Article
Anesthesiology
Alexandra Sideris, Michael-Alexander Malahias, George Birch, Haoyan Zhong, Valeria Rotundo, Brian J. Like, Miguel Otero, Peter K. Sculco, Meghan Kirksey
Summary: This study investigated the cytokine profiles of patients undergoing TKA and found significant differences in four cytokines among those who developed persistent postoperative pain. Lower levels of IL-10 in prearthrotomy synovial fluid were associated with the development of persistent pain.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Article
Orthopedics
Nerea Goicoechea, Pedro Hinarejos, Raul Torres-Claramunt, Joan Leal-Blanquet, Juan Sanchez-Soler, Joan Carles Monllau
Summary: The study indicates that performing patellar denervation during total knee arthroplasty does not significantly improve anterior knee pain and clinical outcomes compared to patellar replacement without denervation.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Immunology
Nils Kappelmann, Darina Czamara, Nicolas Rost, Sylvain Moser, Vanessa Schmoll, Lucia Trastulla, Jan Stochl, Susanne Lucae, Elisabeth B. Binder, Golam M. Khandaker, Janine Arloth
Summary: Genetic predisposition to higher systemic inflammatory markers is primarily associated with somatic/neurovegetative symptoms of depression such as changes in appetite and fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Anesthesiology
M. T. Kluger, D. A. Rice, R. Borotkanics, G. N. Lewis, A. A. Somogyi, D. T. Barratt, M. Walker, P. J. McNair
Summary: Persistent pain following knee arthroplasty occurs in up to 20% of patients and is associated with pre-operative opioid use. Persistent opioid use >= 6 months after surgery is strongly associated with pre-operative opioid use, increased body mass index, and multiple comorbid pain sites.
Article
Orthopedics
Viju Daniel Varghese, David Liu, Donald Ngo, Suzanne Edwards
Summary: For patients undergoing total hip and knee arthroplasty, universal pre-operative iron studies and iron infusion may reduce the need for allogenic blood transfusions and are cost-neutral. Additionally, there is a potential benefit of diagnosing asymptomatic malignancies in patients. Further research is needed to confirm the true benefits of universal pre-operative iron screening.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Medicine, General & Internal
Tizian Heinz, Annette Eidmann, Philip Anderson, Manuel Weissenberger, Axel Jakuscheit, Maximilian Rudert, Ioannis Stratos
Summary: Alignment strategies for primary total knee arthroplasty have shifted towards a more individualized goal, with computer-assisted surgery gaining interest. However, the routine use of robotics and navigation for TKA remains unclear.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Anna M. Anderson, Christine Comer, Toby O. Smith, Benjamin T. Drew, Hemant Pandit, Deborah Antcliff, Anthony C. Redmond, Gretl A. McHugh
Summary: This study aimed to develop evidence- and consensus-based recommendations on pre-operative TKR education and prehabilitation. A comprehensive set of recommendations was developed through a three-round online modified Delphi study with a 60-member expert panel. The final recommendations include 34 education topics, 18 education delivery approaches, 10 exercise types, 13 exercise delivery approaches, and two other treatments, which will need to be interpreted and reviewed periodically in light of emerging evidence.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Thomas L. Bernasek, T. Kyle Stoops, Meera Gill, Corey Engel, Peter Simon
Summary: This study compared the clinical outcomes of cruciate-retaining and posterior-stabilized total knee arthroplasty, showing significant improvement in both at a minimum 2-year follow-up without differences in passive range of motion, Knee Society Scores, or stair function postoperatively.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Timothy Rooney, Robert L. Barrack, John C. Clohisy, Ryan M. Nunley, Charles M. Lawrie
Summary: The study investigated the use of apixaban for VTE prophylaxis after primary THA and TKA in patients at high risk for VTE, previously on apixaban, and with contraindication to aspirin. The results showed a low risk of VTE and bleeding complications in this patient population.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Orthopedics
Chang-Rack Lee, Chang-Wan Kim, Dae-Hyun Park, Yong-Uk Kwon, Jun-Min Yoon
Summary: This study aimed to evaluate whether there is a difference in infection rates between septic and aseptic revision total knee arthroplasty (TKA). The results showed that septic revision TKA had a higher infection rate.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Neurosciences
Asmahan Elgellaie, Susan J. J. Thomas, Jacqueline Kaelle, Jessica Bartschi, Theresa Larkin
Summary: This study found that pro-inflammatory cytokines IL-1 alpha, IL-6, and TNF-alpha are associated with major depressive disorder, psychological distress, cardiovascular health, and obesity. However, there is limited research on the multiple associations between these variables, especially among untreated individuals with major depressive disorder, compared to a control group, and including sex differences. The study analyzed data from 60 individuals with major depressive disorder and 60 controls, measuring various factors such as plasma levels of cytokines, adiposity measures, cardiovascular health indices, and psychological symptoms. The results showed that plasma IL-1 alpha and IL-6 were higher in the major depressive disorder group compared to the control group, with a sex interaction observed for IL-6. TNF-alpha did not differ between the groups. Moreover, IL-1 alpha and IL-6 were correlated with depressive severity, anxiety, hostility, and stress, while TNF-alpha only correlated with anxiety and hostility. The association between psychopathology and pro-inflammatory cytokines varied by sex. None of the cytokines were correlated with measures of adiposity, cardiovascular health indices, or psychological health. The findings suggest that the group by sex interaction for IL-6 and the sex-specific associations between pro-inflammatory cytokines and psychometrics could have important implications for depression interventions and treatments, particularly for females. Further research is warranted.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Orthopedics
Mohammad S. Abdelaal, Daniel Calem, Matthew B. Sherman, Peter F. Sharkey
Summary: This study compared the safety and complications of simultaneous bilateral total knee arthroplasty (sim-BTKA) with staged surgery (stag-BTKA), finding that sim-BTKA is associated with more complications and revisions. Performing the second-stage TKA within 90 days after the first TKA does not increase the risk of complications.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Biology
Liming Shu, Jiang Yao, Ko Yamamoto, Takashi Sato, Naohiko Sugita
Summary: The study developed a musculoskeletal model with detailed constraints under dynamic loadings to simulate knee joint kinematics, demonstrating high predictive accuracy in mimicking knee joint dynamics.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Orthopedics
Frank Graef, Hagen Hommel, Roman Falk, Serafeim Tsitsilonis, Robert Karl Zahn, Carsten Perka
Summary: This study found that excessive correction of the knee joint position in TKA surgery is associated with increased postoperative ankle symptoms in patients with high-grade valgus osteoarthritis. Surgeons should be aware that performing TKA surgery in these patients may trigger or worsen ankle symptoms, especially in cases with a stiff subtalar joint.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)