkats. The results suggest that meerkats have a well-defined accessory olfactory bulb lamination pattern and a comparable level of development in the main olfactory bulb compared to other mammals. This study supports the functionality of the olfactory and vomeronasal integrative centers in meerkats and provides important information for understanding their chemical senses.
Article
Agriculture, Dairy & Animal Science
Stefano Aicardi, Matteo Bozzo, Andrea Amaroli, Lorenzo Gallus, Beatrice Risso, Erica Carlig, Davide Di Blasi, Marino Vacchi, Laura Ghigliotti, Sara Ferrando
Summary: This study provides a morphological description of the peripheral olfactory system of the Antarctic silverfish and uses quantitative methods. The head of the Antarctic silverfish is specialized to maintain contact between the olfactory organ and a large volume of water. The fish invests energy in the detection and processing of olfactory signals and relies considerably on olfaction.
Article
Plant Sciences
Ying Feng, Han Dong, Liyan Zheng
Summary: Ligustrazine was found to inhibit inflammation in Endometriosis (EMs) by regulating the STAT3/IGF2BP1/RELA axis. These findings propose a new agent against EMs and support the development of ligustrazine-based treatment strategies for EMs.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis Tsioufis, Panagiotis Theofilis, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary atherosclerosis is a chronic disease involving inflammation, endothelial dysfunction, and lipoprotein dysregulation. Inflammatory cytokines, such as interleukins, tumor necrosis factor-alpha, and chemokines, play a role in the development and progression of coronary artery disease. Targeting these cytokines with drugs like IL-1 beta and colchicine has shown promise in reducing cardiovascular risk. Other cytokine-targeted treatments are being explored, but more research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Chen, Zichen Bian, Jing Chen, Jialin Meng, Meng Zhang, Chaozhao Liang
Summary: This study analyzed immune mediators in patients with CP/CPPS and experimental autoimmune prostatitis, finding that TNF-α, IL-1β, IL-6, and IL-8 were elevated in most samples. The results suggest that immune responses play significant roles in the pathogenesis of CP/CPPS.
Article
Genetics & Heredity
Yinhao Wei, Zhongyi Zhao, Zhonghao Wang, Keyi Zhang, Zhuoyun Tang, Chuanmin Tao
Summary: The study identified associations between IL-1 beta, TNF-alpha gene polymorphisms and HBV infection, with IL-1 beta rs1143634, TNF-alpha rs1799724, and rs1799964 potentially serving as genetic biomarkers in HBV infection.
Article
Plant Sciences
Goutami G. Ambati, Kamalender Yadav, Ruchika Maurya, K. K. Kondepudi, Mahendra Bishnoi, Sanjay M. Jachak
Summary: Gymnosporia montana leaves have been traditionally used for toothache and inflammation, and this study demonstrated their significant anti-inflammatory activity through in vitro and in vivo assays.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
Victor H. Leyva-Grado, Gene S. Tan, Paul E. Leon, Mark Yondola, Peter Palese
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Microbiology
Victor H. Leyva-Grado, Megan E. Ermler, Michael Schotsaert, Ma G. Gonzalez, Virginia Gillespie, Jean K. Lim, Adolfo Garcia-Sastre
Article
Biochemistry & Molecular Biology
Victor H. Leyva-Grado, Rong Hai, Fiona Fernandes, Alan Belicha-Villanueva, Carol Carter, Mark A. Yondola
JOURNAL OF MOLECULAR BIOLOGY
(2014)
Article
Virology
Nicholas S. Heaton, Victor H. Leyva-Grado, Gene S. Tan, Dirk Eggink, Rong Hai, Peter Palese
JOURNAL OF VIROLOGY
(2013)
Article
Virology
David Riegger, Rong Hai, Dominik Dornfeld, Benjamin Maenz, Victor Leyva-Grado, Maria T. Sanchez-Aparicio, Randy A. Albrecht, Peter Palese, Otto Haller, Martin Schwemmle, Adolfo Garcia-Sastre, Georg Kochs, Mirco Schmolke
JOURNAL OF VIROLOGY
(2015)
Article
Virology
Florian Krammer, Rong Hai, Mark Yondola, Gene S. Tan, Victor H. Leyva-Grado, Alex B. Ryder, Matthew S. Miller, John K. Rose, Peter Palese, Adolfo Garcia-Sastre, Randy A. Albrecht
JOURNAL OF VIROLOGY
(2014)
Article
Multidisciplinary Sciences
Rong Hai, Mirco Schmolke, Victor H. Leyva-Grado, Rajagowthamee R. Thangavel, Irina Margine, Eric L. Jaffe, Florian Krammer, Alicia Solorzano, Adolfo Garcia-Sastre, Peter Palese, Nicole M. Bouvier
NATURE COMMUNICATIONS
(2013)
Article
Multidisciplinary Sciences
Mark J. Bailey, James Duehr, Harrison Dulin, Felix Broecker, Julia A. Brown, Fortuna O. Arumemi, Maria C. Bermudez Gonzalez, Victor H. Leyva-Grado, Matthew J. Evans, Viviana Simon, Jean K. Lim, Florian Krammer, Rong Hai, Peter Palese, Gene S. Tan
NATURE COMMUNICATIONS
(2018)
Article
Infectious Diseases
Mazyar Ziyaeyan, Mohammad Amin Behzadi, Victor Hugo Leyva-Grado, Kourosh Azizi, Gholamreza Pouladfar, Hedayat Dorzaban, Atoosa Ziyaeyan, Sanaz Salek, Aghyl Jaber Hashemi, Marzieh Jamalidoust
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Review
Microbiology
Mohammad Amin Behzadi, Victor H. Leyva-Grado
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Chemistry, Medicinal
Ryan O'Hanlon, Victor H. Leyva-Grado, Marion Sourisseau, Matthew J. Evans, Megan L. Shaw
ACS INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Mohammad Amin Behzadi, Victor Hugo Leyva-Grado, Mandana Namayandeh, Atoosa Ziyaeyan, Roya Feyznezhad, Hedayat Dorzaban, Marzieh Jamalidoust, Mazyar Ziyaeyan
BMC INFECTIOUS DISEASES
(2019)
Article
Immunology
Victor Leyva-Grado, Pavel Pugach, Nazlie Sadeghi-Latefi
Summary: Sore throat is a significant public health concern with few over-the-counter medications effectively treating the inflammation. A novel treatment containing low-dose ASA showed promise in reducing inflammation in the upper respiratory epithelia. Surprisingly, many common over-the-counter sore throat therapies were found to exacerbate inflammation, potentially leading to further respiratory complications.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Pharmacology & Pharmacy
Victor H. Leyva-Grado, Peter Palese
ANTIVIRAL RESEARCH
(2017)
Article
Immunology
Victor H. Leyva-Grado, Samira Mubareka, Florian Krammer, Washington B. Cardenas, Peter Palese
EMERGING INFECTIOUS DISEASES
(2012)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)